• Food Science of Animal Resources
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• v.37 no.6
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• pp.889-897
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• 2017

In this study, a nanoemulsion formulation for encapsulating turmeric extract was developed and its physicochemical characteristics including particle diameter, zeta potential, polydispersity index, and stability were determined. The turmeric nanoemulsion (TE-NE) droplets exhibited small diameter (165 nm), low PDI (0.17), and high zeta potential (-31.80 mV), all desirable characteristics in nanoemulsions, as well as stability in a wide range of pH. The TE-NE was spray-dried as a means to allow its incorporation into food products and reduce potential transport and storage costs. The resulting powder exhibited a pale yellowish appearance and had a curcuminoids content of 0.39 mg/g. The spray-dried TE-NE powder was incorporated into minced pork to make canned ham, and the sensory characteristics of the ham were evaluated. As a result, the canned ham incorporating TE-NE powder received the same overall acceptability score as the control, and only exhibited slight yellowing. By contrast, ham incorporating turmeric extract exhibited substantial yellowing, and its appearance was considered less acceptable by the panelists. Therefore, the TE-NE formulation could be incorporated into canned ham and other meat products without substantially affecting their sensory qualities.

• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 2005.10a
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• pp.557-562
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• 2005

The field scale experiment was performed to examine the effect of plant coverage on the constructed wetland performance and recommend the optimum development and management of macrophyte communities. Four sets(each set of 0.88ha) of wetland (0.8ha) and pond(0.08ha) systems were used. Water flowing into the Seokmoon estuarine reservoir from the Dangjin stream was pumped into wetland system. Water depth was maintained at $0.3{\sim}0.5m$ and hydraulic retention time was managed to about $2{\sim}5$ days; emergent plants were allowed to grow in the wetlands. After three growing seasons of the construction of wetlands, plant coverage was about 95%, even with no plantation, from bare soil surfaces at the initial stage. Dead vegetation affected nitrogen removal during winter because it is a source of organic carbon which is an essential parameter in denitrification. Biomass harvesting is not a realistic management option for most constructed wetland systems because it could only slightly increase the removal rate and provide a minor nitrogen removal pathway due to lack of organic carbon.

• Bulletin of the Society of Naval Architects of Korea
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• v.30 no.2
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• pp.44-52
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• 1993

선박에 있어서 철의장품은 종류와 수량이 다양하고 형상이 불규칙하여 대부분의 사업장에서 설계 전산화가 이루어지지 못하고 있는 실정이다. 의장설계실에서는 이를 전산화하기 위하여 먼저 철의장품의 표준을 제정 및 극대화하고 설계작업절차와 물량의 흐름을 전산과 연계하여 체계화 및 표준화하였다. 또한 선박의 전구역에 설치되는 철의장품들을 관련 양식과 함께 국제표준을 근거로 BASICA CADDS, SURFACE DESING, SDDP(structural Design ＆ Detailing Package) SOFTWARE를 이용하여 2차원(2-dimension) 및 3차원(3-dimension) 데이터베이스(database)화 하였으며 이를 POP-UP MENU를 이용, 쉽게 선택함으로써 모델링(modeling) 작업시수를 대폭 감소 시켰으며, 그래픽(graphic)에서 추출한 의장품의 데이터(data)를 의장품의 표준정보 FILE과 연계하여 라벨(LABEL) 및 치수(DIMENSION)를 기입하여 배치도를 추출하고 의장품의 제작, 설치, 계산 및 관리에 소요되는 설치도, 제작도 및 관련 보고서인 BOM(bill of material), PML(pallet material list), 의장제작품 LIST, COG(center of gravity), 관리점 등을 자동추출 및 관리전산망(PC-lan)과 연계할 수 있는 DECOM(철의장 전산설계 전용 package)을 89년에 개 발하여 의장설계에 적용하여 왔으며 ORACLE사의 RDBMS(relational database management system)를 도입하여 이를 보완하므로써 정보의 일관화 및 공유화가 가능하게 되었다. 그 결과 설계 M/H절감, 생산성 향상, 자재 및 관련 정보 전달에 혁신적인 변화 향상을 가져오게 되었다.

• Archives of Pharmacal Research
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• v.28 no.11
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• pp.1302-1310
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• 2005

Glucosylated polyethylenimine (GPEI) was synthesized as a tumor-targeting gene carrier through facilitative glucose metabolism by tumor glucose transporter. Particle sizes of GPEI/DNA complex increased in proportion to glucose content of GPEI, whereas surface charge of the complex was not dependent on glucosylation, partially due to inefficient shielding of the short hydrophilic group introduced. GPEI with higher glucosylation (36 mol-$\%$) had no cytotoxic effect on cells even at polymer concentrations higher than 200 $\mu$g/mL. Compared to unglucosylated PEl. glucosylation induced less than one-order decrease of transfection efficiency. Transfection of GPEI/DNA complex into tumor cells possibly occurred through specific interaction between glucose-related cell receptors and glucose moiety of GPEI. Gamma imaging technique revealed GPEI/DNA complex was distributed in liver. spleen. and tumors.

• Proceedings of the Korea Information Processing Society Conference
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• 2015.10a
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• pp.415-417
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• 2015

사용자는 자신의 주변상황에 대한 정보를 수집 및 공유하기 위하여 SNS, 포탈사이트 및 커뮤니티를 사용한다. 본 논문에서는 사용자의 특성을 고려한 지역정보 수집 아이디어와 방법론을 제시한다. 또한 각각의 웹 시스템의 데이터를 수집하여, 광범위한 지역정보를 마이닝을 수행하고 가공해내는 시스템을 제안한다. 이를 위해 해결해야하는 이슈는 다음과 같다. 각 웹시스템의 문서들은 운영 체제에 따라 인코딩이 달리 사용되는데, 흔히 발생되는 오류 중 하나인 문자깨짐 현상이 그 예이다. 해결방법으로써 문서가 작성된 운영체제의 인코딩정보를 획득해야하며, 이 정보는 서버에서 제공하는 헤더정보에 명시되었거나 문서내에 내장되어 있다. 하지만 일부 웹사이트는 인코딩 정보를 제공하지 않으며, 국가별 인코딩이 다르기 때문에 이를 알기 쉽지않다. 그리하여 본 논문에서 제안하는 방법론은 텍스트 마이닝에 앞서 웹서버에서 제공하는 웹페이지를 읽어들여 인코딩정보를 획득하고, 문자의 깨짐없이 표시할 수 있도록 시스템을 구축하기 위해 Response Header, HTML의 meta tag 및 읽어드린 문서의 BOM(Byte Order Mark) 정보 및 인코딩 패턴을 통해 인식하도록 하여 글자 깨짐을 완하하도록 시스템을 설계하였다.

• Journal of Microbiology and Biotechnology
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• v.29 no.4
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• pp.571-576
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• 2019

Microenvironmental stress, which is naturally observed in solid tumors, has been implicated in anticancer drug resistance. This tumor-specific stress causes the degradation of topoisomerase $II{\alpha}$, rendering cells resistant to topoisomerase $II{\alpha}$-targeted anticancer agents. In addition, microenvironmental stress can induce the overexpression of 78kDa glucose regulated protein (GRP78), which can subsequently block the activation of apoptosis induced by treatment with anticancer agents. Therefore, inhibition of topoisomerase $II{\alpha}$ degradation and reduction in GRP78 expression may be effective strategies for inhibiting anticancer drug resistance. In this study, we investigated the active compound arctigenin, which inhibited microenvironmental stress-induced etoposide resistance in HT-29 cells. Arctigenin was also highly toxic to etoposide-resistant HT-29 cells, with an $IC_{50}$ value of $10{\mu}M$ for colony formation. We further showed that arctigenin inhibited the degradation of topoisomerase $II{\alpha}$ and reduced the expression of GRP78. Thus, these results suggest that arctigenin is a novel therapeutic agent that inhibits resistance to etoposide associated with microenvironmental stress conditions.

• The Korean Journal of Nuclear Medicine
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• v.33 no.2
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• pp.172-177
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• 1999

Purpose: The purpose of this study was to ascertain whether radiation adaptive response could be induced by Tc-99m-methylene diphosphonate (Tc-99m-MDP) in peripheral lymphocytes of patients undergoing bone scintigraphy. Materials and Methods: Lymphocytes from 22 patients (6 males, 16 females, mean age $50{\pm}14$ years) were collected before and after bone scintigraphy using 740 MBq Tc-99m-MDP Lymphocytes from 10 controls (6 males, 4 females, mean age $43{\pm}7$ years) were also collected. They were exposed to challenge dose of 2 Gy gamma rays using a cell irradiator. Number of ring-form and dicentric chromosomes per 600 cells (chromosomal aberrations) was counted under the light microscope. Results: Chromosomal aberrations in patients before bone scintigraphy ($385.1{\pm}30.5$) was not different from that of controls ($367.8{\pm}36.6$). However, chromosomal aberrations in patients after bone scintigraphy was significantly decreased to $192.6{\pm}22.1$ (p=0.0001). Conclusion: Low dose gamma-irradiation by Tc-99m-MDP used for bone scintigraphy induces a cytogenetic adaptive response in peripheral lymphocytes.

• The Korean Journal of Nuclear Medicine
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• v.26 no.2
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• pp.274-279
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• 1992

Clinical role of $^{99m}Tc-MIBI$ myocardial scintigraphy in the diagnosis of coronary artery disease (CAD) is now well accepted, however, the role of it in the identification of viable myocardium in patients with chronic CAD has not yet been clarified. To determine the usefulness of rest-injected $^{99m}Tc-MIBI$ scan as a marker of myocardial viability, the regional uptake of this agent at rest was compared with that of $^{201}Tl$ on reinjection and 24 hours after reinjection images. Subject patients were 13 chronic CAD patients who showed irreversible perfusion defect(s) on standard pharmacologic (dipyridamole) stress-redistribution images. Immediately after the redistribution images were obtained, 37 MBq thallium was injected at rest, and images were reacquired at 10 minutes and 24 hours after reinjection. After then 740 MBq $^{99m}Tc-MIBI$ was injected, and 1 hour later rest MIBI myocardial imaging was performed. Five sets of imagestress, redistribution, reinjection, delayed images of thallium, and rest image of MIBI) were then analyzed qualitatively and quantitatively. Left ventricle was arbitrarily divided into 9 segments (apex, basal and apical portions of anterior, septal, inferior, and lateral walls). Seven patients and 30 regions showed a fixed perfusion defect on the stress-redistribution images. Among 30 regions, 15 showed positive uptakes and 6 showed negative uptakes on both $^{201}Tl$ reinjection/delayed images and $^{99m}Tc-MIBI$ rest images. Five regions showed only thallium uptake and were regarded as viable clinically. Of four regions which showed only $^{99m}Tc-MIBI$ uptake, two were regarded as viable, while the other two were regarded as a nonviable scar tissue clinically. In conclusion, $^{201}Tl$ reinjection technique was more reliable in the identification of viable myocardium. However, the role of $^{99m}Tc-MIBI$ in identification of viable myocardium was still remained to be clarified because 2 of 9 regions showed only $^{99m}Tc-MIBI$ uptake and were regarded as viable tissues.

• The Korean Journal of Nuclear Medicine
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• v.32 no.2
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• pp.137-142
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• 1998

Purpose: $^{99m}Tc$-tetrofosmin(TF) is a recently proposed myocardial imaging agent which has similar biokinetic characteristics to $^{99m}Tc$-sestamibi(MIBI). The aim of this study was to compare TF and MIBI myocardial perfusion SPECTs in detecting coronary artery disease. Materials and Methods: One hundred and sixty patients(101 males, 59 females, mean age $57{\pm}9yr$) who had undergone both myocardial perfusion SPECT(M-SPECT) and coronary angiography within 1 month were studied. M-SPECT was performed using TF in 115 patients and MIBI in 45 patients. Stress-rest one day protocol was used in all patients. A coronary stenosis was considered significant when the luminal diameter ${\geq}$50% was compromised. The chi square test was used to compare differences in sensitivity and specificity between the two groups. Results: There was no difference in age and diseased coronary artery branches between the two groups. There were more male patients in TF group: Male-to-female ratios of TF and MIBI groups were 78:37 and 23:22, respectively(p<0.05). The overall sensitivity of TF study was 92% and specificity 36%. The overall sensitivity and specificity of MIBI study were 93% and 30%, respectively. There was no difference between TF and MIBI groups in identifying individual diseased coronary artery branches. Conclusion: One day stress-rest myocardial SPECT using either TF or MIBI was comparable and was a very sensitive test in detecting coronary artery disease.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.27 no.5
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• pp.619-628
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• 2009

LiDAR has capability of rapid data acquisition and provides useful information for reconstructing surface of the Earth. However, Extracting information from LiDAR data is not easy task because LiDAR data consist of irregularly distributed point clouds of 3D coordinates and lack of semantic and visual information. This thesis proposed methods for automatic extraction of buildings and 3D detail modeling using airborne LiDAR data. As for preprocessing, noise and unnecessary data were removed by iterative surface fitting and then classification of ground and non-ground data was performed by analyzing histogram. Footprints of the buildings were extracted by tracing points on the building boundaries. The refined footprints were obtained by regularization based on the building hypothesis. The accuracy of building footprints were evaluated by comparing with 1:1,000 digital vector maps. The horizontal RMSE was 0.56m for test areas. Finally, a method of 3D modeling of roof superstructure was developed. Statistical and geometric information of the LiDAR data on building roof were analyzed to segment data and to determine roof shape. The superstructures on the roof were modeled by 3D analytical functions that were derived by least square method. The accuracy of the 3D modeling was estimated using simulation data. The RMSEs were 0.91m, 1.43m, 1.85m and 1.97m for flat, sloped, arch and dome shapes, respectively. The methods developed in study show that the automation of 3D building modeling process was effectively performed.