• Korean Chemical Engineering Research
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• v.54 no.3
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• pp.340-349
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• 2016

Electro oxidation system was designed in this study for the reduction of COD (Chemical Oxygen Demand) from high-strength wastewater, produced during refinery turnaround period. First, BDD (Boron Doped Diamond) electrode was synthesized and electro oxidation system of actual industrial wastewater was developed by adopting the synthesized BDD electrode. The experiments were carried out under various operating conditions under certain range of current density, pH, electrolyte concentration and reaction time. Secondly, reaction kinetics were identified based on the experimental results, and the kinetics were embedded into a genetic mathematical model of the electro oxidation system. Lastly, design and operating parameters of the process were optimized to maximize the efficiency of the pretreatment system. The coefficient of determination ($R^2$) of the model was found to be 0.982, and it proved high accuracy of the model compared with experimental results.

• Proceedings of the IEEK Conference
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• 2001.10a
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• pp.393-397
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• 2001

The innovatory process, that is the direct separation and recovery of the iron and zinc metals contained in the high temperature exhaust gas generated from the electric arc furnace fer the inn scrap melting and/or the dust treatment, has been proposed. This proposed process consists of the moving coke bed filter that is directly connected to the electric furnace, and the following heavy metal condenser. The exhaust gas passes through the filter and the condenser right after exhausting from the electric furnace. The moving coke bed filter is being controlled at about 1000℃ and collects iron and slag components contained in the high temperature exhaust gas. Heavy metals such as zinc and lead pass through the filter as vapor. Based on the thermodynamic considerations, the iron oxide and the zinc oxide are reduced in the filter. The solution loss reaction rate is comparatively low at about 1000℃ in the coke bed filter by the analysis using the mathematical simulation model. The heavy metal condenser is installed in the position after the coke bed filter, and rapidly cools the gas from about 1000℃ to 450℃ by a full of the cooling medium like the solid ceramic ball in addition to the cooling from the wall. The zinc and lead vapor condense and separate f개m the gas in a liquid state. The investigation of the characteristics of the exhaust gas of the commercial electric arc furnace, the fundamental experiments of the laboratory scale and the bench scale ensured the formation of this proposed process. A small-scale pilot plant examination is carrying out at present to confirm the formation of the process. It is certain that the dust generation of the electric arc furnace is extremely decreased, and it can save the energy consumption of usual dust treatment processes by the realization of this process.

• Journal of Korean Society on Water Environment
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• v.30 no.3
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• pp.269-282
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• 2014

The objective of this study is to find out whether the developed semi-empirical biofilm model can be applicable to real BAF pilot-scale wastewater treatment. In addition, the optimum operating conditions of BAF as a function of process variables such as organic loading change can be drawn based on the simulation results of model. The results will provide the economic and efficient BAF process design and operating control. As a result, developed semi-empirical biofilm model which is relatively simple compared to mathematical model can simulate three BAF processes consisted of 25 layers within 1 seconds. When this model was used for simulating real pilot scale BAF process and the simulated water quality values were compared to experimental ones, simulated TCOD, SCOD, TN, $NH_4{^+}$-N, $NO_x{^-}$-N, alkalinity values were different to experimental ones within 21%, 20%, 8.1%, 48%, 10%, and 23%, respectively. Therefore, if the BAF system was equipped with automatic control, the BAF process can be better efficiently adapted under the condition of significant change of influent loading.

• Molecules and Cells
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• v.38 no.5
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• pp.416-425
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• 2015

NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor, has recently received a great deal of attention as an important molecule that enhances antioxidative defenses and induces resistance to chemotherapy or radiotherapy. In this study, we investigated the apoptosis-inducing and Nrf2- upregulating effects of quercetin on malignant mesothelioma (MM) MSTO-211H and H2452 cells. Quercetin treatment inhibited cell growth and led to upregulation of Nrf2 at both the mRNA and protein levels without altering the ubiquitination and extending the half-life of the Nrf2 protein. Following treatment with quercetin, analyses of the nuclear level of Nrf2, Nrf2 antioxidant response element-binding assay, Nrf2 promoter-luc assay, and RT-PCR toward the Nrf2-regulated gene, heme oxygenase-1, demonstrated that the induced Nrf2 is transcriptionally active. Knockdown of Nrf2 expression with siRNA enhanced cytotoxicity due to the induction of apoptosis, as evidenced by an increase in the level of proapoptotic Bax, a decrease in the level of antiapoptotic Bcl-2 with enhanced cleavage of caspase-3 and PARP proteins, the appearance of a sub-$G_0/G_1$ peak in the flow cytometric assay, and increased percentage of apoptotic propensities in the annexin V binding assay. Effective reversal of apoptosis was observed following pretreatment with the pan-caspase inhibitor Z-VAD. Moreover, Nrf2 knockdown exhibited increased sensitivity to the anticancer drug, cisplatin, presumably by potentiating the oxidative stress induced by cisplatin. Collectively, our data demonstrate the importance of Nrf2 in cytoprotection, survival, and drug resistance with implications for the potential significance of targeting Nrf2 as a promising strategy for overcoming resistance to chemotherapeutics in MM.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.449-449
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• 2011

We reported the direct effect of intrinsic surface energy of dry adhesive material to the Van der Waals and capillary forces contributions of the total adhesion force in an artificial gecko-inspired adhesion system. To mimic the gecko foot we fabricated tilted nanohairy structures using both lithography and ion beam treatment. The nanohairy structures were replicated from Si wafer mold using UV curable polymeric materials. The control of nanohairs slanting angles was based on the uniform linear argon ion irradiation to the nanohairy polymeric surface. The surface energy was studied utilizing subsequent conventional oxygen ion treatment on the nanohairy structures which resulted in gradient surface energy. Our shear adhesion test results were found in good agreement with the accepted Van der Waals and capillary forces theory in the gecko adhesion system. Surface energy would give a direct impact to the effective Hamaker constant in Van der Waals force and the filling angle (${\varphi}$) of water meniscus in capillary force contributions of gecko inspired adhesion system. With the increasing surface energy, the effective Hamaker constant also increased but the filling angle decreased, resulting in a competition between the two forces. Using a simple mathematical model, we compared our experimental results to show the quantitative contributions of Van der Waals and capillary forces in a single adhesion system on both hydrophobic and hydrophilic surfaces. We found that the Van der Waals force contributes about 82.75% and 89.97% to the total adhesion force on hydrophilic and hydrophobic test surfaces, respectively, while the remaining contribution was occupied by capillary force. We also showed that it is possible to design ultrahigh dry adhesive with adhesion strength of more than 10 times higher than apparent gecko adhesion force by controlling the surface energy and the slanting angle induced-contact line of dry adhesive the materials.

• Journal of the Society of Naval Architects of Korea
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• v.43 no.1 s.145
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• pp.15-21
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• 2006

Recently, the attention to large container ships whose size is greater than 10,000 TEU container ship has been increased due to their increasing demand. The large container ship has twin skegs because of the engine capacity and large beam-draft ratio. In this paper, the maneuvering characteristics of a container ship with twin skegs were investigated through 4DOF(four degree of freedom) HPMM(Horizontal Planar Motion Mechanism) test and computer simulation. A mathematical model for maneuvering motion with 4DOF of twin skegs system was established to include effects of roll motion on the maneuvering motion. And to obtain roll-coupling hydrodynamic coefficients of a container ship, 4DOF HPMM system of MOERI which has a roll moment measurement system was used. HPMM tests were carried out for a 12,000 TEU class container ship with twin skegs at scantling load condition. Using the hydrodynamic coefficients obtained, simulations were made to predict the maneuvering motion. Rudder forces of twin-rudders were measured at the angles of drift and rudder. The neutral rudder angles with drift angles of ship was quite different with those of single skeg ship. So other treatment of flow straightening coefficient $\gamma_R$ was used and the simulation results was compared with general simulation result. The treatment of experimental result at static drift and rudder test was very important to predict the maneuverability of a container ship with twin skegs.

• Membrane and Water Treatment
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• v.2 no.3
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• pp.159-173
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• 2011

The air gap membrane distillation (AGMD) process was applied for water desalination. The main objective of the present work was to study the heat and mass transfer mechanism of the process. The experiments were performed on a flat sheet module using aqueous NaCl solutions as a feed. The membrane employed was hydrophobic PTFE of pore size 0.22 ${\mu}m$. A mathematical model is proposed to evaluate the membrane mass transfer coefficient, thermal boundary layers' heat transfer coefficients, membrane / liquid interface temperatures and the temperature polarization coefficients. The mass transfer model was validated by the experimentally and fitted well with the combined Knudsen and molecular diffusion mechanism. The mass transfer coefficient increased with an increase in feed bulk temperature. The experimental parameters such as, feed temperature, 313 to 333 K, feed velocity, 0.8 to 1.8 m/s (turbulent flow region) were analyzed. The permeation fluxes increased with feed temperature and velocity. The effect of feed bulk temperature on the boundary layers' heat transfer coefficients was shown and fairly discussed. The temperature polarization coefficient increased with feed velocity and decreased with temperature. The values obtained were 0.56 to 0.82, indicating the effective heat transfer of the system. The fouling was observed during the 90 h experimental run in the application of natural ground water and seawater. The time dependent fouling resistance can be added in the total transport resistance.

• 한국생물공학회:학술대회논문집
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• 2000.04a
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• pp.370-373
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• 2000

In this work, an extractive membrane bioreactor containing coulture broth of Burkholderia cepacia G4 PR1 constitutively expressing the TCE-degrading enzyme, tolune-ortho-monooxygenase(TOM), was used for the degradation of TCE. The membrane bioreactor operates by seperating the TCE-containing waste gas from the aerated biomedium, by which the air-stripping of TCE without degradation was overcome that could occur in conventional aerobic biological treatments of TCE-contaminated waste gases. This was achieved by a silicone rubber membrane which was coiled around a perspex draft tube. TCE from the gas phase diffuses across the silicone rubber membrane into microbial culture broth that was continuously fed from a separate aerobic CSTR. Therefore, TCE degradation occured without the TCE being directly exposed to the aerating gas stream. Of the TCE supplied to the membrane bioreactor, 72.6% was biodegraded during the operation of this system. To construct a mathematical model for this system, parameters describing microbial growth kinetics on TCE were determined using a CSTR bioreactor. Else parameters used for numerical simulation were determined from either indepedent experiments or values reported in the literature. The model was compared with the experimental data, and there was a good agreement between the predicted and the measured TCE concentrations in the system. To achieve a higher treatment efficiency, various operating conditions were simulated as well.

• Journal of applied mathematics & informatics
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• v.31 no.5_6
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• pp.747-767
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• 2013

In this paper we have constructed a mathematical model of alcohol abuse which consists of four compartments corresponding to four population classes, namely, moderate and occasional drinkers, heavy drinkers, drinkers in treatment and temporarily recovered class. Basic reproduction number $R_0$ has been determined and sensitivity analysis of $R_0$ indicates that ${\beta}1$ (the transmission coefficient from moderate and occasional drinker to heavy drinker) is the most useful parameter for preventing drinking habit. Stability analysis of the model is made using the basic reproduction number. The model is locally asymptotically stable at disease free or problem free equilibrium (DFE) $E_0$ when $R_0<1$. It is found that, when $R_0=1$, a backward bifurcation can occur and when $R_0>1$, the endemic equilibrium $E^*$ becomes stable. Further analysis gives the global asymptotic stability of DFE under some conditions. Our important analytical findings are illustrated through computer simulation. Epidemiological implications of our analytical findings are addressed critically.

• Journal of KSNVE
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• v.7 no.6
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• pp.993-1000
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• 1997

This paper presents a new technique of mathematical treatment using a finite element model for analyzing the vibration of the towed line array. Since the towed line array has the axisymmetricity, axisymmetric elements are used in finite element modeling for the towed array structure. The fluid-structure interaction is also considered. The array consists of a series of identical substructures which can include internal structures such as spacers, hydrophones and ropes. That periodicity of substrucutres permits the substructure synthesis technique using characteristic wave guide for analyzing the response of towed array system. This synthesis technique can reduce the cost of computing the array response. It is suggested that a response of towed array can be computed by the finite element method and substructure synthesis technique using wave guide. Several experiments for towed array were performed to verify the present computation technique. The predicted vibration for the towed array shows good agreement with the measured result.