• Journal of Preventive Medicine and Public Health
• /
• v.51 no.3
• /
• pp.148-153
• /
• 2018

Objectives: Malaria remains a public health concern worldwide, including Indonesia. Purworejo is a district in which endemic of malaria, they have re-setup to entering malaria elimination in 2021. Accordingly, actions must be taken to accelerate and guaranty that the goal will reach based on an understanding of the risk factors for malaria. Thus, we analysed malaria risk factors based on human and housing conditions in Kaligesing, Purworejo, Indonesia. Methods: A case-control study was carried out in Kaligesing subdistrict, Purworejo, Indonesia in July to August 2017. A structured questionnaire and checklist were used to collect data from 96 participants, who consisted of 48 controls and 48 cases. Univariate, bivariate, and multivariate analyses were performed. Results: Bivariate analysis found that education level, the presence of a cattle cage within 100 m of the house, not sleeping under a bednet the previous night, and not closing the doors and windows from 6 p.m. to 5 a.m. were significantly ($p{\leq}0.25$) associated with malaria. Of these factors, only not sleeping under a bednet the previous night and not closing the doors and windows from 6 p.m. to 5 a.m. were significantly associated with malaria. Conclusions: The findings of this study demonstrate that potential risk factor for Malaria should be paid of attention all the time, particularly for an area which is targeting Malaria elimination.

• Journal of Microbiology and Biotechnology
• /
• v.27 no.1
• /
• pp.149-154
• /
• 2017

Transfer of Micropolyspora internatus into the genus Saccharomonospora as "Saccharomonospora internatus comb. nov." was proposed by Kurup and Greiner-Mai, but the nomenclatural change has not been validly published. Although the inclusion of M. internatus in the genus Saccharomonospora has not being established, the synonymy of "Saccharomonospora internatus" and S. viridis was proposed by Greiner-Mai. A number of recent publications regarded M. internatus as a synonym of S. viridis, but the name M. internatus is still used in some cases instead of S. viridis. This is because of the complicated history of M. internatus and S. viridis, but it is different from the generally accepted view of prokaryotic taxonomy. To clearly verify the synonymy of M. internatus and S. viridis, a literature review and experimental verification were conducted in this study. Based on the genomic and phenotypic characteristics obtained in this study, the synonymy of the two species was obvious. The emended description of S. viridis is given.

• Toxicological Research
• /
• v.33 no.2
• /
• pp.149-156
• /
• 2017

The purpose of this study was to investigate the wound healing effect of acai berry water extracts (ABWE) and a possible underlying mechanism involved in its action using various in vitro and in vivo models. The wound healing effect of ABWE was evaluated by migration assay using HS68 fibroblast cells. In addition, its effect on mRNA expression of procollagen, fibronectin, and MMP-1 was determined. Moreover, the wound healing effect of ABWE was evaluated in in vivo wound models through macroscopic and microscopic observation. In addition, mRNA expression levels of wound related genes were determined. Results revealed that ABWE was not cytotoxic. It increased migration of HS68 fibroblast cells. ABWE increased mRNA expression levels of fibronectin but decreased the mRNA expression levels of MMP-1. ABWE also showed significantly potent wound healing effect in vivo based on macroscopic and histopathological observation and mRNA expression evaluation for wound related genes. Taken together, our results indicated that ABWE might have potential as a wound healing agent.

• Journal of Environmental Health Sciences
• /
• v.30 no.5 s.81
• /
• pp.402-409
• /
• 2004

I performed the research about the drinking water treatment by precoat filtration and activated carbon adsorption process in the D water treatment plant at Gwangju. D water treatment plant inlet water is supplied from Juam lake in Jeollanamdo. The results are as follows; 1. Element disk used in this experiment are R(pore size $10{\mu}m$), B(pore size $20{\mu}m$). And diatomaceous earth are A(cake pore size $3.5{\mu}m$), B(cake pore size $7{\mu}m$) and C(cake pore size $17{\mu}m$) 2. Filtrate of precoat filter during 30 min are B-C 10.2 > BB 5.7 > R-A 5.4 ($m^3/m^2$). 3. The water quality through B-C+AC and R-A+AC are DOC 1.76 mg/1, 1.288 m/l respectively. 4. total THMs produced by chlorination are $84.2{\mu}g/l$(B-C+AC), $66.11{\mu}g/l$ (R-A+AC), $97{\mu}g/l$ (rapid sand filtration water) respectively. 5. The R-A+AC and B-C+AC process can be substitute of CWTS.

• Environmental Analysis Health and Toxicology
• /
• v.22 no.2 s.57
• /
• pp.185-188
• /
• 2007

PM10 and PM2.5 in ambient air were collected in Seongbuk-gu area of Seoul for one year, from April 2005 to February 2006, and the concentration of PM-bound mercury was monitored. The annual concentrations of particles were $66.4{\pm}43.2{\mu}g/m^3\;(47.6{\pm}19.1{\mu}g/m^3-106.1{\pm}78.0{\mu}g/m^3)$ in PM10 and $37.2{\pm}20.4{\mu}g/m^3\;(28.0{\pm}23.4{\mu}g/m^3{\sim}42.7{\pm}21.4{\mu}g/m^3)$ in PM2.5, which is about 56% of PM10 concentration. The annual average concentrations of mercury were $0.125{\pm}0.078ng/m^3\;in\;PM10\;and\;0.141{\pm}0.080ng/m^3$ in PM2.5, respectively. In April of Asian dust season in Korea, mercury showed the highest concentration in both PM10 and PM2.5.

• Journal of Korean Clinical Health Science
• /
• v.5 no.4
• /
• pp.1021-1025
• /
• 2017

Purpose: Changes in corneal thickness after wearing hydrogel lens and silicone-hydrogel lens with different oxygen transmission rates wew syudied. Methods: Experiments were performed on 11 subjects(22 eyes). corneal thickness was measured after wearing contact lenses for 8 hours. Corneal thickness was measured using ORB Scan II(ver. 3.14) Results: In the results of the corneal thickness measurement by direction, in the case of the hydrogel-tor lens, the center thickness was $33.63{\mu}m$, the nasal was $34.29{\mu}m$, the temporal was $27.17{\mu}m$, the inferior was $27.17{\mu}m$, the superior was $18.90{\mu}m$, and change rates were 6.28%, 5.71%, 5.40%, 4.75% and 3.09%, respectively. In the results of the corneal thickness measurement by diameter, in the case of the hydrogel-tor lens, the center was $33.63{\mu}m$, the mid-peripheral was $28.19{\mu}m$, the peripheral was $24.18{\mu}m$, and change rates were 6.28%, 4.76%, and 3.79%, respectively. Conclusions: The hydrogel lenses with relatively low oxygen transmission rates resulted in a significant increase in thickness over the entire cornea compared to silicon-hydrogel lenses with high oxygen transmission rates.

• Food Science of Animal Resources
• /
• v.28 no.5
• /
• pp.623-628
• /
• 2008

This study was undertaken to determine the concentrations of airborne bacteria, fungi, particles, and endotoxin in swine and chicken houses. Six swine buildings and seven chicken houses were randomly selected in southern Gyonggi Province, South Korea. The geometric mean concentrations of airborne bacteria in swine and chicken houses were $2.7{\times}10^5\;CFU/m^3$ and $5.6{\times}10^7\;CFU/m^3$, respectively. The airborne bacteria concentrations in chicken houses were significantly higher than those of swine houses (p<0.05). The geometric mean concentration of airborne fungi in swine houses was $4.9{\times}10^3\;CFU/m^3$, which was higher than the value of $2.1{\times}10^3\;CFU/m^3$ found in chicken houses. The mean concentrations of airborne particles and endotoxin in swine houses were $3.48\;mg/m^3$ and $943.1\;EU/m^3$, and they were $15.43\;mg/m^3$ and $1,430.5\;EU/m^3$ in chicken houses, respectively. A significant difference between swine and chicken houses was found for total dust (p<0.05), but not for endotoxin. In this study, the concentrations of endotoxin in both swine and chicken houses as well as particles in chicken houses were high, and in about 50% of the samples exceeded the worker health safety levels of $614\;EU/m^3$ suggested in previous studies. These results may indicate a considerable respiratory hazard for workers in these environments.

• Journal of Environmental Health Sciences
• /
• v.31 no.4 s.85
• /
• pp.316-321
• /
• 2005

4개 업종(축전지제조업, 광명단 제조업, 2차 제련업, 라디에타 제조업)에서 근무하는 총 100명의 근로자를 대상으로 8단계다단충돌기(eight stages personal cascade imparter)에 의한 입자 크기 별 납농도를 측정하였다 크기 별 납 농도는 총납(PbA), 흡입성납(IPM-PbA), 흉곽성납(TPM-PbA), 호흡성납(RPM-PbA), $1{\mu}m$ 미만의 납$(Pb_{1\mu})$ 그리고 $1{\mu}m$ 이상의 소화성납$(Pb_{ing})$이었다. 동일한 근로자(100명)를 대상으로 혈액에서 납농도를 측정하였다. 혈액 중 납은 원자흡광광도계(atomic absorption spectrometry)의 Zeeman effect graphite furnace를 이용하여 분석하였다. 총 납의 노출농도는 노출기준$(50\;ug/m^3)$을 크게 초과하였다. 평균 호흡성 납 노출농도$(115.7\;ug/m^3)$ 총 납의 노출기준을 훨씬 초과하였다. $1{\mu}m$미만의 납$(Pb_{1\mu})$ 노출농도의 범위는 0.7에서 $(492.2\;ug/m^3)$이나 되었다. 근로자의 $46\%$가 혈액 중 납 농도 40 ug/dL을 초과하였다. 60 ug/dL을 초과한 경우도 $13\%$나 되었다. 입자 크기가 큰 납인 총납, 흡입성 납 그리고 호흡성 납 농도는 혈액 중 납 농도와 유의한 상관을 보였다(p<0.0001). 그러나 가장 높은 상관은 $1{\mu}m$미만의 납$(Pb_{1\mu})$ 혈액 중 납과의 관계였다. T-test에서 $50ug/m^3$이상의 호흡성 납을 나타낸 근로자 그룹과 $50ug/m^3$ 이하의 근로자 그룹간에의 혈액 중 납 농도는 유의한 차이가 있는 것으로 나타났다(p=0.000). 이러한 연구결과는 입자크기 구분이 없는 현재의 총납에 의한 노출기준과 측정방법은 미세 납 먼지에 노출되는 근로자의 납흡수를 보호하는데 한계점이 있다는 것을 의미한다. 향후 납 입자크기는 물론 근로자의 개인적인 위생과 작업내용 등을 변수로 납 흡수에 영향을 미치는 종합적인 요인을 찾아내는 연구를 진행할 필요가 있다.

• Journal of dental hygiene science
• /
• v.22 no.3
• /
• pp.164-170
• /
• 2022

Background: When cells are damaged by nicotine, cellular senescence due to oxidative stress accelerates. In addition, stress-induced inflammatory response and cellular senescence cause the accumulation of damaged organelles in cells, and autophagy appears to remove them. Conversely, when autophagy is reduced, harmful cell components accumulate, and aging is accelerated. This study aimed to determine the association between nicotine-induced cellular senescence and autophagy expression patterns in human gingival fibroblasts. Methods: Cells were treated with various concentrations of nicotine (0, 0.1, 0.5, 1, 2, and 5 mM) and 10 nM rapamycin was added to 1 mM nicotine to investigate the relationship between autophagy and cellular senescence. Cell viability was confirmed using WST-8 and the degree of cellular senescence was measured by SA-β-gal staining. The expression of the inflammatory proteins (COX-2 and iNOS) and autophagy markers (LC3-II, p62, and Beclin-1) was analyzed by western blotting. Results: The cell viability tended to decrease in a concentration-dependent manner. COX-2 showed no concentration-dependent expression and iNOS increased in the 0.5 mM nicotine treated group. The degree of cellular senescence was the highest in the 1 mM nicotine treatment group. In the group treated with rapamycin and nicotine, the conversion ratio of LC3-II to LC3-I was the highest, that of p62 was the lowest, and the level of Beclin-1 proteins was significantly increased. Furthermore, the degree of cellular senescence was reduced in the group in which rapamycin was added to nicotine compared to that in the group treated with nicotine alone. Conclusion: This study provides evidence that autophagy activated in an aging environment reduces cellular senescence to a certain some extent.

• Journal of Korean Public Health Nursing
• /
• v.34 no.2
• /
• pp.225-237
• /
• 2020

Purpose: This descriptive correlational study examined the acculturation, health literacy, and factors affecting the health literacy of Vietnamese and Chinese female marriage immigrants. Methods: The sample consisted of 90 Vietnamese and 89 Chinese female marriage immigrants who participated in Multicultural Family Support Centers' programs in metropolitan city A. The health literacy was measured by HLI-FMI (Health Literacy Index for Female Marriage Immigrants), acculturation was measured using the Acculturation Index for female marriage immigrants. Descriptive statistics, t-test, Chi-square, one-way ANOVA, Scheffé test, Pearson correlation coefficient, and multiple linear regression were performed for data analysis. Results: The Chinese group (M=9.80±2.72) showed a significantly higher health literacy than the Vietnamese group (M=8.07±3.57). The factors affecting health literacy among Chinese were the length of residence (β=.442 p<.001), and adaptation to Korean culture (β=.381, p=.007). Conclusion: To develope graded education programs for promoting the health literacy of Chinese and Vietnamese female marriage immigrants, the length of residence can be considered. Continuously providing a support system to help them adapt to Korean culture can also have a positive effect on health literacy.