• Journal of Pharmaceutical Investigation
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• v.31 no.1
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• pp.7-12
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• 2001

Amphotericin B (AmB) is a drug of choice for the treatment of systemic fungal diseases, but its use is considerably limited due to a high incidence of toxicity, particularly nephrotoxicity. It has been demonstrated that the toxicity of AmB is caused by self-aggregated species of the drug and that unaggregated (monomeric) drug is nontoxic but still expresses antifungal activity. Poly (ethylene oxide) (PEO) is a water-soluble polymer, which may impact the aggregation state of AmB. We have studied the aggregation state of AmB as a function of PEO molecular weight and concentration. At 3,000 and 8,000 g/mole, there was minimal or no change of critical aggregation concentration (CAC) of AmB regardless of the concentration of polymer. By contrast at 20,000 g/mole, the CAC of AmB strikingly increased to 24.3 and $37.5\;{\mu}M$ at 5.0% and 10 % w/v of polymer, respectively. The critical overlap concentration (COC) of PEO 20,000 g/mole was 5.5%. It appears that an interaction between monomeric AmB and polymer coil increases above the COC, competing with self-aggregation of the drug. Accordingly, the degree of aggregation of AmB stayed low and the toxicity became less. There was no such effect at 3,000 and 8,000 g/mole of PEO, owing perhaps to small dimensions in comparison to AmB. Based upon these findings, less toxic AmB formulation may be developed by a pharmaceutical technique such as solid dispersion system containing both AmB and PEO 20,000 g/mole.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.38 no.3
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• pp.247-257
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• 2001

New methods are proposed for printing a full resolution image on a limited output device. The proposed algorithm uses a dot-pattern database that models overlapping phenomena among neighbor printing dots. To solve the problem of dot-overlap, the gray levels of dot-pattern sets were calculated using a circular dot-overlap model and then measured by a spectrometer. Thereafter, in order to improve the visual quality of the color dithering, the contrast sensitivity function of the human visual system was used. As a result, the optimal dot-pattern can be selected from the database. Consequently, the proposed algorithm can produce high quality images while using low-cost color devices.

• Bulletin of the Korean Chemical Society
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• v.33 no.4
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• pp.1165-1169
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• 2012

The fluorescence intensity of DNA-intercalated ethidium with [ethidium]/[DNA base] being 0.005 was quenched upon the binding of another intercalating ligand, meso-tetrakis(N-methylpyridinium-4-yl)porphyrin (TMPyP). Addition of $Ca^{2+}$ enhanced the quenching efficiency. The range of separations between donor and acceptor molecules, within which total quenching occurs, was calculated using a one-dimensional resonance energy transfer mechanism to be 9.5 base-pairs or $32.3{\AA}$ in the absence of $Ca^{2+}$ ions. The distance increased to 18.7 base-pairs or about $63.6{\AA}$ in the presence $100{\mu}M$ $Ca^{2+}$. Considering that (1) $Ca^{2+}$ had little effect on the binding modes of ethidium and TMPyP, which was investigated by reduced linear dichroism and (2) spectral overlap between the emission spectrum of ethidium and the absorption spectrum of TMPyP was maintained in the presence of $Ca^{2+}$, contributions from orientation factor and spectral overlap to $Ca^{2+}$-induced enhancement in DNA mediated energy transfer was limited. Although there is no direct evidence, electron transfer along the DNA stem may accompany the observed fluorescence quenching. In this respect, DNA bound $Ca^{2+}$ act as a partially conducting medium.

• Journal of Ocean Engineering and Technology
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• v.18 no.6 s.61
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• pp.79-83
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• 2004

The curved blocks which compose the bow and stem of a ship contain many skewed joints that are inclined horizontally and vertically. Most of these joints have a large fitness error and are continuously changing their form and are not easily accessible. The welding position and parameter values should be appropriately set in correspondence to the shape and the inclination of the joints. The welding parameters such as current, voltage, travel speed, and melting rate, are related to each other and their values must be in a specific limited range for the sound welding. These correlations and the ranges are dependent up on the kind and size of wire, shielding gas, joint shape and fitness. To determine these relationships, extensive welding experiments were performed. The experimental data were processed using several information processing technologies. The regression method was used to determine the relationship between current voltage, and deposition rate. When a joint is inclined, the weld bead should be confined to a the limited size, inorder to avoid undercut as well as overlap due to flowing down of molten metal by gravity. The dependency of the limited weld size which is defined as the critical deposited area on various factors such as the horizontally and vertically inclined angle of the joint, skewed angle of the joint, up or down welding direction and weaving was investigated through a number of welding experiments. On the basis of this result, an ANN system was developed to estimate the critical deposited area. The ANN system consists of a 4 layer structure and uses an error back propagation learning algorithm. The estimated values of the ANN were validated using experimental values.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.3
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• pp.841-847
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• 2014

Urban runoff models have been continuously developing with concerns for urban flood. Recently, models that be able to quantitatively analyze surface inundation caused by overflowed water from storm sewer were also developed by coupling 1-dimensional sewer model and 2-dimensional surface flow model. However, only overflowed water from storm sewer can be analyzed by the models have been developed until now. They are limited to be not able to analyze surface inundation caused by surface runoff that could not flow into the storm sewer. In order to overcome the limitation, basin-overlap method was devised adding a dummy 1-dimensional sewer layer to the model, so it can consider the efficiency of inflow to the storm sewer system. XP-SWMM 2011 is applied for urban runoff model and the flood event occurred on July 27, 2011 in basin-shaped Sadangcheon watershed is chosen for study inundation event. According to simulation results basin-overlap method reappear the observed inundation event more precisely than traditional method. This results suggest that drainage system has to be improved for reducing inundation caused by surface runoff and would be used as considerations for planning an urban basin design magnitude.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.49 no.4
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• pp.17-22
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• 2012

Convolution filtering methods have been widely applied to various digital signal processing fields for image blurring, sharpening, edge detection, and noise reduction, etc. According to their application purpose, the filter mask size or shape and the mask value are selected in advance, and the designed filter is applied to input image for the convolution processing. In this paper, we proposed an image processing acceleration method for the convolution processing by using two-dimensional Look-up table (LUT) and overlap-region buffering technique. First, based on the fixed convolution mask value, the multiplication operation between 8 or 10 bit pixel values of the input image and the filter mask values is performed a priori, and the results memorized in LUT are referred during the convolution process. Second, based on symmetric structural characteristics of the convolution filters, inherent duplicated operation region is analysed, and the saved operation results in one step before in the predefined memory buffer is recalled and reused in current operation step. Through this buffering, unnecessary repeated filter operation on the same regions is minimized in sequential manner. As the proposed algorithms minimize the computational amount needed for the convolution operation, they work well under the operation environments utilizing embedded systems with limited computational resources or the environments of utilizing general personnel computers. A series of experiments under various situations verifies the effectiveness and usefulness of the proposed methods.

• Journal of Power Electronics
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• v.9 no.3
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• pp.447-455
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• 2009

The power supply systems, which require low-voltage / high-current output has been changing from the conventional centralized power system to a distributed power system. The distributed power system consists of a bus converter and POL. The most important factor is the system stability in bus architecture design. The overlap between the output impedance of a bus converter input impedance of POL causes system instability and has been an actual problem. By increasing the bus capacitor, the system stability can be easily improved. However, due to limited space on the system board, the increasing of bus capacitors is impractical. An urgent solution of this issue is strongly desired. This paper presents the output impedance design for on-board distributed power system by means of three control schemes of a bus converter. The output impedance peak of the bus converter and the input impedance of the POL are analyzed and then conformed experimentally for stability criterion. Furthermore, the design process of each control schemes for system stability is proposed.

• Computers and Concrete
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• v.6 no.2
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• pp.133-153
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• 2009

Discrete element modeling (DEM) in concrete technology is concerned with design and use of models that constitute a schematization of reality with operational potentials. This paper discusses the material science principles governing the design of DEM systems and evaluates the consequences for their operational potentials. It surveys the two families in physical discrete element modeling in concrete technology, only touching upon probabilistic DEM concepts as alternatives. Many common DEM systems are based on random sequential addition (RSA) procedures; their operational potentials are limited to low configuration-sensitivity features of material structure, underlying material performance characteristics of low structure-sensitivity. The second family of DEM systems employs concurrent algorithms, involving particle interaction mechanisms. Static and dynamic solutions are realized to solve particle overlap. This second family offers a far more realistic schematization of reality as to particle configuration. The operational potentials of this family involve valid approaches to structure-sensitive mechanical or durability properties. Illustrative 2D examples of fresh cement particle packing and pore formation during maturation are elaborated to demonstrate this. Mainstream fields of present day and expected application of DEM are sketched. Violation of the scientific knowledge of to day underlying these operational potentials will give rise to unreliable solutions.

• Proceedings of the KSMRM Conference
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• 2002.11a
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• pp.80-80
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• 2002

Purpose： Three tesla high field MR has been important to those disciplines that are SNR limited, such as MR spectroscopy. Additionally, increased spectral dispersion is critical for minimizing spectral overlap and simplifying resonance structures. The purpose of this study was to assess clinical proton MR spectroscopy (MRS) as a noninvasive method for evaluating brain tumor malignancy at 3T high field system Materials and Methods： Using 3T MRI/MRS system, localized water-suppressed single-voxel technique in patients with brain tumors was employed to evaluate spectra with peaks of N-acetyl aspartate (NAA), choline-containing compounds (Cho), creatine/phosphocreatine (Cr) and lactate. On the basis of Cr, these peak areas were quantificated as a relative ratio.

• Journal of Communications and Networks
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• v.17 no.2
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• pp.100-109
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• 2015

Mobile phone carriers face challenges from three synergistic dimensions: Wireless, social, and mobile. Despite significant advances that have been made about social networks and human mobility, respectively, our knowledge about the interplay between two layers remains largely limited, partly due to the difficulty in obtaining large-scale datasets that could offer at the same time social and mobile information across a substantial population over an extended period of time. In this paper, we take advantage of a massive, longitudinal mobile phone dataset that consists of human mobility and social network information simultaneously, allowing us to explore the impact of human mobility patterns on the underlying social network. We find that human mobility plays an important role in shaping both local and global structural properties of social network. In contrast to the lack of scale in social networks and human movements, we discovered a characteristic distance in physical space between 10 and 20 km that impacts both local clustering and modular structure in social network. We also find a surprising distinction in trajectory overlap that segments social ties into two categories. Our results are of fundamental relevance to quantitative studies of human behavior, and could serve as the basis of anchoring potential theoretical models of human behavior and building and developing new applications using social and mobile technologies.