• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 1998년도 The Third Asian Fuzzy Systems Symposium
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• pp.432-437
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• 1998

Power systems have uncertain dynamics due to a variety of effects such as lightning, severe storms and equipment failures. The variation of the effective reactance of a transmission line due to a fault is an example of uncertainty in power system dynamics. Hence, a robust controller to cope with these uncertainties is needed. Recently fuzzy controllers have become quite popular for robust control due to its capability of dealing with unstructured uncertainty. Thus in this paper we design an adaptive fuzzy controller using an input-output linearization approach for the transient stabilization and voltage regulation of a power system under a sudden fault. Simulation results show that satisfactory performance is achieved by the proposed controller.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2003년도 생물공학의 동향(XII)
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• pp.743-746
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• 2003

The major pathological lesion in Parkinson's disease(PD) is selective degeneration and loss of pigmented dopaminergic neurons in substantia nigra (SN). Although the initial cause and subsequent molecular signaling mechanisms leading to the dopaminergic cell death underlying the PD process is elusive, the potent neurotrophic factors (NTFs), brain derived neurotrophic factor (BDNF) and glial cell line derived neurotrophic factor (GDNF), are known to exert dopaminergic neuroprotection both in vivo and in vitro models of PD employing the neurotoxin, MPTP. BDNF and its receptor, trkB are expressed in SN dopaminergic neurons and their innervation target. Thus, neurotrophins may have autocrine, paracrine and retrograde transport effects on the SN dopaminergic neurons. This study determined the BDNF secretion from SN dopaminergic neurons by ELISA. Regulation of BDNF synthesis/release and changes in signaling pathways are monitored in the presence of free radical donor, NO donor and mitochondrial inhibitors. Also, this study shows that BDNF is able to promote survival and phenotypic differentiation of SN dopaminergic neurons in culture and protect them against MPTP-induced neurotoxicity via MAP kinase pathway.

• 한국자동차공학회논문집
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• 제10권3호
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• pp.201-208
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• 2002

In this paper, the control strategy of ratio changing system for a metal belt CVT adopting primary pressure regulation is developed, and the shirting performance of pressure regulating type CVT with the suggested control strategy is investigated. The control strategy suggested in this study is composed of 2 feedback loop, one is speed ratio feedback and the other is primary pressure feedback. The pressure feedback is adopted to ensure prohibiting a belt slip during transient period in a fast downshift mode. Simulation results show that the system with suggested control strategy gives appropriate response time and tracking Performance for upshift and also gives a proper primary pressure which can prohibit the belt slip. In addition, it is fecund that the given system has an acceptable servo property in tracking the target speed ratio and robustness for the disturbance of line pressure.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 학술회의 논문집 정보 및 제어부문 A
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• pp.87-90
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• 2003

There are generally two temperature control methods using ac voltage regulators - the phase control method and the on-off control method. The phase control method uses thyristor's angles of extinction for the output power regulation and the on-off control method uses the control of on and off times for the output power regulation. Both of methods have the problems that are the unbalance of the three phase and surge current caused system's destruction. The main object of this study proposes a solution of problems of surge currents and unbalance of three phase when thyristor voltage regulator is switching. To solve the problem, It is proposes that the solution of surge currents is using a tap transformer and an additional switch with adjustable resistance and applies zero crossing of switching voltage of two input line to power load. This method is discuss and verified by computer simulations and experiments.

• 한국정밀공학회지
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• 제12권4호
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• pp.55-66
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• 1995

This paper presents an explicit pole-assignment adaptive servocontrol shceme and its application to cutting force regulation for feedrate maximization. The controller structure of the suggested adaptive control scheme is based on robust control theory. This controller structure is then combined with an on-line model estimation algorithm. The whole scheme is applied to a milling process control. The results of real time cutting experimental studies show that the asymptotic regulation of milling peak cutting forces can be achieved with robust- ness against the time varying perturbations to the process model parameters, which are caused by nonlinear cutting dynamics.

• International Journal of Control, Automation, and Systems
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• 제3권spc2호
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• pp.302-307
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• 2005

A novel neuro controller based simple neuro-structure with modified error function is introduced in this paper. This controller consists of two independent controllers, known as the voltage regulator and the angular controller. The voltage regulator is used to modify terminal voltage for the purpose of tracking a reference voltage. The angular controller is utilized to guarantee the stability of the system. In this structure each neuron uses a linear hard limit activation function that depends on the controlled variable and its derivatives. There is no need for parameter identification or any off-line training data. Two proposed controllers are merged by a smooth switch to build a complete controller. The effectiveness of the proposed novel control action is demonstrated through some computer simulations on a Single-Machine Infinite-Bus (SMIB) power system.

• Journal of Ginseng Research
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• 제22권3호
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• pp.216-221
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• 1998

We examined the anti-invasive activity of ginsenosides Rhl, Rha on the highly metastatic HT1080 human fibrosarcoma cell line. In vitro invasion assay showed ginsenoside Rhr reduced tumor cell invasion through a reconstituted basement membrane in a transwell chamber more than ginsenoside Rh1. Significant down-regulation of matrix metalloproteinase-9 (MMP-9) by ginsenosides Rh, and Rh2 was detected by Northern blot analysis. However, the expression of MMP-2 was not affected by Rh, and Rhr. The expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) was increased by Rhl after 0.5, 1 or 3 day-treatment but reduced after 6 day-treatment. However, the expression of TIMP-2 was not changed by treatment with Rh2. Plasminogen activator inhibitor (PAI) and urokinase-type plasmlnogen activator (uPA) were not changed by treatment with Rh1 and Rh2 for 3 and 6 days. Quantitative gelatin-based zymography confirmed a markedly reduced expression of MMP-9 but MMP-2 after treatments with ginsenosides Rhl and Rha. These results suggest that down-regulation of MMP-9 contributes to the anti-invasive activity of ginsenosides Rhl and Rhr in the HT1080 cells.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.1909-1912
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• 2014

It is becoming progressively more understandable that between transcription and translation there lies another versatile regulator that quantitatively controls the expression of mRNAs. Identification of miRNAs as key regulators of wide ranging signaling cascades and modulators of different cell-type and context dependent activities attracted basic and clinical scientists to study modes and mechanisms in details. In line with this approach overwhelmingly increasing in vivo and in vitro studies are deepening our understanding regarding miR-421, mir-155 and miR-650 mediated regulation of cellular activities. We also attempt to provide an overview of long non coding RNAs.

• 대한전기학회논문지:전력기술부문A
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• 제49권7호
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• pp.332-338
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• 2000

In this paper, a robust nonlinear excitation controller is proposed to achieve both voltage regulation and system stability enhancement for single machine-infinite power systems. The proposed method employs backstepping technique and combines this with an adaptation algorithm for estimating the effective reactance of transmission line, thereby leading to adaptive nonlinear control. Simulation results show that power that angle stabilization as well as voltage regulation is achieved in a satisfactory manner, regardless of the system operating conditions and system structure.

• Molecules and Cells
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• 제39권2호
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• pp.136-140
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• 2016

Eph receptors and their ligands, ephrins, mediate cell-to-cell contacts in a specific brain region and their bidirectional signaling is implicated in the regulation of apoptosis during early brain development. In this report, we used the alpha(${\alpha}$)-Cre transgenic line to induce ephrin-A5 over-expression in the distal region of the neural retina. Using this double transgenic embryo, we show that the over-expression of ephrin-A5 was responsible for inducing massive apoptosis in both the nasal and temporal retinas. In addition, the number of differentiated retinal neurons with the exception of the bipolar neuron was significantly reduced, whereas the laminar organization of the mature retina remained intact. Consistent with this finding, an analysis of the mature retina revealed that the size of the whole retina-particularly the nasal and temporal regions-is markedly reduced. These results strongly suggest that the level of ephrin-A5 expression plays a role in the regulation of the size of the retinal progenitor pool in the neural retina.