• YAKHAK HOEJI
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• v.55 no.6
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• pp.466-472
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• 2011

NF-E2-related factor 2 (Nrf2), a master regulator of antioxidant genes in animals, has been associated with the resistance of cancer cells to several cytotoxic chemotherapeutics. Bortezomib, a reversible inhibitor of the 26S proteasome, is a novel class anti-cancer therapeutics approved for the treatment of refractory multiple myeloma. However, the molecular mechanism of drug-resistance remains elusive. In the present study, bortezomib sensitivity has been investigated in Nrf2 knockdown ovarian cancer cells. When Nrf2 expression is stably repressed using interfering RNA expression, bortezomib-induced apoptosis and cell death were significantly enhanced compared to nonspecific RNA control cells. Knockdown cells showed elevated expression in the catalytic subunit PSMB5, PSMB6, and PSMB7 compared to the control, and failed to induce heme oxygenase-1 expression following bortezomib treatment. These indicate that differential proteasome levels and altered expression of stress-response genes could be underlying mechanisms of bortezomib sensitization in Nrf2-inhibited ovarian cancer cells.

• Journal of Institute of Control, Robotics and Systems
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• v.16 no.3
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• pp.293-299
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• 2010

The multiple block localization method in a wide area for multiple robots using iGS is proposed in this paper. The iGS is developed for the indoor global localization using ultrasonic and RF sensors. To measure the distance between a mobile robot and a beacon, the tag on the mobile robot wakes up one beacon to send out the ultrasonic signal and measures the traveling time from the beacon to the mobile robot. As the number of robots is increased, the sampling time of localization also becomes longer. Note that only one robot can localize its own position calling beacons one by one during each of the sampling interval. This is a severe constraint for the localization of multiple robots in a wide area. This paper proposes an efficient localization algorithm for the multiple robots in a wide area which can be divided into multiple blocks. For a given block, a master beacon is designated to synchronize robots. By the access of the synchronization signal, each beacon in the selected group sends out an ultrasonic signal. When the robots in the block receive the ultrasonic signal, they can calculate their own locations based on the distances to the beacons, which are obtained by the multiplication of flight time and velocity of the ultrasonic signal. The efficiency of the algorithm is verified through the real experiments.

• Journal of Institute of Control, Robotics and Systems
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• v.18 no.2
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• pp.156-160
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• 2012

In this paper, we investigate the effect of asynchronous haptic and video feedback on the performance of teleoperation. To analyze the effect, a tele-manipulation experiment is specially designed, which operator moves square objects from one place to another place by using master/slave telerobotic system. Task completion time and total number of falling of the object are used for evaluating the performance. Subjective study was conducted with 10 subjects in 16 different combinations of video and haptic feedback while participants didn't have any prior information about the amount of each delay. Initially we assume that synchronized haptic and video feedback would give best performance. However as a result, we found that the accuracy was increased when haptic and video feedback was synchronized, and the completion time was decreased when one of the feedback (either haptic or video) was decreased. Another interesting fact that we found in this experiment is that it showed even better accuracy when haptic information arrives little bit earlier than video information, than the case when those are synchronized.

• The KIPS Transactions:PartC
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• v.9C no.6
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• pp.953-960
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• 2002

Rel-time application programs have constraints which need to be met between media-data. It is client-leading synchronization that is absorbing variable transmission delay time and that is synchronizing by feedback control and palyout control. It is the important factor for playback rate and QoS if the buffer level is normal or not. This paper, The method of maintenance buffer normal state transmits in multimedia server by appling feedback of filtering function. And synchronization method is processing adaptive playout time for smooth presentation without cut-off while media frame is skip. When audio frame which is master media is in upper threshold buffer level we decrease play out time gradually, low threshold buffer level increase it slowly.

• The KIPS Transactions:PartC
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• v.10C no.4
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• pp.493-500
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• 2003

In this paper, we defined agent interface standard and messages for the control and management of agent. Agent interface is defined by messages exchanged between each component of the agent system environment, such as agent, agent system that creates and controls the agent, client that requests the service, agent master that mediates the service, agent manager that performs management functions of the agent. Agent interface is defined after the MAF of the OMG and the agent standard of the FIPA. Experiments are done for the application using agent interface and messages of this paper. The test network was the content distribution network using agent service, and we controled and managed the test network through the agent interface.

• Journal of Drive and Control
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• v.17 no.4
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• pp.152-159
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• 2020

This study reviews the rear or tag axle steering system's concepts and technology applied to commercial vehicles. Most commercial vehicles are large in size with more than two axles. Maneuvering them around tight corners, narrow roads, and spaces is a difficult job if only the front axle is steerable. Furthermore, wear and tear in tires will increase as turn angle and number of axles are increased. This problem can be solved using rear axle steering technology that is being used in commercial vehicles nowadays. Rear axle steering system technology uses a cylinder mounted on one of rear axles called a steering cylinder. Cylinder control is the primary objective of the real axle steering system. There are two types of such steering mechanisms. One uses master and slave cylinder concept while the other concept is relatively new. It goes by the name of smart axle, self-steered axle, or smart steering axle driven independently from the front wheel steering. All these different types of steering mechanisms are discussed in this study with detailed description, advantages, disadvantages, and safety considerations.

• Nuclear Engineering and Technology
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• v.56 no.6
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• pp.2428-2435
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• 2024

Training for radiation protection and control requires a visual understanding of radiation, which cannot be perceived by the human senses. Trainees must also master the effective use of measuring instruments. Traditionally, such training has exposed trainees to radiation sources. Here, we present a novel e-training strategy that enables safe, exposure-free handling of a radiation measuring tool called a survey meter. Our mixed reality radiation-training system merges the physical world with a digital one. Collaborating with a mixed reality headset (HoloLens 2), this system constructs a mock-up of a survey meter in real-world space. The HoloLens 2 employs a browser-based application to visualize radiation and to simulate/share the use of the survey meter, including its physical movements. To provide a dynamic learning experience, the system adjusts the survey-meter mock-up readings according to the operator's movements, distance from the radiation source, the response time of survey meter, and shielding levels. Through this approach, we expect that trainees will acquire practical skills in interpreting survey-meter readings and gain a visual understanding of radiation in real-world situations.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.37 no.5
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• pp.22-33
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• 2000

Since the heavy-duty power manipulator generally has high ratio gear reducers at its joints, its dynamic characteristics is much slower than that of the master manipulator and it is likely to encounter the saturation in the input magnitude when it is used as the slave manipulator in telemanipulation systems. This paper proposes a force reflecting and compliant control scheme for the heavy-duty power telemanipulator. The main advantage of the proposed scheme is that it provides a precise position and compliant control performance for a telemanipulator with control input saturation. The stability of the proposed scheme is analyzed and a series of experiments shows its performance.

• The Journal of Korean Physical Therapy
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• v.24 no.2
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• pp.118-126
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• 2012

Purpose: The purpose of this study was to investigate pain relief and functional recovery after total knee replacement. Methods: The treatment was performed by dividing individuals into a control group ($n_1=5$), ultrasound treatment group ($n_2=5$), and micro-current treatment group ($n_3=5$). The control group applied the hot pack for 15 minutes, Transcutaneous Electrical Nerve Stimulation (TENS) for 15 minutes, and Continuous Passive Movement (CPM) for 40 minutes. The ultrasound therapy group applied the frequency of 1 MHz, intensity of 1.0 $W/cm^2$ for five minutes following the same treatment as the control group. The micro-current therapy group applied the intensity of 25 ${\mu}A$, and pulsation frequency 5 pps for 15 minutes following the same treatment as the control group. After treatment, Visual Analogue Scale (VAS), Korean Western Ontario and McMaster Universities Arthritis Index (K-WOMAC), Berg Balance Scale (BBS), Range of Movement (ROM) and wound length was measured. Results: VAS showed significant effect in the control group and micro-current therapy group during the treatment period. According to the treatment of K-WOMACK, BBS, ROM, and Healing wounds showed main effects between groups. Conclusion: According to the results of this study, data showed improvement of pain relief, wound healing effects, and range of motion recovery. Thus, these selected treatments were effective after total knee replacement. In other words, electrical treatment continues to influence pain relief and functional recovery after total knee replacement.

• The Journal of the Korea institute of electronic communication sciences
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• v.6 no.3
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• pp.397-404
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• 2011

In this research, wish to suggest method to embody system that can accommodate defect of PLC and find actual propriety. Defect permission control system minimizes production damage because enables repair and checking without discontinuance and improve believability about whole system. Propose duplexing of system to embody this fault tolerant system. Therefore, composed control system that can permit defect or breakdown duplexings of various module proposing this system, and confirms to simulation and actuality kiln of defect permission control system through an application experiment, and compares for mean time between defect by estimate and defect special quality and system configuration of failure(failure) to improve believability of PLC control system together. In proposed system expression method and system mode and relation with operation mode, error discovery mode and switching tube of duplexing mode, and PLC's central processing unit of node study algorithm about master-standby conversion driving and continuous operation of 2 channels method that have 2 that is not one and deduced continuous operation method and result about defect permission in this algorithm and applies this result to actuality kiln control system and confirms continuous operation about PLC defect permission.