• Genomics & Informatics
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• v.9 no.4
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• pp.143-151
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• 2011

In this study, we propose a novel, intuitive method of constructing an expression quantitative trait (eQT) network that is related to the metabolic syndrome using LOD scores and peak loci for selected eQTs, based on the concept of gene-gene interactions. We selected 49 eQTs that were related to insulin resistance. A variance component linkage analysis was performed to explore the expression loci of each of the eQTs. The linkage peak loci were investigated, and the "support zone" was defined within boundaries of an LOD score of 0.5 from the peak. If one gene was located within the "support zone" of the peak loci for the eQT of another gene, the relationship was considered as a potential "directed causal pathway" from the former to the latter gene. SNP markers under the linkage peaks or within the support zone were searched for in the database to identify the genes at the loci. Two groups of gene networks were formed separately around the genes IRS2 and UGCGL2. The findings indicated evidence of networks between genes that were related to the metabolic syndrome. The use of linkage analysis enabled the construction of directed causal networks. This methodology showed that characterizing and locating eQTs can provide an effective means of constructing a genetic network.

• Communications for Statistical Applications and Methods
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• v.13 no.3
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• pp.635-649
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• 2006

In this paper, we perform a simulation study of genetic model-free age-of-onset methods in linkage tests which has been proposed by Zhu et al. (1997). They performe. Haseman-Elston regression on a set of bipolar pedigree data using each of three dependent variables: a binary trait indicating disease concordance or discordance, a binary trait adjusted for age-of-onset, and the residuals from a survival analysis. We compare the powers of the proposed test statistics for various situations. Simulations that we have carried out show that the gains in power are observed when the residuals from a survival analysis are used in linkage tests.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.776-777
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• 2008

It is important to understand the relationship accurately between linkage flux distributions and machine characteristics for better design of multilayer-buried interior permanent magnet synchronous machines(IPMSM). This paper presents a improved calculation method for linkage flux of multilayer-buried IPMSM. From the analysis result, The proposed method shows that the calculated d,q linkage flux reflects a electromagnetic characteristic well in analysis model.

• Transactions of Materials Processing
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• v.6 no.6
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• pp.471-481
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• 1997

This paper is concerned with the kinematic analysis of several linkage drives for mechanical presses. Load and velocity characteristics of conventional presses are illustrated and a design of new drive for a mechanical press is represented. In this regard, a crank-slider mechanism with arc crank-pin guide is introduced and compared with other linkage drives. Kinematic performances are analyzed in respect of load capacity, slide velocity characteristics using a developed SS-Plot program. The new linkage drive turns out to be effective in terms of load and velocity characteristics, and productivity.

• The Korean Journal of Health Service Management
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• v.6 no.3
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• pp.219-229
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• 2012

In these days, the interest on medical industry is increasing around the world. This paper attempts to estimate the economic effects of the medical and measuring instrument industry through the Input-Output Analysis. Especially, 78*78 Sector Tables were used as the first analysis tool. So then, 79*79 Sector Tables adjusted were used for that industry. The main analysis tools of this study are comparing and analyzing backward and forward linkage effect, the induced effect of the self industry and other industries and the induced coefficients such as products, value-added, employee's pay, sales surplus, employment. According to the result of analysis, the medical and measuring instrument industry has great economic impacts which affects the major macroeconomic factors such as production and backward linkage effect. And the induced effects of the self medical and measuring instrument industry are significant compared to other industries in aspects of production, employee's pay and sales surplus.

• The Korean Journal of Health Service Management
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• v.7 no.3
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• pp.57-69
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• 2013

In these days, the interest on health industry is increasing around the world. This paper attempts to estimate the economic effects of the Cosmetic Industrydusing the Input-Output Analysis. Especially, 78*78 Sector Tables were used as the first analysis tool. So then, 79*79 Sector Tables adjusted were used for that industry. The main analysis tools of this study are comparing and analyzing backward and forward linkage effects, the induced effects of the self industry and other industries and the induced coefficients such as product, value-added, job and employment. According to the result of analysis, the cosmetic industry has great economic impacts which affects the major macroeconomic factors such as product, value added and backward linkage effect. And the induced effects of the self cosmetic industry are significant compared to other industries in aspects of product, value-added, and employment.

• Journal of Sericultural and Entomological Science
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• v.43 no.2
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• pp.67-76
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• 2001

The "crescent-egg" a new spontaneous mutant was detected in a white egg strain k37. Studies were carried out the linkage analysis, to investigate phenotypic characteristics and biochemical analysis of haemolymph and ovarian protein. The mutant, ore was independent from 20 linkage groups P(2), Ze(3),L(4), oc(5), sn8), Ia(9), w-1(10), K(11), ch(13), U(14), bl(15), cts(16), bts(17), mln(18), nb(19), oh(20),Lan(21), or(22), tub(23) and Xan(27). The fertilization, hatchability and larval growth were not different from the those of normal eggs. The content and composition of yolk protein were similared to normal eggs. Scanning electron microscopy revealed the areal specific structure in dorsal region of egg-shell of cre mutant. Analysis of chorion protein by isoelectrofocusing(IEF), was resolved no difference in the composite of the chorion protein. We conclude that the egg mutant ere is expressed only in the egg-shape formation and region specific determination.

• Advances in Computational Design
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• v.7 no.3
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• pp.189-210
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• 2022

Deployable structures have the ability to shift from a compact state to an expanded functional configuration. By extension, reconfigurability is another function that relies on embedded computation and actuators. Linkage-based mechanisms constitute promising systems in the development of deployable and reconfigurable structures with high flexibility and controllability. The present paper investigates the deployment and reconfigurability of modular linkage structures with a pin and a sliding support, the latter connected to a linear motion actuator. An appropriate control sequence consists of stepwise reconfigurations that involve the selective releasing of one intermediate joint in each closed-loop linkage, effectively reducing it to a 1-DOF "effective crank-slider" mechanism. This approach enables low self-weight and reduced energy consumption. A kinematics and finite-element analysis of different linkage systems, in all intermediate reconfiguration steps of a sequence, have been conducted for different lengths and geometrical characteristics of the members, as well as different actuation methods, i.e., direct and cable-driven actuation. The study provides insight into the impact of various structural typological and geometrical factors on the systems' behavior.

• Journal of Forest and Environmental Science
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• v.36 no.3
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• pp.243-254
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• 2020

This study was conducted to develop a forest education program through middle school curriculum linkage. We used the ADDIE model, comprising the five phases of Analysis, Design, Development, Implementation and Evaluation, to secure the objectivity of the program. In the Analysis phase, middle school textbooks were analyzed while considering middle school students' needs for curriculum linkage and the developmental stages of adolescents. The Design phase focused on promoting an understanding of curriculum subjects based on what was reviewed in the Analysis phase and concretized and organized a program that can be implemented in the forest, with a focus on science and physical education, based on the results of middle school students' needs. We also established the objectives and goals of curriculum linkage forest education, established the concept of the program, and selected the educational contents, teaching-learning methods, and evaluation methods. In the Development phase, we developed a 2-night, 3-day program linkage with the middle school curriculum and created a manual for instructors and a workbook for students. In the Implementation phase, we revised and supplemented the program through the first test operation with 24 students in their second year of middle school, after which, we carried out a six-session program for the 2-night, 3-day as the second test operation with 17 students in their second year of middle school. In the Evaluation phase, the program was evaluated by the students who participated in the second test operation using questionnaires on satisfaction and curriculum linkage understanding as well as rating scales for attitudes toward forests and environmental sensitivity. The results showed that middle school students showed positive significance in satisfaction and understanding of the middle school curriculum as well as attitudes toward forests and environmental sensitivity through the forest education program.

• Asian-Australasian Journal of Animal Sciences
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• v.8 no.6
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• pp.651-655
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• 1995

A simulation study on detection of linkage between genetic markers and QTL in backcross design was conducted. The effects of various sample sizes and the degree of QTL dominance on detention of linkage were examined by using a simple regression analysis. The results indicated that as sample size increased, the standard error of the estimated slope became smaller. When the dominance effect of QTL was complete, the estimated slope tended to be negative but was statistically not significant at all with type I error of greater than 50%. With complete linkage between genetic Marker and QTL, the estimated intercept value was smallest but the estimated slope was largest as expected. In most cases with various degree of dominance and sample sizes, when the actual recombination rate became larger, greater values were obtained for the slope except in the case of complete dominance of QTL.