• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제10권1호
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• pp.121-133
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• 1999

치사성 긴장증은 긴장증의 한 유형이지만 극단적인 임상양상과 높은 치사율로 인하여 따로 분류하여서 하나의 증상군으로 취급되고 있다. 최근 정신 약물학의 발전과 질병 초기에 적절하고 집중적인 치료를 시행함으로써 전세계적으로 치사성 긴장증의 발생율이 현저하게 감소되었다. 본 저자들은 급성으로 발생된 고열, 자율신경계 이상, 다양한 긴장성 증상 및 긴장성 흥분과 혼미상태를 보였던 11세 남아에서의 치사성 긴장증 1례에 대한 매우 드문 경험을 소개하였다. 특히, 본 증례는 전형적인 경과에 비하여 경한 초기증상을 보인 치사성 긴장증에서 초기에 집중적인 대증요법과 정신약물 투여, 전기충격요법의 병행이 성공적인 치료 효과를 거둘 수 있음을 보여준 사례라 할 수 있다.

• Journal of Ecology and Environment
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• 제44권3호
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• pp.162-177
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• 2020

Background: Ecologists have achieved much progress in the study of mechanisms that maintain species coexistence and diversity. In this paper, we reviewed a wide range of past research related to these topics, focusing on five theoretical bodies: (1) coexistence by niche differentiation, (2) coexistence without niche differentiation, (3) coexistence along environmental stress gradients, (4) coexistence under non-equilibrium versus equilibrium conditions, and (5) modern perspectives. Results: From the review, we identified that there are few models that can be generally and confidently applicable to different ecological systems. This problem arises mainly because most theories have not been substantiated by enough empirical research based on field data to test various coexistence hypotheses at different spatial scales. We also found that little is still known about the mechanisms of species coexistence under harsh environmental conditions. This is because most previous models treat disturbance as a key factor shaping community structure, but they do not explicitly deal with stressful systems with non-lethal conditions. We evaluated the mainstream ideas of niche differentiation and stochasticity for the coexistence of plant species across salt marsh creeks in southwestern Denmark. The results showed that diversity indices, such as Shannon-Wiener diversity, richness, and evenness, decreased with increasing surface elevation and increased with increasing niche overlap and niche breadth. The two niche parameters linearly decreased with increasing elevation. These findings imply a substantial influence of an equalizing mechanism that reduces differences in relative fitness among species in the highly stressful environments of the marsh. We propose that species evenness increases under very harsh conditions if the associated stress is not lethal. Finally, we present a conceptual model of patterns related to the level of environmental stress and niche characteristics along a microhabitat gradient (i.e., surface elevation). Conclusions: The ecology of stressful systems with non-lethal conditions will be increasingly important as ongoing global-scale climate change extends the period of chronic stresses that are not necessarily fatal to inhabiting plants. We recommend that more ecologists continue this line of research.

• 한국해양학회지
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• 제13권1호
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• pp.35-43
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• 1978

Short-term acute toxicity of mercury, cadmium and copper to arkshell, Anadara broughtonii, and to oyster, Crassostrea gigas, was determinedby static bioassays from 20 May to 27 June in 1977. During the observations of the opening rate of the shell mercury was the most sensitive toxicant of the three toxic substances to the test animals and caused them to close their shellvalves together after being exposed to a mercury solution for an hour during the test. Opening rate to cadmium and copper increased gradually at the higher concentration. the 96hr-LC50 values for the test animals are 4.84mg/l for mercury and 1.86mg/l for cadmium, while the 72hr-LC50 value for copper is 0.31mg/l. the death rate of oysters for cadmium showed lower than that of the mercury and copper test solutions. The 96hr-LC50 values of mercury, copper and cadmium were 1.1mg/l, 2.54mg/l and 19.5mg/l, respectively. For oysters mercury was the most toxic substance, and cadmium was the least toxic one. the medium lethal time (LT 50) value decreased gradually at higher concentration of heavy metals. The LT 50 of 2mg/l was found within 96 hours ofr copper, 104 hours for mercury and 121 hours for cadmium. The lethal threshold concentrations for 7 days were found to be about 1mg/l for mercury and copper, and 2mg/l for cadmium.

• 한국환경보건학회지
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• 제9권1호
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• pp.1-13
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• 1983

This study was carried out to investigate nitrification in the main stream of the Naktong river for two times, 12-13 August and 23-26 September 1982. The results of this study were as follows : 1. The increase of nitrogen concentration was due to inflow of Geumho river, which was polluted by the municipal and industrial wastewater of Daegu city. 2. The rate constant of ammonia calculated for three reaches was high according to the stream flow and was eminently low in the reach from Goroung to Gangjung. (0.068-0.116 $day^{-1}$). This phenomena might be attributed to the sublethal or even lethal effect upon aquatic life by relatively low DO concentration and high heavy metal concentration. 3. DO consumption rate by nitrification was highest for the reach from Goroung to Daeam where was affected by Geumho river. (56.7-147.8%). This phenomena might be attributed to low DO concentration and high nitrogen concentration. Especially, the less stream flow was, the higher DO consumption was. And so, nitrification in the station where is low DO concentration, especially under the low flow condition, might cause more serious water quality management problem. Therefore, for the purpose of effective conservation of water quality in the Naktong river, it was suggested that We have more concern about the nitrogen compound, and more study on the nitrification phenomena.

• Journal of Ginseng Research
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• 제32권4호
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• pp.315-323
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• 2008

In the previous studies, we isolated the compound K rich fractions (CKRF) and showed that CKRF inhibited Toll-like receptor (TLR) 4- or TLR9-induced inflammatory signaling. To extend our previous studies,1) we investigated the molecular mechanisms of CKRF in the TLR4-associated signaling via nuclear factor (NF)-${\kappa}B$, and in vivo role of CKRF for induction of tolerance in lipopolysaccharide (LPS)-induced septic shock. In murine bone marrow-dervied macrophages, CKRF significantly inhibited the induction of mRNA expression of proinflammatory mediators such as tumor necrosis factor-${\alpha}$, interleukin-6, cyclooxygenase-2, and inducible nitric oxide synthase. In addition, CKRF significantly attenuated the transcriptional activities of TLR4/LPS-induced NF-${\kappa}B$. Nuclear translocation of NF-${\kappa}B$ in response to LPS stimulation was significantly abrogated by pre-treatment with CKRF. Furthermore, CKRF inhibited the recruitment of p65 to the interferon-sensitive response element flanking region in response to LPS. Finally, oral administration of CKRF significantly protected mice from Gram-negative bacterial LPS-induced lethal shock and inhibited systemic inflammatory cytokine levels. Together, these results demonstrate that CKRF modulates the TLR4-dependent NF-${\kappa}B$ activation, and suggest a therapeutic role for Gram-negative septic shock.

• Journal of Microbiology and Biotechnology
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• 제21권6호
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• pp.604-612
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• 2011

Beauveria bassiana SFB-205 supernatant can effectively control cotton aphid populations, which is closely associated with its chitinase activity. The present work extends to optimizing a culture medium to produce more efficacious supernatant in flask conditions, followed by scale-up in 7 L, 300 L and 1.2 KL fermentors with the parameter of chitinase. In flask conditions, a combination of soluble starch and yeast extract produced the greatest amount of chitinase (5.1 units/ml) and its supernatant had the highest aphicidal activity. An optimal quantitative combination of the two substrates, estimated by a response surface method, enabled the supernatant to have 15.7 units/ml of chitinase activity and 3.7 ml/l of median lethal concentration ($LC_{50}$) of toxicity against cotton aphid adults in laboratory conditions. In the scale-up conditions, overall supernatant had 25-28 units/ml of chitinase activity. Decrease in pH and limitation of dissolved oxygen (DO) during cultures were significantly related to the yield of chitinase. These results suggest that the substrate-dependent chitinase production can be background information for optimizing a culture medium, and pH and DO are critical factors in maximizing the production in scale-up conditions.

• 한국수산과학회지
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• 제28권3호
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• pp.373-381
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• 1995

유용 해산어류에 대한 산소소비 경향을 파악하기 위하여 넙치 Paralichthys olivaceus, 자주복 Takifugu rubripes, 조피볼락 Sebastes schlegeli, 농어 Lateolabrax japonicus, 참돔 Pagrus major, 감성돔 Acanthopagrus schlegeli 등 6종의 추어를 주대상으로 수온별, 밀도별, 체중별 산소소비량및 치사산소량에 관한 실험을 실시하였다. 모든 어종에서 산소소비량 $(Oc,\;ml/kg\;\cdot\;hr)$은 수온$(T,\;^{\circ}C)$의 상승에 비례하여 증가하였으며, 그 경향은 다음과 같은 회귀직선식으로 표시되었다. 넙치= Oc=34.0515T-339.5987 $(r^2=0.9730)$, 자주복. Oc=34.4941T-479.8732 $(r^2=0.9483),$, 조피볼락: Oc=44.7970T-634.2627 $(r^2=0.9718),$, 농어: Oc=26.1488T-318.0633 $(r^2=0.9316),$, 참돔: Oc=61.1020T-722.8926 $(r^2= 0.9805),$, 감성돔: Oc=75.1460T-947.9370 $(r^2=0.9392).$. 어체의 수용밀도가 증가함에 따라 단위체중당 산소소비량은 감소하는 경향을 보였다. 넙치는 체중(W, g) 증가에 파라 산소소비량이 감소함으로써 Oc=2532.0268W-0.6565 $(r^2=0.9229)$의 관계를 나타냈다. 넙치, 조피볼락, 자주복, 참돔의 치사산소량은 각각 0.66, 0.79, 0.75 및 1.36m1/1였다

• 한국농공학회논문집
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• 제54권6호
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• pp.121-131
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• 2012

Many of the falling which is the number one risk factor in lethal accidents in construction could have been prevented if the right activity or supervising had been taken in time. All other measures do not preventive the fall, but rather intercept the fallen itself or preventive severe injury. The most common and the bets measures on the preventive measures are guardrails which are to be worn on the site. Workers always exposed the risk of serious accidents induced by causal effects related with environments around construction sites. In order to represent how to decrease the risk of workers, this study was accomplished with a number of interview with experienced site director, cheief of instructors, workers. And the questionaire survey (2012. 5~2012. 10) were used to make proposed policies which are expected to reduce critical disastrous accidents and strength authorized limits of director's management automatically.

• 한국수정란이식학회지
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• 제7권1호
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• pp.49-55
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• 1992

Animal experiments need numerous kinds of animal which are suitable for every research. About 300 mouse strains are developed up to the present, but they do not give satisfaction to every researchers. So we must build up the methods of breading animals which are newly developed and of maintenance of characteristics which were developed before. To maintain experimental animal is not only proceeding the generation but also increasing the animal populations, it needs geneticai control. Genetic factors which influence to reproduction are very important to maintain colony. These factors include lethal gene, chromosomal abberation, sterility gene, etc.. With the recent development of transgenic technology, scientists now can deliberately creat numerous specific animal models. To know how to manage the colony which has genetic defect on reproduction and transgenic mice is one of the key to study in vitro fertilization.

• 대한기관식도과학회지
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• 제17권1호
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• pp.65-67
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• 2011

Pyriform sinus perforation is a rare complication of endotracheal intubation. It most commonly occurs at the hands of the less experienced physician in emergency situations. It can occur after traumatic intubation and is potentially lethal. The site most commonly perforated is the pharynx, posterior to the cricopharyngeal muscle; the second most common site is the pyriform sinus. We report a case of pyriform sinus perforation after endotracheal intubation, which was successfully treated with primary closure.