• 제목/요약/키워드: low body surface area

검색결과 82건 처리시간 0.026초

Low-dose Epidermal Growth Factor Receptor (EGFR)-Tyrosine Kinase Inhibition of EGFR Mutation-positive Lung Cancer: Therapeutic Benefits and Associations Between Dosage, Efficacy and Body Surface Area

  • Hirano, Ryosuke;Uchino, Junji;Ueno, Miho;Fujita, Masaki;Watanabe, Kentaro
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권2호
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    • pp.785-789
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    • 2016
  • A key drug for treatment of EGFR mutation-positive non-small cell lung cancer is epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). While the dosage of many general anti-tumor drugs is adjusted according to the patient body surface area, one uniform dose of most TKIs is recommended regardless of body size. In many cases, dose reduction or drug cessation is necessary due to adverse effects. Disease control, however, is frequently still effective, even after dose reduction. In this study, we retrospectively reviewed the characteristics of 26 patients at Fukuoka University Hospital between January 2004 and January 2015 in whom the EGFR-TKI dose was reduced with respect to progression free survival and overall survival. There were 10 and 16 patients in the gefitinib group and the erlotinib group, respectively. The median progression-free survival in the gefitinib group and the erlotinib group was 22.4 months and 14.1 months, respectively, and the median overall survival was 30.5 months and 32.4 months, respectively. After stratification of patients by body surface area, the overall median progression-free survival was significantly more prolonged in the low body surface area (<1.45 m2) group (25.6 months) compared to the high body surface area (>1.45 m2) group (9.7 months) (p=0.0131). These results indicate that low-dose EGFR-TKI may sufficiently control disease without side effects in lung cancer patients with a small body size.

20대 여성을 위한 새로운 체표면적 산출식에 관한 연구 (A Study of the New Body Surface Area Calculation for Twenties Women)

  • 임순
    • 복식문화연구
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    • 제7권2호
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    • pp.275-288
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    • 1999
  • The purpose of this is providing a simple, relatively errorless body surface area calculation. Subjects were 10 married women and 10 singles women whose age was 20 to 29 years old. The Gypsum method has applied for the sampling of body surface. The Weight method has been used to measure body surface by means of transferring gypsum shape on uniform plane polypropylene films. In this study, compare analyzed errors between the traditional formulas for measuring body surface area and measuring data in this experiment. More than all, it has been to induce a regression equation for measuring body surface area, which is so simple to calculate with less errors, with variable factors as weight and height. The results of this experiment as follows : 1. In the traditional formulas, weight formula was shown high average error : Niya\`s height formula. which was modified K value as 0.62 in the height formula (S = KH) is shown lower average error than Lassabliere\`s Height formula. 2. In the weight-height formula (S=K √WH), it was shown high average error according to the increasing of K value. Kawanami\`s formula, which 5.378 as K value, was shown low average error both the singles and the married women. 3. Dubois weight-heingt formula (S=W/sup a/·H/sub b/·K) was shown low average error than the weight, height, weight-height (S=K√WH) formula. 4. The regression equations with variable factors as weight and height are 156.74W + 86.05H - 660.25 (Single women) and 136.02W + 90.57H - 6241.32 (Married women) the average error and absolute average error to the singles are 0.09%, 0.94% and resoectively -0.13%, 1.16% for the married women.

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Water body extraction in SAR image using water body texture index

  • Ye, Chul-Soo
    • 대한원격탐사학회지
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    • 제31권4호
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    • pp.337-346
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    • 2015
  • Water body extraction based on backscatter information is an essential process to analyze floodaffected areas from Synthetic Aperture Radar (SAR) image. Water body in SAR image tends to have low backscatter values due to homogeneous surface of water, while non-water body has higher backscatter values than water body. Non-water body, however, may also have low backscatter values in high resolution SAR image such as Kompsat-5 image, depending on surface characteristic of the ground. The objective of this paper is to present a method to increase backscatter contrast between water body and non-water body and also to remove efficiently misclassified pixels beyond true water body area. We create an entropy image using a Gray Level Co-occurrence Matrix (GLCM) and classify the entropy image into water body and non-water body pixels by thresholding of the entropy image. In order to reduce the effect of threshold value, we also propose Water Body Texture Index (WBTI), which measures simultaneously the occurrence of repeated water body pixel pair and the uniformity of water body in the binary entropy image. The proposed method produced high overall accuracy of 99.00% and Kappa coefficient of 90.38% in water body extraction using Kompsat-5 image. The accuracy analysis indicates that the proposed WBTI method is less affected by the choice of threshold value and successfully maintains high overall accuracy and Kappa coefficient in wide threshold range.

한복의 보온력 평가를 위한 컴퓨터 시뮬레이션 (Computer Simulation for Calculation of Thermal Insulation in Korean Folk Clothes)

  • 권오경;성수광
    • 한국의류학회지
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    • 제21권7호
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    • pp.1153-1161
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    • 1997
  • The insulation provided by clothing system is usually expressed in terms of a coo units and its distribution of the body, directly affect convective, conductive, and radiant heat loss from the skin to the environment Evaporated heat loss is dependent upon fabric permeability, the amount of body surface area covered by clothing, and the pumping of air between the body and garment layers. Persons at low to medium activity levels, dressed in conventional apparel in door environments, usually do not lose a large amount of heat through evaporation. Thermal manikin technology is used to measure the resistance to heat transfer provided by clothing systems. The reciprocal of this value, 6.45 W/m2.$^{\circ}C$ is often used in calculations for convenience. The purpose of this study was to implement a research program for calculation the insulation value (clo), body surface area and basal metabolic rate of selected clothing system. The project provided for the building of an insulation data base for use in evaluating and comparing new and improved garments.

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인체 부착형 기기를 고려한 변형된 Alford 루프 안테나 설계 (Design of a Modified Alford Loop Antenna for On-Body Devices)

  • 박중기;이준석;최재훈
    • 한국전자파학회논문지
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    • 제25권1호
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    • pp.25-31
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    • 2014
  • 본 논문에서는 인체 내 외부간 근거리 통신망인 WBAN(Wireless Body Area Network)에서 인체 부착형 기기간 통신링크를 원활하게 구성하기 위한 변형된 Alford 안테나를 제안하였다. 제안된 안테나는 인체의 영향을 고려해 설계하였으며, ISM(The Industrial, Scientific and Medical, 2.4~2.485 GHz) 대역에서 동작한다. 기존 Alford 루프 안테나는 low-profile인 장점이 있지만, 인체 부착용 시스템의 다른 부품을 설치할 접지면이 존재하지 않고 balanced 급전 구조를 사용하기 때문에 on-body 안테나로 적합하지 않다. 따라서 본 논문에서는 on-body 환경에서 동작할 수 있는 접지면이 포함된 unbalanced 급전 구조를 갖는 안테나를 제안하였다. 또한, 안테나가 인체에 부착되어 안테나 성능에 미치는 영향을 고려하기 위해 모의 인체를 통해 모의실험과 측정을 수행하였다. 제안된 안테나는 모노폴 형태의 방사 패턴을 갖는 low-profile 구조이며, ISM 대역 내에서 10 dB 반사 손실을 만족한다. 안테나는 on-body 통신 환경에 적합한 표면지향성 특성을 갖는다.

시판 임산부용 거들의 착용감 및 착용효과에 관한 연구 (A Study on the Wear comfort and the Wearing Effects of Maternity Girdles)

  • 최혜선
    • 대한가정학회지
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    • 제29권3호
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    • pp.11-21
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    • 1991
  • The study has been intended to find out meaningful information about the development of a prototype of enhanced maternity girdle. The girdles of three different models which were available in the market have been carried out by three six-month pregnant women and three nine-month pregnant women. The results of the study are as follows. 1. All three girdles showed improved wear effects in order of model A, model B, model C. Body surface area measurement and two body surface angles of abdomen are significantly dicreased by wearing and type of girdles. It is presumed that the reasons of good wear effect of model A is low expansion rate of the material and tight fitness of the model. Model B is made of material whose expansion rate is higher than model A. Also abdominal part of the model B is bias cut which is considered to result better stretch and consequently lower wear effect. 2. For wear comfort, subjects preferred in order of model B, model C, and model A. All subjects feel more comfortable after wearing girdles 30 minutes than after wearing girdles 1 day. Comparing 2 subject groups, 6-month pregnant group feel more comfortable about wearing girdles than 9-month pregnant group. 3. The girdles are expanded as a whole in order of model B, model C and model A. Considering the expansion rate of some specific area of the girdles, abdominal area expands more than hip area which expands more than thigh area. The expansion rates of girdles worn to 6-month pregnant group are very low at all area, while the expansion rates of girdles worn to 9-month pregnant group are very high.

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거주공간에서의 복선열교환에 관한 연구 -착의시의 착의부와 노출부의 열수수 (A study on the radiant heat exchange in living space)

  • 윤정숙
    • 대한가정학회지
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    • 제24권2호
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    • pp.75-82
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    • 1986
  • This study was measured experimentally the Configuration factor of the adult female with the purpose of explaning quantitatively the human body's radiant heat exchange in a small scale of a house. And it is a investigatio about human clothed body's heat resistance which have great influence on radiant heat exchange. The result of this study was diagrammatized the [Shape×Area Factor] for the sake of making it easy to calculate the quantity of the actual human body's radiant heat exchange, and designed a diagram to make it easy to find the value of the human clothed body's heat resistance and clothing surface temperature. Thus, this research can be used as a basic resource for not only calculating wuantitatively radiant heat exchange of human clothed body and unclothed body in the radiant heating system of low temperature but also designing the thermal environment in a room.

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SAR 영상을 활용한 저수지 수표면적 탐지 알고리즘 비교 연구 (A Comparative Study of Reservoir Surface Area Detection Algorithm Using SAR Image)

  • 정하규;박종수;이달근;이준우
    • 대한원격탐사학회지
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    • 제38권6_3호
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    • pp.1777-1788
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    • 2022
  • 저수지는 국내 영농환경에서 주요한 용수 공급처이며, 저수지의 저수량 파악은 농업용수의 활용 및 관리차원에서 중요하다. 위성영상을 활용한 원격탐사는 저수지와 같이 광역적으로 분포하는 객체에 대하여 정기적인 모니터링을 할 수 있는 효과적인 수단으로, 본 연구에서는 Sentinel-1 Synthetic Aperture Radar (SAR) 영상을 통해 영상분류 및 영상분할 알고리즘을 적용하여 국내 저수지 53개소의 수표면적 탐지를 수행하였다. 사용한 알고리즘은 Neural Network (NN), Support Vector Machine (SVM), Random Forest (RF), Otsu, Watershed (WS), Chan-Vese (CV)로 총 6가지이며, 드론으로 촬영한 실측 정사영상으로 수표면적 탐지 결과를 평가하였다. 각 알고리즘으로부터 산출된 수표면적과 실측 수표면적간의 상관성은 NN 0.9941, SVM 0.9942, RF 0.9940, Otsu 0.9922, WS 0.9709, CV 0.9736로 나타났으며, 저수지 유효저수량의 규모가 클수록 더 높은 선형 상관관계를 보였다. 혼동 행렬로부터 산출한 정확도, 정밀도, 재현율을 통해 알고리즘간 수표면적 탐지 정확도와 탐지 경향을 분석하였다. 정확도의 경우 각 10만 m3 미만 저수지에서 WS가 0.8752, 10만~30만 m3에서 Otsu가 0.8845, 30만~50만 m3에서 RF가 0.9100, 50만 m3 이상에서 Otsu와 CV가 0.9400으로 가장 높은 수치를 보였다. WS의 경우 수표면적을 미탐지하는 경향으로 인해 낮은 재현율을 보였고, NN, SVM, RF의 경우 과대 탐지로 인한 낮은 정밀도를 보였다. SAR 영상을 통한 수표면적 탐지 시 저수지 수표면의 수생식물 및 인공건축물이 미탐지를 발생시키는 오차 요소로 작용함을 분석결과 및 실측영상을 통해 확인하였다.

공침법에 의한 CaO 첨가 안정화 $ZrO_2$의 미분말 합성 및 그 소결특성 (Fine Powder Synthesis and It첨s Sintering Characteristics of CaO-Stabilized $ZrO_2$ by Coprecipitation Method)

  • 박정일;이주신;최태운
    • 한국세라믹학회지
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    • 제33권5호
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    • pp.563-571
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    • 1996
  • In order to fabricate solid electrolyte CaO-stabilized ZrO2 of high density sintered body economically 13 mol% CaO-stabilized ZrO2 powders were synthesized by the coprecipitation method. The characteristics and sintering behavior of fine powder were investigated. The precipitates has the specific surface area of 193 m2/g and apperaed to be fine and spherical primary particles with a size of approximately 5nm. The crystalliza-tion temperture of CaO-stabilized ZrO2 was 462$^{\circ}C$. The tetragonal phase was stable in the low calcining tempe-rature regions and the cubic zirconia solid solution was formed from above 120$0^{\circ}C$ through an intermediate stage of formation of CaZrO3 By introducing fine powders washed with alcohol and ball-milling process after calcination the sintered body was possible to attain the value of above 92% of the theoretical density at low temperature of 120$0^{\circ}C$.

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DICOM 영상과 설계 모델링을 융합한 외이도의 형태적 변화 관찰 연구 (An Observational Study on the Morphological Changes of the External Ear Canal by Converging DICOM Imaging and Design Modeling)

  • 김형균
    • 한국융합학회논문지
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    • 제10권11호
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    • pp.173-179
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    • 2019
  • DICOM 영상은 인체의 진단과 치료에 중요한 역할을 하고 있으며 설계모델링은 목적에 따라 형상을 3차원으로 계획하는 기술이다. 본 연구는 이러한 두 가지 기술을 융합하여 외이도의 형태적 변화에 대한 횡단면, 부피, 표면적의 관계를 관찰하고자 하였다. 실험은 인체의 단면 획득 의료영상기술을 적용하여 19귀의 외이도를 추출한 3차원 형상을 스테레오리소그래피, 3-매틱(matic) 프로그램으로 센터라인 생성 및 분할 기술을 적용하였다. 그 결과 외이도의 횡단면 구조는 타원형(38.5%), 반원형(28.2%), 혼재형(17.9%), 네모형(10.2%), 주름형(5.1%)등 다양한 형태가 나타났다. 또한 외이도 길이가 길수록 위상별 횡단면 면적은 크게 나타났으며 부피와 표면적은 고막방향으로 갈수록 감소하였지만 그 감소율은 상대적으로 낮게 나타났다. 이는 외이도의 형태가 고막방향으로 갈수록 불규칙한 구조로 되어 있음을 나타냈다.