• Journal of Yeungnam Medical Science
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• v.35 no.1
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• pp.63-69
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• 2018

Background: Kinovea software that tracking semi-automatically the motion in video screen has been used to study motion-related tasks in several studies. However, the validation of this software in open field test to assess locomotor activity have not been studied yet. Therefore, this study aimed to examine the reliability and validity of this software in analyzing locomotor activities. Methods: Thirty male Institute Cancer Research mice were subjected in this study. The results examined by this software and the classical method were compared. Test-retest reliability and inter-rater reliability were analyzed with Pearson's correlation coefficient and intraclass correlation coefficient (ICC). The validity of this software was analyzed with Pearson's correlation coefficient. Results: This software showed good test-retest reliability (ICC=0.997, 95% confidence interval [CI]=0.975-0.994, p<0.001). This software also showed good inter-rater reliability (ICC=0.987, 95% CI=0.973-0.994, p<0.001). Furthermore, in three analyses for the validity of this software, there were significant correlations between two methods (Pearson's correlation coefficient=0.928-0.972, p<0.001). In addition, this software showed good reliability and validity in the analysis locomotor activity according to time interval. Conclusion: This study showed that this software in analyzing drug-induced locomotor activity has good reliability and validity. This software can be effectively used in animal study using the analysis of locomotor activity.

• PNF and Movement
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• v.16 no.3
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• pp.397-404
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• 2018

Purpose: The purpose of this study was to investigate the effect of climbing training combined with coordinative locomotor training on muscle thickness in normal adults and to provide basic data regarding its applicability to clinical practice. Methods: Coordinative locomotor and climbing training was conducted three times per week for six weeks. Each exercise session consisted of ten minutes of warm-up and 40 minutes of the main exercise. A post-test was conducted six weeks after the training began, and a follow-up test was done two weeks after the training ended. Results: There were significant differences in the participants' external and internal oblique abdominis muscles over time (p<0.05). There were also significant interactions in the external and internal oblique abdominis muscles over time and according to group (p<0.05). Conclusion: The findings indicate that coordinative locomotor training with climbing had positive effects in normal adults, including increased thickness of the external and internal oblique abdominis muscles. The findings hold value for patient rehabilitation and clinical applications and interventions using coordinative locomotor training in combination with climbing.

• PNF and Movement
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• v.16 no.1
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• pp.7-17
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• 2018

Purpose: The aim of this study was to investigate the effects of coordinative locomotor training in a chronic stroke patient. Methods: A left hemiplegic patient diagnosed with a right middle cerebral artery stroke participated in this research. The patient's functional conditions were assessed, and a coordinative locomotor training program was initiated to resolve the problems identified. A set of movements deemed difficult based on the brief International Classification of Functioning, Disability and Health core set for stroke and d4501 (long-distance walking) were agreed as improvement targets. The program comprised warm up, main, cool-down, and home exercises. Repeated measurements were obtained, as follows: five times at baseline (A), 10 times during the intervention (B), and five times after the intervention (A). The study period was 7 weeks, and the intervention period was 1 h per day, twice a week for 5 weeks. Various tools, including the community walking test (CWT), 10-m walking test (10 MWT), 6-min walking test (6 MWT), and timed up and go (TUG) test, were conducted to assess the patient's walking ability. Changes in functional domains before and after the ICF Qualifier were compared. The mean values of the descriptive statistics were calculated, and a visual analysis using graphs was used to compare the rates of change. Results: The results showed that the CWT, 10 MWT, 6 MWT, and TUG test scores during the intervention period improved and that this improvement remained, even during the baseline period. In addition, the ICF Qualifier before and after the comparison decreased from moderate to mild. Conclusion: Based on the results, we propose that coordinative locomotor training can have positive effects on community ambulation of chronic stroke patients.

• Physical Therapy Korea
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• v.20 no.1
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• pp.74-80
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• 2013

We evaluated whether group locomotor imagery training-combined knowledge of performance (KP) lead to improvements in gait function in community dwelling individuals with chronic stroke. Ten adults who had suffered a hemiparetic stroke at least 6 months earlier participated in group locomotor imagery training-combined KP for 5 weeks, twice per week, with 2 h intensive training. Dynamic gait index scores increased significantly after the group locomotor imagery training-combined KP. However, times for the timed up-and-go test did not improve significantly after the training. Group locomotor imagery training-combined KP may be a useful option for the relearning of gait performance for community dwelling individuals with chronic hemiparetic stroke.

• Journal of Ginseng Research
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• v.28 no.3
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• pp.132-135
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• 2004

This study was performed to investigate the anxiolytic effects of total sponin fraction from Ginseng Radix Rubra (KRG) in mice using the elevated plus-maze model. The water extract of KRG and ginseng total saponins (GTS) purified from the water extract of KRG were administered orally to mice. One hour after administration of KRG water extract and GTS, mice were tested on the elevated plus-maze. The water extract of KRG 100 mg/kg, and GTS 25 and 50 mg/kg did not increase open arm entries and time spent on open arm. However, GTS 100 mg/kg increased the number of open arm entries and time spent on open arm. On the other hand, as the plus-maze test was affected by changes in locomotor activity, an additional test was carried out with the specific aim of monitoring locomotor activity. The water extract of KRG 100 mg/kg, and GTS 25 and 50 mg/kg did not affect the locomotor activity. However, GTS 100 mg/kg significantly decreased locomotor activity. From this study, we suggest that GTS may play an imponant role on the anxiolytic effects in the plus-maze model.

• Journal of the Korean Society of Physical Medicine
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• v.18 no.1
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• pp.59-66
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• 2023

PURPOSE: This study examined the foot pressure distribution using the sprinter and skater patterns of coordinative locomotor training. METHODS: Thirty healthy adults, comprising 11 men and 19 women, participated in the study. All the participants performed patterns in sprinter pattern conditions 1-3 and skater pattern conditions 1-3, and were measured using a pedoscan to determine the applied foot pressure distribution. RESULTS: The participants significantly differed in the big toe during the sprinter pattern. As a result of the post hoc test, opposite and opposite sprinters showed a significant difference from the same sprinters (same sprinter; 21.33 ± 5.92, opposite sprinter; 23.54 ± 5.41, and reopposite sprinter; 24.14 ± 6.46). There was a significant difference in the lateral side during the skater pattern. As a result of the post hoc test, reopposite and same skaters showed a significant difference from opposite skaters (same skater; 49.88 ± 5.75, opposite skater; 48.78 ± 5.64, and reopposite skater; 51.15 ± 5.37). CONCLUSION: The foot pressure was distributed toward the hallux and fifth toe according to the sprinter and skater patterns of coordinative locomotor training.

• Journal of the Korean Society of Physical Medicine
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• v.14 no.3
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• pp.63-71
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• 2019

PURPOSE: This study was examined the effects of coordinative locomotor training (CLT) on the postural imbalance and gait in children. METHODS: Four children were sampled as subjects. A single subject study (A-B-A') was conducted by measuring the following: baseline five sessions;, intervention phase, 15 sessions;, and postline (A') five sessions. The research period was eight weeks. The CLT program consisted of warming-up exercise, main exercise, and finishing exercise, and it was performed for one hour per day. A oneleg standing test (OLST) was performed determine the static balance. A functional reach test (FRT) was performed determine the reactionary balance. To determine the dynamic balance, the time up and go test (TUG) was performed. A 10m walking test (10 MWT) was performed to determine the walking ability. A statistical test was performed through descriptive statistics to present the average and standard deviation, and the variation rate was compared using a visual analysis method with graphs. RESULTS: As a result of CLT application, all four subjects improved the OLST, FRT, TUG, and 10 MWT compared to the intervention period baseline, and postline period. CONCLUSION: CLT appeared to improve the posture imbalance and gait in children.

• PNF and Movement
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• v.15 no.3
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• pp.247-252
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• 2017

Purpose: This study sought to examine the effect of coordinative locomotor training (CLT) program on the balance and gait of stroke patients and to develop effective programs and training methods to improve the functions of such patients. Methods: Subjects included 29 patients with hemiplegia caused by stroke. The subjects were randomly divided into an experimental group (n=14) that participated in CLT program and a control group (n=15) that participated in general exercise therapy. The experimental group underwent CLT program, while the control group underwent general exercise therapy, for 30 minutes, 3 days per week for a 6-week period. timed up and go test (TUG), four square step test (FSST), figure-of-8-walk test (F8WT), and 10m walking test (10MWT) were conducted to evaluate changes in balance and gait. Results: After the intervention, significant differences (p<0.05) were seen in the TUG, FSST, F8WT, and 10MWT in both groups. The experimental group showed more significant improvement than the control group(p<0.05). Conclusion: The results from this study indicate that a CLT program is extremely effective for improving the balance and gait in stroke patients.

• Journal of the Korean Society of Physical Medicine
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• v.16 no.3
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• pp.89-97
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• 2021

PURPOSE: This study examined the effects of coordinative locomotor training on the spine appearance and quality of life of patients with idiopathic scoliosis. METHODS: This study included two patients with idiopathic scoliosis: one with a thoracic and lumbar type scoliosis and the other with thoracic type scoliosis. The study design was a single case study (A-B-A'), with a baseline-intervention/phase-post-intervention. The baseline (A) was designed and measured five times, intervention phase (B) ten times, and post-intervention (A') five times. The coordinative locomotor training program was divided into 10 minutes of warm-up exercise, 30 minutes of the main exercise, and 10 minutes of the finishing exercise, for 50 minutes each time. The primary outcome measurements were measured using the Cobb's angle, Adam's test, and Gait view pro 2.0 to determine the changes in the spine appearance. The secondary outcome measurements were compared before and after using the SRS-22 questionnaire to determine the quality of life of the scoliosis patients. A statistical test analyzed the mean and standard deviation, and the rate of change was presented by a visual analysis method using descriptive statistics and graphs. RESULTS: The findings showed that the spine appearance and quality of life of the two subjects were improved compared to the baseline measurements during the intervention phase, and the improved state was maintained during the post-intervention period. CONCLUSION: These findings indicate that coordinative locomotor training may help improve the spine appearance and quality of life of patients with idiopathic scoliosis.

• Biomolecules & Therapeutics
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• v.16 no.3
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• pp.261-269
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• 2008

This experiment was performed to investigate the anxiolytic-like effects of cyclopeptide fraction alkaloids of Zizyphi Spinosi Semen (CFAZ), by using the experimental paradigms of anxiety, and compared with those of a known anxiolytic, diazepam. CFAZ (8.0 mg/kg, p.o.) increased the percentage of time spent on the open arms and the number of open arms entries in the elevated plus-maze test, increased the number of head dips in the hole-board test, and increased the percentage of center zone ambulatory time in the open-field box. However, CFAZ has no effect on the locomotor activity, while diazepam (2.0 mg/kg, p.o.) significantly reduced locomotor activity. CFAZ did not influence the grip force in the grip strength meter test, either. From the molecular experiments, CFAZ increased chloride influx in cultured cerebellar granule cells. In addition, $GABA_A$ receptors $\gamma$-subunit were over-expressed by CFAZ in cultured cerebellar granule cells. It is concluded that CFAZ may have anxiolytic-like effects, and these effects may be mediated by $GABA_A$ receptors.