• Journal of Electrodiagnosis and Neuromuscular Diseases
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• v.20 no.2
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• pp.135-138
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• 2018

Peroneal neuropathy scarcely can develop after massive weight reduction. A 21-year-old man complained left foot drop after 28% weight reduction (from 94 kgs to 67.5 kgs). During previous seven months, he played PC games with sitting cross-legged more than seven hours a day. In addition, he started a heavily restricted diet three months ago. Except for those, he had neither any medical history nor trauma to his knee. Electrophysiologic study showed the partial conduction block of left peroneal neuropathy at the fibular head. Four-week well balanced diet and physical therapy improved his foot drop. For the prevention of peroneal neuropathy related to weight reduction, well balanced diet and lifestyle modification are needed.

• Medical Lasers
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• v.10 no.1
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• pp.49-51
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• 2021

The perioral region, which is one of the most conspicuous parts of the face, plays a significant role in interpersonal communication. However, the perioral region is highly susceptible to scarring and pigmentation and is difficult to treat. The causes of perioral hyperpigmentation are many, including physiologic reasons, systemic diseases, drugs, and infections. In the treatment of perioral hyperpigmentation, the cause of the disease must be diagnosed first. Management includes lifestyle modifications such as reducing the UVA exposure time, use of topical treatments including hydroquinone and retinoids, and physical therapy including laser therapy. We report a case of perioral hyperpigmentation treated with 1,064-nm Q-switched neodymium:yttrium-aluminum-garnet laser toning.

• Childhood Kidney Diseases
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• v.26 no.1
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• pp.25-30
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• 2022

Dyslipidemia in nephrotic syndrome (NS) is often characterized by marked increases in the levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, and other lipoproteins, such as very low-density lipoprotein, intermediate-density lipoprotein, and lipoprotein(a). It has been suggested that impaired catabolism of lipoproteins and cholesterol is mainly due to decreased lipoprotein lipase and hepatic lipase activity, and increased biosynthesis of lipoproteins in the liver. The management strategies for dyslipidemia in patients with NS consist of lifestyle modification, lipid-lowering agents represented by statins, second-line agents such as fibrates and bile acid sequestrants, and lipid apheresis. Compared with dyslipidemia in adult NS patients, whose risks of atherosclerotic disease and progressive renal injury are considered high, clinical data on dyslipidemia in pediatric NS patients are limited. Therefore, it is necessary to pay more attention to the evaluation and management of dyslipidemia in pediatric patients with NS in clinical practice.

• Archives of Obesity and Metabolism
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• v.2 no.2
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• pp.37-44
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• 2023

Weight gain is defined as the increase in body weight, increasing the prevalence of obesity, and results in metabolic diseases. Weight gain was reportedly caused by the interaction between the obesogenic environmental factors and individual metabolic factors. Sociodemographic and environmental factors (demographic factors, lifestyle/behavioral factors, food/nutritional factors, socioeconomic factors), drug-related secondary causes (some of the corticosteroids, antihyperglycemics, antihypertensives, antidepressants, etc.), and metabolic factors (aging and hormonal changes, menopause and decreased sex hormones, decreased adipocyte degradation, decreased fibroblast growth factor 21, central sympathetic nervous system hyperactivity, decreased sympathetic-adrenomedullary system activity) are significant factors related to weight gain. It is crucial to prevent weight gain and maintain an ideal weight, but studies on the risk factors of weight gain are insufficient. Therefore, this study evaluated the factors associated with weight gain to find strategies for preventing unnecessary weight gain.

• International Journal of Advanced Culture Technology
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• v.12 no.1
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• pp.100-107
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• 2024

Addressing challenges posed by an aging society, this study explores inclusive design orientations for digital medical interfaces catering to the elderly. The aim is to enhance inclusiveness and optimize interactive experiences within the medical system for senior users. Employing inclusive design concepts, the study analyzes characteristics through literature, focusing on functional purpose, interactive behavior, and emotional expression in digital medical interface design for the elderly. User research methods, including in-depth interviews and field research, generate user personas and behavioral analysis diagrams, organizing and categorizing pain points for elderly patients with chronic diseases. The study proposes principles for improving service touchpoints based on inclusiveness, optimizing pain point types and design processes in age-friendly services. These enhancements aim to help the elderly adapt to and integrate into a digital lifestyle.Incorporating inclusive design principles enhances the inclusiveness of service design, improving the service experience for the elderly. Age-friendly service design with inclusiveness serves as a valuable entry point for research targeting elderly populations and provides practical strategies for age-friendly medical service process design.

• BMB Reports
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• v.44 no.5
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• pp.298-305
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• 2011

Most intracellular reactive oxygen species (ROS), especially superoxide anion ($O_2^{{\bullet}_-}$) that is converted from oxygen, are overproduced by excessive electron leakage from the mitochondrial respiratory chain. Intracellular oxidative stress that damages cellular components can contribute to lifestyle-related diseases such as diabetes and arteriosclerosis, and age-related diseases such as cancer and neuronal degenerative diseases. We have previously demonstrated that the excessive mitochondrial $O_2^{{\bullet}_-}$ production caused by SDHC mutations (G71E in C. elegans, I71E in Drosophila and V69E in mouse) results in premature death in C. elegans and Drosophila, cancer in mouse embryonic fibroblast cells and infertility in transgenic mice. SDHC is a subunit of mitochondrial complex II. In humans, it has been reported that mutations in SDHB, SDHC or SDHD often result in inherited head and neck paragangliomas (PGLs). Recently, we established Tet-mev-1 conditional transgenic mice using our uniquely developed Tet-On/Off system, which equilibrates transgene expression to endogenous levels. These mice experienced mitochondrial respiratory chain dysfunction that resulted in $O_2^{{\bullet}_-}$ overproduction. The mitochondrial oxidative stress caused excessive apoptosis leading to low birth weight and growth retardation in the neonatal developmental phase in Tet-mev-1 mice. Here, we briefly describe the relationships between mitochondrial $O_2^{{\bullet}_-}$ and aging phenomena in mev-1 animal models

• Journal of Oriental Medical Thermology
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• v.8 no.1
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• pp.33-38
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• 2010

Purpose : Dam-eum and women about this disease is closely related to the fact that research is not developed encounter the report. The purpose of this disorder is associated with women with Dameum hew to evaluate the affects around Dongulbogam Search and compare some of the knowledge gained. are reported. Methods : Donguibogam focused on search and related papers were. Results : In Donguibogam Dam-eum(痰), Yoen(涎), Eum(飮) to distinguish, but the reason was that one, 痰飮 sap needed to nutritious the body, such as a material or normal for various reasons by the sap from the leaves to cause disease states may be the cause. Conclusion: Digestive, respiratory-related, but now the recognition of the Dameum changes in diet and lack of exercise, stress, lifestyle diseases due to climate change are increasing asa Dameum and women in the pathogenesis of disease high enough proportion of the treatment for Dameum Applications will be denied a lot of disease is considered.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.1
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• pp.215-223
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• 2006

This research surveyed oriental medicine therapies currently used in oriental medicine circles by referring to oriental medicine books-based existing traditional authentic therapies, as well as market-sold supplementary therapy-related ordinary health books and Internet information, and supplementary therapy-related dissertations, reviewed the fundamental operating significance of these therapies, and pursued their clinical operating measures based on their clinical information as follows Various therapies currently used in oriental medicine circles are categorized into authentic therapies and supplementary therapies in oriental medicine. Authentic therapies in Oriental medicine are based on bodily self-vitality abilities, pursue positive methods of treating diseases, and include medication therapies, acupuncture therapies, and external therapies. Supplementary therapies in oriental medicine are based on bodily self-vitality abilities, pursue indirect methods of treating diseases, and consist of lifestyle therapy and body management therapy. Authentic and supplementary therapies in Oriental medicine are used either separately or together according to clinical treatment methods. In treating diseases, clinical operating methods exclusively based on traditional authentic therapies and supplementary therapies include Donguibogam (anthology of ancient oriental medicine), Uihakipmun (introduction to medicine), Somun school, and bodily acupuncture according to diagnoses of symptoms, as well as sasangbang (prescription based on four types of bodily constitution), myeongribang prescription, hyeongsangbang prescription, and bodily constitution-based acupuncture according to diagnoses of bodily constitutions. In clinical operation of Oriental medicine, supplementary therapies are parity duplicated dy alternative medicine. However, given patients' needs and clinical practicality, Oriental medicine circles should establish a system based on the fundamental viewpoint of Oriental medicine theories, and corresponding policies should also be researched.

• Korean Journal of Clinical Pharmacy
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• v.31 no.3
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• pp.231-236
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• 2021

Background: Sarcopenia is a skeletal muscle disorder that involves the loss of muscle mass and function. Handgrip strength (HGS) is the most commonly used tool to assess muscle strength to diagnose sarcopenia. HGS is also associated with various diseases and health outcomes. Thus, we aimed this study to examine the HGS status in Korean adults and relevant factors of HGS. Methods: Data was obtained from the 7th Korea National Health and Nutrition Examination Survey (KNHANES), a population-based nationwide survey. The estimated mean value of HGS was calculated in each age group. The mean HGS in men and women aged over 40 was compared according to the household income level, lifestyle factors, and comorbidities. Results: A total of 16,708 participants were included in this study. The mean HGS showed a maximum value in the 30s for both men and women, and then tended to decrease with increasing age. When analyzed for people aged 40 or older, the mean HGS was significantly higher in the current or past smoker, drinker, and aerobic exercise groups in both men and women. The mean HGS was lower in the group with comorbidities such as hypertension, dyslipidemia, type 2 diabetes, and bone diseases. Conclusion: Our study found that the mean HGS was significantly different between those with and without underlying chronic diseases. In groups with relevant comorbidities, close monitoring for the development of sarcopenia and taking preventive measures such as exercise and nutritional support may be recommended.

• Journal of Pharmacopuncture
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• v.25 no.3
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• pp.224-232
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• 2022

Objectives: Routine therapies cannot control refractory stable angina, leading to a high economic burden and an impaired quality of life. Persian medicine incorporates exceptional attention to lifestyle and nutrition to prevent and treat various diseases. Previous studies have reported the analgesic and anti-inflammatory effects of wet cupping. The present study aims to determine the effects of nutrition and cupping on refractory stable angina patients. Methods: Forty male patients with refractory stable angina were randomly allocated to four groups, including nutrition modification based on Persian medicine, wet cupping, nutrition modification along with wet cupping, and control. The primary outcomes were the changes in pain score using a visual analog scale and quality of life using the Seattle angina questionnaire. The secondary outcomes were changes in the exercise test and blood pressure. Results: The results of the present study revealed that 30 days of treatment with nutrition modification based on Persian medicine, cupping, and modified nutrition and cupping along with standard treatment for stable angina significantly increased the patient's quality of life and exercise test results while reducing pain, and systolic and diastolic blood pressure. Conclusion: Applying complementary Persian medicine methods such as nutrition modification and cupping along with the classical medical treatments may improve outcomes for refractory stable angina patients.