• Journal of Pharmaceutical Investigation
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• 제32권1호
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• pp.47-54
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• 2002

Cimetropium bromide, a quaternary ammonium compound which is chemically related to scopolamine, exhibits its antispasmodic activity by competing with acetylcholine for the muscarinic receptors of the smooth muscle of gastrointestinal tract. The drug has been used for the treatment of various disorders involving spasms of the musculature of the gastrointestinal, biliary and genitourinary tracts. The purpose of the present study was to evaluate the bioequivalence of two cimetropium bromide tablets, $Algiron^{TM}$ (Boehringer Ingelheim Korea Ltd.) and $Alpit^{TM}$ (Hana Pharmaceutical Co., Ltd.), according to the prior and revised guidelines of Korea Food and Drug Administration (KFDA). The cimetropium bromide release from the two cimetropium bromide tablets in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty normal male volunteers, $25.25{\pm}2.10$ years in age and $65.76{\pm}6.39$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After three tablets containing 50 mg of cimetropium bromide per tablet were orally administered, blood was taken at predetermined time intervals and the concentrations of cimetropium bromide in serum were determined using HPLC method with UV detector. The dissolution profiles of two cimetropium bromide tablets were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using non-transformed and logarithmically transformed $AUC_t\;and\;C_{max}$. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets based on the $Algiron^{TM}$ were 2.19%, -5.97% and 3.49%, respectively. Minimum detectable differences $({\Delta})\;at \;{\alpha}=0.05\;and\;1-{\beta}=0.8$ were less than 20% (e.g., 13.71 %, 19.05% and 15.11% for $AUC_t,\;C_{max}\;and\;T_{max}$, respectively). The powers $(1-{\beta})\;at\;{\alpha}=0.05,\;{\Delta}=0.2\;for\;AUC_t$, $C_{max}\;and\;T_{max}$ were 97.79%, 83.22% and 95.60%, respectively. The 90% confidence intervals were within ${\pm}20%$ (e.g., $-5.84{\sim}10.21,\;-17.11{\sim}5.18\;and\;-5.35{\sim}12.33\;for\;AUC_t,\;C_{max}\;and\;T_{max}$, respectively). There were no sequence effect between two tablets in logarithmically transformed $AUC_t\;and\;C_{max}$. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., $0.94{\sim}1.10\;and\;0.85{\sim}1.05\;for\;AUC_t\;and\;C_{max}$, respectively). Two parameters met the criteria of prior and revised KFDA guideline for bioequivalence, indicating that $Alpit^{TM}$ tablet is bioequivalent to $Algiron^{TM}$ tablet.

• 대한물리의학회지
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• 제3권2호
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• pp.135-144
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• 2008

Purpose : The purpose of this study was to identify the effect of body weight support treadmill training (BWSTT) and parallel bar gait training(P-bar) on gait and balance ability of subacute stroke patients. The subjects were consisted of 27 patients with subacute stroke, and they were randomly devided into two groups which were BWSTT group and P-bar group. Method : The timed up and go(TUG), 10m gait speed were used to measure gait speed, Bergs balance scale(BBS) was used to measure dynamic balance ability, and balance performance monitor(BPM) was used to measure sway area, sway path, max velocity. Result : 1. The TUG and 10m gait speed of BWSTT group and P-bar group were significantly decreased (p<.05). The TUG and 10m gait speed were different significantly between BWSTT group and P-bar group(p<.05). 2. The BBS and sway area of BWSTT group and P-bar group were significantly decreased (p<.05). The BBS and sway area were not different significantly between BWSTT group and P-bar group(p>.05). 3. The sway path and max velocity of BWSTT group and P-bar group were significantly decreased (p<.05). The sway path and max velocity were not different significantly between BWSTI group and P-bar group(p>.05). Conclusion : The outcomes suggest that patient with subacute stroke can improve their gait and balance through body weight support treadmill training.

• 환경생물
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• 제24권2호
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• pp.179-185
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• 2006

자연산 및 양식산 민어, Miichthys miiuy의 체성분 및 탄력의 계절적 변화를 조사하였다. 민어육에 대하여 수분, 조단백질, 지방, 회분 및 아미노산 조성을 자연산과 양식으로 구분하고 아울러 비교 분석하였다. 양식산 민어는 천연산에 비해 수분함량이 다소 많은 반면 조단백질, 조지방 함량은 약간 적었으나 대체로 성분조성이 비슷하였다. 아미노산 함유량의 경우 전체적으로 자연산이 양식산 민어육보다 함량이 높은 경향을 나타내었다. 이러한 결과는 필수아미노산과 아미노산의 비에서도 위와 유사한 경향을 보였으며, 필수아미노산과 전체 아미노산의 비는 자연산과 양식산 모두 같거나 비교적 큰 차이를 나타내지 않았다. 불포화지방산인 EPA (Eicosapentaenoic Acid)와 DHA (Docosahexaenoic Acid) 조성은 자연산보다 양식산에서 높게 나타났다. 민어육의 탄력을 나타낸 gel strength, max weight 및 hardness는 자연산이 양식산에 비해 높은 경향을 나타냈었다.

• 화약ㆍ발파
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• 제20권2호
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• pp.21-31
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• 2002

We did bench blasting upon the natural rock which it's uniaxial compressive strength was about $1,420~1,476kgf/\textrm{cm}^2$. This is the results we inferred after measuring, analyzing the ground vibration velocity of the front and back direction from the free face of the bench blasting. We have to induce the square and cube root scaled equation and the general equation to guarantee confidence upon the data when analyzing the measurement data of the test blasting. The variable distance is in reverse proportion to the permitted ground vibration velocity. The shorter is the exploding point to a protection structure, the bigger is the reflection that the direction of the free face experts the ground vibration velocity, The ground vibration velocity front of the free face tends become reduced about 38~46% compare with back of the free face in the range that the permitted ground vibration velocity is 2.0~5.0mm/sec. In case of 2.0mm/sec, when a protection structure is within about 95m, the max. allowable charge weight per delay on positing front of the free face can be more used about 2.61 times than that on positing back of the free face, in case of 3.0mm/sec within about 78m more about 2.38 times, in case of 5.0mm/sec within 60m more about 2.10 times. In case of 2.0~5.0mm/sec when a protection structure is within about 200m front from the free face, the max. allowable charge weight per delay can become about 1.52 times than the case on back to the free face.

• 한국작물학회지
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• 제45권2호
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• pp.88-92
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• 2000

Excessive soil water in paddy field induces growth losses during the vegetative stages of soybean plants. Our objectives were to know growth responses of soybean as affected by the level of ridge heights. A field experiment was conducted at the Research Farm of Korea University near Seoul in 1996. Ten cultivars of soybean (Glycine max (L.) Merrill) were planted at the ridge heights of 10, 30, and 50cm in paddy soil on 27 June. Total dry matter accumulation at the 10cm ridge height was severely decreased until the growth stage of R5 as compared to the ridge heights of 30 and 50cm, and this decrement was mainly due to both reduced leaf and stem dry weights. However, seed dry weight was not significantly decreased at the lower ridge height with the increment of harvest index. Cultivar differences were found on seed dry weight, crop growth rate from R1 to R5, and leaf/stem ratio of R5. From the above results, soybean growth responses to excessive soil water in paddy field were different between seed filling stage and late vegetative to early reproductive growth stages.

• 한국작물학회지
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• 제45권5호
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• pp.282-287
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• 2000

Soybean [Glycine max (L.) Merrill] crops, grown in a rice soybean rotation, can suffer when grown in soil with excessive moisture. The objective of this work were to determine the reduction in growth and yield, responses of vegetative and reproductive growth of soybean to excessive soil moisture achieved by prolonged irrigation. Responses of different cultivars were determined at growth stages from V6 to R8 to clarify the sensitive growth stages or characteristics to excessive soil moisture. Cultivar differences in response to excessive soil moisture condition were conspicuous in seed dry weight and harvest index (HI) but not in the response of seed number or pod number per plant. The timing of irrigation causing the condition of excessive soil moisture influenced the vegetative or reproductive traits. Soybean plants were more affected by irrigation commencing at the pre-flowering than at the post-flowering stage. Post-flowering irrigation did not reduce growth of vegetative organs significantly; in fact the growth of stems and leaves was facilitated by the prolonged irrigation commencing at flowering. Differences between cultivar response to prolonged irrigation were assumed to relate to the reduced amount of assimilates translocated to the reproductive organ.

• Mycobiology
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• 제34권1호
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• pp.34-37
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• 2006

Growth responses of Zea mays and Glycine max to colonization by mixture of combination of three species of arbuscular mycorrhizal (AM) fungi, two species of Glomus and a species of Scutellospora were compared. In Zea mays, plants inoculated with single species of AM fungi showed significantly higher in dry weight than non-mycorrhizal plant for all three AM fungal species. Also, growth of plants inoculated with spores of two species of AM fungi was significantly higher than nonmycorrhizal control except for plants inoculated with two Glomus species. When three species of AM fungi were inoculated, the plants showed the highest growth. In Glycine max, plants with single AM fungal species inoculation were not significantly different in plant growth from nonmycorrhizal plants. When the plants were inoculated with combination of two or more AM fungal species, their growth significantly increased compared to nonmycorrhizal plants. In both plant species, mycorrhizal root colonization by Scutellospora species was significantly lower than by Glomus species.

• 한국식품영양과학회지
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• 제38권10호
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• pp.1430-1437
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• 2009

다시마를 Vibrio sp.로 분해하여 제조한 SCD로 기능성 빵을 만들기 위하여 mixture design을 이용한 원료의 최적 배합 비율을 구하였다. 다시마 SCD 빵의 max weight, strength, hardness 및 비용적의 값은 밀가루와 물의 첨가량이 증가할수록 감소하는 반면, SCD의 첨가량이 증가할수록 증가하였다. 밀가루와 물의 첨가량이 증가할수록 SCD의 첨가량이 감소할수록 발효팽창력의 값은 증가하였다. 밀가루의 첨가량이 증가할수록 SCD의 첨가량이 감소할수록 SCD 빵의 L(명도) 값과 b(황색도) 값은 증가하였으며, 밀가루와 물의 첨가량이 증가할수록 SCD의 첨가량이 감소할수록 다시마 SCD 빵의 a(적색도) 값은 감소하였다. ANOVA 분석에 의한 다시마 SCD 빵의 max weight, strength, hardness, 비용적, 색도 b(황색도) 값 및 수분흡착력은 linear model이 결정되었으며, distance, 발효팽창력, 색도 L(명도) 및 a(적색도) 값은 nonlinear model(quadratic model)이 선정되었다. Constraint coefficient 값의 분석 결과 SCD는 SCD 빵의 texture에 가장 큰 영향을 주었으며, 물은 발효팽창력, 비용적 및 수분흡착력에 가장 큰 영향을 미쳤다. 또한 밀가루는 SCD 빵의 색도에 가장 큰 영향을 미쳤다. Distance에서는 flour-SCD 및 water-SCD 상호작용이 있었으며, 발효팽창력에서는 flour-SCD 상호작용이 있었다. 또한 SCD 빵 색도의 L(명도)에서는 flour-SCD의 상호작용이 나타났으며, a (적색도)에서는 flour-SCD 및 water-SCD 상호작용이 있었다. Mixture(modified distance) design에 의해 결정된 다시마 SCD 빵의 밀가루, 물 및 SCD의 최적 배합비율은 각각 48.25, 30.89 및 3.86%이었다. 관능검사 결과 전해수로 처리한 SCD 빵은 시중제품보다 모든 면에서 품질이 낮았으나, 전해수 처리 SCD 빵은 대조구(전해수 미처리)보다 월등히 높은 점수를 받아 전해수로 처리된 SCD 빵의 맛, 조직감 및 향을 개선한다면 SCD의 산업화가 가능할거라 판단된다.

• 한국자원식물학회지
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• 제9권1호
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• pp.23-29
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• 1996

원황정(原黃精)(충층둥글레) 재배시(栽培時) 적합(適合)한 종근(種根)을 선발(選拔)하고자, 청주(淸州)와 제천(提川)에서 충북(忠北) 지방(地方) 재래종(在來種)을 공시(供試)하여, 종근(種根)의 크기를 15g, 30g, 45g, 60g($\pm2g$) 별로 시험(試驗)을 수행(遂行)한 결과를 요약하면 다음과 같다. 1. 출현기(出現期)는 파종(播種) 당년(當年)에는 제천(提川)보다 청주(淸州)에서 5일 늦었으나 파종(播種) 2 - 3년차(年次)부터는 제천(提川)보다 청주(淸州)에서 4 - 7일 빨랐으며 작은 종근(種根)보다 큰 종근(種根)일수록 빨라지는 경향(傾向)이었다. 2. 초장(草長)과 경장(莖長)은 청주(淸州)보다 제천(提川)에서 짧았고 종근간(種根間)에는 15g 종근(種根)보다 60g 종근(種根)에서 더 길었다. 3 엽장(葉長)은 청주(淸州)보다 제천(提川)에서 짧았고 종근간(種根間)에는 청주(淸州), 제천(提川) 공히 15g 종근(種根) < 30g < 45g < 60g 종근(種根) 순(順)으로 큰 종근(種根)에서 길었으며 엽폭(葉幅)은 큰차이(差異)가 없었다. 4. 10a당 수량(收量)은 청주(淸州), 제천(提川) 공히 1,600kg/10a 이었으나 종근간(種根間)에서 15g의 종근(種根) 청주(淸州) 869kg, 제천(提川) 830kg에 비(比)하여 30g은 64 - 79%, 45g은 111 - 135%, 60g 종근(種根)은 157 - 161%가 각각 증수(增收)되었으나 중부지방(中部地方)에서 원황정(原黃精) 재배시(栽培時) 종근비(種根費) 등을 고려(考慮)하면 45g 내외(內外)의 종근(種根)이 유리(有利) 할 것으로 판단(判斷) 되었다.

• 분석과학
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• 제9권2호
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• pp.134-138
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• 1996

봄무우 유식물에서 $Cd^{2+}$ 은 자엽, 줄기와 뿌리에서 그의 독특한 운반자를 통해서 세포 내로 수송되었다. $Cd^{2+}$의 수송은 대사 방해물질인 DNP에 의해 방해되었다. $Cd^{2+}$의 운반자에 대한 $K_m$ 값은 자엽은 0.77ppm, 줄기는 1.72ppm, 뿌리는 0.33ppm이고, $V_{max}$는 자엽에서 $400ppm{\cdot}h^{-1}{\cdot}g{\cdot}fresh\;weight^{-1}$, 줄기에서는 $313ppm{\cdot}h^{-1}{\cdot}g{\cdot}fresh\;weight^{-1}$, 뿌리에서는 $606ppm{\cdot}h^{-1}{\cdot}g{\cdot}fresh\;weight^{-1}$이다. 봄무우 유식물에서 $Cd^{2+}$은 세포내에 proline의 축적을 유도시키지 못했다. 그러므로 세포내에 proline의 축적을 환경오염의 척도로 사용할 수 없다.