• Parasites, Hosts and Diseases
• /
• v.58 no.3
• /
• pp.267-278
• /
• 2020

The heterogeneity and complexity of malaria involves political and natural environments, socioeconomic development, cross-border movement, and vector biology; factors that cannot be changed in a short time. This study aimed to assess the impact of economic growth and cross-border movement, toward elimination of malaria in Yunnan Province during its pre-elimination phase. Malaria data during 2011-2016 were extracted from 18 counties of Yunnan and from 7 villages, 11 displaced person camps of the Kachin Special Region II of Myanmar. Data of per-capita gross domestic product (GDP) were obtained from Yunnan Bureau of Statistics. Data were analyzed and mapped to determine spatiotemporal heterogeneity at county and village levels. There were a total 2,117 malaria cases with 85.2% imported cases; most imported cases came from Myanmar (78.5%). Along the demarcation line, malaria incidence rates in villages/camps in Myanmar were significantly higher than those of the neighboring villages in China. The spatial and temporal trends suggested that increasing per-capita GDP may have an indirect effect on the reduction of malaria cases when observed at macro level; however, malaria persists owing to complex, multi-faceted factors including poverty at individual level and cross-border movement of the workforce. In moving toward malaria elimination, despite economic growth, cooperative efforts with neighboring countries are critical to interrupt local transmission and prevent reintroduction of malaria via imported cases. Cross-border workers should be educated in preventive measures through effective behavior change communication, and investment is needed in active surveillance systems and novel diagnostic and treatment services during the elimination phase.

• Korean Security Journal
• /
• no.24
• /
• pp.67-90
• /
• 2010

Today, the police alone can not prevent a crime. And the police is limited to meet for people's the increased needs on public safety. So the police and the community needs the cooperation of a variety of resources. Police in cooperation with community resources to respond to the crime's most professional and the private sector is a private security. However, the role of private security for cooperation policing is insufficient in South Korea. So for this study to build a cooperative policing in South Korea as private security for the following four kinds of directions are presented. First, as a private security of the United States and Japan, specializes in diversified business sectors. Simple human-oriented private security of the building security get out. Instead, take the high-tech crime prevention or industry complex security should be changed to a professional organization. Second, the interaction between police and private security should be increased. Police and private security through regular meetings between the need for mutual interests and build consensus is needed. The role of private security companies to be represented on the Security Association of South Korea's active role in the matter. Third, efforts to improve the image of private security activities and the publiciy activity of private security is needed. Some of the private security in an effort to escape a negative image to the people and actively promote a positive image is necessary. Finally, for South Korea to the level the cooperation between the police and private security are required to develop system models. Front-line policing priority in the field and the mutual understanding between the police and private security in an effort to have a positive perception is needed. Equal partners, especially the police and private security to private security companies to have recognized experts in their own recruitment and training should be improved by strengthening the expertise.

• The KIPS Transactions:PartD
• /
• v.10D no.3
• /
• pp.407-416
• /
• 2003

As the usage of database systems dramatically increases and the amount of data pouring into them is massive, the performance administration techniques for using database systems effectively are getting more important. Especially in data warehouses, the performance management is much more significant mainly because of large volume of data and complex queries. The objectives and characteristics of data warehouses are different from those of other operational systems so adequate techniques for performance monitoring and tuning are needed. In this paper we extend functionalities of the DBMax, a performance administration tool for Oracle database systems, to apply it to data warehouse systems. First we analyze requirements based on summary management and ETL functions they are supported for data warehouse performance improvement in Oracle 9i. Then, we design architecture for extending DBMax functionalities and implement it. In specifics, we support SQL tuning by providing details of schema objects for summary management and ETL processes and statistics information. Also we provide new function that advises useful materialized views on workload extracted from DBMax log files and analyze usage of existing materialized views.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
• /
• v.9 no.3
• /
• pp.83-92
• /
• 2004

A continuous monitoring of textural characteristics of surface sediments, sedimentation rates and beach profile was carried out to investigate the seasonal variations of sedimentary processes in the Imjado beach, southwestern coast of Korea for two years. The beach profiles consist of steep beach face and relatively flat middle and low tide beaches. The slope of the beach face increases in summer and decreases in winter, in good accordance with the standard beach cycle. Ridge and runnel systems are well developed in the middle and low tide beaches during the summer, but these structures are replaced by mega-ripples during the winter. The sediments are fining southward as well as landward. The mean grain-size tends to be increasingly coarser during seasons of autumn and winter on the north beach and during seasons of winter and spring on the south one. In addition, the sediments are eroded on the north beach and accumulated on the south one as a whole. These are probably due to southward transportation of the sediments as long-shore current (NE-SW) runs around the coastal line of the beach. However, the seasonal variations in accumulation rates are very complex and irregular. It is considered that the Imjado beach represents in non-equilibrium state, as a result of coastal and submarine topographic changes by artificial agents and sea-level uprising associated with global warming.

• Journal of Microbiology and Biotechnology
• /
• v.16 no.12
• /
• pp.1919-1927
• /
• 2006

Tumor cells genetically engineered to secrete cytokines are effective in tumor therapy, but various unexpected side effects are observed, which may result from the bulk activation of various bystander cells. In this study, we tested tumor vaccines expressing various membrane-bound forms of IL-2 (mbIL-2) on MethA fibrosarcoma cells to focus antitumor immune responses to CTL. Chimeric forms of IL-2 with whole CD4, deletion forms of CD4, and TNF were expressed on the tumor cell surface, respectively. Tumor clones expressing mbIL-2 or secretory form of IL-2 were able to support the cell growth of CTLL-2, an IL-2-dependent T cell line, and the proliferation of spleen cells from 2C TCR transgenic mice that are responsive to the $p2Ca/L^d$ MHC class I complex. Expression of mbIL-2 on tumor cells reduced the tumorigenicity of tumor cells, and the mice that once rejected the live IL-2/TNF tumor clone acquired systemic immunity against wild-type MethA cells. The IL-2/TNF clone was inferior to other clones in tumor formation, and superior in the stimulation of the CD8+ T cell population in vitro. These results suggest that the IL-2/TNF clone is the best tumor vaccine, and may stimulate CD8+ T cells by direct priming. Expression of IL-2/TNF on tumor cells may serve as an effective gene therapy method to ameliorate the side effects encountered in the recombinant cytokine therapy and the conventional cytokine gene therapy using the secretory form of IL-2.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.6
• /
• pp.692-696
• /
• 2017

The shape of press components is becoming increasingly complex due to customer demands, process shortening and cost savings. In addition, the stability of the pressing process frequently varies during mass production due to the influence of many factors. In order to ensure the process stability, it is necessary to establish a process in which reproducibility is realized in tolerance, which is sufficient for advance study of shape, material, press, mold and lubrication. However, unforeseen changes in process parameters cause disruptions in production line shutdowns and production planning. In this paper, we introduce a method to monitor a real time process by applying a sensor to a press mold. A non-contact type sensor for measuring the flow of a sheet material and an example of an experiment using the optical sensor which is highly applicable to mass production are presented. An optical sensor was installed in a cylindrical drawing mold to test its potential application while changing the material, blank holder force, and drawing ratio. We also quantitatively determined that the flow of other sheet materials was quantified locally using a square drawing die and that the measured value was always smaller than the drawing depth due to the material elongation. Finally, we propose a field that can be used by attaching the sensor to the press mold. We hope that the consequent cost reduction will contribute to increasing global mold competitiveness.

• The Korean Journal of Physiology and Pharmacology
• /
• v.9 no.6
• /
• pp.333-339
• /
• 2005

B/K protein is a novel protein containing double C2-like domains. We examined the specific signaling pathway that regulates the transcription of B/K in PC12 cells. When the cells were treated with forskolin ($50{\mu}M$), B/K mRNA and protein levels were time-dependently decreased, reaching the lowest level at 3 or 4 hr, and thereafter returning to the control level. Chemicals such as dibutyryl-cAMP, cellpermeable cyclic AMP (cAMP) analogue and CGS21680, adenosine receptor $A_{2A}$ agonist, also repressed the B/K transcription. However, 1,9-dideoxyforskolin did not show inhibitory effect on B/K transcription, suggesting direct involvement of cAMP in the forskolin-induced inhibition of B/K transcription. Effect of forskolin, dibutyryl cAMP and CGS21680 was significantly reduced in PKA-deficient PC12 cell line (PC12-123.7). One cAMP-response element (CRE)-like sequence (B/K CLS) was found in the promoter region of B/K DNA, and electrophoretic mobility shift assay indicated its binding to CREM and CREB. Forskolin significantly suppressed the promoter activity in CHO-K1 cells transfected with the constructs containing B/K CLS, but not with the construct in which B/K CLS was mutated (AC：TG). Taken together, we suggest that the transcription of B/K gene in PC12 cells may be regulated by PKA-dependent mechanism.

• Journal of Korea Multimedia Society
• /
• v.13 no.7
• /
• pp.1000-1015
• /
• 2010

In this paper, we propose a novel algorithm for hand gesture recognition. The hand detection method is based on human skin color, and we use the boundary energy information to locate the hand region accurately, then the moment method will be employed to locate the hand palm center. Hand gesture recognition can be separated into 2 step: firstly, the hand posture recognition: we employ the parallel NNs to deal with problem of hand posture recognition, pattern of a hand posture can be extracted by utilize the fitting ellipses method, which separates the detected hand region by 12 ellipses and calculates the white pixels rate in ellipse line. the pattern will be input to the NNs with 12 input nodes, the NNs contains 4 output nodes, each output node out a value within 0~1, the posture is then represented by composed of the 4 output codes. Secondly, the hand gesture tracking and recognition: we employed the Kalman filter to predict the position information of gesture to create the position sequence, distance relationship between positions will be used to confirm the gesture. The simulation have been performed on Windows XP to evaluate the efficiency of the algorithm, for recognizing the hand posture, we used 300 training images to train the recognizing machine and used 200 images to test the machine, the correct number is up to 194. And for testing the hand tracking recognition part, we make 1200 times gesture (each gesture 400 times), the total correct number is 1002 times. These results shows that the proposed gesture recognition algorithm can achieve an endurable job for detecting the hand and its' gesture.

• Journal of the Korean Society for Railway
• /
• v.13 no.1
• /
• pp.58-64
• /
• 2010

As a modem urban train is getting complex in terms of high-technology in its systems and components, the failure management should be performed with scientific and systematic technique. FMEA is a technique to analyze the failure trends of component parts and influences to the higher level system in order to discover the design incompleteness and potential defects, which is for improving reliability. Especially, FMECA (Failure Mode Effects, and Criticality Analysis) is used in case that the criticality that has an immense influence to the system is important. In case of urban train, in its design and manufacturing steps, FMEA is frequently used as an analysis technique to meet the safety objectives and eliminate potential hazards/failures since the concepts of reliability of train is introduced these days. Though, FMEA technique in the maintenances steps lacks in its investigation and applications yet. FMEA is also not applied to the trains operated by Seoul metro in the design and manufacture steps excepts the newest trains. In this paper, through analyzing the failures/maintenance data of the belt-type door systems used in trains operated in Seoul metro Line 1, which is accumulated in RIMS (Rolling-stock Information Maintenance System), FMEA procedures to the belt-type door engines are proposed. Especially, an effort is made, to approach the detailed FMECA procedures to the door magnet valve and switch and door engine devices which vastly influences the customer safety and satisfaction.

• Journal of the Mineralogical Society of Korea
• /
• v.17 no.1
• /
• pp.1-9
• /
• 2004

Copper(II) sorbed on kaolinite (KGa-lb) was studied using electron paramagnetic resonance (EPR) and extended X-ray absorption fine structure (EXAFS) spectroscopy. The sorbed copper(II) had an isotropic EPR signal with $g_{iso}\;=\;2.19$ at room temperature. At 77 K, the isotropic signal converted to an axially symmetric anisotropic signal with $g_{\$\mid$}\;=\;2.40,\;g_{\bot}\;=\;2.08,\;and\;A_{\$\mid$}\;=\;131\;G$. These EPR results suggest that the sorbed copper(II) forms an outer-sphere surface complex with a tetragonally distorted $CuO_{6}$ octahedral structure on the kaolinite. In the sorption measurement, the amount of sorbed copper increased with increasing pH of the solution. However, the intensity of the isotropic EPR line was not directly proportional to the amount of sorbed copper. This discrepancy was resolved by assuming the formation of a surface precipitate at higher pH that is invisible by EPR. The EXAFS data confirmed the existence of the surface precipitate. The best fit for the EXAFS of the sorbed copper showed that each copper on the kaolinite had 6.8 copper neighbors located $3.08\;{\AA}$ from it, in addition to the first shell oxygen neighbors, including 4 equatorial O at $1.96\;{\AA}$ and 2 axial O at $2.31\;{\AA}$. This work shows that the local environment of the copper sorbed on the kaolinite changes as a function of pH and surface loading, and that the EPR and EXAFS are useful in studying such changes.