• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.12
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• pp.1711-1717
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• 2020

X-ray of up to 9MeV are used for container inspection. X-ray intensity must be maintained stably regardless of changes in time. If dose is not constant, it may affect the image quality, and as a result, may affect the inspection of abnormal cargo. Therefore, to acquire high-quality images, continuous dose monitoring is required. In this study, the ion-chamber based device was developed for monitoring the dose change in high-energy x-ray. And to estimate the performance of signal-processing device change according to the environmental change, the output changing due to the change of temperature and humidity was observed. In addition, verification of the device was performed by measuring the output change. As a result of the measurement, there was no significant difference in performance due to changes in temperature and humidity, and the change in output according to the change in exposure was linear. Therefore, it was found that the developed device is suitable for the dose monitoring of high-energy x-ray.

• Journal of radiological science and technology
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• v.45 no.5
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• pp.449-455
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• 2022

This study is to present a Geant4 code for the simulation of the absorbed dose distribution given by a medical linac for 6 MV photon beam. The dose distribution was verified by comparison with calculated beam data and beam data measured in water phantom. They were performed for percentage depth dose(PDD) and beam profile of cross-plane for two field sizes of 10 × 10 and 15 × 15 cm². Deviations of a percentage and distance were obtained. In energy spectrum, the mean energy was 1.69 MeV. Results were in agreement with PDD and beam profile of the phantom with a tolerance limit. The differences in the central beam axis data 𝜹₁ for PDD had been less than 2% and in the build up region, these differences increased up to 4.40% for 10 cm square field. The maximum differences of 𝜹₂ for beam profile were calculated with a result of 4.35% and 5.32% for 10 cm, 15 cm square fields, respectively. It can be observed that the difference was below 4% in 𝜹₃ and 𝜹₄. For two field sizes of 𝜹_50-90 and RW₅₀, the results agreed to within 2 mm. The results of the t-test showed that no statistically significant differences were found between the data for PDD of 𝜹₁, p>0.05. A significant difference on PDD was observed for field sizes of 10 × 10 cm², p=0.041. No significant differences were found in the beam profile of 𝜹₃, 𝜹₄, RW₅₀, and 𝜹_50-90. Significant differences on beam profile of 𝜹₂ were observed for field sizes of 10 × 10 cm², p=0.025 and for 15 × 15 cm², p=0.037. This work described the development and reproducibility of Geant4 code for verification of dose distribution.

• Journal of the Korean Society of Radiology
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• v.16 no.7
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• pp.851-856
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• 2022

The purpose of this study is to confirm the effect of reducing the surface dose around the radiation field in breast cancer radiotherapy using the Field-in-Field (FIF) technique. X-ray was exposed from a linear accelerator (Linac) was used for irradiation, and the surface dose was measured with a glass dosimeter. The source-to-surface distance (SSD) was 90 cm, the field size is 10 × 10 cm², and the X-ray energy was 6 MV and 10 MV, respectively. The surface dose of the FIF was compared with the dose measured in the physical wedge (PW) and dynamic wedge (DW). Wedge angles of 15° and 30° were used in the PW and DW, respectively. Surface dose was measured at 1 cm, 3 cm, and 5 cm from the center of the field size, respectively. According to the results, FIF showed lower surface dose compared to PW and DW regardless of the energy of the X-ray beam, wedge angle, and dose measurement point. Since FIF could reduce the radiation dose in periphery of the field size in breast cancer treatment, it is expected to be able to reduce the secondary damage caused by the radiation beam as well as to obtain a uniform dose distribution on the target.

• Journal of the Korean Society of Radiology
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• v.16 no.7
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• pp.863-870
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• 2022

DLG (Dosimetric Leaf Gap) and transmission factor are important parameters of MLC modeling in treatment planning system. In this study, DLG and transmission factor of HD-MLC were measured using detector with different measuring volumes, and the accuracy of the treatment plans was evaluated according to the DLG values. DLG was measured using the dynamic sweeping gap method with Semiflux3D and MicroDiamond detectors. Then, 10 radiation treatment plans were generated to optimize the DLG value and compared with the measurement results. Photon energies 6, 8, 10 MV, the DLG measured by Semiflux3D were 0.76, 0.83, and 0.85 mm, and DLG measured by MicroDiamond were 0.78, 0.86, and 0.9 mm. All plans were measured by portal dosimetry and analyzed using Gamma Evaluation. In the 6 MV photon beams, the average gamma passing rate were 94.3% and 98.4% for DLG 0.78 mm and 1.15 mm. In the 10 MV photon beam, the average gamma passing rate were 91.2% and 97.6% for DLG 0.9 mm and 1.25 mm. HD-MLC needs accurate modeling in the treatment planning system. DLG could be used measured data using small volume detector. However, for better radiation therapy, DLG should be optimized at the commissioning stage of LINAC.

• Progress in Medical Physics
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• v.32 no.4
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• pp.99-106
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• 2021

Purpose: In this study, we aimed to manufacture a patient-specific gel phantom combining three-dimensional (3D) printing and polymer gel and evaluate the radiation dose and dose profile using gel dosimetry. Methods: The patient-specific head phantom was manufactured based on the patient's computed tomography (CT) scan data to create an anatomically replicated phantom; this was then produced using a ColorJet 3D printer. A 3D polymer gel dosimeter called RTgel-100 is contained inside the 3D printing head phantom, and irradiation was performed using a 6 MV LINAC (Varian Clinac) X-ray beam, a linear accelerator for treatment. The irradiated phantom was scanned using magnetic resonance imaging (Siemens) with a magnetic field of 3 Tesla (3T) of the Korea Institute of Nuclear Medicine, and then compared the irradiated head phantom with the dose calculated by the patient's treatment planning system (TPS). Results: The comparison between the Hounsfield unit (HU) values of the CT image of the patient and those of the phantom revealed that they were almost similar. The electron density value of the patient's bone and brain was 996±167 HU and 58±15 HU, respectively, and that of the head phantom bone and brain material was 986±25 HU and 45±17 HU, respectively. The comparison of the data of TPS and 3D gel revealed that the difference in gamma index was 2%/2 mm and the passing rate was within 95%. Conclusions: 3D printing allows us to manufacture variable density phantoms for patient-specific dosimetric quality assurance (DQA), develop a customized body phantom of the patient in the future, and perform a patient-specific dosimetry with film, ion chamber, gel, and so on.

• The Journal of Korean Society for Radiation Therapy
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• v.25 no.2
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• pp.175-180
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• 2013

Purpose: Modern radiation therapy technique such as IGRT has become a routine clinical practice on LINAC for decrease patient's set-up error. CBCT can be used to adjust patient set-up error and treat patient more accurately. The Purpose of this study is to evaluate field size of CBCT for improving Image quality and suggest reference date of CBCT field size. Materials and Methods: Image date were acquired using KV CBCT and Catphan phantom (Half fan and full fan mode were scanned from 2 ~16 cm, at intervals of 2 cm). Field size were categorized by Small field size (2 cm, 4 cm), Medium field size (8 cm, 10 cm), Large field size (more than 14 cm) and evaluate. To estimated the CTDi using CTDi phantom and Ion chamber. Results: CT number linearity of Small and Large field size are greater than Medium field size. Spatial resolution are not significantly different without Small field size. But half fan mode is more different than full fan mode. In full fan, except Medium field size, all field size exceed recommendation for HU uniformity. But half pan has stability for all field except Small field size. CTDi makes radical sign function graph in Medium field size. Conclusion: The worst result was given by Small field size for Image quality and practically. Medium field size can be useful to prevent patient from radiation exposure and give better Image quality. So this study recommends that Medium field size (8~10 cm) is more suitable for CBCT.

• Progress in Medical Physics
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• v.22 no.4
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• pp.216-223
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• 2011

Recently PTW developed a MicroLion liquid ionization chamber which is water_equivalent and has a small sensitive volume of $0.002cm^3$. The aim of this work is to investigate such dosimetric characteristics as dose linearity, dose rate dependency, spatial resolution, and output factors of the chamber for the external radiotherapy photon beam. The results were compared to those of Semiflex chamber, Pinpoint chamber and Diode chamber with the sensitive volumes of $0.125cm^3$, $0.03cm^3$ and $0.0025cm^3$, respectively and evaluated to be suitable for small fields. This study was performed in the 6MV photon energy from a Varian 2300 C/D linac accelerator and the MP3 water phantom (PTW, Freiburg) was used. Penumbras in the varios field sizes ranged from $0.5{\times}0.5cm^2$ to $10{\times}10cm^2$ were used to evaluate the spatial resolution. Output factors were measured in the field sizes of $0.5{\times}0.5$ to $40{\times}40cm^2$. Readings of the chamber was linearly proportional to dose. Dose rate dependency was measured from 100 MU/min to 600 MU/min, showed a maximum difference of 5.0%, and outputs decreased with dose rates. The spatial resolutions determined with comparing profiles for the field sizes of $0.5{\times}0.5cm^2$ to $10{\times}10cm^2$ agreed between every detector except the Semiflex chamber to within 2%. Outputs of detectors were compared to that of Semiflex chamber and showed good agreements within 2% for every chamber. This study shows that MicroLion chamber characterized by a high signal-to-noise ratio and water equivalence could be suitable for the small field dosimetry.

• The Journal of Korean Society for Radiation Therapy
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• v.28 no.1
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• pp.77-86
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• 2016

Purpose : When a radiation treatment, there is an attenuation by Carbon Fiber Couch. In this study, we tried to evaluate the usability of the Varian Standard Couch(VSC) by modeling with Treatment Planning System (TPS) Materials and Methods : VSC was scanned by CBCT(Cone Beam Computed Tomography) of the Linac(Clinac IX, VARIAN, USA), following the three conditions of VSC, Side Rail OutGrid(SROG), Side Rail InGrid(SRIG), Side Rail In OutSpine Down Bar(SRIOS). After scan, the data was transferred to TPS and modeled by contouring Side Rail, Side Bar Upper, Side Bar Lower, Spine Down Bar automatically. We scanned the Cheese Phantom(Middelton, USA) using Computed Tomography(Light Speed RT 16, GE, USA) and transfer the data to TPS, and apply VSC modeled previously with TPS to it. Dose was measured at the isocenter of Ion Chamber(A1SL, Standard imaging, USA) in Cheese Phantom using 4 and 10 MV radiation for every $5^{\circ}$ gantry angle in a different filed size($3{\times}3cm^2$, $10{\times}10cm^2$) without any change of MU(=100), and then we compared the calculated dose and measured dose. Also we included dose at the $127^{\circ}$ in SRIG to compare the attenuation by Side Bar Upper. Results : The density of VSC by CBCT in TPS was $0.9g/cm^3$, and in the case of Spine Down Bar, it was $0.7g/cm^3$. The radiation was attenuated by 17.49%, 16.49%, 8.54%, and 7.59% at the Side Rail, Side Bar Upper, Side Bar Lower, and Spine Down Bar. For the accuracy of modeling, calculated dose and measured dose were compared. The average error was 1.13% and the maximum error was 1.98% at the $170^{\circ}beam$ crossing the Spine Down Bar. Conclusion : To evaluate the usability for the VSC modeled by TPS, the maximum error was 1.98% as a result of compassion between calculated dose and measured dose. We found out that VSC modeling helped expect the dose, so we think that it will be helpful for the more accurate treatment.

• Radiation Oncology Journal
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• v.21 no.3
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• pp.227-237
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• 2003

Purpose: The human chronic myelogenous leukemia cell line, K562, expresses the chimeric bcr-abl oncoprotein, whose deregulated protein tyrosine kinase activity antagonizes via DNA damaging agents. Previous experiments have shown that nanomolar concentrations of herbimycin A (HWA) coupled with X-irradiation have a synergistic effect in inducing apoptosis in the Ph-positive K562 leukemia cell line, but genistein, a PTK inhibitor, is non selective for the radiation-induced apoptosils on $p210^{bcr/abl}$ protected K562 cells. In these experiments, the cytoplasmic signal transduction pathways, the Induction on a number of transcription factors and the differential gene expression in this model were investigated. Materials and Methids: K562 cells in the exponential growth phase were used in this study. The cells were irradiated with 0.5-12 Gy, using a 6 Mev Linac (Clinac 1800, Varian, USA). Immediately after irradiation, the cells were treated with $0.25/muM$ of HMA and $25/muM$ of genistein, and the expressions and the activities of abl kinase, MAPK family, NF- kB, c-fos, c-myc, and thymidine kinase1 (TK1) were examined. The differential gene expressions induced by PTK inhibitors were also investigated. Results: The modulating effects of herbimycin A and genistein on the radiosensitivity of K562 cells were not related to the bcr-abl kinase activity. The signaling responses through the MAPK family of proteins, were not involved either in association with the radiation-induced apoptosis, which is accelerated by HMA, the expression of c-myc was increased. The combined treatment of genistein, with irradiation, enhanced NF- kB activity and the TK1 expression and activity. Conclusion: The effects of HMA and genistein on the radiosensitivity on the K562 cells were not related to the bcr-abl kinase activity in this study, another signaling pathway, besides the WAPK family responses to radiation to K562 cells, was found. Further evaluation using this model will provide valuable information for the optional radiosensitization or radioprotection.

• Radiation Oncology Journal
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• v.9 no.1
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• pp.123-130
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• 1991

A docking intraoperative electron beam applicator system, which is easily docking in the collimator for a linear accelerator after setting a sterilized transparent cone on the tumor bearing area in the operation room, has been designed to optimize dose distribution and to improve the efficiency of radiation treatment method with linear accelerator. This applicator system consisted of collimator holder with shielded metals and docking cone with transparent acrylic cylinder, A number of technical innovations have been used in the design of this system, this dooking cone gives a improving latral dose coverage at therapeutic volume. The position of $90\%$ isodose curve under suface of 8 cm diameter cone was extended $4\sim7$ mm at 12 MeV electron and the isodose measurements beneath the cone wall showed hot spots as great as $106\%$ for acrylic cone. The leakage radiation dose to tissues outside the cone wall was reduced as $3\sim5\%$ of output dose. A comprehensive set of dosimetric characteristics of the intraoperative radiation therapy applicator system is presented.