• Title/Summary/Keyword: long-term failure analysis

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A Study of the Determination of the Priority of Strategies for the Activation of the Business Ecosystem of Big Science: With a Focus on Nuclear Fusion and Accelerator Devices (거대과학 산업생태계 활성화 전략의 우선순위 결정에 관한 연구: 핵융합과 가속기 장치를 중심으로)

  • Cho, Wonjae;Kim, Youbean;Tho, Hyunsoo;Chang, Hansoo
    • Journal of Korea Technology Innovation Society
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    • v.16 no.4
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    • pp.1163-1186
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    • 2013
  • Big science such as nuclear fusion accelerators shares the characteristic of requiring long-term and massive budget input, human power, and related state-of-the-art technology. Because big science, by nature, thus requires large-scale budgets and facilities yet harbors the possibility of failure, most projects are led by the government. When the actual circumstances are examined, however, such projects are often implemented through the formation of cooperative relations with small and medium businesses (SMBs) possessing outstanding technological capacity. On the other hand, the reality is that the entry of corporations into the business ecosystem of big science is not easy and that even those that have once entered big science likewise fail to find sales outlets for technology that they have developed following the supply of single items, thus leading their technological capacity to lie idle. Consequently, based on an awareness of the problem, the present study seeks to propose strategies for activating the business ecosystem of nuclear fusion and accelerators and to present alternatives regarding which policy tasks must be pursued first by using the analytic hierarchy process (AHP) technique. The present study derived the four policy alternatives of approach, care, expansion, and infrastructures in accordance with the results of empirical analysis to activate the business ecosystem of nuclear fusion and accelerators and analyzed their priority in terms of urgency and effectiveness, the results of which were, in this order: care-approach-expansion-infrastructures. The significance of such research results lie in presenting the policy direction when the government determines which policy task must be pursued first and implements strategies for the activation of the business ecosystem of nuclear fusion and accelerators with limited financial resources in the future.

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Adjuvant Chemotherapy after Surgical Resection for Small-Cell Carcinoma of Lung (소세포폐암에서 수술 후 복합화학요법의 성적)

  • Kim, Hak-Ryul;Jung, Jong-Hoon;Kim, Hwi-Jung;Yang, Sei-Hoon;Jeong, Eun-Taik
    • Tuberculosis and Respiratory Diseases
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    • v.57 no.5
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    • pp.443-448
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    • 2004
  • Background : Small-cell carcinomas of lung have a tendency for rapid growth and early wide metastasis. Despite the high response rates of combination chemotherapy alone or with radiotherapy, the overall long-term survival rate is very disappointing. According to autopsy findings, the common cause of failure is local recurrence in the primary cancer site. Therefore, surgical resection with combined chemotherapy has recently been attempted for very early stage small-cell carcinomas of the lung. Methods : 10 patients (TNM I & II: 5 cases each) undergoing surgical resection for small-cell carcinomas of the lung were treated with adjuvant chemotherapy in an attempt to prolong survival. Of these, 9 patients received chemotherapy, and a retrospective study for survival undertaken (Kaplan-Meier analysis). Results : The median survival time was 26 months, and the 2- and 5-year survival rates were 68.6 and 46.7%, respectively. If the 1 patient not having undergone chemotherapy was excluded, the 2-, 5-year survival rates were 76.2 and 50.8%, respectively? No difference in the survival rate was seen between patients with TNM stages I and II. Conclusion : Adjuvant chemotherapy after surgical resection results in prolonged survival for patients with TNM stages I and II small-cell carcinomas of the lung.

Analysis of critical failure factors on the causes of profitability in international construction projects (해외건설사업의 수익성 인자분석에 관한 연구)

  • Sun Seung-Min;Ryu Ho-Dong;Jeon Ji-Ho;Han Seung-Heon
    • Proceedings of the Korean Institute Of Construction Engineering and Management
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    • autumn
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    • pp.306-310
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    • 2002
  • Agreements such as the Uruguay Round and the New Round have dramatically changed international construction markets. The globalization of the construction industry provides tremendous opportunities for construction industry, while it generates the complex skeins of risks to contractors wllo would like to expand into new foreign markets. According to ENR, recently about $13.9\%$ of contractors that entered international construction markets have experienced loss in projects and furthermore, their average profits have also declined continuously. Accordingly, contractors need a strategic risk management system for assessing various risks and improving Profitability for overseas construction projects. This paper discusses the long-term trend of profitability performed by Korean contractors in international construction markets during the last 35 years. Then, it identifies the key factors that affect the profitability significantly through the structured surveys from 59 actual overseas projects. These factors can be used for developing a risk management system for international construction project.

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Progesterone and Estrogen Levels in Holstein Blood and Milk Following Artificial Insemination and Embryo Transfer (인공수정 및 수정란이식 후 젖소의 혈액과 유즙에서 Progesterone과 Estrogen 농도 변화와 수태율과의 상관관계)

  • Han, Rong-Xun;Kim, Hong-Rye;Diao, Yun-Fei;Kim, Young-Hoon;Woo, Je-Seok;Jin, Dong-Il
    • Korean Journal of Agricultural Science
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    • v.37 no.3
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    • pp.393-398
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    • 2010
  • Early pregnancy diagnosis of bovine is an essential component for efficient reproductive plan in farms because long term of non-pregnancy results in economic losses by failure of offspring production and low milk yield in dairy cattle. The major steroid hormones related with reproduction are known to be progesterone and estrogen in bovine pregnancy. To evaluate detection level of hormones in milk, plasma and milk progestrone and estrogen of Holstein cows was analyzed during artificial insemination (AI) and embryo transfer (ET). Progesterone concentration at 21 days postestrus was significantly different in plasma and milk between pregnant and non-pregnant cows. Estrogen concentration at estrus was higher in pregnant recipients than that in non-pregnant recipients. To analyze correlation between hormone levels and conception rates in Holstein, the conception and return rates were checked following AI, and the returned cows were on the track of pregnancy after consecutive AI. Pregnant cows following first AI were considered as high conception group while pregnant cows following third AI were rated as low conception group. Proportion of high and low conception groups in this study was 78.2% and 9.1%, respectively. Hormone analysis indicated that high conception group had higher estrogen level during estrus than low conception group ($26.45{\pm}3.32$ vs $19.017{\pm}2.97$). Progesterone level was not different between high and low conception groups during estrus but increased significantly after 21 days postestrus (21 day: $4.95{\pm}1.12$ vs $0.95{\pm}0.23$, 35 day: $12.47{\pm}3.82$ vs $2.41{\pm}1.21$). In conclusion, the pattern of progesterone and estrogen secretion in Holstein milk samples could be a good candidate for early pregnancy detection and selection of recipients during ET.

Basic Income: Norms and Experience of Policy Scientific Analysis - In the Center of the Youth Dividend Ordinance Discussion - (기본소득: 규범과 경험의 정책 과학적 분석 - 청년배당 지급조례 논의를 중심으로 -)

  • Lee, Myoung Hyun
    • Korean Journal of Social Welfare
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    • v.68 no.4
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    • pp.119-141
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    • 2016
  • This study analyzed on the basis of the norms and experience the Seongnam youth dividend ordinance. Youth dividend pros in the normative dimension to understand in order to achieve social justice. Further, youth dividend can replace the existing policy. On the other hand, the opposite of youth dividend is pointed out that the policy is ambiguous without morally justifiable. Also it has been pointed out inefficiencies means. Youth dividend Pros empirical dimension is a social considerations measures, there is a need for innovation by the failure of existing measures. On the other hand, youth dividend opposed to target efficiency is low, and that the problem is often to the contents of the salary. Because both sides are too contrast, consensus is difficult, can be political point of view is a significant impact. The basic income is a new thought experiment for human self-realization. Therefore, the production social welfare policy personality is a different policy science. That is, it is a long-term care social policy that requires a holistic life support. In addition, a non-empirical policy that requires a material support for the substantial freedom. Therefore, it is necessary to understand the philosophical meaning than scientific evaluation of traditional policy aiming to realize autonomous life. Therefore, radio waves of basic income through the welfare politics and exercise is still important strategy.

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Desirable Suggestions for Korean Geo-technology R&D through Analysis of the Global Grand Challenges and Moonshot Projects (글로벌 과학난제 도전연구프로젝트 분석을 통한 우리나라 지질자원기술에의 바람직한 제언)

  • Kim, Seong-Yong;Sung, Changmo
    • Economic and Environmental Geology
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    • v.53 no.1
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    • pp.111-120
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    • 2020
  • Remarkable scientific and technological achievements are mainly shown in the 'super-convergence' or 'convergence of convergence' among cross- disciplinary fields, and advanced countries are promoting the 'high-risk, high-return research' ecosystem. Google LLC is carrying out numerous new challenges in terms of a non-failure perspective. Innovative research by the US Defense Advanced Research Projects Agency (DARPA) has produced such breakthroughs as the Internet, GPS, semiconductors, the computer mouse, autonomous vehicles, and drones. China is pioneering a 'Moon Village' and planning the world's largest nuclear fusion energy and ultra-large particle accelerator project. Japan has also launched 'the moonshot technology development research system' to promote disruptive innovation. In Korea, the government is preparing a new research program to tackle the global scientific challenges. Therefore, it is necessary to determine the reasonable geoscientific challenges to be addressed and to conduct a preliminary study on these topics. For this purpose, it is necessary to conduct long-term creative research projects centered on young researchers, select outstanding principal investigators, extract innovative topics without prior research or reference, simplify research proposal procedures, innovate the selection solely based on key ideas, and evaluate results by collective intelligence in the form of conferences.

A qualitative study on the psychological difficulties of conglomerates executives after involuntary retirement (대기업 임원들이 비자발적 퇴직 이후 겪는 심리적 어려움에 대한 질적 연구)

  • Jabok Koo;Taeyun Jung
    • Korean Journal of Culture and Social Issue
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    • v.25 no.4
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    • pp.249-277
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    • 2019
  • This study examined the involuntary retirement of executives in conglomerates based on Williams' need-threat temporal model of ostracism(2009), which explains the psychology of individuals facing social exclusion in the stages of reflexive, reflective and resignation. In-depth interviews were conducted on 15 retirees from conglomerates, and their contents were used for phenomenological method of analysis. As a result, in the reflexive stage of need-threat temporal model of ostracism, they experienced cognitive panic and emotional panic immediately following retirement. Due to an unexpected shocking experience of retirement notice, they experienced cognitive numbness first, and repressed the following negative feelings cognitively to hide them. In the reflective stage, retirees dream of 'a complete restoration to their best performance in the past', but as such expectation fails, they don't adjust to the reality more due to 'unrealistic thought', 'self-deception', and 'shift responsibility'. In resignation stage, a long-term failure to satisfy the desire led them to experience a sense of defeat and helplessness. Such results were reviewed and compared to Williams' need-threat temporal model of ostracism, and the implications of such result on the nation, companies and retirees in terms of the response to retirement.

Study on collapse mechanism and treatment measures of portal slope of a high-speed railway tunnel

  • Guoping Hu;Yingzhi Xia;Lianggen Zhong;Xiaoxue Ruan;Hui Li
    • Geomechanics and Engineering
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    • v.32 no.1
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    • pp.111-123
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    • 2023
  • The slope of an open cut tunnel is located above the exit of the Leijia tunnel on the Changgan high-speed railway. During the excavation of the open cut tunnel foundation pit, the slope slipped twice, a large landslide of 92500 m3 formed. The landslide body and unstable slope body not only caused the foundation pit of the open cut tunnel to be buried and the anchor piles to be damaged but also directly threatened the operational safety of the later high-speed railway. Therefore, to study the stability change in the slope of the open cut tunnel under heavy rain and excavation conditions, a 3D numerical calculation model of the slope is carried out by Midas GTS software, the deformation mechanism is analyzed, anti-sliding measures are proposed, and the effectiveness of the anti-sliding measures is analyzed according to the field monitoring results. The results show that when rainfall occurs, rainwater collects in the open cut tunnel area, resulting in a transient saturation zone on the slope on the right side of the open cut tunnel, which reduces the shear strength of the slope soil; the excavation at the slope toe reduces the anti-sliding capacity of the slope toe. Under the combined action of excavation and rainfall, when the soil above the top of the anchor pile is excavated, two potential sliding surfaces are bounded by the top of the excavation area, and the shear outlet is located at the top of the anchor pile. After the excavation of the open cut tunnel, the potential sliding surface is mainly concentrated at the lower part of the downhill area, and the shear outlet moves down to the bottom of the open cut tunnel. Based on the deformation characteristics and the failure mechanism of the landslides, comprehensive control measures, including interim emergency mitigation measures and long-term mitigation measures, are proposed. The field monitoring results further verify the accuracy of the anti-sliding mechanism analysis and the effectiveness of anti-sliding measures.

Rainfall Forecasting Using Satellite Information and Integrated Flood Runoff and Inundation Analysis (I): Theory and Development of Model (위성정보에 의한 강우예측과 홍수유출 및 범람 연계 해석 (I): 이론 및 모형의 개발)

  • Choi, Hyuk Joon;Han, Kun Yeun;Kim, Gwangseob
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.26 no.6B
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    • pp.597-603
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    • 2006
  • The purpose of this study is to improve the short term rainfall forecast skill using neural network model that can deal with the non-linear behavior between satellite data and ground observation, and minimize the flood damage. To overcome the geographical limitation of Korean peninsula and get the long forecast lead time of 3 to 6 hour, the developed rainfall forecast model took satellite imageries and wide range AWS data. The architecture of neural network model is a multi-layer neural network which consists of one input layer, one hidden layer, and one output layer. Neural network is trained using a momentum back propagation algorithm. Flood was estimated using rainfall forecasts. We developed a dynamic flood inundation model which is associated with 1-dimensional flood routing model. Therefore the model can forecast flood aspect in a protected lowland by levee failure of river. In the case of multiple levee breaks at main stream and tributaries, the developed flood inundation model can estimate flood level in a river and inundation level and area in a protected lowland simultaneously.

Efficacy and Safety of Sirolimus-Eluting Stent With Biodegradable Polymer UltimasterTM in Unselected Korean Population: A Multicenter, Prospective, Observational Study From Korean Multicenter Ultimaster Registry

  • Soohyung Park;Seung-Woon Rha;Byoung Geol Choi;Jae-Bin Seo;Ik Jun Choi;Sung-Il Woo;Soo-Han Kim;Tae Hoon Ahn;Jae Sang Kim;Ae-Young Her;Ji-Hun Ahn;Han Cheol Lee;Jaewoong Choi;Jin Soo Byon;Markz RMP Sinurat;Se Yeon Choi;Jinah Cha;Su Jin Hyun;Cheol Ung Choi;Chang Gyu Park
    • Korean Circulation Journal
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    • v.54 no.6
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    • pp.339-350
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    • 2024
  • Background and Objectives: UltimasterTM, a third-generation sirolimus-eluting stent using biodegradable polymer, has been introduced to overcome long term adverse vascular events, such as restenosis or stent thrombosis. In the present study, we aimed to evaluate the 12-month clinical outcomes of UltimasterTM stents in Korean patients with coronary artery disease. Methods: This study is a multicenter, prospective, observational registry across 12 hospitals. To reflect real-world clinical evidence, non-selective subtypes of patients and lesions were included in this study. The study end point was target lesion failure (TLF) (the composite of cardiac death, target vessel myocardial infarction [MI], and target lesion revascularization [TLR]) at 12-month clinical follow up. Results: A total of 576 patients were enrolled between November 2016 and May 2021. Most of the patients were male (76.5%), with a mean age of 66.0±11.2 years. Among the included patients, 40.1% had diabetes mellitus (DM) and 67.9% had acute coronary syndrome (ACS). At 12 months, the incidence of TLF was 4.1%. The incidence of cardiac death was 1.5%, MI was 1.0%, TLR was 2.7%, and stent thrombosis was 0.6%. In subgroup analysis based on the presence of ACS, DM, hypertension, dyslipidemia, or bifurcation, there were no major differences in the incidence of the primary endpoint. Conclusions: The present registry shows that UltimasterTM stent is safe and effective for routine real-world clinical practice in non-selective Korean patients, having a low rate of adverse events at least up to 12 months.