• Food Science and Preservation
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• v.21 no.6
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• pp.878-884
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• 2014

Increased antimutagenic and in vitro anticancer effects were observed by the fermentation process during Kochujang manufacturing. In order to confirm the increased functionality, wheat grain, first fermented wheat grains (FFWG), second fermented wheat grains (SFWG), final fermented wheat grains (FiFWG), red pepper powder (RPP), and commercial Kochujang (CK) were prepared. Kochujang manufactured with final fermented wheat grains and red pepper powder were further fermented for 15 days and 30 days. The antimutagenic effects were determined by counting the number of revertants in Salmonella Typhimurium TA100 against N-methyl-N'-nitro-nitrosoguanidine (MNNG, 1.0mg/mL). The final fermented wheat grains (52% inhibition) showed higher antimutagenic effects than the wheat grain (34%), and the commercial Kochujang showed the highest antimutagenic effects (55%). We tested the inhibitory effect on the growth of HT-29 human colon carcinoma cells and AGS human gastric adenocarcinoma cells by using MTT (3-(4,5-dimethyl-thiazol)-2,5-diphenyltetrazolium bromide) assay. The results showed that increased fermentation process continually increased the growth inhibitory effect on both cancer cells. The further fermentation for 15 days of the Kochujang product also increased inhibitory growth of the AGS cancer cells. In conclusion, the methanol extract from fermented wheat grains and commercial Kochujang showed sequentially increased antimutagenic and in vitro anticancer activity, and thus the final commercial Kochujang revealed the highest effect.

• Membrane and Water Treatment
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• v.1 no.1
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• pp.13-37
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• 2010

The performance of an electrodialyzer for concentrating seawater is predicted by means of a computer simulation, which includes the following five steps; Step 1 mass transport; Step 2 current density distribution; Step 3 cell voltage; Step 4 NaCl concentration in a concentrated solution and energy consumption; Step 5 limiting current density. The program is developed on the basis of the following assumption; (1) Solution leakage and electric current leakage in an electrodialyzer are negligible. (2) Direct current electric resistance of a membrane includes the electric resistance of a boundary layer formed on the desalting surface of the membrane due to concentration polarization. (3) Frequency distribution of solution velocity ratio in desalting cells is equated by the normal distribution. (4) Current density i at x distant from the inlets of desalting cells is approximated by the quadratic equation. (5) Voltage difference between the electrodes at the entrance of desalting cells is equal to the value at the exits. (6) Limiting current density of an electrodialyzer is defined as average current density applied to an electrodialyzer when current density reaches the limit of an ion exchange membrane at the outlet of a desalting cell in which linear velocity and electrolyte concentration are the least. (7) Concentrated solutions are extracted from concentrating cells to the outside of the process. The validity of the computer simulation model is demonstrated by comparing the computed results with the performance of electrodialyzers operating in salt-manufacturing plants. The model makes it possible to discuss optimum specifications and operating conditions of a practical-scale electrodialyzer.

• Journal of the Semiconductor & Display Technology
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• v.13 no.3
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• pp.21-25
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• 2014

The texturing is one of the most important processes for high efficiency crystalline silicon solar cells. The rear side flatness of silicon solar cell is very important for increasing the light reflectance and forming uniform back surface field(BSF) region in manufacturing high efficiency crystalline silicon solar cells. We investigated texturing difference between front and rear side of wafer by texturing of two adhered wafers. As a result, the flatter rear side was obtained by forming less pyramid size compared to the front side and improved reflectance of long wavelength and back surface field(BSF) region were also achieved. Therefore, the texturing of two adhered wafers can be expected to improve the efficiency of silicon solar cells due to increased short circuit current(Isc).

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2006.06a
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• pp.354-355
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• 2006

We manufactured photoelectrode of dye-sensitized solar cells (DSC) by using three methods such as squeeze method, spray method, and combination method (squeeze method first, spray method second). We examined how the morphology of an electrode's surface, the pore between particles, and condensation have an effect on an open-circuit voltage, photocurrent, fill factor, and energy conversion efficiency. Open-circuit voltage of dye-sensitized solar cells manufactured by using three methods is about 0.66V when the photoelectrode of the three DSCs is about $5{\mu}m$ thick. Photocurrent and fill factor and conversion efficiency of DSC manufactured by using squeeze method is 18.5 and 34 and 7.8, respectively. Photocurrent and fill factor and conversion efficiency of DSC manufactured by using spray method is 3.62 and 62 and 2.8, respectively. Photocurrent and fill factor and conversion efficiency of DSC manufactured by using combination method is 10.7 and 46 and 5.9, respectively. In conclusion, we find that the combination method is better than the other two methods in such respects as energy conversion efficiency and fill factor.

• Microbiology and Biotechnology Letters
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• v.50 no.2
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• pp.218-227
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• 2022

Glycosylation of aesculetin was performed using amylosucrase from the hyperthermophilic bacterium Deinococcus geothermalis DSM 11300 to improve the solubility and biological activity of aesculetin. A newly synthesized aesculetin glycoside was identified as α-cichoriin (aesculetin 7-α-D-glucoside) by nuclear magnetic resonance analysis. The solubility of α-cichoriin was 11 times higher than that of aesculetin because of the attached glucose moiety. Aesculetin and α-cichoriin had no significant effect on the proliferation of normal cells, such as RAW 264.7, but they showed a cell proliferation inhibitory effect on B16F10 melanoma cells. Unlike treatment with aesculetin and α-cichoriin, aesculin (aesculetin 6-β-D-glucoside) showed no antiproliferative activity in B16F10 cells. Based on the molecular structures of aesculin and α-cichoriin, the position where glucose binds to aesculetin and the anomeric configuration between glucose and aesculetin are thought to be important for exerting an antiproliferative effect on the B16F10 cell line. Based on these results, we propose that α-cichoriin, the α-glycosylated form of aesculetin, may serve as a model for developing phytochemical analogs with therapeutic potential for the treatment of diseases associated with tumor cell proliferation without cytotoxicity to normal cells.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.4 no.1
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• pp.84-89
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• 2004

The machine cell formation problem is the problem to group machines into machine families and parts into part families so as to minimize bottleneck machines, exceptional parts, and inter-cell part movements in cellular manufacturing systems and flexible manufacturing systems. This paper proposes a new machine cell formation method based on the adaptive Hamming net which is a kind of neural network model. To show the applicability of the proposed method, it presents some experiment results and compares the method with other cell formation methods. From the experiments, we observed that the proposed method could produce good cells for the machine cell formation problem.

• IE interfaces
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• v.15 no.4
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• pp.364-373
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• 2002

This paper developed an operating software for the manufacturing cell of a model plant. The model plant, which was manufactured by Fishertechnik, consists of an assembly cell, a machining cell, and supplementary material handling equipments. Each I/O module of the model plant communicates with the INTERBUS controller devices via High-level Language Interface(HLI). The machining center has two machining cells, which consists of 4 machines respectively, two 3-axis portal transporters, and a rail guided vehicle(RGV). The Petri-Net was used to investigate the dynamics of each machining cell, e.g., the relation of material handling equipments and machines. The operating software was analyzed and designed by Object Oriented Technique. The software was implemented using Delphi 3.0 under Windows 95/NT operating system.

• Journal of Microbiology and Biotechnology
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• v.10 no.4
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• pp.554-558
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• 2000

Bacteria were isolated and identified from an advanced high-purity water system that supplies ultra-high purity water (UHPW) for 16-megabyte DRAM semiconductor manufacturing. Scanning electron microscopic and microbiological observations revealed that the primary source of the bacteria isolated from the UHPW was detached cells from biofilms developed on the pipe wall through which the UHPW, a man-made and extremely nutrient poor environment, was passing. About 63-65% of the bacteria isolated from the UHPW and the pipe wall were Gram-positive, whereas only 10% of the bacteria isolated from the feed water were Gram-positive. The of Gram-positive bacteria and seven genera of Gram-negative bacteria. Strains of the UHPW bacteria effectively adhered to and formed a biofilm on the surface of polyvinyl chloride (PVC) pipe.

• Journal of the Korean Operations Research and Management Science Society
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• v.23 no.1
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• pp.17-28
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• 1998

This study suggests a procedure for designing cellular manufacturing systems (CMS) which are combined with automated guided vehicles (AGVs) using a tandem configuration. So far most of the previous studies have dealt with conventional design problems not considering the layout and the characteristics of transporters used in CMS. A mathematical model is developed using the service time to perform material transfers as a suitable meassure. The service capacity of AGVs and space limitations are also reflected in this model. As the model can be shown strongly NP-hard, a heuristic algorithm is presented, in which each cell is temporarily formed using both the set covering model and similarity coefficients, and then locations of the cells are determined by means of tabu search and finally machine perturbations are carried out. An example problem is solved to demonstrate the algorithm developed.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.14 no.5
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• pp.126-133
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• 2015

Recently, there has been demand for polymeric porous membranes in various fields, such as environmental engineering, pharmaceutics, tissue engineering, drug delivery, biology, and fuel cells. In this study, it is proposed that a polymer particle-based porous membrane can be fabricated using electrospraying and sintering processes. Electrospraying can fabricate polymeric particles with diameters ranging from several micrometers to tens of nanometers without the cumbersome particle aggregation problem. Additionally, the particles can be sintered through thermo-compression under the glass transition temperature. In this study, a polymethyl methacrylate particle-based porous membrane with an average pore size of less than 500 nm is fabricated using the proposed method.