• 생물정신의학
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• 제18권1호
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• pp.36-45
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• 2011

Objectives : Though a proportion of Alzheimer's disease(AD) patients treated with donepezil have shown positive response on cognition, but the responders' characteristics are still uncertain. This study attempts to identify whether a single oral dose of donepezil(5mg) can change cognition and the relationship between single dose responder items and long-term responder are examined. Methods : Twenty-three AD patients for single donepezil challenge study group and eleven AD patients for controls were participated in the study. Seven days after baseline study for neuropsychological test and EEG, same studies were rechecked after donepezil medication in study group. In donepezil study groups, 12 weeks after donepezil medication, neuropsychological test and EEG were rechecked. Results : After single donepezil challenge, forward digit span, Rey-Osterrieth Complex Figure Test copy, SVLT delayed recall were significantly improved, and beta spectra power in anterior, theta spectra power in posterior field were significantly decreased. According to linear regression analysis, forward digit span after single donepezil challenge was significantly positive correlated with long-term responders. Conclusions : This study suggests that single donepezil medication can significantly change cognitive functions and EEG in AD patients. Among these responsive items, forward digit span was significantly correlated with long-term responder.

• Structural Engineering and Mechanics
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• 제33권3호
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• pp.373-385
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• 2009

The purpose of this paper is to study shear locking-free parametric earthquake analysis of thick and thin plates using Mindlin's theory, to determine the effects of the thickness/span ratio, the aspect ratio and the boundary conditions on the linear responses of thick and thin plates subjected to earthquake excitations. In the analysis, finite element method is used for spatial integration and the Newmark-${\beta}$ method is used for the time integration. Finite element formulation of the equations of the thick plate theory is derived by using higher order displacement shape functions. A computer program using finite element method is coded in C++ to analyze the plates clamped or simply supported along all four edges. In the analysis, 17-noded finite element is used. Graphs are presented that should help engineers in the design of thick plates subjected to earthquake excitations. It is concluded that 17-noded finite element can be effectively used in the earthquake analysis of thick and thin plates. It is also concluded that, in general, the changes in the thickness/span ratio are more effective on the maximum responses considered in this study than the changes in the aspect ratio.

• Wind and Structures
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• 제32권2호
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• pp.89-104
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• 2021

Non-synoptic winds generated by tornadoes, downbursts or gust fronts exhibit significant non-stationarity and can cause significant wind load effect on flexible structures such as long-span bridges. However, conventional assumptions on stationarity used to evaluate the structural wind-induced vibration are inadequate. In this paper, an efficient frequency domain scheme based on fast CQC method, which can predict non-stationary buffeting random responses of long-span bridges, is presented, and then this approach is applied to evaluate the buffeting response of a long-span suspension bridge located in a complex mountainous wind environment as an example. In this study, the data-driven method based on one available measured wind speed sample is firstly presented to establish non-stationary wind models, including time-varying mean wind speed, time-varying intensity envelope function and uniformly modulated fluctuating spectrum. Then, a linear time-variant (LTV) system based on the proposed scheme can be generally applied to calculate the non-stationary buffeting responses. The effectiveness and accuracy of the proposed scheme are verified through Monte Carlo time domain simulation implemented in ANSYS platform. Also, the transient effect nature of the bridge responses is further illustrated by comparison of the non-stationary, quasistationary and steady-state cases. Finally, buffeting response analysis with traditional stationary treatment (10 min constant mean plus stationary wind fluctuation) is performed to illustrate the importance of the non-stationary characteristics embedded in original wind speed samples.

• Structural Engineering and Mechanics
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• 제71권2호
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• pp.153-163
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• 2019

Longitudinal fracture behavior of non-linear elastic beam configurations is studied in terms of the strain energy release rate. It is assumed that the beams exhibit continuous material inhomogeneity along the width as well as along the height of the crosssection. The Ramberg-Osgood stress-strain relation is used for describing the non-linear mechanical behavior of the inhomogeneous material. A solution to strain energy release rate is derived that holds for inhomogeneous beams of arbitrary cross-section under combination of axial force and bending moments. Besides, the solution may be applied at any law of continuous distribution of the modulus of elasticity in the beam cross-section. The longitudinal crack may be located arbitrary along the beam height. The solution is used to investigate a longitudinal crack in a beam configuration of rectangular cross-section under four-point bending. The crack is located symmetrically with respect to the beam mid-span. It is assumed that the modulus of elasticity varies continuously according a cosine law in the beam cross-section. The longitudinal fracture behavior of the inhomogeneous beam is studied also by applying the J-integral approach for verification of the non-linear solution to the strain energy release rate derived in the present paper. Effects of material inhomogeneity, crack location along the beam height and non-linear mechanical behavior of the material on the longitudinal fracture behavior are evaluated. Thus, the solution derived in the present paper can be used in engineering design of inhomogeneous non-linear elastic structural members to assess the influence of various material and geometrical parameters on longitudinal fracture.

• 한국전산유체공학회지
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• 제10권1호
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• pp.31-38
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• 2005

Three-dimensional flow over the sand dunes have been studied numerically by using Large-Eddy Simulation (LES) method. In the direction of initial flow and span direction cyclic boundary conditions are imposed for velocity and pressure. The movement of the sand dune which is formed by converging wind direction has been investigated. The numerical method employed in this study can be divided into three parts: (i) calculation of the air flow over the sand dune using standard MAC method with a generalized coordinate system; (ii) estimation of the sand transfer caused by the flow through the friction; (iii) determination of the shape of the sand surface. Since the computational area has been changed due to step (iii), (i)-(iii) are repeated. The simulated dune, which has initially elliptic cross section, extends at the converging direction, which is known as linear dunes.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2002년도 봄 학술발표회 논문집
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• pp.107-114
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• 2002

This paper deals with the non-linear analysis of cantilever beams with constant volume. Numerical methods are developed for solving the elastica of cantilever ben subjected to a tip Point load and a tip couple. The linear, parabolic and sinusoidal tapers with the regular polygon cross-section are considered, whose material volume and span length are always held constant. The Runge-Kutta and Regula-Falsi methods, respectively, are used to integrate the governing differential equations and to compute the unknown value of the tip deflection. The numerical results obtained herein are shown in tables and figures. Also the shapes of strongest beams are determined by reading the minimum values form the deflection versus section ratio curves.

• Wind and Structures
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• 제31권6호
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• pp.549-560
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• 2020

Methods for stochastic simulation of non-Gaussian wind pressure have increasingly addressed the efficiency and accuracy contents to offer an accurate description of the extreme value estimation of the long-span and high-rise structures. This paper presents a linear prediction and z-transform (LPZ) based Cumulative distribution function (CDF) mapping algorithm for the simulation of multivariate non-Gaussian fluctuating wind pressure. The new algorithm generates realizations of non-Gaussian with prescribed marginal probability distribution function (PDF) and prescribed spectral density function (PSD). The inverse linear prediction and z-transform function (ILPZ) is deduced. LPZ is improved and applied to non-Gaussian wind pressure simulation for the first time. The new algorithm is demonstrated to be efficient, flexible, and more accurate in comparison with the FFT-based method and Hermite polynomial model method in two examples for transverse softening and longitudinal hardening non-Gaussian wind pressures.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2007년도 정기총회 및 학술발표대회
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• pp.53-56
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• 2007

It was previously introduced a new displacement measuring technique using terrestrial laser scanning (TLS) that remotely samples the surface of an object using laser pulses and generates the three-dimensional (3D) coordinates of numerous points on the surface. In this paper, for an assessment of the capabilities of the measuring technique about existing structures, the field tests for vertical displacement measurement of an existing long span steel box-girder are experimentally carried out. The performance of the technique is evaluated by comparing the displacements obtained from TLS system and displacements directly measured from linear variable displacement transducer (LVDT).

• International Journal of Korean Welding Society
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• 제5권1호
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• pp.29-34
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• 2005

Finite element analysis (FEA) and experimental studies on an elastic bending method have been performed in order to control the angular distortion at the fillet weldment for curved panel. Process parameters for the elastic bending method such as clamping span and release time were analyzed with reference to welding condition and geometric effect of the curved panel, which can minimize or prevent the angular distortion by producing a proper skin stress to the fillet weldment. The amounts of the angular distortion decrease almost in a linear manner with an increase in the skin stress. The skin stress required for non-angular distortion at the fillet weldment is strongly dependent on the plate thickness, not the heat intensity applied. The clamping span for obtaining uniform skin stress was defined as functions of the plate thickness and length of the free edge. Clamp should be removed after the fillet weldment is cooled down to room temperature for non-angular distortion. Effectiveness of the elastic bending method established was verified by its application to an actual curved panel.

• 대한기계학회논문집
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• 제17권12호
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• pp.3148-3165
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• 1993

A cascade wind tunnel test for a turbine nozzle, which was designed for a small turbo jet engine in a previous study, has been conducted to evaluate its aerodynamic performance and losses. The large-scale blades were based on the mid-span profile of the nozzle. Oil film flow structure, and then 3-dimensional velocity components were measured in the flow passage with a 5-hold pressure probe, in addition to turbulent intensities at mid-span of cascade exit using a hot-wire anemometer. From this study, 3-dimensional growth of horseshoe and passage vortices in the downstream direction was clearly understood with near-wall flow phenomena. In addition, secondary flow and losses associated with the blade configuration were obtained in detail.