• Journal of Ginseng Research
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• v.45 no.3
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• pp.401-407
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• 2021

Background: Gintonin is an exogenous ginseng-derived G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. LPA induces in vitro morphological changes and migration through neuronal LPA1 receptor. Recently, we reported that systemic administration of gintonin increases blood-brain barrier (BBB) permeability via the paracellular pathway and its binding to brain neurons. However, little is known about the influences of gintonin on in vivo neuron morphology and migration in the brain. Materials and methods: We examined the effects of gintonin on in vitro migration and morphology using primary hippocampal neural precursor cells (hNPC) and in vivo effects of gintonin on adult brain neurons using real time microscopic analysis and immunohistochemical analysis to observe the morphological and locational changes induced by gintonin treatment. Results: We found that treating hNPCs with gintonin induced morphological changes with a cell rounding following cell aggregation and return to individual neurons with time relapses. However, the in vitro effects of gintonin on hNPCs were blocked by the LPA1/3 receptor antagonist, Ki16425, and Rho kinase inhibitor, Y27632. We also examined the in vivo effects of gintonin on the morphological changes and migration of neurons in adult mouse brains using anti-NeuN and -neurofilament H antibodies. We found that acute intravenous administration of gintonin induced morphological and migrational changes in brain neurons. Gintonin induced some migrations of neurons with shortened neurofilament H in the cortex. The in vivo effects of gintonin were also blocked by Ki16425. Conclusion: The present report raises the possibility that gintonin could enter the brain and exert its influences on the migration and morphology of adult mouse brain neurons and possibly explains the therapeutic effects of neurological diseases behind the gintonin administration.

• Land and Housing Review
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• v.9 no.3
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• pp.29-36
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• 2018

This study aims at suggesting directions to make children's parks considering the actual groups using them by comparative analysis of age distribution in residents within area of use and locations of children's parks with regards to changes in population structure of low birth rate and aging. Cheongju was selected for the study, and the current status of children's parks and population structure were categorized into six stages and the investigation and analysis were conducted by statistics by population group and by using Arc GIS Program. As a result of the analysis, children under 13 were 13.1% of the entire population in Cheongju and share of middle-aged and aged group including middle-aged was 31.3%. Park area per one children under 13 was 5.9㎡ and based on walking use area(250m), average number of parks available by autonomous district was eight. As a result of the analysis of characteristics of distribution of children's parks, they are densely located in old downtowns or the distribution density was relatively high in newly developed areas such as Osong-eup or Ochang-eup. However, outer rural areas have no children's parks or relatively low rate. As a result of the analysis on population structure and co-efficient of park location, in nine autonomous districts, aged group is increasing, leading to decrease use of children's parks. If resident rate aged group is higher in the region where a children's park is located, it is necessary to re-compose the existing one to different one or to change purposes of parks to be planned. Also, in the area with similar rates in both children's group and aged group, composing complex parks for both of them could be considered. This study has limitations by not conducting field studies about the current status of use of children's parks in areas where the population structure has been changing and not suggesting specifically new types of parks according to changes in population structure. It is necessary to conduct the following studies about relationship between children's parks and policies for composing parks responding to changes in population structure in neighboring regions in future.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.5
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• pp.77-90
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• 2016

This study is to examine the importance of site selection and service quality in franchise business as food service franchise became one of the fastest-growing service industries today. The chief finding of this study is as follows: First, a survey in locational and service quality factors affecting food service franchise shows that responders are more concerned with hygiene and visibility of the store than proximity and transportation advantages which reflects low statistical significance, thus the distance did not seem to be a big problem for the responders in the context that they mostly visit nearby food franchise. Second, the examination of the influence by the service quality factors and customer satisfaction shows significant positive relation with customer response, speed and accuracy, and accuracy factors which reveals that the responders prefer prompt response and swift judgment toward the customer's needs and expectations, professional knowledge services to the credibility factors in which little correlation with the customer satisfaction were found. Third, the examination of the influence by the service quality factors, locational factors, and re-visit reveals that customer response and specialty showed statistically significant correlation with intention of WOM (Word of Mouth) and revisit, which suggests that swift judgment and response toward the customer's needs and expectations, professional knowledge services is of great importance to both customer satisfaction and revisit. The study on the aspects of locational and service quality factors affecting franchise industry's customer satisfaction was conducted as above, an investigation in both factors' influence on the customer satisfaction was made, and based on the results of the analysis, this research seeks an optimal operation strategy of a franchise business. Food service franchise are relatively very competent to business adminstration and reaction capability to consumption changes due to the already established market, and there are stores springing up everywhere inspired by the founders who are too confident of their success in the franchise business. However, it is necessary for the franchise beginners to figure out a zone oriented, regular customer oriented business strategy than just complying with the head office manual. Owing to an increasing trend of opening medium to large sized stores and investments in the wake of converting to multiple business type Korean food franchise, there is growing need to set up new concept of store development and operational management strategy in order to overcome the excessive competition and limited sales volume of the old-fashioned small sized, small capital franchise stores. Furthermore, as most business category of food service franchise serve very similar menus, from a product differentiation point of view, it is required to map out flexible sales concept including the adoption of competitive and low-price strategy. In conclusion, as is shown in the analytical research, the customers' optimal choice fluctuate over their preferences like customer convenience and circumstances rather than insisting on specific brand, thus it will be necessary for the franchise stores to draw up aggressive strategy and planning in running food service franchise to maximize their profits.

• Journal of the Korean Geographical Society
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• v.31 no.2
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• pp.160-197
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• 1996

The purpose of this study is to review research trends and issues of economic geography in Korea for the last fifty years by sub-fields of agricultural geography, industrial geography, commercial and service geography, and transportation geography. Research in Korean economic geography has progressed significantly in terms of the scope and the number of papers published during the last a half a century. Agricultural geography was a leading field of economic geography in Korea before mid-1970s. Since the mid-1970s, however, agricultural geography has turned over the leading role in economic geography to industrial geography. Classification and structure of agricultural region has been the most popular research theme in Korea, even though diverse topics has been dealt in the research of agricultulal geography in Korea during the last fifty years. In recent years, emphasis is given to study on the dynamics of agricultural region and regional differentiation of part-time farming. It is suggested that the future issues of research in agricultural geography in Korea are agricultural restructuring and changes in agricultural space under the WTO system, changes in rural area and agricultural region with the progress of informatization, changes in agricultural structures and rural society by the increase of part-time farming, governments agricultulal policy and its impacts, competitive advantages of Korean agricultulal products, and environmental impacts of agricultural restructuring. Research in industrial geography has remarkably progressed since the 1980s. Locational changes, regional industrial structure and formation of industrial region were the major topics of interest in the research of industrial geography in Korea before 1980. Since the early 1980s, in addition to the topics which were interested in before 1980, changes of industrial organization and industrial location, changes of production systems and industrial space development of high technology industries and science parks, industrial restructuring and regional economy, foreign direct investments, industrial linkages and industrial districts, and industrial policy and regional development have been the major research themes of industrial geography in Korea. Considerable number of papers has been published both in Korean journals and in foreign journals during this period. Considering global changes in the organization of industrial space, future research should be more focused on firms strategy for regaining competitive advantages, local and global perspectives of industry, industry and environmental changes, in addition to the topics which have been dealt in recent years. Research in commercial and service geography and transportation geography was negligible in Korea before the late 1970s. These two sub-fields in economic geography have begun to develop since 1980s. Periodic markets, structure of commercial area, and distribution of products were the major topics of interest in the 1980s in the commercial and service geography in Korea. In the 1990s, however reserch in producer services has been active with growth of producer services in Korean economy. It is suggested that regional changes with progress of informatization and technology, changes of international trade and regional changes, development of efficient distribution system, role of producer services in regional development, and network of producer services are the major issues to be studied in the future in the field of commercial and service geography in Korea. Commuting, distribution of products, and transportation networks have been the major topics of research in transportation geography in Korea. Diverse quantitative techniques have been applied in the most of the researches in transportation geography. It is required that future studies in transportation geography should also focus on societal and behavioral issues, policy issues regional impacts of new transportation facilities, an analysis of transportation system at the global or international level. Since the 1980s economic geography in Korea has considerably progressed with publication of papers and books. The progress can be regarded as successful in quantitative aspect, but not in quantitative aspects. For the development of Korean economic geography in both quantitative and qualitative aspects, it is necessary to promote international collaborative researches and interdisciplinary cooperations. Attention should also be given to the research on changes in competitive advantages and economic restructuring, changes of economic space with the development of high technology and the progress of informatization. economic development and culture. and foreign regional studies.

• Journal of the Economic Geographical Society of Korea
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• v.18 no.1
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• pp.45-59
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• 2015

The urban-rural consolidated city has emerged in order to promote the balanced development of urban region and rural region. Targeted 11 urban-rural consolidated cities in Gyeonggi Province, this paper investigated the changes of economic space in accordance with the location of industrial activities. The number of establishments has increased in all cities. From the analysis of the changes in the economic space divided into urban regions and rural regions, concentration phenomenon of economic activities in urban regions was strengthened in 9 cities with the exception of Icheon-si and Anseong-si. Concentration of economic activities in urban region was noticeable in Namyangju-si, Pocheon-si, and Yongin-si. 5 types were derived from the classification on the basis of locational changes of economic activities in urban region and rural region. They are 1) urban-rural gap deepen type, 2) urban region growth slowdown type, 3) rural region growth type, 4) urban-rural balanced growth type, and 5) urban region-led growth type. While urban-rural gap of the cities close to highly urbanized city or metropolis has intensified, the growth of urban region was weakened in the cities located away from the metropolis.

• Journal of the Economic Geographical Society of Korea
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• v.17 no.4
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• pp.832-847
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• 2014

The main aim of this paper is to contribute to building some strategic foundations for future Korean foreign investors in Cambodia by investigating trends and institutional changes in inward foreign direct investment and working conditions in Cambodia. Rapid increase in labor costs, and investment incentives centering on high-tech industries in China and Vietnam has led to the relocation of labor-intensive industries into low wage countries since the early 2000. As a result, Cambodia has emerged as a new alternative investment region in which enable to off-set existing locational and institutional advantages, so that it has implicated in changes in Asian economic geographies. In addition, the Cambodian government has operated two labor relations projects - Better Factory Cambodia and Labor Dispute Resolution Project - with ILO to improve the working conditions of foreign investment firms. These projects could provide an insight into constructing strategies for foreign investment, and also imply institutional embeddedness in Cambodia.

• Korean Journal of Applied Biomechanics
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• v.18 no.1
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• pp.203-212
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• 2008

The purpose of this study is to propose appropriate model for 3 staged Didimsae movement to Jajinmori rhythm and to provide information for ideal foot step movements. For the locational change of body center, the height of body center is lowered at the moment of forward step and during forward intersection of the feet, forward direction linear motion is converted to vertical motion to maintain stability. Speed change of body center reduces flow of body on step forward moment and controls rapid forward movement for stabled movement and position when preventing fast forward horizontal direction movement of centroid speed while knee joint and foot joint are vertically risen for heel bone contacts the ground. For angle changes of joints, in order to prevent hyperextension of lower leg, hip joint is extended and knee joint is curved to secure stability of movement for smooth curves and extension. When centroid of foot joint is moved from top of the feet to whole foot sole and when left foot makes dorsal curve, stabled movement is accomplished.

• Journal of the Korean Institute of Rural Architecture
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• v.17 no.1
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• pp.73-81
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• 2015

The purpose of this study is to analyze the approach characteristics, relation to other facilities, and current status focusing on 28 total of exhibition-culture facilities in Gangneung. The results are following as. First, 19 facilities are located in urban area and nine are located in country side. With locational characteristics of Gangneung which is mountains in west and sea to east, three are located in high hill side and four are in sea shore among nine facilities. Facilities in urban area converge to Gungpodae and Ojukhuk which are symbol space in Gangneung. Those facilities started to have been increased from 1990s and rapidly increased from 2000s. The reason is that people have been interested in culture and art in society in general. In building structure, buildings related with traditional contents were constructed with wooden structure while buildings have been mainly constructed with modern ways such as steel and reinforced concrete structure. Second, the 28 facilities are classified into three types by function of other space or facilities within same a site or a building. The three types are themselves usage only, multi-function, and park type. The multi-function type is re-classified into two; public type and commercial type. Those functions have changed according to changes of society and times. Finally, for approaching to the exhibition-culture facilities with general transportation, the mean distance from the closest bus stop to those facilities each is 280m and 27 facilities are located within 670m from the closest bus stop. For approaching way using by car creates movement along road-building site-parking space-main entrance of building. When based on main entrance by the movement, parking space located in front side of main entrance is the largest, next is in the side, and the least is in back side. Various factors such as approaching form from road to parking space and space size between main entrance and parking space influence to approaching ways of exhibition-culture facilities in Gangneung.

• Journal of the Korean Geographical Society
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• v.36 no.4
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• pp.418-433
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• 2001

The paper is to examine the university as an object for geographical research and to review its related studies. Although the higher education system in Korea has much expanded its capacities since the 1980s, there are few studies that carry out geographical investigations on the themes including locational changes of universities, regional impacts of the university, and interactions between universities and regional development. Therefore, focusing on the university as an innovative element for the regional development in a coming knowledge-based society, this paper first tries to examine and conceptualize new roles and changing functions of the university in facilitating regional economic and social development. It then reviews various studies of educational geography and research shifts on the role of the university in the context of the western developed countries. Finally this study suggests a series of research themes that we should investigate in the future.

• Journal of the Economic Geographical Society of Korea
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• v.2 no.1_2
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• pp.47-61
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• 1999

This study focuses on the impact of government deregulation policies since the early 1990s on the change of industrial location anti the accompanying problems, especially of land use and environment. Since 1960s, the planned industrial location has played a leading role for the development of industrial location. However. since mid-1990s, individual(unplanned) industrial location has been increasing, especially in semi-agricultural area and in the Capital region, reflecting the impact of the deregulation policies on the industrial location. The effective policies are required to solve the problems caused by the increase of the individual industrial location. in that the standard of the environmental control for individual industrial location is much lower than for the planned industrial location.