• Animal Bioscience
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• 제36권1호
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• pp.84-97
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• 2023

Objective: One hundred hybrid male ducks (Mojosari×Alabio) were used to examine the efficacy of chicory supplementation as nutritional feed manipulation on production performance, and blood lipid profile of hybrid ducks. Methods: The ducks were tagged, weighed, and then allotted randomly to one of the four treatment diets using a completely randomized design. The experimental diets were: i) P0 (100% basal diets+0% chicory as control), ii) P1 (95% basal diets+5% chicory), iii) P2 (90% basal diets+10% chicory) and iv) P3 (85% basal diets+15% chicory). For each treatment group, there were 5 replicates of 5 birds each. All experimental diets were isonitrogenous and isocaloric using locally available ingredients. Results: Hybrid ducks with fed diets supplemented fresh chicory (5%, 10%, and 15%) showed increased feed intake and body weight gain, as well as feed conversion ratio to be smaller than those ducks fed diets without chicory supplementation (control). The ducks fed 10% chicory supplementation contained significantly (p<0.05) lower ash and higher organic matter contents of meat than those ducks fed other diets. The ducks fed 15% chicory supplementation showed the lowest crude protein and cholesterol content of meat among the treatment diets. Ducks fed chicory supplementation showed lower (p<0.05) blood cholesterol and triglyceride levels than those ducks fed without chicory supplementation, while dietary interventions had no major (p>0.05) influence on low-density lipoprotein and high-density lipoprotein levels in duck blood. Conclusion: In this study, 10% chicory supplementation showed the best results characterized by an increase in growth performance, carcass quality, small intestinal histomorphology, and lower cholesterol levels of meat.

• 한국응용과학기술학회지
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• 제40권5호
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• pp.1104-1115
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• 2023

본 연구는 미세전류자극이 비만인의 체성분과 혈중지질성분의 변화에 미치는 효과를 규명하고, 복합운동의 효과와 비교함으로써 효과적인 체형 관리 방안으로서 미세전류자극의 유용성을 밝히고자 하였다. 체지방율 30% 이상인 여대생 30명을 통제집단, 복합운동집단, 미세전류자극집단으로 분류하였으며, 각 집단 별 4주간의 처치 전후 체중, 체지방율, 허리 둘레 등의 체성분 요인과 TG, TC, apolipoprotein 등의 혈중지질성분을 측정한 자료를 분석하여 다음과 같은 결과를 얻었다. 통제집단에서는 모든 측정 항목에서 통계적으로 유의한 차이가 나타나지 않은 반면 복합운동 집단에서는 허리둘레와 TC가 유의하게 감소한 것으로 나타났고, 미세전류자극 집단에서는 체중, 체지방율, 허리둘레, apolipoprotein 등이 유의하게 감소한 것으로 나타났다. 이러한 연구결과를 고려할 때 미세전류 자극은 비만인의 체성분과 혈중지질성분을 개선시켜 건강한 신체를 갖도록 하는데 효과적인 중재 방안으로 제안할 수 있다.

• Bulletin of the Korean Chemical Society
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• 제30권9호
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• pp.2087-2092
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• 2009

We performed molecular dynamics simulations on dimyristoylphosphatidylcholine lipid bilayer with 50 mol% halothane. The structural properties, electron density profile, segmental order parameter of acyl chains, headgroup orientation distribution, water dipole orientation distribution, have been examined. Overall the effects of the halothane molecules on structural properties of DMPC lipid bilayer were found to be small. The electron density profiles, the segmental order parameter, the headgroup orientation, the water dipole orientation were not affected significantly by the halothane molecules. Pressure tensor calculations shows that the lateral pressure increases at the hydrocarbon tail region and the headgroup region, and decreases at the water-headgroup interfacial region.

• 생명과학회지
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• 제10권5호
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• pp.467-474
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• 2000

Male mice (ddY strain) were fed a laboratory chow diet containing the water extract from stem bark of Rhus verniciflua Stokes (RVS) for 14 days. There were no significant difference in body weight gain, feed intake, the hepatic lipid profile and serum total cholesterol and phodpholipid concentrations. The concentration of triglyceride in serum was significantly lower in the RVS group than that in the control group. The concentration of high-density-lipoprotein cholestrol in serum was significantly higher in the RVS group than that in the control group. The methanol extract from RVS stem bark effectively inhibited the formation of thiobarbituric acid-reactive substances as a marker of lipid peroxidation of liver microsomes in a concentration-dependent manner. This study showed that the water extract from stem bark of RVS decreased the serum triglyceride concentration and methanol extract has an antioxidative activity.

• 한국식품영양과학회지
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• 제29권3호
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• pp.453-459
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• 2000

This study was performed to investigate the effect of dietary crab shell powder on lipid metabolism in diet induced hyperlippidemic rats. Sixteen male Sprague-Dawley rats were divided into two groups and fed 20% (w/w) carb shell powder supplemented diet for 4 weeks. Energy intake and weight gain were lower in experimental group than in control group. Concentrations of plasma triglyceride, total cholesterol, LDL-cholesterol, and atherogenic index (AI) were decreased and concentration of HDL-cholesterol was increased by crab shell powder supplementation. Concentrations of liver total cholesterol and triglyceride were significantly lower in experimental group. The crab shell decreased triglyceride and cholesterol concentration in plasma and liver, and increased bile acid excretion in feces. Therefore, the crab shell powder is assumed to exhibit function of chitin or chitosan that effects on lipid metabolism and cholesterol reabsorption.

• 한국식품영양학회지
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• 제28권2호
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• pp.171-177
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• 2015

본 동물실험은 STZ로 유도한 C57BL/6에게 5% sodium butyrate를 급여했을 때 항당뇨 및 항염증 효과를 연구하고자 하였다. 본 연구에서 STZ로 당뇨를 유발한 마우스에게 5% sodium butyrate를 급여했을 때 체중과 식이섭취량에서는 크게 유의적 차이가 없음을 확인하였다(p<0.05). STZ에 의한 당뇨 쥐는 인슐린의 분비가 감소되면서 당대사의 불균형을 초래하며 간 등이 비대해진다고 알려져 있으나, 본 연구에서는 간의 장기 무게에서는 크게 실험군 간에 유의적인 차이가 없었다(p<0.05). 또한 비장과 흉선의 무게는 0.5% sodium butyrate 첨가 식이군에서 유의적으로 낮아짐을 알 수 있었다(p<0.05). 당뇨병은 염증 상태로서 고혈당으로 인하여 monocyte에서는 여러 염증성 사이토카인이 분비가 활성화된다. TNF-${\alpha}$, IL-6 등은 염증성 사이토카인으로서 혈관염증의 중요한 마커로 인식되고 있고, 당뇨병 환자들은 이러한 염증성 사이토카인이 높은 수준으로 활성화 된다. STZ 처리 시 마우스 혈청에서의 염증성 사이토카인의 분비 및 발현이 증가되었으나, 5% sodium butyrate를 급여했을 때 염증성 사이토카인의 분비 및 발현이 저해됨을 확인할 수 있었다. 본 연구는 sodium butyrate 보충은 당뇨병이 유발된 동물모델에서 혈청지질 농도 및 혈당 조절, 염증 상태를 개선에 다소간의 효과가 있는 것으로 나타났다. 이에 따라 당뇨병과 같은 만성적인 대사질환 개선에 sodium butyrate가 효과적인 식이인자가 될 것으로 생각된다. 그러나 앞으로 더 명확한 효능을 탐색하기 위해서 시료 첨가수준의 다각화 및 여러 가지 보완연구가 필요할 것으로 생각 된다.

• Journal of Nutrition and Health
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• 제36권6호
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• pp.589-602
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• 2003

This study was designed to investigate the effects of weight reduction and changes in serum lipid composition using a commercial uncooked powdered food (UPF) diet on 27 obese hyperlipidemic women over a period of 12 weeks. We replaced the standard breakfast and dinner of each of the subjects with UPF. Their dietary intake status was evaluated by 24-hour recall method. Their body compositions were measured using a body fat analyzer. Also, we conducted hematological, clinical and lipid profile analyses of their blood. Their intake of energy, lipid and protein significantly decreased as the subjects started to take UPF, but their intake of vitamins and minerals, other than iron, increased. Due to the energy intake decrease, the subjects' weight, body fat and waist circumference significantly decreased. Among the lost weight the percentage of the body fat was high. We judged that this process of losing weight was successful in obese hyperlipidemic women. Serum HDL-cholesterol gradually increased and serum total-cholesterol, LDL-cholesterol, triglyceride levels showed gradual decreases. When obese hyperlipidemic women replaced two of three meals with UPF for 3 months, we were able to see useful changes like decreased body fat and serum lipid. Complete judgment on the usefulness of UPF may be difficult but if people take a standard meal once a day and replenish their iron by taking UPF twice a day, we assume that replacing UPF with balanced regular meal not be a problem in nutritional status. Our results show that UPF is effective in the diet therapy of obese hyperlipidemic women.

• Journal of Nutrition and Health
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• 제38권9호
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• pp.698-705
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• 2005

The purpose of this research was to investigate the effect of the boron supplementation on lipid profiles and antioxidant capacities in ovariectomized (OVX) rats. Rats were divided into 3 groups and fed diet with intake levels of boron (0.5 ppm,50 ppm,100 ppm) for 4 weeks. The half of rats in each group was ovariectomized and the others were sham-operated. And rats were fed same diets for 8 weeks after operation. Feed intake and weight gain were significantly increased by increasing boron intake and higher in OVX group than those in sham-operated. FER was significantly higher in OVX group than that of sham-operated. There were no significant differences in serum lipid profiles among the groups. The contents of hepatic total lipid were significantly higher in OVX group than those of sham-operated and the lowest in high-boron group. Hepatic GST activity was significantly decreased by ovariectomy and the lowest in very high-boron group. Hepatic catalase activity was the lowest in high-boron group of OVX. Hepatic TBARS level of high-boron group was the lowest in sham-operated groups. Hepatic TBARS level induced by AAPH was significantly decreased by increasement of boron supplementation. Taken together, this results suggest that the boron supplementation have the potential role for improving lipid profiles and antioxidant capacities in OVX rats.

• Macromolecular Research
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• 제15권6호
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• pp.547-552
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• 2007

Water soluble polymer, poly(vinyl pyrrolidone) was chosen to conjugate with 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (N-succinyl DPPE) to make a new drug delivery system. PVP with an amine group (amino-PVP) was polymerized by free radical polymerization. The amine group of amino-PVP was conjugated with the carboxylic group of N-succinyl DPPE. The resultant conjugate could form nanoparticles in the aqueous solution; these nanoparticles were termed a lipid-polymer system. The critical aggregation concentration was measured with pyrene to give a value of $1{\times}10^{-3}g/L$. The particle size of the lipid-polymer system, as measured by DLS, AFM and TEM, was about 70 nm. Lipophilic component in the inner part of the lipid-polymer system could derive the physical interaction with hydrophobic drugs. Griseofulvin was used as a model drug in this study. The loading efficiency and release profile of the drug were measured by HPLC. The loading efficiency was about 54%. The release behavior was sustained for a prolonged time of 12 days. The proposed lipid-polymer system with biodegradable and biocompatible properties has promising potential as a passive-targeting drug delivery carrier because of its small particle size.

• Journal of Nutrition and Health
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• 제32권8호
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• pp.927-934
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• 1999

Dietary and other factors affecting serum lipid levels of 103 rural women aged 30-76 years were assessed. Data for dietary intakes were obtained by 24-hour recall method. Body weight, height and blood pressure were measured and BMI was calculated from the anthropometric data. Serum samples were collected and analyzed for TG and lipoprotein fractions. Relation of the factors with serum lipid concentration was analyzed by Pearson's correlation coefficient(r). The results were summarized as follows: The weight, hight and BMI of the subjects were 56.8kg, 152.4cm and 24.5k/==, respectively. 31.8% of the subjects under 50 years of age($\leq$49yr group) and 61.0% of the subjects from 50 years up(==50yr group) were classified as hyperlipidemia. Most of the subjects had normal blood pressure but 8.5% were hypertensive. Total food intake of hyperlipidemic subjects was more than those of normal subjects in both age groups. Nutrients intake also tended to be higher in hyperlipidemic subjects of $\geq$50yr group. Intake of some foods like nuts, milk, or meat affected serum lipid profile even though the effects was somewhat different between two age groups. Body weight was positively related with serum TG and VLDL-cholesterol in $\leq$49yr group, and body weight as well as height and BMI affected serum lipid level in $\geq$50yr group. In summarization, it appeared that hyperlipidemia was a serious health problem in rural women. Hypertriglyceridemia due to sharp increase after 50 years old was remarkable and further research should be performed to determine the related factors in the near future.