• Proceedings of the Korean Society of Sericultural Science Conference
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• 2003.10a
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• pp.91-92
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• 2003

For studies of unfolded protein response (UPR), we isolated differentially expressed genes in Bm5 cell line induced with treatment of tunicamycin, the synthesis inhibitor of N-linked oligosaccharides in cells and constructed the subtractive cDNA library enriching UPR-related genes. (omitted)

• Journal of Preventive Medicine and Public Health
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• v.51 no.4
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• pp.169-172
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• 2018

In recent years, a number of studies have been reported on the various types of cancer arising from epigenetic alterations, including reports that these epigenetic alterations occur as a result of radiation exposure or infection. Thyroid cancer and breast cancer, in particular, have high cancer burden, and it has been confirmed that radiation exposure or onco-viral infection are linked to increased risk of development of these two types of cancer, respectively. Thus, the environment-epigenetic alteration-cancer occurrence (EEC) hypothesis has been suggested. This paper reviews the trends in research supporting this hypothesis for radiation exposure and onco-viral infection. If more evidences accumulate for the EEC hypothesis from future research, those findings may greatly aid in the prevention, early diagnosis, treatment, and prognosis of the thyroid cancer and breast cancer.

• Korean Journal of Microbiology
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• v.26 no.2
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• pp.93-100
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• 1988

In order to understand the regulation of glutamate dehydrogenase(GDH) synthesis in Brevibacterium flavum, we have isolated a mutant lacking NADP-linked GDH activity by ethlmethane sulfonate treatment. The $gdh^-$ mutant was grown on the minimal plate with 1mM ammonium chloride and not that with 300mM ammonium chloride. The cell-free extracts from $gdh^-$ mutant and prototroph were also examined with glutamine synthetase(GS) and glutamate synthase (GOGAT) production by niteogen sources. The growth of $gdh^-$ mutant in presence of 20mM ammonium chloride means that GOGAT synthesis is sufficient to allow growth in this condition. GS production of $gdh^-$ mutant as well as parental strain was induced by 1mM urea and ammonium tartrate, but it was repressed by higher concentration of ammonia, and also induced by 20mM to 50mM glutamate as a substrate. It was special attention that GOGAT synthesis from $gdh^-$ strain was more repressed by higher concentration of ammonia than prototroph as described in E. coli system.

• Journal of Advanced Navigation Technology
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• v.15 no.5
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• pp.845-849
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• 2011

Until now, many researchers have studied and raised issues on medicine tourism. However, the studies for invigoration of medicine tourism from chinese medicine perspective have not been sufficient. The chinese medicine tourism is a new generated concept that combined health medical service of chinese treatment with health-related tour activity as a kind of health tourism. In this paper, we try to search developmental suggestions and propose alternatives for vitalization of chinese medicine tourism from aerial service view.

• International Journal of Advanced Culture Technology
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• v.8 no.3
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• pp.275-279
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• 2020

Due to the recent rapid industrialization worldwide, the number of pediatric asthma patients is increasing. And the fine dust containing heavy metals is linked to the characteristics of high toxic lead due to the increase heating in factory operation and automobile driving. It is the reason of arsenic increasing. In the treatment of pediatric asthma patients, drug administration, oral drug entry, and HMPC (Home Management Plan of Care) are used. In this paper, we analyze the relationship between the onset of asthma and the method of prescription for specific childhood asthma in the United States using EM (Expectation Maximization) and MDL (Minimum Description Length) algorithms. And the association is also analyzed by comparing the nature of specific congestion between the past prevalence of digestive asthma and the recent prevalence of environmental pollution.

• Korean Journal of Clinical Pharmacy
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• v.19 no.2
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• pp.89-95
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• 2009

Gemtuzumab ozogamicin (GO) is an antibody-targeted chemotherapeutic agent consisting of calicheamicin, a potent cytotoxic antibiotic linked to a recombinant humanized anti CD33 monoclonal antibody directed against the CD33 antigen present on leukemic myeloblasts in most patients with acute myeloid leukemia (AML). GO is indicated for the treatment of patients with CD33 positive AML in first relapse who are 60 years of age or older and who are not considered candidates for cytotoxic chemotherapy. GO has shown moderate activity as a single agent in patients with CD33-positive refractory or relapsed acute myeloid leukaemia, with more promising results in acute promyelocytic leukaemia. The side effect profile may be an improvement on conventional chemotherapy, except for a higher frequency of veno-occlusive disease or sinusoidal obstructive syndrome, especially after a subsequent haematopoietic stem cell transplantation. Because of the different mechanisms of action and non-overlapping toxicities, the integration of this immunoconjugate with standard chemotherapy is a rational approach.

• Proceedings of the IEEK Conference
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• 2001.10a
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• pp.220-224
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• 2001

Waste tires are a significant problem with the increasing in number of automobiles. Therefore, many researches have been studied on this field. Recycling is the one of the popular method aspect to environmental and economical in the treatment methods of the waste tire, which loads that the reuse of scrap tire rubber has been a challenge in the past. However, it is not easy method to melt down and mold into new products because the in rubber is a cross-linked polymer. Most difficulty in recycling is the recycled product is not economic. Therefore, the goal of this study is to develop the high valuable products for reused waste tires. In this paper, we try to make an economic recycled technology using scrapped waste tires. This technology may applied for manufacturing the end products such as a rubber block and a ballast mat for high-speed train.

• Perspectives in Nursing Science
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• v.2 no.1
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• pp.92-104
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• 2005

Obesity rates are increasing worldwide, associated with excess acute and chronic disease risk. In most countries, obesity rates among women exceed rates in men, particularly during the post menopausal years. Many factors affect body weight and appetite, including age, metabolic rate, physical activity level, stress, cultural factors, socioeconomic status, health status and health literacy, diet composition, attitudes, and beliefs. Gender affects appetite and body weight indirectly by altering factors contributing to food choice. However, there is emerging evidence that gender affects appetite and body weight directly, altering the physiological control systems regulating appetite. The follicular menstrual cycle phase (estrogen-rich) is associated with relative suppression of appetite. Lower estrogen levels are associated with increased food intake, body weight gain, and altered body fat distribution in humans and animals. This paper reviews the linkages between estrogen and appetite regulation. While relationships among appetite, body weight, and gender-linked hormones are complex, research elucidating these interrelationships could lead to development of gender-specific treatment approaches for obesity and appetite dysregulation.

• Journal of Industrial Technology
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• v.19
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• pp.279-285
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• 1999

An integrated sewer management system was developed for the analysis of sewer flow and for optimal operation of sewer works using ArcView and SWMM. SWMM and ArcView were dynamically linked together using Avenue in order to construct user-friendly management system. The developed system was applied to a residential area in Choonchun city to verify its utilities. All the relevant field data were analyzed on the basis of developed system, and the modeling of sewer flow was implemented using RUNOFF, EXTRAN, TRANSPORT in SWMM. This system is now in the process of connection to the management system of watershed and surface environment in order to develope an integrated environmental management system. Futhermore, this system will be a critical part of overall control system of sewer works including sewer line and wastewater treatment plant. As this system can provide comprehensive prediction of flow and pollution profiles, it could serve as a tool not only for optimal management, but also for decision support system to examine the efficiency of planning and implementation of sewer projects.

• Journal of the korean academy of Pediatric Dentistry
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• v.23 no.3
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• pp.575-581
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• 1996

Hemophilia is a hereditary condition in which one of the normal blood clotting factors is absent. This sex-linked, recessive disease, transmitted by the female and expressed in some of her male offspring, is characterized by significantly delayed coagulation times and by the tendency to hemorrhage. On the dental treatment especially, surgical procedure, appropriate methods of hemorrhage control are required. These methods are replacement therapy, antifibrinolytic agents, and local hemostatic methods. In this case, we successfully extract residual roots of hemophiliac patient without eccessive post operative bleeding using replacement therapy and surgical splint.