• Korean Institute of Interior Design Journal
• /
• v.15 no.3 s.56
• /
• pp.126-135
• /
• 2006

The concept of the Hospital run for medical treatment changing to the forms of theme complex hospital with design by the impact of a boutique design. Especially, this design's element emboss with strongly to form a ring around the special hospital as the dentistry, dermatology and plastic surgery, the woman hospital of a lying-in hospital etc. that is the higher value-added industrial among groups of medical, even general hospital that is not depend on the design relatively, the application of the interior design is extending farther. Also, this special hospital shape up become bigger, form a group and competition for admission to medical industry. For dentistry, the more departmentalize and definite service as implant, children dental clinic holding an absolute dominant position about management, and effective environmental exchange can be essential element for the most profits. Accordingly, In this study I would like to see about the space composition of the dentistry that changing with the times, suggest direction from now on the bigger, specialization and a characteristic of a space focused on recently dentistry project.

• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.23 no.2
• /
• pp.164-168
• /
• 2013

Objectives: This study was aimed at the examination of the lead exposure status of smelting process workers in steelmaking using scrap iron. Methods: The study was conducted from July to September 2012 by means of measurements taken during the smelting process, with 45 minutes set for a one-time smelting work cycle when it comes to personal air sample and area air sample. As such, daily work hours were classified into 360 minutes for measurement. The analysis of lead concentration was conducted using AAs based on the NIOSH 7300 method. Results: In the case of the personal specimens that were subjected to periodical measurement 45 minutes per one session during the smelting process, 40 out of 42 specimens measured were found to contain lead, with an average concentration level of $0.028mg/m^3$ (Max: $0.182mg/m^3$, Min: $0.005mg/m^3$, TWA-more than 50%: 4 out of 6 units). In the case of regional specimens, lead was detected in 45 out of 48 specimens measured, with an average concentration level of $0.037mg/m^3$ (Max: $0.220mg/m^3$, Min: $0.007mg/m^3$ ). In the case of regional specimens subjected to measurement using a day as the work cycle, lead was detected in 15 out of 15 specimens measured, with an average concentration level of $0.049mg/m^3$ (Max: $0.478mg/m^3$, Min: $0.005mg/m^3$ ). Conclusions: It concluded that smelting process workers in steelmaking are exposed to lead because scrap iron is used as a raw material. It is thus necessary to introduce legal management to prevent occupation-related disease in smelting process workers in steelmaking.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.3
• /
• pp.2091-2095
• /
• 2013

Background: The $7^{th}$ TNM staging is the first authoritative standard for evaluation of effectiveness of treatment of gastric cancer worldwide. However, revision of pN classification within TNM needs to be discussed. In particular, the N3 sub-stage is becoming more conspicuous. Methods: Clinical data of 302 pN3M0 stage gastric cancer patients who received radical gastrectomy in Tianjin Medical University Cancer Institute and Hospital from January 2001 to May 2006 were retrospectively analyzed. Results: Location of tumor, depth of invasion, extranodal metastasis, gastric resection, combined organs resection, lymph node metastasis, rate of lymph node metastasis, negative lymph nodes count were important prognostic factors of pN3M0 stage gastric cancers. TNM stage was also associated with prognosis. Patients at T2N3M0 stage had a better prognosis than other sub-classification. T3N3M0 and T4aN3aM0 patients had equal prognosis which followed the T2N3M0. T4aN3bM0 and T4bN3aM0 had lower survival rate than the formers. T4bN3bM0 had worst prognosis. In multivariate analysis, TNM stage group and rate of lymph node metastasis were independent prognostic factors. Conclusions: The sub-stage of N3 may be useful for more accurate prediction of prognosis; it should therefore be applied in the TNM stage system.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.17
• /
• pp.7195-7200
• /
• 2014

Background: The aim of this study was to evaluate how CYP2C19 affects icotinib and metabolite' exposure, and to determine whether the exposure and EGFR genotype influences survival time, tumor metastasis and adverse drug reactions. Materials and Methods: 274 NSCLC patients who accepted 125mg icotinib/t.i.d. were chosen from a phase III study. Blood samples were obtained in $672^{nd}$ ($4^{th}$ week) and $1,680^{th}$ hours ($10^{th}$ week), and plasma was used to quantify the concentration of icotinib and blood cells were sampled to check the genotypes. Clinical data were also collected at the same time, including EGFR genotypes. Plasma concentrations were assessed by HPLC-MS/MS and genotype by sequencing. All data were analyzed through SPSS 17.0 and SAS 9.2. Results: CYP 2C19 genotypes affected bio-transformation from icotinib to M24 and M26, especially in poor-metabolisers. Higher icotinib concentrations (>1000 ng/mL) not only increased patient PFS and OS but also reduced tumor metastasis. Patients with mutant EGFR experienced a higher median PFS and OS (234 and 627 days), especially those with the 19del genotype demonstrating higher PR ratio. Patients who suffered grade II skin toxicity had a higher icotinib exposure than those with grade I skin toxicity or no adverse effects. Liver toxic reactions might occur in patients with greater M20 and M23 plasma concentrations. Conclusions: CYP2C19 polymorphisms significantly affect icotinib, M24 and M26 exposure. Patients with mutant EGFR genotype and higher icotinib concentration might have increased PFS and OS and lower tumor metastasis. Liver ADR events and serious skin effects might be respectively induced by greater M20, M23 and icotinib concentrations.

• 대한생식의학회:학술대회논문집
• /
• 2004.11a
• /
• pp.68-69
• /
• 2004

• 대한생식의학회:학술대회논문집
• /
• 2001.11a
• /
• pp.97.1-97.1
• /
• 2001

• 대한핵의학회:학술대회논문집
• /
• 1998.11a
• /
• pp.47.2-47.2
• /
• 1998

• IE interfaces
• /
• v.23 no.3
• /
• pp.246-256
• /
• 2010

As wireless and mobile technologies have advanced significantly, lots of large sized healthcare organizations have implemented so called mobile hospital (m-Hospital) which provides a location independent and point of care (POC) clinical environment. Implementation of m-Hospital enhances quality of care because health professionals such as physicians and nurses can use hospital information systems at the very place where patients are located without any delay. This paper presents a real-time patient monitoring system based on wireless network technologies. A general framework for the patient monitoring process is introduced and the architecture and components of the proposed monitoring system is described. The system collects and analyzes biometric signals of in-patients who suffer from cancer. Specifically, it continuously monitors oxygen saturation of patients in bed and alarms health professionals instantly when an abnormal status of the patient is detected. The monitoring system has been used and clinically verified in a university hospital.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.14
• /
• pp.5741-5745
• /
• 2014

Purpose: To study the expression of insulin-like growth factor binding proteins (IGFBPs) in paclitaxel-treated gastric cancer SGC-7901 cells, and to further investigate underlying mechanisms. Materials and Methods: Real time PCR and Western blot assays were applied to detect the mRNA and protein expression of IGFBP-2, -3 and -5 after paclitaxel (10 nM) treatment of SGC-7901 cells. In addition IGFBP-3 expression was silenced by RNA interference to determine effects. Cell viability was determined by MTT assay. Cell cycling and apoptosis were assessed by flow cytometry. Results: Compared to the control group, only IGFBP-3 expression was elevated significantly after paclitaxel (10 nM) treatment (p<0.05). Paclitaxel treatment caused cell cycle arrest and apoptosis via downregulating Bcl-2 expression. However, the effect could be abrogated by IGFBP-3 silencing. Conclusions: IGFBP-3 exhibits anti-apoptotic effects on paclitaxel-treated SGC-7901 cells via elevating Bcl-2 expression.

• Biomolecules & Therapeutics
• /
• v.18 no.1
• /
• pp.56-64
• /
• 2010

Pentoxifylline (PTX) has been used for the local reduction of fat tissue in the clinical setting. However, its safety and efficacy have not been proven. The aim of this study was to evaluate the effects of PTX on cell lines established from fat tissue. Newly cultured human preadipocytes and adipocytes from subcutaneous abdominal fat in addition to purchased human lung fibroblasts and keratinocytes were treated with PTX at different concentrations. Cell viability was determined using the Cell counting kit (CCK)-8 assay and lipolysis was evaluated using an Elisa kit. DNA fragmentation, Western blot analysis, Hoechst and Propidium Iodide (PI) staining and fluorescence activated cell scanning analysis were performed to confirm apoptosis. The viability of adipocytes, preadipocytes, keratinocytes and fibroblasts was markedly decreased at concentrations of PTX above 20 mM. Apoptosis was induced at concentrations of PTX over 40 mM in all cell lines. Lipolysis was increased by 60% at concentrations of PTX of 20 mM compared to the control. In conclusion, the results of this study showed that 20 mM of PTX induced lipolysis. At concentrations over 20 mM, PTX reduced the viability of all cells studied including: adipocytes, preadipocytes, fibroblasts and keratinocytes, in a non-specific manner.