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Reactive Oxygen Species Mediates High Glucose-induced Fibronectin Synthesis in Human Peritoneal Mesothelial Cells

  • Hunjoo Ha;Yu, Mi-Ra;Lee, Hi-Bahl
    • 한국생물물리학회:학술대회논문집
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    • 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
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    • pp.65-65
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    • 2001
  • We have recently demonstrated that high glucose (50 mM D-glucose) upregulates fibronectin mRNA expression and protein synthesis by human peritoneal mesothelial cells (HPMC) through activation of protein kinase C (PKC) and suggested that this may lead to progressive peritoneal fibrosis during a long-term peritoneal dialysis (PD) using glucose as an osmotic agent.(omitted)

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장기 안정성을 고려한 경질유 유량표준장치 불확도 평가 (Long Term Stability of Uncertainty Analysis of Light Oil Elow Standard System)

  • 임기원;최종오
    • 대한기계학회논문집B
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    • 제29권10호
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    • pp.1130-1138
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    • 2005
  • A national standard system for the petroleum field has been developed to calibrate and test the oil flow meters in Korea. The operating system and the uncertainty of the system were evaluated by the peer reviewers of foreign national metrology institutes in 2002. Since the characteristics of the system might be changed by time, the uncertainty of the system is reevaluated with the consideration of the long term stability of the system. It is found that the system has a relative expanded uncertainty of 0.048 $\%$ in the range of $15\~120\;m^3/h$. According to the uncertainty budget, the uncertainties of the fluid density and the final mass measurement, which are temperature dependent, contribute about $94\%$ of the total uncertainty in the oil flow standard system

Strength of FRP RC sections after long-term loading

  • Pisani, M.A.
    • Structural Engineering and Mechanics
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    • 제15권3호
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    • pp.345-365
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    • 2003
  • The adoption of fibre reinforced polymer (FRP) rebars (whose behaviour is elastic-brittle) in reinforced concrete (RC) cross sections requires the assessment of the influence of time-dependent behaviour of concrete on the load-carrying capacity of these sections. This paper presents a method of computing the load-carrying capacity of sections that are at first submitted to a constant long-term service load and then overloaded up to ultimate load. The method solves first a non-linear visco-elastic problem, and then a non-linear instantaneous analysis up to ultimate load that takes into account the self-equilibrated stress distribution previously computed. This method is then adopted to perform a parametric analysis that shows that creep and shrinkage of concrete increase the load-carrying capacity of the cross section reinforced with FRP and allows for the suggestion of simple design rules.

한전계통에서 중장기 조상설비 소요량 산정에 관한 연구 (A Study on the amount of compensators at the KEPCO system in a middle-long term point of view)

  • 김호표;허연;최재명;김상권;이호용
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2006년도 제37회 하계학술대회 논문집 A
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    • pp.187-189
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    • 2006
  • Compensators need to keep the voltage properly at the KEPCO system in a ruddle-long term point of view. Therefore, it is necessary to forecast the amount of compensators. In this paper, we analyze how much compensators are needed and what kind of effects is given on the KEPCO system in a middle-long term point of view. In addition, this analysis is based on the books named "The plan of Transmission and Substation at the KEPCO in 2005" and we used PSS/E program when we analyze the KEPCO system.

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Long-Term Aging Diagnosis of Rotor Steel Using Acoustic Nonlinearity

  • Kim, Chung-Seok;Park, Ik-Keun;Jhang, Kyung-Young;Hyun, Chang-Yong
    • 비파괴검사학회지
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    • 제31권6호
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    • pp.642-649
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    • 2011
  • The long-term aging of ferritic 2.25CrMo steel was characterized using the acoustic nonlinear effect in order to apply to diagnose the degradation behavior of structural materials. We measured the acoustic nonlinearity parameter for each thermally aged specimen by the higher harmonic-generation technique. The acoustic nonlinearity parameter increased with aging time due to equilibrium M6C carbide precipitation, and has a favorable linear relation with Rockwell hardness. This study suggests that acoustic nonlinearity testing may be applicable to diagnostics on strength degradation in rotor steels.

성토지반에 타입된 H 말뚝의 약축방향에 대한 횡방향 장기지지거동 (Lateral long term behavior for web direction of Driven H-Piles in Embankment)

  • 박영호;정경자;김낙영;황영철
    • 한국지반공학회:학술대회논문집
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    • 한국지반공학회 2002년도 기초기술학술발표회
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    • pp.43-56
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    • 2002
  • To find a lateral long term behavior of driven H-piles in embankment, inclinometer is installed at pile and measurement is done during a year. When behavior of measured slope angles is in accord with behavior of nonlinear p-y curves(Reese, Murchison and O'Neil, Matlock's p-y analysis), maximum displacement of pile head, maximum stress and maximum bending moment of pile obtained from the numerical analysis are shown. As results, maximum lateral displacement at pile head, maximum stress and maximum bending moment of pile are shown linear behavior, And maximum lateral load, maximum lateral displacement, and maximum bending moment at pile obtained from the numerical analysis are 8∼12.4tonf, 9∼10.1㎜, and 10.39∼12.67tonf-m per pile according to the curves, respectively.

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COUNTING SUBRINGS OF THE RING ℤm × ℤn

  • Toth, Laszlo
    • 대한수학회지
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    • 제56권6호
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    • pp.1599-1611
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    • 2019
  • Let $m,n{\in}{\mathbb{N}}$. We represent the additive subgroups of the ring ${\mathbb{Z}}_m{\times}{\mathbb{Z}}_n$, which are also (unital) subrings, and deduce explicit formulas for $N^{(s)}(m,n)$ and $N^{(us)}(m,n)$, denoting the number of subrings of the ring ${\mathbb{Z}}_m{\times}{\mathbb{Z}}_n$ and its unital subrings, respectively. We show that the functions $(m,n){\mapsto}N^{u,s}(m,n)$ and $(m,n){\mapsto}N^{(us)}(m,n)$ are multiplicative, viewed as functions of two variables, and their Dirichlet series can be expressed in terms of the Riemann zeta function. We also establish an asymptotic formula for the sum $\sum_{m,n{\leq}x}N^{(s)}(m,n)$, the error term of which is closely related to the Dirichlet divisor problem.

관측자료와 대기질 모사를 이용한 주요 기준성 대기오염물질의 권역별 장기변화 분석 (Long-term Trend Analysis of Key Criteria Air Pollutants over Air Quality Control Regions in South Korea using Observation Data and Air Quality Simulation)

  • 주혜지;김현철;김병욱;김영성;신혜정;김순태
    • 한국대기환경학회지
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    • 제34권1호
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    • pp.101-119
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    • 2018
  • In this study, we analyzed long-term measurements and air quality simulation results of four criteria air pollutants ($PM_{10}$, $O_3$, $NO_2$, and $SO_2$) for 10 years, from 2006 to 2015, with emphasis on trends of annual variabilities. With the observation data, we conducted spatial interpolation using the Kriging method to estimate spatial distribution of pollutant concentrations. We also performed air quality simulations using the CMAQ model to consider the nonlinearity of the secondary air pollutants such as $O_3$ and the influence of long-range transport. In addition, these simulations are used to deduce the effect of long-term meteorological variations on trends of air quality changes because we fixed the emissions inventory while changing meteorological inputs. The nation-wide inter-annual variability of modeled $PM_{10}$ concentrations was $-0.11{\mu}g/m^3/yr$, while that of observed concentrations was $-0.84{\mu}g/m^3/yr$. For the Seoul Metropolitan Area, the inter-annual variability of observed $PM_{10}$ concentrations was $-1.64{\mu}g/m^3/yr$ that is two times rapid improvement compared to other regions. On the other hand, the inter-annual variability of observed $O_3$ concentrations is 0.62 ppb/yr which is larger than the simulated result of 0.13 ppb/yr. Magnitudes of differences between the modeled and observed inter-annual variabilities indicated that decreasing trend of $PM_{10}$ and increasing trend of $O_3$ are more influenced by emissions and oxidation states than meteorological conditions. We also found similar patterns in $NO_2$. However, $NO_2$ trends showed greater regional and seasonal differences than other pollutants. The analytic approach used in this study can be applicable to estimate changes in factors determining air quality such as emissions, weather, and surrounding conditions over a long term. Then analysis results can be used as important data for air quality management planning and evaluation of the chronic impact of air quality.

Long Term Effect of High Glucose and Phosphate Levels on the OPG/RANK/RANKL/TRAIL System in the Progression of Vascular Calcification in rat Aortic Smooth Muscle Cells

  • Kang, Yang Ho;Jin, Jung Sook;Son, Seok Man
    • The Korean Journal of Physiology and Pharmacology
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    • 제19권2호
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    • pp.111-118
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    • 2015
  • Osteoprotegerin (OPG), receptor activator of NF-${\kappa}B$ ligand (RANKL)/receptor activator of NF-${\kappa}B$ (RANK) axis, and TNF-related apoptosis-inducing ligand (TRAIL) participate in vascular calcification process including atherosclerosis, but their contributions under high glucose (HG) and phosphate (HP) condition for a long-term period (more than 2 weeks) have not been fully determined. In this study, we evaluated the effects of HG and HP levels over 2 or 4 weeks on the progression of vascular calcification in rat vascular smooth muscle cells (VSMCs). Calcium deposition in VSMCs was increased in medium containing HG (30 mmol/L D-glucose) with ${\beta}$-glycerophosphate (${\beta}$-GP, 12 mmol/L) after 2 weeks and increased further after 4 weeks. OPG mRNA and protein expressions were unchanged in HG group with or without ${\beta}$-GP after 2 weeks. However, after 4 weeks, OPG mRNA and protein expressions were significantly lower in HG group with ${\beta}$-GP. No significant expression changes were observed in RANKL, RANK, or TRAIL during the experiment. After 4 weeks of treatment in HG group containing ${\beta}$-GP and rhBMP-7, an inhibitor of vascular calcification, OPG expressions were maintained. Furthermore, mRNA expression of alkaline phosphatase (ALP), a marker of vascular mineralization, was lower in the presence of rhBMP-7. These results suggest that low OPG levels after long term HG and phosphate stimulation might reduce the binding of OPG to RANKL and TRAIL, and these changes could increase osteo-inductive VSMC differentiation, especially vascular mineralization reflected by increased ALP activity during vascular calcification.

CONSTRAINTS ON A-DECAYING COSMOLOGY FROM OBSERVATIONAL POINT OF VIEW

  • KOMIYA ZEN;KAWABATA KIYOSHI;HIRANO KOICHI;BUNYA HIROSHI;YAMAMOTO NAOTAKA
    • 천문학회지
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    • 제38권2호
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    • pp.157-160
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    • 2005
  • To constrain the values of the model parameters for the cosmological models involving the time-decaying $\Lambda$ term, we have computed sets of theoretical predictions for the N-m relation of galaxies as well as the CMB angular power spectrum: three types of variation, viz., ${\Lambda}{\propto} T^{-1},\;a^{-m}$, and $H^n$ are thereby assumed following Overduin & Cooperstock (1998), although we concentrate here on the discussion of the results obtained from the first type. Our results for the N-m relation indicate that the observed excess of the galaxy counts N in the faint region beyond the blue apparent magnitude 24 can be reasonably well accounted for with the value of ${\iota}$ in the range between 0.2 and 1. Furthermore, a comparison of our computational results of the CMB spectra with the observational data shows that the models with a mild degree of the $\Lambda$ term decay, viz., with the value of ${\iota}{\le}$0.4, are favorable. In this case, the age of our universe turns out to be larger than or equal to 14 Gyr, the lower limit inferred from some Uranium datings.