• Korean Management Science Review
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• v.16 no.1
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• pp.157-171
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• 1999

In a increasingly competitive marketplace, the manufacturing companies have no choice but looking for ways to improve productivity to sustain their competitiveness and survive in the industry. Recently cellular manufacturing has been under discussion as an option to be easily implemented without burdensome capital investment. The objective of cellular manufacturing is to realize many aspects of efficiencies associated with mass production in the less repetitive job-shop production systems. The very first step for cellular manufacturing is to group the sets of parts having similar processing requirements into part families, and the equipment needed to process a particular part family into machine cells. The underlying problem to determine the part and machine assignments to each manufacturing cell is called the cell formation. The purpose of this study is to develop a clustering algorithm based on the neural network approach which overcomes the drawbacks of ART1 algorithm for cell formation problems. In this paper, a generalized learning vector quantization(GLVQ) algorithm was devised in order to transform a 0/1 part-machine assignment matrix into the matrix with diagonal blocks in such a way to increase clustering performance. Furthermore, an assignment problem model and a rearrangement procedure has been embedded to increase efficiency. The performance of the proposed algorithm has been evaluated using data sets adopted by prior studies on cell formation. The proposed algorithm dominates almost all the cell formation reported so far, based on the grouping index($\alpha$ = 0.2). Among 27 cell formation problems investigated, the result by the proposed algorithm was superior in 11, equal 15, and inferior only in 1.

• Korean Management Science Review
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• v.12 no.1
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• pp.1-17
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• 1995

The success of cell manufacturing applications in FMS rests on the effective cell formation to maintain the independent relations both between machine cells and between part families. This paper presents an integrated method for concurrent formation of cells and families with no E.E (Exceptional Element) in FMS with alternative routings. To determine the maximum number of cell and family with no E.E, mathematical conditions and properties are derived. New concept of nonsimilarity is introduced for each machine and part based on machine-operation incidence matrix and part-operation incidence matrix. To concurrently form the cells and families, integer programming based mathematical models are developed. For the predetermined number of cell or family, model I is used to identify whether E.E exists or not. Model II forms cells and families considering only nonsimilarity. But model III can consider nonsimilarity and processing times. The proposed method is tested and proved by using numerical examples.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.43-43
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• 2010

We have characterized the parametric and functional properties of live cell and cancer cell according to plasma treatment conditions using Atmospheric Pressure (AP) Plasma with uniquely designed low temperature arc-free unit. AP plasma system showed very highly efficient capabilities of reacting and interfacing directly with live and cancer cells. The parametric results with the types of gases, applied power, applied gap, and process times on cells will be presented in accordance with functional studies of the works. The growth of cancer cells is directly influenced by AP plasma exposure with evaluating plasma conditions in several human cancer cells and understanding how plasma exposure alters molecular signaling pathways. The cells exhibit a slower or faster growth rates compared with untreated cells, depending on the cell types. These results strongly support the conclusion that alterations in one or more of each gene are responsible, at least in part, for plasma-induced apoptosis in cancer cells. In addition, it also will be presented that AP plasma has an important role for the improvement of sensor performance due to excellent interface property between enzyme and metal electrode for bio sensor manufacturing process.

• Journal of Adhesion and Interface
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• v.22 no.4
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• pp.113-117
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• 2021

Among the next-generation solar cells, organic solar cells using organic materials are a key energy production device for the future energy generation devices, and have recently been receiving a lot of attention with rapid growth. To improve the efficiency of organic solar cells, interfacial engineering technology has been widely applied. In particular, it is widely used to improve device efficiency through energy level control by using interface engineering on the anode and cathode, which are positive electrodes, and to ultimately utilize interface engineering for tandem organic solar cells to derive excellent electrical and optical performance to produce high-performance devices. In this article, we will summarize and introduce recent research trends on interfacial engineering used in organic solar cells, and discuss the method of manufacturing high-performance organic solar cells.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.10
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• pp.1935-1944
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• 1994

FMS is a distributed system composed of various programmable manufacturing hardware such as robots and NC machines. For the autonomous operation of such a system, an integrated software layer for the control and monitoring in needed on top of the manufacturing hardware. However, constructing and maintaining such a software layer is difficult due to the complexity of a underlying FMS and its frequently changing nature. To cope with this problem, this paper proposes an object-oriented FMS integration model, in which objects acting as virtual manufacturing cells are instantiated for each physical cell in the underlying object-oriented database. Various other entities involved in manufacturing processes and their relationship to the cell objects are also captured in the database. This paper describes the structure of this object-oriented FMS database on our prototype implementation called FREE.

• Journal of Institute of Control, Robotics and Systems
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• v.5 no.5
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• pp.614-621
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• 1999

In this paper, the analytical appproaches are presented for jointly determining the profit-miximizing configuration of the fault-tolerance real time modular cell manufacturing system. The transient(time-dependent) analysis of Markovian models is firstly applied to modular cell manufacturing system from a performability viewpoint whose modeling advantage lies in its ability to express the performance that truly matters - the user's perception of it - as well as various performance measures compositely in the context of application. The modular cells are modeled with hybrid decomposition method and then availability measures such as instantaneous availability, interval availability, expected cumulative operational time are evaluated as special cases of performability. In addition to this evaluation, sensitivity analysis of the entire manufacturing system as well as each machining cell is performed, from which the time of a major repair policy and the optimal configuration among the alternative configurations of the system can be determined. Secondly, the recovery policies from the machine failures by computing the minimal number of redundant machines and also from the task failures by computing the minimum number of tasks equipped with detection schemes of task failure and reworked upon failure detection, to meet the timing requirements are optimized. Some numerical examples are presented to demonstrate the effectiveness of the work.

• Current Photovoltaic Research
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• v.12 no.1
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• pp.17-23
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• 2024

Photovoltaic (PV) power generation is the world's best and largest renewable energy that generates electricity with infinite sunlight. Solar cell modules are a component of photovoltaic power generation and must have a long-term durability of at least 25 years. The development of processes and equipment that can be recovered through the recycling of metals and valuable metals when the solar module's lifespan is over has been completed to the level of commercialization, but few processes have been developed that require repair due to initial defects. This is mainly due to the economic problems caused by remaking. However, if manufacturing processes such as repairing solar cell modules that have been proven to be early defects are established and the technical review of long-term reliability and durability reaches a certain level, it is considered that it will be a recommended process technology for environmental economics. In this paper, assuming that a defective solar cell module occurs artificially, a manufacturing process for replacement of solar cells was developed, and a technical verification of the manufacturing technology was conducted through long-term durability evaluation in accordance with KS C 8561. Through this, it was determined that remanufacturing technology for solar cell replacement of solar cell modules that occurred in a short period of time after installation was possible, and the research results were announced through a journal to commercialize solar modules using manufacturing technology in the solar market in the future.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2001.10a
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• pp.21-24
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• 2001

This study is concerned with the development of efficient p-median approach to nondegenerate cell formation(CF) in group technology(GT) manufacturing. Unlike most of existing CF methodologies allowing degenerate cells or families that contains no parts or machines, this study attempts to find cell configuration where each machine cell contains at least two or more machines processing at least two or more parts so as to fully utilize the similarity in designing and processing parts. Nondegenerate CF seeks to minimize both the exceptional elements outside the diagonal block and the voids within the diagonal block. To find nondegenerate cells, a two-phase p-median methodology is proposed. In phase 1, the classical p-median model is implemented to find initial cells. In phase 2, bottleneck machines and parts are reassigned until no further degenerate cells and families are found. Test results on moderately medium-sized CF problems show the substantial efficiency of the proposed approach.

• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.73-81
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• 2023

Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylase family. They are key regulators of cellular and physiological processes, such as cell survival, senescence, differentiation, DNA damage and stress response, cellular metabolism, and aging. SIRTs also influence carcinogenesis, making them potential targets for anticancer therapeutic strategies. In this study, we investigated the anticancer properties and underlying molecular mechanisms of a novel SIRT1 inhibitor, MHY2251, in human colorectal cancer (CRC) cells. MHY2251 reduced the viability of various human CRC cell lines, especially those with wild-type TP53. MHY2251 inhibited SIRT1 activity and SIRT1/2 protein expression, while promoting p53 acetylation, which is a target of SIRT1 in HCT116 cells. MHY2251 treatment triggered apoptosis in HCT116 cells. It increased the percentage of late apoptotic cells and the sub-G1 fraction (as detected by flow cytometric analysis) and induced DNA fragmentation. In addition, MHY2251 upregulated the expression of FasL and Fas, altered the ratio of Bax/Bcl-2, downregulated the levels of pro-caspase-8, -9, and -3 proteins, and induced subsequent poly(ADP-ribose) polymerase cleavage. The induction of apoptosis by MHY2251 was related to the activation of the caspase cascade, which was significantly attenuated by pre-treatment with Z-VAD-FMK, a pan-caspase inhibitor. Furthermore, MHY2251 stimulated the phosphorylation of c-Jun N-terminal kinase (JNK), and MHY2251-triggered apoptosis was blocked by pre-treatment with SP600125, a JNK inhibitor. This finding indicated the specific involvement of JNK in MHY2251-induced apoptosis. MHY2251 shows considerable potential as a therapeutic agent for targeting human CRC via the inhibition of SIRT1 and activation of JNK/p53 pathway.

• Environmental Analysis Health and Toxicology
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• v.21 no.4 s.55
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• pp.357-363
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• 2006

Chromium compounds are widely used in diverse industries including pigment manufacturing, painting, metal plating and leather tanning. With the wide uses of chromium, various adverse effects of the compounds on the environment and human health have been reported. Among them, hexavalent chromium [Cr (VI)], which is a carcinogenic heavy metal, has been widely studies. Epidemiological investigations have shown that respiratory cancers had been found in workers who had been occupationally exposed to Cr (VI). In this study, cell toxicity and induction of reactive oxygen species (ROS) by Cr (VI) (1, 2, 4, $8{\mu}M$) in cultured human bronchial epithelial cells were investigated. Exposure of the cells to Cr (VI) led to cell death, ROS increase, and cytosolic caspase-3 activation. The ROS increase was related with the decreased level of GSH. Chromatin condensation and fragmentation were occurred by Cr (VI) when evaluated by DAPI staining or agarose gel electrophoresis of the extracted DNA. Expression of ROS related genes including glutathione S-transferase, heme oxygenase-1, metallothionein were significantly induced in Cr (VI) treated cells. This result suggests the toxicity in cultured cells by Cr (VI) was expressed through the apoptotic process with ROS induction.