• Journal of Science Education
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• v.33 no.1
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• pp.31-43
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• 2009

The purpose of this study is to identify a domain-specificity of the scientific creativity and the component of scientific creativity. Conducted from theoretical study, this study suggests that a domain-specific view of creativity offers a more useful and constructive components of scientific creativity based on the literature associated with the component of scientific creativity. Scientific creativity has a domain-specific component and so there is need to distinguish scientific creativity from creativity in general. As a result, scientific creativity is different from other creativity it is concerned with scientific knowledge, science process skill, creative scientific problem finding and solving and so on. And since scientific creativity is a kind of ability, it is possible to improve through a scientific creativity program.

• Journal of Information Processing Systems
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• v.14 no.3
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• pp.751-770
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• 2018

Web applications are indispensable in the software industry and continuously evolve either meeting a newer criteria and/or including new functionalities. However, despite assuring quality via testing, what hinders a straightforward development is the presence of defects. Several factors contribute to defects and are often minimized at high expense in terms of man-hours. Thus, detection of fault proneness in early phases of software development is important. Therefore, a fault prediction model for identifying fault-prone classes in a web application is highly desired. In this work, we compare 14 machine learning techniques to analyse the relationship between object oriented metrics and fault prediction in web applications. The study is carried out using various releases of Apache Click and Apache Rave datasets. En-route to the predictive analysis, the input basis set for each release is first optimized using filter based correlation feature selection (CFS) method. It is found that the LCOM3, WMC, NPM and DAM metrics are the most significant predictors. The statistical analysis of these metrics also finds good conformity with the CFS evaluation and affirms the role of these metrics in the defect prediction of web applications. The overall predictive ability of different fault prediction models is first ranked using Friedman technique and then statistically compared using Nemenyi post-hoc analysis. The results not only upholds the predictive capability of machine learning models for faulty classes using web applications, but also finds that ensemble algorithms are most appropriate for defect prediction in Apache datasets. Further, we also derive a consensus between the metrics selected by the CFS technique and the statistical analysis of the datasets.

• Microbiology and Biotechnology Letters
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• v.27 no.1
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• pp.28-34
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• 1999

Ganoderan (GAN), an immunomodulating ${\beta}$-glucan from mushroom Ganoderma lucidum, was evaluated for its ability to induce formation of nitric oxide (NO), tumor necrosis factor-${\alpha}$(TNF-${\alpha}$) and transforming growth factor (TGF-${\beta}$) from rat Kupffer cell in vitro. Hepatic macrophages activated by GAN significantly elevated concentration of NO and TNF-${\alpha}$ in cultured medium, but not significantly elevated that of TGF-${\beta}$. GAN-activated Kupffer cells secrete 14.9${\mu}$M (p<0.01) of NO and 2619.5${\rho}$g/ml (p<0.01) of TNF-${\alpha}$after 36hr of incubation at 37$^{\circ}C$. The results revealed that GAN enhanced 4-fold production of NO and 19 fold formation of TNF-${\alpha}$ compared to the control. The proliferation of GAN-activated Kupffer cells was inhibited as compared with its negative control. Comparing the activity among glucans derived from microorganisms, highly branched zymosan, glucomannan from Saccharomyces cerevisiae, significantly increased TNF-${\alpha}$ and NO production. These results indicate that the ${\beta}$-glucan from G. lucidum activates rat Kupffer cell and secretes NO and TNF-${\alpha}$. It also suggest that rat Kupffer cell posses certain receptor for ${\beta}$-anomeric glucan.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.10
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• pp.1712-1716
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• 2013

In our study, as many as 29 edible medicinal herbs were selected for testing their ability in the effective treatment of gout based on oriental medicine theory. We extracted each medicinal herb (135 g) with 4 L of distilled water at $100{\sim}105^{\circ}C$ for 210 min. Thereafter, we evaluated both the antioxidant and xanthine oxidase inhibition activities of the extracts obtained. Among all the edible medicinal herbs used in our study, only the extract from Scutellaria baicalensis Georgi (Korean name: hwang-geum) showed (1) the maximum total phenolic content (TPC) (2.25 mg gallic acid equivalent/mL), (2) DPPH radical scavenging activity (94.04%), and (3) xanthine oxidase inhibition activity (87.75%). We also observed that TPC was relatively highly correlated with both the DPPH radical scavenging activity (r=0.63) and xanthine oxidase inhibition activity (r=0.77). Our results suggest that S. baicalensis G. may be a potent antioxidant source for the extraction and development of nutraceuticals that may be utilized for effective treatment of gout.

• The Korean Journal of Nuclear Medicine Technology
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• v.14 no.1
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• pp.147-148
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• 2010

Introduction: A metastatic calcification is known for taking in bone scintigram medicine at metastatic calcification lesion due to abnormal distribution of the calcium and phosphorus. The one paper reports that a metastatic calcification occurs mainly at lung, stomach, kidney and myocardium. Index: The patient is seventy four years old man who is afflicted with clonic kidney disease, hypercalcemia, hypertension. Because of an ability of the multiple myeloma, we take a bone scan after intravenous injection $^{99m}Tc$-DPD 25 mCi in three hours. We found out homogeneous $^{99m}Tc$-DPD uptake at both lung and myocardium. Conclusions: Nothing unusual was found in other bone scan. We obtains a purity beyond 95 percent at $^{99m}Tc$-DPD vial. In spite of no evidence about a myocardial infarction, the patient has a $^{99m}Tc$-DPD uptake at both lung and myocardium.

• Communications of Mathematical Education
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• v.22 no.2
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• pp.229-252
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• 2008

The purpose of this research was to make fair assessment methods which took into account characteristics of mathematically underachievers. The researchers devised an descriptive tests and interviews and applied them to the mathematics underachievers who could not reveal their achievements in the traditional assessment and then analyzed their cognitive and affective characteristics in the alternative assessments. After selecting three students by the normal assessment made of simple subjective and multiple choice questions, the cognitive and affective characteristics found in the general assessment were reflected to the descriptive tests and interviews. The descriptive tests and interviews are comprised of descriptive narrations and informal interview questions. After the assessment, the teacher and students gave feedbacks one another. All the assessment activities were recorded by a camcorder to analyze cognitive and affective characteristics of the children. Throughout the research, the following conclusions were made. The mathematics underachievers showed the characteristics which didn't appeared in the normal assessment. They showed normal abilities of problem solving and communication In the cognitive area. Also they brought in positive result in most parts in the affective area. However, the student B displayed considerable ability of mathematical thinking that is over the average level of mathematical underachievers. This implies that we can definite the mathematical underachievers differently when we use the detailed and relief assessment method instead of the traditional assessment. On the other hand, one student tended to depend on the teacher and another student overheard what the others talk during the study. This defect should be complemented by the further studies about assessment method for the mathematical underachievers. Also appropriate assessment methods should be made for applying to the various mathematical underachievers. Many studies have been concentrated on the learning for mathematical underachievers but there is little concern about the assessment for the mathematical underachievers. However it is the fundamental way to reduce the number of mathematics underachievers that we construct consistent learning methods and assessments for the mathematical underachievers.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.14 no.1
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• pp.63-68
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• 2009

Among various microscopic organisms producing photobiological hydrogen, cyanobacteria have long been recognized as the promising biological agents for hydrogen economy in 21 century. For photobiological production of hydrogen energy, marine unicellular $N_2$-fixing cyanobacteria have been evaluated as an ideal subgroup of Cyanophyceae. To develope the hydrogen production technology using unicellular $N_2$-fixing cyanobacteria, 3 important factors are pre-requisite: 1) isolation of the best strain from marine natural environment, 2) exploration on the strain-specific optimal conditions for the photobiological hydrogen production, and finally 3) application of the molecular genetic tools to improve the natural ability of the strain to produce hydrogen. Here we reviewed the recent research & development to commercialize photobiological hydrogen production technology, and suggest that intensive R&D during next 10-15 years should be imperative for the future Korean initiatives in the field of the photobiological hydrogen production technology using photosynthetic marine unicellular cyanobacterial strains.

• Biomolecules & Therapeutics
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• v.32 no.1
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• pp.56-64
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• 2024

Biased signaling or functional selectivity refers to the ability of an agonist or receptor to selectively activate a subset of transducers such as G protein and arrestin in the case of G protein-coupled receptors (GPCRs). Although signaling through arrestin has been reported from various GPCRs, only a few studies have examined side-by-side how it differs from signaling via G protein. In this study, two signaling pathways were compared using dopamine D₂ receptor (D₂R) mutants engineered via the evolutionary tracer method to selectively transduce signals through G protein or arrestin (D₂G and D₂Arr, respectively). D₂G mediated the inhibition of cAMP production and ERK activation in the cytoplasm. D₂Arr, in contrast, mediated receptor endocytosis accompanied by arrestin ubiquitination and ERK activation in the nucleus as well as in the cytoplasm. D₂Arr-mediated ERK activation occurred in a manner dependent on arrestin3 but not arrestin2, accompanied by the nuclear translocation of arrestin3 via importin1. D₂R-mediated ERK activation, which occurred in both the cytosol and nucleus, was limited to the cytosol when cellular arrestin3 was depleted. This finding supports the results obtained with D₂Arr and D₂G. Taken together, these observations indicate that biased signal transduction pathways activate distinct downstream mechanisms and that the subcellular regions in which they occur could be different when the same effectors are involved. These findings broaden our understanding on the relation between biased receptors and the corresponding downstream signaling, which is critical for elucidating the functional roles of biased pathways.

• Journal of Navigation and Port Research
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• v.31 no.8
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• pp.671-674
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• 2007

In this paper, the EM wave absorber was designed and fabricated for ETC system, because ETC system has some problems including signal error and system-to-system interference. We fabricated some samples in different composition ratio of MnZn-ferrite, Carbon and CPE, confirmed that optimum composition ratio of Mn2n-ferrite, Carbon, CPE was 40 : 15 : 45 wt%. Complex relative permittivity and complex relative permeability was calculated by the measured data. And absorption abilities were simulated according to different thickness of the EM wave absorbers using complex relative permittivity and permeability. The EM wave absorber was fabricated based on simulated data Simulated and measured values agree well. As a result, the developed EM wave absorber has a thickness of 3.38 mm and absorption ability over 20 dB at 5.8 GHz.

• Journal of the Korean School Mathematics Society
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• v.13 no.2
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• pp.303-322
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• 2010

The purpose of this study was to analyze the effects of using the geometric manipulative for the development of spatial sense and thus to find out a better mathematics teaching and learning method that could help develop students' spatial senses. The two fifth grade classes were randomly chosen as an experimental group (31 students) and a control group (32 students), respectively. This study implemented nonequivalent control group pretest-posttest design of quasi-experimental design. The test instrument used in this study was a spatial sense test. The pretest and posttest were implemented with the same instrument. In addition, their classes were observed and videotaped, and the data and their study activities were analyzed. In conclusion, first, the geometric manipulative-aided activities contributes to developing students' spatial senses and their two sub-factors involves perceptual consistency and perception of spatial relationship. Second, the activities of grasping the components of solid figures, sketches and development figures by using the geometric manipulative contribute to boost students' perceptual consistencies and their perceptions of spatial relationship.