• Journal of Chest Surgery
• /
• 제43권2호
• /
• pp.217-220
• /
• 2010

소위 다형선종이라 불리는 혼합종은 주로 침샘에 기원하며 폐에서 발생한 예는 세계적으로 보고된 예가 극히 드물다. 이 신생물은 저악성도를 나타내기도 하나 재발이나 원격전이와 같은 공격적인 성향을 보이는 경우도 있다. 우리는 종양의 완전 절제후 병리학적으로 폐의 일차성 악성 다형선종임을 확인하였고 술 후 다발성 전이와 같은 악성 신생물의 소견을 보이는 증례를 경험하여 이를 보고하는 바이다.

• Investigative Magnetic Resonance Imaging
• /
• 제24권3호
• /
• pp.162-167
• /
• 2020

Disseminated peritoneal leiomyomatosis (DPL) is a very rare benign disease, characterized by multiple solid subperitoneal or peritoneal smooth muscle nodules in abdominopelvic cavity and malignant transformation is extremely rare. Also, uterine smooth muscle tumors of unknown malignant potential (STUMP) is a rare tumor, which is regarded as subclassification in uterine smooth muscle tumors between benign and malignant criteria. Pathogenesis of DPL is uncertain, but increasing evidence of iatrogenic cause including laparoscopic myomectomy has been reported. We report a case of a 28-year-old female with previous history of laparoscopic myomectomy diagnosed with DPL with atypical feature and concurrent uterine STUMP using computed tomography (CT) and magnetic resonance imaging (MRI), as well as present a review of the literature.

• 한국임상수의학회지
• /
• 제19권4호
• /
• pp.450-454
• /
• 2002

A five-year-old, female Great Dane dog with edema, localized trauma, mild pain, and lameness of the right hind limb was referred to the Veterinary Medical Teaching Hospital of Chungbuk National University. This dog had a history of mammary tumor excisions 6 months ago. Abnormal changes were not seen in the values of complete blood count and serum biochemical tests. But pedal direct lymphangiography using aqueous-based radiographic agent showed the obstructed lymph flow in right popliteal lymph node. Based on these observations, the dog was suspected as lymphedema resulted from lymph drainage flilure without any other possibilities of inflammation or other causes. Although recommended chemotherapy and physiotherapy had been applied for resolvinr presented problems for one month, there was no improvement on edema of damaged region and any other clinical signs. Therefore, the necropsy was performed after euthanasia under agreement of the owner of patient. In histopatholofical examination, the most characteristic lesions in the mass of femoral region were diffuse edema fibrosis and neoplastic cells in the lymphatics. Also, the neoplastic cells were very similar to those found in the tumor mass of mammary gland, which had diagnosed as fibrosing carcinoma. These facts suggested that the cause of obstructed lymph flow was the neoplasia in lymphatics of the right hind limb. With these results, a diagnosis of malignant lymphedema was made in this dog.

• Journal of Korean Neurosurgical Society
• /
• 제45권6호
• /
• pp.381-385
• /
• 2009

The first case of intracranial metastases of a cervical intramedullary low-grade astrocytoma without malignant transformation in adult is presented in this report. Seven years ago, a 45 year-old male patient underwent biopsy to confirm pathologic characteristics and received craniocervical radiation and chemotherapy for a grade II astrocytoma in the cervical spinal cord. Two years later, posterior fusion was necessary for progressive kyphosis in the cervical spine. He was well for approximately 7 years after the primary surgery. Two months ago, he presented with partial weakness and incoordination with gait difficulty. MRI Scan demonstrated multiple small lesions in the cerebellar vermis and left hemisphere. After suboccipital craniectomy and posterior cervical exposure, the small masses in the cerebellar vermis and hemispheres were excised to a large extent by guidance of an intraoperative navigation system. The tumor at the cervical and brain lesions was classified as an astrocytoma (WHO grade II). When a patient with low-grade astrocytoma in the spinal cord has new cranial symptoms after surgery, radiaton, and chemotherapy, the possibility of its metastasis should be suspected because it can spread to the intracranial cavity even without malignant transformation as shown in this case.

• 대한영상의학회지
• /
• 제84권1호
• /
• pp.304-310
• /
• 2023

고립성 섬유종은 흉막에서 흔히 발생하는 양성 종양으로 알려져 있으나, 신체 어느 곳에서나 발생할 수 있고 10%-30%에서는 악성이다. 전형적으로, 고립성 섬유종은 단일성의 조영증강되는 종괴로 나타나지만, 척추 주위의 양측성 종괴로 나타나는 경우는 보고되어 있지 않다. 이 증례에서는, 등 통증과 만성 농흉의 병력이 있던 88세 남자 환자의 영상 검사에서 침습적인 양측성 척추 주위 종괴가 발견되었고, 만성 농흉과 연관된 흉부 악성 종양을 먼저 의심하였다. CT 유도하 이중구조 바늘 생검을 통해 진단된 양측성의 척추 주위 악성 고립성 섬유종의 증례를 보고한다.

• 대한세포병리학회지
• /
• 제7권2호
• /
• pp.138-143
• /
• 1996

The diagnostic accuracy of routine cytological preparations from effusions ranges from 60% to 70%. Immunohistochemical markers, especially tumor-associated antigens, have been successfully employed to increase diagnostic sensitivity in effusion cytology. However, more than two different antibodies in diagnosis of effusions are needed. In the view of prevalence of abnormalities of p53 gene in human malignancies we investigated the diagnostic usefulness of demonstration of p53 protein immunoreactivity in distinguishing benign changes versus malignant processes in effusions. p53 protein expression was studied immunohistochemically in 76 effusions(28 malignant and 48 benign) using anti-human p53 antibody p53 immunoreactivity was identified in 19 of 28(67.9%) malignant effusions. In contrast, no p53 immunoreactivity was observed in all benign effusions. A specificity of 100% and a sensitivity of 67.9% were observed. These results suggest that immunohistochemical detection of p53 protein seems to be helpful in distinguishing benign changes versus malignant processes in effusions, although its principal limitation is its relatively low sensitivity.

• Journal of Chest Surgery
• /
• 제23권6호
• /
• pp.1225-1232
• /
• 1990

From March 1986 to June 1990, the percutaneous Fine Needle Aspiration Biopsy[FNAB] of 102 thoracic lesions were performed with Westcott needle [slotted 20G or 22G thin needle], for the purpose of identifying and diagnosing thoracic lesions. There were 94 lung lesions [67 malignant tumors, 27 benign lesions] and 8 mediastinal and chest wall lesions. The results of FNAB were compared with sputum cytology and bronchoscopic examinations. The sputum cytologic examinations were performed in 54 cases of malignant lung tumor and the malignant cell was found at the 18 cases [33%]. We bronchoscopic examinations were performed in 24 cases and the malignant cell was found at the 12 cases [55%]. The positive diagnostic rate of malignancy was 100% by FNAB. Among them, 55 cases [82%] were diagnosed by cytologic examinations and 43 cases[64%] by both. The specific diagnoses for benign lung lesions in 15 cases[55%] and for mediastinal and chest well lesions in 5 cases[62%]. The 7 patients[6.9%] developed the pneumothorax and 5 of them required the treatment. Therefore, the FNAB of thoracic lesions may be a preferred diagnostic method because of its safety, simplicity and accuracy.

• Radiation Oncology Journal
• /
• 제5권1호
• /
• pp.43-47
• /
• 1987

척수의 원발성 흑색종양은 매우 희귀한 것으로 알려져 있다. 이러한 종양의 가장 유효한 치료로서는 가능한 종양을 완전히 제거하는 것이며, 수술 후에 방사선치료를 같이 병행하고 있으나 증례가 적어서 방사선치료의 효과는 아직 잘 알려져 있지 많다. 치료 후 2년 생존율은 $16\%$ 이하로 극히 저조하며, 대부분이 1연 내에 사망하는 아주 예후가 나쁜 종양으로 보고되고 있다.

• 대한두경부종양학회지
• /
• 제8권1호
• /
• pp.44-49
• /
• 1992

Malignant schwannoma is a rare tumor arising from the schwann sheath of the nerve fibers. It spreads early to reginal node and metastasis to the lung. Radical surgery have performed for treatment of choice but combined modalities such as radiotherapy or adjuvant chemotherapy have been recommanded recently. The authors experienced two cases of malignant schwannoma originating from the ethmoid sinus and ventricular fold of larynx. and we report these cases briefly.

• Journal of Korean Neurosurgical Society
• /
• 제57권3호
• /
• pp.211-214
• /
• 2015

Ganglioneuromas are benign tumors. Surgical excision is the treatment of choice with very good prognosis. However, neuroblastomatous malignant transformation of ganglioneuromas was previously reported. We report a patient with spinal neuroblastoma recurrent from a ganglioneuroblastoma after disease free survival of 13 years. This is one of the rare examples of spinal neuroblastoma and to our knowledge the second case report with malignant transformation from a ganglioneuroblastoma or a ganglioneuroma. The present case is the only report in the literature with further genetic investigations.