• Korean Journal of Pharmacognosy
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• v.11 no.3_4 s.43
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• pp.133-140
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• 1980

In order to develop the radio-immunoassay procedure for the ginsenoside $Rg_1$ we prepared the $Rg_1-BSA$ conjugate and $Rg_1-tyramine$ conjugate by condensing the $Rg_1-azide$, which was prepared by a series of six step chemical modification of the $Rg_1-side$ chain, with bovine serum albumin(BSA) or with tyramine. Rabbits were immunized by repeated injection of $Rg_1-BSA$ conjugate with Freund's Complete Adjuvant for 5 month long to obtain very potent $anti-Rg_1$ serum. The radio-labelled haptene was prepared by direct radio-iodination $(125_J)$ of $Rg_1-tyramine$ according to the chloramine-T method. The radio-immunoassay procedure was successfully furnished by using DCC method (dextran coated charcoal) and the anti-body titer of the anti-serum was found as being $1600{\sim}3200$ by using 15000cpm tracer per test. Calibration test using non-labelled $Rg_1$ showed linear competetive binding response in the $(8-300){\times}34pg$. range of non-labelled $Rg_1$. The cross reaction test using 19 ginsenoside analogues enabled us a full structure-activity analysis on the antigen-antibody reaction that the anti-body in the serum would recognize the full structure of ginsenoside $Rg_1$ except the side chain moiety.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.4A
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• pp.310-315
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• 2002

The Bark Coherence Function (BCF) defies a coherence function within perceptual domain as a new cognition module, robust to linear distortions due to the analog interface of digital mobile system. Our previous experiments have shown the superiority of BCF over current measures. In this paper, a new BCF suitable for VoIP is developed. The unproved BCF is based on the wavelet series expansion that provides good frequency resolution while keeping good time locality. The proposed Wavelet based Bark Coherence function (WBCF) is robust to variable delay often observed in packet-based telephony such as Voice over Internet Protocol (VoIP). We also show that the refinement of time synchronization after signal decomposition can improve the performance of the WBCF. The regression analysis was performed with VoIP speech data. The correlation coefficients and the standard error of estimates computed using the WBCF showed noticeable improvement over the Perceptual Speech Quality Measure (PSQM) that is recommended by ITU-T.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.4
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• pp.387-393
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• 2012

A roller rack pinion (RRP) system, which consists of a rack-bar and a cam pinion, transforms a rotation motion into a linear one. The rack-bar has a series of roller trains, and meshes with the cam pinion. This paper first proposes the exact tooth profile of the cam pinion and the non-undercut condition to satisfy the required performance by introducing the profile shift coefficient. The paper then investigates the load stress factors under various shape design parameters to predict the gear surface fatigue limit, which was strongly related to the gear noise and vibration at the contact patch. The results show that the pitting life can be extended significantly with an increase in the profile shift coefficient.

• Journal of the Korean Society for Nondestructive Testing
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• v.19 no.2
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• pp.110-117
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• 1999

In order to ultrasonically evaluate creep cavities pure copper samples were subjected to creep test and their microstructures were examined. Ultrasonic velocities. frequency-dependent magnitude spectra and attenuations were measured on a series of copper samples obtained from the different stages of creep test. Velocities measured in three directions with respect to the loading axis decreased and their anisotropy increased as a function of the creep-induced porosity. The anisotropic behavior could be attributed to the progressive change of pore shape and preferred orientation as the creep advanced. The 2% porosity by volume decreased the longitudinal and shear wave velocities by 11% and 4%, respectively. Furthermore, both velocities decreased nonlinearly with the porosity. As the creep damage developed, the magnitude spectra lost high frequency components and their central frequencies shifted to lower values. The attenuation showed almost linear behavior in the frequency range used. Normalized velocity, central frequency shift and attenuation slope were selected as nondestructive evaluation parameters. These results were presented and showed good relations with the porosity content.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.4 no.4
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• pp.575-594
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• 2010

In this study, we propose a space search algorithm (SSA) and then introduce a hybrid optimization of fuzzy inference systems based on SSA and information granulation (IG). In comparison with "conventional" evolutionary algorithms (such as PSO), SSA leads no.t only to better search performance to find global optimization but is also more computationally effective when dealing with the optimization of the fuzzy models. In the hybrid optimization of fuzzy inference system, SSA is exploited to carry out the parametric optimization of the fuzzy model as well as to realize its structural optimization. IG realized with the aid of C-Means clustering helps determine the initial values of the apex parameters of the membership function of fuzzy model. The overall hybrid identification of fuzzy inference systems comes in the form of two optimization mechanisms: structure identification (such as the number of input variables to be used, a specific subset of input variables, the number of membership functions, and polyno.mial type) and parameter identification (viz. the apexes of membership function). The structure identification is developed by SSA and C-Means while the parameter estimation is realized via SSA and a standard least square method. The evaluation of the performance of the proposed model was carried out by using four representative numerical examples such as No.n-linear function, gas furnace, NO.x emission process data, and Mackey-Glass time series. A comparative study of SSA and PSO demonstrates that SSA leads to improved performance both in terms of the quality of the model and the computing time required. The proposed model is also contrasted with the quality of some "conventional" fuzzy models already encountered in the literature.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.1
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• pp.101-111
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• 1993

Many processes such as machining, injection-moulding and metal-forming are usually operated by hydraulic servo-systems. The dynamic characteristics of these systems are complex and highly non-linear and are often subjected to the uncertain external disturbances associated with the processes. Consequently, the conventional approach to the controller design for these systems may not guarantee accurate tracking control performance. An effective neuro-fuzzy controller is proposed to realize an accurate hydraulic servo-system regardless of the uncertainties and the external disturbances. For this purpose, first, we develop a simplified fuzzy logic controller which have multidimensional and unsymmetric membership functions. Secondly, we develop a neural network which consists of the parameters of the fuzzy logic controller. It is show that the neural network has both learning capability and linguistic representation capability. The proposed controller was implemented on a hydraulic servo-system. Feedback error learning architecture is adopted which uses the feedback error directly without passing through the dynamics or inverse transfer function of the hydraulic servo-system to train the neuro-fuzzy controller. A series of simulations was performed for the position-tracking control of the system subjected to external disturbances. The results of simulations show that regardless of inherent non-linearities and disturbances, an accuracy tracking-control performance is obtained using the proposed neuro-fuzzy controller.

• Applied Biological Chemistry
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• v.35 no.1
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• pp.14-22
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• 1992

A series of new N-[1-(benzotriazol-1-yl)aryl]arylamine derivatives were synthesized and their antifungal activities $(pI_{50})$ in vitro against Pyricularia oryzae, Fusarium oxysporum f. sp. sesami, Valsa ceratosperma and Botrytis cinerea were dertermined by the agar medium dilution method. From the results of the quantitative structure-activity relationships $(QSAR_S)$ analysis, $hydrophobicity({\pi})$, $electronic({\Sigma\sigma})$ and molar $refractivity({\Sigma}M_R)$ parameter of X & Y-substituents on the phenyl group were also shown to be important factor in determining the variation in the antifungal activity. 4-Bromo group substituents (1d & 2b) were the most effective compounds and the $half-life(T_{1/2})$ on the hydrolysis of X(1) at netural pH was about 1.5 day. Molecular orbital(MO) functions of substrate compound, linear free energy relationships$(LFER_S)$ on the antifungal reactivity arid the results of molecular design were also discussed.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.29 no.5
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• pp.228-238
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• 2017

In coastal region, tidal harmonic constants of semi-diurnal tides and nonlinear tides were collected. The observed tide data of KHOA were analyzed by a tide harmonic analysis method. In the southwestern coasts and Han river estuary, nonlinear tides are clearly generated. The generation of tide non-linearity and tide asymmetry is closely related with tide form factor in Korean coastal zone. Tide non-linearity and asymmetry in Mokpo harbour have increased by a series of coastal development projects. The increase has caused rise of high water level and drop of low water level, and increase of tidal range. In Kunsan Outport, tidal range has been declined due to inter-annual change of nonlinear tides after completion of Samangeum sea-dyke.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.10 no.2
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• pp.119-123
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• 1999

Background and Objectives : Conditions such as muscle atrophy, stretching of strap muscles, and continued craniofacial growth factors have been cited as contributing to the changes observed in the vocal tract structure and function in elderly speakers. The purpose of the present study is to compare F$_1$ and F$_2$ frequency levels in elderly and young adult male and female speakers producing a series of vowels ranging from high-front to low-back placement. Material and Methods : The subjects were two groups of young adults(10 males, 10 females, mean age 21 years old range 19-24 years) and two groups of elderly speakers(10 males, 10 females, mean age 67 years : range 60-84 years). Each subject participated in speech pathologist to be a speaker of unimpared standard Korean. The headphone was positioned 2 cm from the speakers lips. Each speaker sustained the five vowels for 5 s. Formant frequency measures were obtained from an analysis of linear predictive coding in CSL model 4300B(Kay co). Results : Repeated measure AVOVA procedures were completed on the $F_1$ and $F_2$ data for the male and female speakers. $F_2$ formant frequency levels were proven to be significantly lower fir elderly speakers. Conclusions : We presume $F_2$ vocal cavity(from the point of tongue constriction to lip) lengthening in elderly speakers. The research designed to observe dynamic speech production more directly will be needed.

• Applied Microscopy
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• v.22 no.2
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• pp.30-45
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• 1992

An experimental study on the acute irradiation effects on the substantia nigra of head-irradiated rats were carried out. Rats anesthetized with sodium thiopental, were exposed only on their head areas with a single dose of 3,000 rads or 6,000 rads, respectively. Radiation was produced by Mitsubishi linear accelerator at the speed of 200 rads/min. Aminals were sacrificed on 6 hours, 2 days and 6 days following irradiations. By the perfusion fixation through the heart, rats were fixed with 1% glutaraldehyde-1% paraformaldehyde solution. Two hours later, brains were exposed and immersed in the same fixatives over night. Tissue blocks from subtantia nigra were punched out, and they were refixed in the 2% osmium tetroxide solution. Blocks were dehydrated through alcohol series, and embedded in the araldite mixture. Ultrathin sections were stained with uranyl acetate and lead citrate solutions, From the ultrastructural study, following results were made: 1. Six hours after irradiation, severe depletion of synaptic vesicles was occurred in the many axon terminals of the nigral neuropil. 2. Dramatical decrease of lysosomes and dense granules was observed. 3. Two days following irradiation, alterations of ribosomes, granular endoplasmic reticula, mitochondria, etc, were noticed. 4. Many of the malformations were seen to be repaired on the 6th day. 5. Above results were interpreted as follows. At the acute stage of heavy irradiation, neurotransmitters in the substantia nigra are released severely. But they are recovered within 6 days. It is concluded that acute head-irradiation may result severe disturbance of nigral motor control function during the first few days.