• Title/Summary/Keyword: lipid metabolic abnormality

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3 Cases Reports of Psoriasis Treated by Damwi-hwan - Focused on Lipid Metabolic Abnomarilty (담위환(膽胃丸) 투약을 통한 건선환자 치험 3례 - 지질대사이상 증상을 중심으로)

  • Cho, Jae-Gon;Yang, Yoon-Hong;Han, Su-Ryun;Cho, Ah-Ra
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.30 no.4
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    • pp.167-175
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    • 2017
  • Objectives : The purpose of this study is to present 3 cases reports of psoriasis treated by Damwi-hwan - focused on lipid metabolic abnomarilty. Methods : We administered Damwi-hwan to three patients who showed psoriasis with lipid metabolic abnormality and evaluated the results by Psoriasis Area and Severity Index(PASI). Results : After the treatment three patients showed improvements in PASI. PASI of patient 1 changed from 15.4 to 0.4; patient 2 from 32.7 to 1.2 ; patient 3 from 7.6 to 0.6. Conclusions : The results suggest that Damwi-hwan can be an effective treatment for psoriasis who has lipid metabolic abnormality.

Congenital Metabolic Disorders with Cutaneous Changes (피부계 이상을 동반하는 선천성대사질환)

  • Sang Eun, Lee
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.22 no.2
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    • pp.53-57
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    • 2022
  • Congenital metabolic disorders are rare inherited disorders resulting from a defect in biochemical and metabolic pathways affecting proteins, fats, carbohydrates metabolism or impaired organelle function. Depending on the abnormality of biochemical metabolism, various precursors and their abnormal metabolites can accumulate in the body and the final products which are critical in normal physiology can be deficient, resulting in disease. Congenital metabolic disorders present complicated medical conditions involving several human organ systems, including nervous system, eyes, liver, and kidneys. Various proteins and lipids are involved in the development and homeostasis of the skin, so many congenital metabolic disorders present abnormal changes in skin and hair. In this review, congenital metabolic diseases related to amino acid and lipid metabolism accompanying skin abnormalities will be discussed.

A Proposal and Considerations for Treatment Approaches of Psoriasis (건선의 치료 접근법에 대한 고찰 및 제언)

  • Kang, Dong-Won;Han, Chang-Yi;Kim, Jun-Dong;Kim, Kyu-Seok;Kim, Yoon-Bum
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.33 no.3
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    • pp.99-114
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    • 2020
  • Objectives : To investigate treatment approaches of psoriasis, and to provide universal and holistic standards to assist in optimizing patient care and future research. Methods : Review articles of psoriasis regarding pathophysiology, risk factor or treatment were searched from Pubmed (January 2016 to June 2020). Treatment approaches were investigated based on the searched articles. Additional data collecting was done for further discussion by searching Pubmed and Google scholar with keywords relevant to the approaches, and the relevant references of articles retrieved were manually inspected to be included. Results : Modalities to directly regulate the relevant helper T cell or inflammatory cytokines can constitute the treatment approaches of psoriasis. Modalities to treat gastrointestinal tract inflammation, to correct metabolic syndrome and to improve epidermal lipid abnormality via whole body lipid metabolism can also constitute the treatment approaches of psoriasis. Probable adverse effects of long term use of western medication should be addressed carefully, and alleviating the hazards of western medication can be a treatment approach of psoriasis. Conclusion : Treatment of psoriasis should take account of systemic aspects such as gastrointestinal tract and lipid metabolism. Treatment approaches of psoriasis established on the pathophysiological basis can serve as universal standards.

Characterization of Plasma Carnitine Level in Obese Adolescent Korean Women

  • Yoo, Hye-Hyun;Yoon, Ho-Joo;Shin, Hye-Jung;Lee, Sang-Hyup;Yoon, Hye-Ran
    • Biomolecules & Therapeutics
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    • v.17 no.2
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    • pp.181-187
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    • 2009
  • Carnitine is known to be involved in lipid metabolism and affects body composition as well as energy metabolism of the whole body. Improvement of obesity by L-carnitine supplement suggests that obesity can be related with the abnormality of carnitine metabolism and therefore, plasma carnitine level in normal and obesity groups was investigated. For the characterization of plasma carnitine level in obese people, 60 plasma samples collected from Korean women subjects were analyzed using LC/MS and plasma fatty acid level was also determined using GC/MS. Additionally, several clinical chemical parameters including fasting glucose, cholesterol, AST, and ALT level were measured. All the data obtained were combined and pattern recognition analysis was carried out with the dataset. Obese group showed a different metabolic pattern compared with normal group. Plasma acylcarnitine level of the obese group was found to be $11.7{\mu}g/ml$, which was higher than that of normal group ($8.0{\mu}g/ml$). Statistically significant differences in plasma fatty acid level were not observed between the two groups. Other clinical parameters for the obese group were within normal ranges but AST and ALT levels were slightly elevated compared to normal group. The obese group showed elevated plasma acylcarnitine level.