• Journal of Korea Port Economic Association
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• v.29 no.2
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• pp.81-111
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• 2013

Along with a general growth in living standards there has been a corresponding increase in the demand for tourism. Cruise based tourism, in particular, has become one of the most dynamic and dramatic growth sectors in the tourism industry over the last 20 years, including in the Northeast Asian region. In line with the growth of passenger numbers, the number of cruise ships and their berth capacities has increased significantly since the late 1970s. Korea, as a peninsular nation, has also experienced a rapid growth in cruise passenger numbers. The national economy has greatly benefited from this as the industry acts as an income generator, creating new jobs and potential investments and in developing local tourism. Ports play an important role in the development of any national cruise industry, providing not only ship berths but supply and bunkering facilities and a gateway to local tourism opportunities. The selection of the optimal cruise port location is an important and complex problem because the decision makers have to consider a large number of criteria which have a significant effect on the economy, environment, human life, and society. This paper investigates those criteria that are significant in developing a successful cruise port by employing a questionnaire survey of major cruise port users - shipping companies and tourism companies. The ports, surveyed in this study are Busan, Incheon, Yeosu and Jeju. All have been identified as important potential cruise ports in the Korean Government's 'The 3rd Port Basic Plan (2011-2020)'.

• Journal of Science and Technology Studies
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• v.7 no.1
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• pp.67-90
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• 2007

Could STS throw another-colored light on the Hwang's Affair, the scientific fraud committed by Hwang Woo-Suk and his research team in Korea? And could analytic tools of STS unfold another meanings which have been overlooked in most of the traditionally social-sciences-oriented analyses? In this essay, I try to answer these questions by analyzing the Hwang's Affair in the view of STS, especially by using some concepts of actor-network theory(ANT): movement, translation and displacement. I want to say that the Hwang's Affair seems to be a part of normal scientific activity, not an abnormal phenomenon, and as an evidence, focus on the similarities of their life styles between "pure/real scientist" Louis Pasteur and "impure/political scientist" Hwang Woo-Suk. I try to mobilize some concepts of ANT, especially movement, and find out why scientists came to move toward the opposed direction on the pure/real-impure/political line. I suggest that there exists "laboratory politics" as the key factor in this bifurcation. My tentative conclusion is that Pasteur can take a position to make his great world, so-called the Pasteurian world, owing to the success of "double movement" in which he treated his laboratory as a fulcrum to lift up the world, but Hwang degrades himself to "ugly scientific politician" due to the loss of the momentum of his movement; Hwang treated his laboratory only as the symbolic resources and in turn failed to solidify material entities, his real political resources, even though he knew the importance of laboratory.

• Journal of the Economic Geographical Society of Korea
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• v.9 no.3
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• pp.379-395
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• 2006

The purpose of this study is to analyze the spatial characteristics of travel patterns and travel behaviors of transit users in the Metropolitan Seoul area. We apply the data mining techniques to explore the travel patterns of transit users from the T-money card database which has been produced over 10,000,000 transaction records per day. The database contains the information of locations and times of origin, transfer, and destination points for each transaction as well as the informations of transit modes taken via the transaction. We develop an data mining algorithm to explore traversal patterns from the enormous information. The algorithm determines the travel sequences of each passenger, and produce the volumes of support on each points (stops) of transportation networks in the Metropolitan Seoul area. In order to visualize the spatial patterns of travel demands for transit systems we apply GIS techniques, and attempt to investigate the spatial characteristics of travel patterns and travel demand. Subway stops located in the Gangnam area appear the highest peak for the travel origin and destination, while the CBD in the Gangbuk stands at the second position. Two or three sub-peaks appear at the densely populated residential areas developed as the high-rise apartment complex. Subway stations located along the Subway Line 2, especially from Guro to Samsung receive heavy travel demand (total support), while bus stops located at the CBD in the Gangbuk stands the highest travel demand by bus.

• Journal of Korean Society of Transportation
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• v.20 no.4
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• pp.151-162
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• 2002

The object of this study is to develop an operating time prediction model for expressways using toll collection data. A Prediction model based on modular neural network model was developed and tested using real data. Two toll collection system(TCS) data set. Seoul-Suwon section for short range and Seoul-Daejeon section for long range, in Kyongbu expressway line were collected and analyzed. A time series analysis on TCS data indicated that operating times on both ranges are in reasonable prediction ranges. It was also found that prediction for the long section was more complex than that for the short section. However, a long term prediction for the short section turned out to be more difficult than that for the long section because of the higher sensitivity to initial condition. An application of the suggested model produced accurate prediction time. The features of suggested prediction model are in the requirement of minimum (3) input layers and in the ability of stable operating time prediction.

• Tuberculosis and Respiratory Diseases
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• v.68 no.3
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• pp.168-174
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• 2010

Background: Sepsis still has a high mortality rate despite adequate supportive care. Newer therapeutic modalities have been developed but they have generally ended in failure. Recently, insulin was reported to have an anti-inflammatory effect by inhibiting the $I{\kappa}B/NF-{\kappa}B$ pathway, and may have therapeutic potential in sepsis. However, the precise mechanism of the anti-inflammatory effect of insulin is unclear. This study examined the role of insulin in activating $I{\kappa}B/NF-{\kappa}B$ in macrophage. Methods: Raw 264.7 cells, a murine macrophage cell line, were used in this experiment. Western blotting using $I{\kappa}B$ Ab and phosphor-specific $I{\kappa}B$ Ab was performed to evaluate the degradation and phosphorylation of $I{\kappa}B$ cells. For the $I{\kappa}B$ Kinase (IKK) activity, an immune complex kinase assay was performed. The level of interleukin-6 (IL-6) was measured by ELISA to determine the level of proinflammatory cytokine. Results: $I{\kappa}B{\alpha}$ degradation began 30 min after lipopolysaccharide (LPS) treatment. However, an insulin pretreatment suppressed the $I{\kappa}B{\alpha}$ degradation caused by the LPS treatment. The phosphorylation of $I{\kappa}B{\alpha}$ and IKK activity was also inhibited by the insulin pretreatment. Finally, the insulin pretreatment showed a tendency to suppress the induction of IL-6 by LPS. Conclusion: Insulin might have an anti-inflammatory effect though partial inhibition of the $I{\kappa}B/NF{\kappa}B$ pathway in macrophage cell lines.

• Journal of Arbitration Studies
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• v.21 no.2
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• pp.85-112
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• 2011

These days utilization of copyright in daily life and economic activities is becoming more important than ever, and IT technology is developing day by day. Along with those fact, copyright infringement and dispute is naturally increasing. This thesis dealt with the 3 different issues of ADR on copyright. The First part, introduce ADR system that was performed by Korea Copyright Committee according to Copyright law. This paper evaluate the committee's efforts to provide resolution of copyright disputes via conciliation was effective. So it needs to be look over several countries' ADR, beside conventional judicial remedy. And Korea's copyright conciliation system which is successfully operating also introduced. Second, In many countries, including South Korea are take advantage of conciliation as the way to settle down the dispute over copyright. Furthermore, looked over if we can use arbitration as tool to settle dispute or not. Currently in Korea, patent dispute is handled by Industrial Property Dispute Conciliation Committee(The Invention Promotion Act Ch.5) and Layout-design Review and Mediation Committee(The Act on the Layout-designs of Semiconductor Integrated Circuits Art.29-34), but using performance of those two committee is still too low. In comparison, the copyright committee, a affiliation organization of the ministry of culture, sports and tourism has much more result in conciliation compare with patent dispute. Copyright disputes has arbitrability of it's subject-matter and many regulating organs are interested in it. (especially, binding of arbitral award and final resolution). Take advantage of both conciliation and arbitration could be good way to resolve copyright disputes. Third, the writer look at the proposal on the creation of Northeast Regional Center for Intellectual Property ADR. Because of the nature of copyright and rapid development of internet technology, international use of work become more frequent and accordingly infringement cases are increasing. The role of commercial arbitration regimes and institutions which has progressed significantly worldwide level, but which has only just begun in the intellectual property ADR area, leads also to a clash of often very different legal cultures and protection in a market economy. International cooperation in regional area with conflict interests becomes an important alternative. But it will depend on the building of regional institutions and mechanisms. The feasibility of this proposal and preconditions were examined. Establishment of new international organization requires a lot of time, cost and efforts. And risk of failure is much too high. Therefore factual, statistical review should be preceded. In addition, technical measures, such as on-line arbitration is necessary to review also. Furthermore in order to establish new organization, the relative law, legal environment, public sentiment and international compliance must be carefully considered with factual review about the needs and economic benefits of each country Yet on complex regulatory matters such as IP and ADR, a great deal of the potential benefits from international standards arises not from the international legal framework nor even the formal content of national legislation, but from the informed and effective use made of the possibilities within the system, including by policymakers and regulators.

• Journal of Korean Society for Geospatial Information Science
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• v.15 no.2 s.40
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• pp.59-66
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• 2007

The digital working environment and its related technology have been rapidly expanding. In the surveying field, we have changed from using optical film cameras and plotters to digital cameras, multi sensors like GPS/INS etc,. The old analog work flow is replaced by a new digital work flow. Accurate data of the land is used in various fields, efficient utilization and management of land, urban planning, disaster and environment management. It is important because it is an essential infrastructure. For this study, LiDAR surveying was used to get points clouds in the study area. It has a high vegetation penetrating advantage and we used a digital process from planning to the final products. Contour lines were made from LiDAR data and compared with national digital base maps (scale 1/1,000 and 1/5,000). As a result, the accuracy and the economical efficiency were evaluated. The accuracy of LiDAR contour data was average $0.089m{\pm}0.062\;m$ and showed high ground detail in complex areas. Compared with 1/1,000 scale contour line production when surveying an area over $100\;km^2$, approximately 48% of the cost was reduced. Therefore we prepose LiDAR surveying as an alternative to modify and update national base maps.

• The Journal of the Korea Contents Association
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• v.13 no.11
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• pp.957-967
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• 2013

While a vast number of cad drawings are produced in the life cycle of construction projects from the planning, design, and construction phases to the maintenance and control phases, the creation and distribution of non-standard drawings make it difficult for the construction parties to communicate with one another and to recycle, maintain, and control drawings by project phase. The Korea standard of CAD drawing in construction CALS/EC, which stipulates the standard for construction CAD drawings, is based on roads, rivers, and railways in line- and unit-based structures, allowing the creation of standardized CAD drawings. Such standard, however, cannot be easily applied to construction projects with multiple facilities like harbors, housing sites, or lands consisting of surface forms. In particular, port field consist of complex docks and amenities located in a certain coastal area based on multiple objectives. They also contain the concept of housing sites, like background land, and are composed of various civil engineering facilities, construction facilities, and port field, so that the existing CAD drawing standard cannot be easily implemented. Therefore, the purpose of this study is to maximize the efficiency of the information related to drawing information and to ultimately support smooth information exchanges in construction design by conducting a development research on the expansion of the CAD drawing standard that meets the needs of port field.

• Biomedical Science Letters
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• v.11 no.2
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• pp.165-173
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• 2005

A potent demethylating agent, 5-Azacytidine (5-AzaC) has been widely used as in many studies on DNA methylation, regulation of gene expression, and cancer biology. The mechanisms of the demethylating activity were known to be formation of complex between DNA and DNA methyltransferase (MTase), which depletes cellular MTase activity. However, 5-AzaC can also induce hypermethylation of a transgene in a transgenic cell line, G12 cells and it was explained as a result of defense mechanisms to inactivate foreign gene(s) somehow. This finding evoked the question that whether the phenomenon of hypermethylation induced by 5-AzaC is limited to the transgene or it can be occurred in endogenous gene(s). In order to answer the question, mutagenicity test of 5-AzaC and molecular characterization of mutants obtained from the test were performed using an endogenous gene, thymidine kinase (tk) in Chinese hamster V79 cells. When V79 and V79-J3 subclone cells were treated with 1, 2.5 ,5, $10{\mu}M$ of 5-AzaC for 48 hours, their maximum mutant frequencies were revealed as $6\times10^{-3}\;at\;5{\mu}M$(350-fold induction over background) and $8\times10^{-3}\;at\;2.5{\mu}M$ (l,800-fold induction over background) respectively. Since the induction rates were too high to be induced by true mutations, many trifluorothymidine (TFT)-resistant $(TFT^R)$ cells were subjected to Northern blot analysis to check the presence of tk transcripts. Surprisingly, all clones tested possessed the transcripts in a similar level, that implicates the $TFT^R$ phenotype induced by 5-AzaC has not given rise to hypermethylation of the gene in spite of unusually high mutation frequency. In addition, it has shown that the TK activity in the pool of 5-AzaC-induced $TFT^R$ cells has about a half of that in spontaneously-induced $TFT^R$ cells or in non-selected parental V79-J3 cells. This result suggests that the mechanism(s) underlying the TFT-resistance between spontaneously occurred and 5-AzaC-induced cells may be different. These findings have shown that the $TFT^R$ phenotype induced by 5-AzaC has not given rise to hypermethylation of the tk gene, and 5-AzaC may be induced by one or combined pathways among many drug resistance mechanisms. The exact mechanisms for the 5-AzaC-induced $TFT^R$ phenotype remain to elucidate.

• The Transactions of the Korea Information Processing Society
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• v.6 no.6
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• pp.1656-1666
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• 1999

The more complex and large digital circuits become, the more important delay test becomes which guarantees that circuits operate in time. In this paper, the proposed algorithm is developed, which enable the fast indirect implication for efficient test pattern generation in sequential circuits of standard scan environment. Static learning algorithm enables application of a new implication value using contrapositive proposition. The static learning procedure found structurally, analyzes the gate structure in the preprocessing phase and store the information of learning occurrence so that it can be used in the test pattern generation procedure if it satisfies the implication condition. If there exists a signal line which include all paths from some particular primary inputs, it is a partitioning point. If paths passing that point have the same partial path from primary input to the signal or from the signal to primary output, they will need the same primary input values which separated by the partitioning point. In this paper test pattern generation can be more effective by using this partitioning technique. Finally, an efficient delay fault test pattern generator using indirect implication is developed and the effectiveness of these algorithms is demonstrated by experiments.