• Clinical and Experimental Reproductive Medicine
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• v.40 no.4
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• pp.174-176
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• 2013

Klinefelter syndrome is the most common genetic form of male hypogonadism, but the phenotype becomes evident only after puberty. It is characterized by infertility, small testes, sparse body and facial hair, increased body weight, gynecomastia, increased LH and FSH, and a low level of testosterone. Early recognition and treatment of Klinefelter syndrome can significantly improve the patient's quality of life and prevent serious consequences. Here, we report an infertile man with a rare variant of Klinefelter syndrome with a 47, XY, i(X)(q10) karyotype.

• Korean Journal of Poultry Science
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• v.30 no.2
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• pp.95-99
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• 2003

A total of 112 male and 1208 female Ross broiler breeders (30-wk-old) were used in this study to investigate whether a male to female (M/F) ratio of broiler breeder chickens may influence fertility and hatchability of hatching eggs. There were three treatments, each consisting of four pens with a size of 3.2 m ${\times}$ 6.4 m. Each pen housed approx. 100 females and 10 males to give the M/F ratio as follows: T1, 1/9; T2, 1/11; and T3, 1/13, respectively. The fertility of broiler breeder eggs ranged between 93 to 94％ at 30 wk of age. At 35 wk of age, breeder eggs from T3 tended to be less fertile (P>0.05) than those from T1 and T2. The low fertility observed in T3 at 35 wk of age further reduced to reach a statistical significance at 46 wk of age (P<0.05) when compared to those of T1 and T2. Hatchability of breeder eggs among treatments tended to follow a similar trend as shown in fertility, keeping hatchability of breeder eggs from T3 low when compared to the groups of T1 and T2. Our results indicated that the M/F ratio influenced fertility and consequently hatchability of breeder eggs. Furthermore, our study suggests that either 1/9 or 1/11 M/F ratio, but not 1/13 M/F ratio, seems suitable to sustain reproductive performance of broiler breeders throughout the laying periods.

• Journal of Genetic Medicine
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• v.13 no.1
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• pp.14-19
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• 2016

Purpose: We examined the prevalence and CGG/AGG repeat structure of expanded alleles of the FMR1 gene in preconceptional and pregnant Korean women. Materials and Methods: The CGG repeats in the FMR1 genes of 1,408 women were analyzed by polymerase chain reaction and Southern blot analysis. To estimate the prevalence of expansion alleles, the individuals were divided into low risk and high risk group. Results: Within this population, 98.4% had normal alleles and 1.6% had abnormal alleles including intermediate (0.6%), premutation (0.5%), full mutation (0.1%), and hemizygous (0.4%) alleles. There were 2 premutation alleles (1:666, 95% confidence interval [CI] 1:250-1,776) in the low risk group and 5 premutation alleles (1:15, 95% 1:6-36) in the high risk group. There were 8 intermediate alleles (1:167, 95% CI 1:130-213) in the low risk group and 1 intermediate alleles (1:76, 95% CI 1:11-533) in the high group. Six of the 7 premutation alleles did not contain AGG interruptions within the repeats and 1 had a single AGG interruption. Four of the 9 intermediate alleles contained 2-3 AGG, 4 had a single AGG, and 1 had no AGG interruptions. Conclusion: Our study demonstrates the prevalence and CGG/AGG structure of expansion alleles in Korean women. The identified premutation prevalence is higher than that of other Asian populations and lower than that of Caucasian populations. Although our study is limited by size and population bias, our findings could prove useful for genetic counseling of preconceptional or pregnant women.

• Korean Journal of Child Studies
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• v.30 no.6
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• pp.75-84
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• 2009

Recently, low birthrate has been recognized as a social problem, which is expressed as catastrophy of population. There are several reasons why low birth rate has occurred directly and indirectly, generating total economic and social burden for our society. That is, low birthrate should not be simply regarded as reduction of population. The present study identified the reasons of low birthrate and the current status of infertility, and examined practical and theoretical issues in terms of low birthrate. It is our contention that low birthrate and infertility is one of the most important governmental issue to enhance quality of life of the public. Thus, integrated and systematic policy must be developed and implemented to effectively meet the issues.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.34 no.1
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• pp.106-112
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• 1989

To investigate varietal differences of anther size, pollen shape, pollen fertility and other agronomic characters under low temperature condition. twenty rice varieties (5 Tongil and 15 Japonica type) were treated at 19$^{\circ}C$ water temperature from booting to heading stage. There was varietal difference of low temperature response which was indicated by the delayed heading, the shortening of culm and panicle length. and the decrease of grain fertility and yield potential resulted from cooling treatment at booting stage. The varieties with low fertility damaged by the low temperature treatment at booting stage showed low pollen density per anther. small or abnormal anthers and pollen, and many sterile pollens. Anther length was correlated significantly with the number of pollens per anther and pollen fertility.

• Clinical and Experimental Reproductive Medicine
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• v.47 no.4
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• pp.237-244
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• 2020

Endometrial cancer (EC) in young women tends to be early-stage and low-grade; therefore, such cases have good prognoses. Fertility-sparing treatment with progestin is a potential alternative to definitive treatment (i.e., total hysterectomy, bilateral salpingo-oophorectomy, pelvic washing, and/or lymphadenectomy) for selected patients. However, no evidence-based consensus or guidelines yet exist, and this topic is subject to much debate. Generally, the ideal candidates for fertility-sparing treatment have been suggested to be young women with grade 1 endometrioid adenocarcinoma confined to the endometrium. Magnetic resonance imaging should be performed to rule out myometrial invasion and extrauterine disease before initiating fertility-sparing treatment. Although various fertility-sparing treatment methods exist, including the levonorgestrel-intrauterine system, metformin, gonadotropin-releasing hormone agonists, photodynamic therapy, and hysteroscopic resection, the most common method is high-dose oral progestin (medroxyprogesterone acetate at 500-600 mg daily or megestrol acetate at 160 mg daily). During treatment, re-evaluation of the endometrium with dilation and curettage at 3 months is recommended. Although no consensus exists regarding the ideal duration of maintenance treatment after achieving regression, it is reasonable to consider maintaining the progestin therapy until pregnancy with individualization. According to the literature, the ovarian stimulation drugs used for fertility treatments appear safe. Hysterectomy should be performed after childbearing, and hysterectomy without oophorectomy can also be considered for young women. The available evidence suggests that fertility-sparing treatment is effective and does not appear to worsen the prognosis. If an eligible patient strongly desires fertility despite the risk of recurrence, the clinician should consider fertility-sparing treatment with close follow-up.

• Korea journal of population studies
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• v.33 no.2
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• pp.137-163
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• 2010

This study examines how individual, familial, and social factors are associated with persistent very low fertility in Busan Metropolitan City and contemplates family-friendly environments and social strategies for fertility increase. Fertility decline in Busan Metropolitan City recorded the lowest birth rate nationwide recent years among metropolitan cities and provinces in Korea. Birthrates are low partly because of multiple factors such as high age at childbearing and at marriage, decline in marriage, high divorce rate, the phenomena of marriage avoidance among unmarried women, traditional gender role attitude of men, low domestic work participation of husbands among dual career couples, low marital satisfaction and family life satisfaction, abortion, and more broader attiributes such as family policy, availability of childcare, education expenses, and family-friendlyness of a society. In addition, women of dual career couples in Busan strained from domestic work overload under traditional norms of gender role, and marital satisfaction recorded below average nationwide along with espeacially low marital satisfaction of wives compared to that of husbands. Major aspects of implications and considerations for higher birth rate and family friendly policy in Busan are discussed.

• Korean Journal of Culture and Social Issue
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• v.18 no.1
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• pp.111-125
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• 2012

The total fertility rate of our nation has been in the world's lowest level with constant falling since it reached an all-time low in 1983. The increase in economic participation of women, difficulties to balance work and family life, and traditional gender role and family norms in our society have been blamed for causing low birth rates. In addition, the current economic recession and increased polarization of wealth make it more difficult for working families to balance work and family life, resulting in lowering fertility rates. The Korean government has recently prepared the second five-year basic plan(2011-2015) to deal with low fertility and population ageing. The basic plan aims at providing support for working families in balancing work and family life and helping people ease the burden of marriage, childbirth, and raising their children. The work-family balance policies based on gender equality will do much to increase fertility rates in the future. In this context, this study examined current status and problems of balancing work and family life in our society, the Korean government and corporate policies for work-family balance, and the effects of policies on childbirth. Suggestions for future directions are presented.

• Journal of Veterinary Science
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• v.24 no.1
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• pp.4.1-4.16
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• 2023

Background: In vitro culture of preantral follicles is a promising technology for fertility preservation. Objectives: This study aims to investigate an optimized three-dimensional (3D) fetal bovine serum (FBS)-free preantral follicle culture system having a simple and easy operation. Methods: The isolated follicles from mouse ovaries were randomly divided in an ultra-low attachment 96-well plates supplement with FBS or bovine serum albumin (BSA) culture or encapsulated with an alginate supplement with FBS or BSA culture. Meanwhile, estradiol (E₂) concentration was assessed through enzyme-linked immunosorbent assay of culture supernatants. The diameter of follicular growth was measured, and the lumen of the follicle was photographed. Spindle microtubules of oocytes were detected via immunofluorescence. The ability of oocytes to fertilize was assessed using in vitro fertilization. Results: The diameters were larger for the growing secondary follicles cultured in ultra-low attachment 96-well plates than in the alginate gel on days 6, 8, and 10 (p < 0.05). Meanwhile, the E2 concentration in the BSA-supplemented medium was significantly higher in the alginate gel than in the other three groups on days 6 and 8 (p < 0.05), and the oocytes in the FBS-free system could complete meiosis and fertilization in vitro. Conclusions: The present study furnishes insights into the mature oocytes obtained from the 3D culture of the preantral follicle by using ultra-low attachment 96-well plate with an FBS-free system in vitro and supports the clinical practices to achieve competent, mature oocytes for in vitro fertilization.

• The Korean Journal of Health Service Management
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• v.6 no.3
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• pp.197-208
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• 2012

There's an opinion that it may be a combination of change of values and social economic factors that caused low fertility of Korean society. This study intends to analyze actual conditions of family children values and gender role centered on university students in a marriageable age so draw a policy implication for overcoming low fertility. Main findings of this study are like following. First, as for analysis of childbirth intention shows average score of $3.35{\pm}1.142$ presented sex distinction that men have a higher tendency to women. Second, in gender role attitudes, it shows that gender role related on women's social activities($2.06{\pm}0.739$), traditional gender role in family($2.41{\pm}0.789$) influence on childbirth intention (p<0.001). Third, in family children values indicates moderate scores($2.95{\pm}0.648$) that son's position in family ($2.33{\pm}0.911$), relation between children and parents($2.80{\pm}1.050$), individual's position in family($3.56{\pm}0.671$) influence on childbirth intention(p<0.000) in the traditional values. Measures against low fertility will prove effective when family values are established favorable to marriage, childbirth, rearing, gender equality is settled in a society as a whole and related systems.