• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.8
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• pp.105-116
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• 2018

The architecture reflects geographical characteristics such as geographical environments and climate, it has the characteristics and cultural characteristics of the region that has been constructed. Hansen Village constructed in Period of Japanese Occupation at 'Sorok-Island' in Go-heung, Jeollanam-do was also based on this point. The village, which is a ward of Sorok-Island Province, consists of a village in which patients are self-sufficient in economic and social activities, unlike the modern hospital systems where patients and treatments are concentrated in a single room. Additionally, the facilities for patient acceptance were gradually expanded, with limited interaction with external. Sorok-island shows the expansion of the village center where the new village is formed with the increase of the number of the early adopters in the 1910s and the accommodation facility is built, and it gradually increases the necessary space by opening and repairing the existing facilities by the 1990s Change. In addition, the spatial composition of the village can be divided into three types : decentralized, centralized and single-shift ; it has the same causal relationship as the village's formation. The purpose of this study is identifying the uniqueness of Sorok-Island by analyzing the correlation between the formation of a village to accommodate Hansen Patients in Sorok-Island and the spatial Component Factor.

• Proceedings of the Microbiological Society of Korea Conference
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• 1997.04a
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• pp.27-41
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• 1997

• The Journal of the Korean Society for Microbiology
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• v.19 no.1
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• pp.109-119
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• 1984

• Annals of Clinical Neurophysiology
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• v.15 no.1
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• pp.19-23
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• 2013

Some patients with leprosy may present with atypical features, such as isolated peripheral neuropathy without skin lesions, or marked proprioceptive dysfunction. We report a 56-year-old female who presented with predominant proprioceptive loss without skin lesion, but was finally confirmed as leprous neuropathy by sural nerve biopsy. It is postulated that large myelinated fibers were affected by chronic immunological reactions triggered by inactive bacterial particles, producing a peripheral neuropathy presenting as predominant proprioceptive sensory loss without typical skin lesions.

• The Journal of Korean Physical Therapy
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• v.10 no.1
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• pp.139-148
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• 1998

The purpose of this study was to investigate the actual condition of physical therapy for leprosy patients of invalide home in Korea. The subjects were 928 leprosy patients who answered for the questionnaires kindly and lived in invalide homes such as An-Dong & San-Chung. The questionnaires survey was carried out from July to August 1997. The results of this study were as follows : 1. $67.6\%$ of the subjects said that they were knowing of physical therapy. 2. $88.4\%$ of the subjects who had been served physical therapy said that they were satisfied with it. 3. Between no physical therapy service group and physical therapy service group, treatment of pain was done in a different way. In physical therapy service group, for example, physical therapy treatment was most frequently used. But in no physical therapy service group, drug treatment was most frequently used. 4. The majority of the subjects responded that physical therapy was needed. 5. Each group expressed different kinds of difficulties with regard to physical therapy. No physical therapy service group, on the one hand, found it very difficult to visit physical therapy rooms. Physical therapy service group, on the other hand, complained of not having sufficient physical therapy appliance. 6. The situation of disability and disease was much worse in no physical therapy service group than in physical therapy service group. Especially, in case of low back pain and joint pain, no physical therapy service group complained of than suffering from these pains twice as often as physical therapy service group.

• Journal of The Korea Institute of Healthcare Architecture
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• v.19 no.4
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• pp.7-18
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• 2013

Purpose: The aim of this paper is to reduce the stress and the disturbance occur in selective action of patient. This article will also help us to control spreading and reduce the order and bacteria produced by leprosy disease among the lepers. This will be achieved with the help of several variables and these variables help us on health benefits is 5S (Sort, Straighten, Shine, Standardize, Sustain) i.e. ratio of sectional morphology, lessor 90 degree angles, day light, universal design building and maximum ventilation. The replies from the questionnaire were collected based on varying levels of satisfaction and gloominess on the scale of 1-10. Methods: The multi-layer methodological framework for maximising the healing environment obtained from the observation of schemes and parameters of ANOVA: (Analysis Of Variance between five deciding factors) are. Firstly applied for the calculation of the patient's satisfaction for U.V light from sun on ECOTECT simulation, secondly the number of $90^{\circ}$ angle, along the corridors. Thirdly understanding the ways to represent people's perceptual structures and way finding with Space Syntax software. Fourthly the ratio of depth to height of the building typology and finally interviewing the subjects describing their special experiences based on scale value. The focus of this testing of human subjects was to receive data for the existence of image scheme in way-finding and to identify the mechanisms by which sun light impacts human (lepers) health. Results: AMPVA studies concluded that there is similarity between I and O plan as well as L and H plan whereas U plan was difference among the five selected architectural shapes. Implications: The purpose of this research is to show the effects of the I-type, L-type, C-type, U-type and O-type plan design, and to analyse the morphology for EBD (Evidence-Based Design) healing environment which is a universal design for Munghopir Karachi, in Pakistan.

• The Journal of the Korean Society for Microbiology
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• v.13 no.1
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• pp.49-54
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• 1978

Antibodies to Propionibacterium acnes in patients with tumor, leprosy, schizophrenia and normal human were measured by using a microtiter bacterial agglutination test. They were found in all sera examined, including normal human sera. It was comfirmed that a microtiter bacterial agglutination test on P. acnes is found to be an easy and satisfactory method for the measurement of antibody to P. acnes. The agglutinin titers of tumor patients, particularly hepatoma and gastric cancer patients, were significantly lower as compared with those of normal human sera. Antibody titers in leprosy patients were somewhat lower when compared with those in normal human sera. Antibody titers of lepromatous type of leprosy patient were lower than those of tuberculoid type. However, antibody levels were the same in schizophrenia patient and normal human. No correlation between antibody titers and age or sex of the patients and normal human was found.

• The Journal of the Korean Society for Microbiology
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• v.21 no.2
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• pp.251-259
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• 1986

This study was performed to assess the effect of inosiplex(ISP) on the resistance of mice Candida albicans infection, the migration of chicken leukocytes, the production of leukocyte migration inhibitory factor(LIF), and the cell-mediated immunity(CMI) to lepomin in multibacillary lepromatous leprosy patients. The treatment with ISP before or on the time of infection with C. albicans had no or deliterious effect, and treatment with ISP after infection had no effect on the recovery of C. albicans from the kidneys of mice. The migratory ability of chicken leukocytes and the production of LIF from splenocytes of mice were not affected by ISP treatment. However, ISP decreased the migration of chicken leukocytes in vitro, and this decrease was dose-dependent. The therapy of lepromatous leprosy patients with ISP for 10 or 30 days clearly showed the increase of the significant positive rate of Mitsuda skin test to lepromin. The immune recovery as a result of the therapy was found to be the best in the group of patients treated for 30 days. This results suggest that (1) the effect of ISP in renal candidiasis can vary depending on the time of treatment relative to infection, (2) ISP can primarily change the migratory ability of chicken leukocytes but does not affect the production of LIF in mice, and (3) the classical therapy combined with ISP can reinforce or restore the defences of lepromatous leprosy patients against Mycobacterium leprae.

• BMB Reports
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• v.48 no.5
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• pp.243-248
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• 2015

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease (PD). As such, functions and dysfunctions of LRRK2 in PD have been the subject of extensive investigation. In addition to PD, increasing evidence is suggesting that LRRK2 is associated with a wide range of diseases. Genome-wide association studies have implicated LRRK2 in Crohn's disease (CD) and leprosy, and the carriers with pathogenic mutations of LRRK2 show increased risk to develop particular types of cancer. LRRK2 mutations are rarely found in Alzheimer's disease (AD), but LRRK2 might play a part in tauopathies. The association of LRRK2 with the pathogenesis of apparently unrelated diseases remains enigmatic, but it might be related to the yet unknown diverse functions of LRRK2. Here, we reviewed current knowledge on the link between LRRK2 and several diseases, including PD, AD, CD, leprosy, and cancer, and discussed the possibility of targeting LRRK2 in such diseases. [BMB Reports 2015; 48(5): 243-248]

• Journal of Korean Academy of Nursing
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• v.44 no.6
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• pp.639-648
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• 2014

Purpose: The purpose of this study was to identify life experiences of Korean patients with Hansen's disease (leprosy). Methods: For this study, 5 participants from Sorok Island Hospital were purposively chosen. Data were collected through in-depth individual interviews from June to July 2014. Data analysis method was based on Colaizzi's approach. Results: The study results showed that experiences of patients with Hansen's disease consisted of 14 themes and six theme clusters: 1) Bad disease approaching as fate; 2) Family breakup and far from the village; 3) New life in Sorok Island Hospital; 4) Treatment of Hansen's disease and disability; 5) Life in the disease community; 6) Comfort and hope of life. Conclusion: The findings of this study indicate that health care professionals should pay attention to patients with Hansen's disease not only to reduce their physical and psychological suffering, but also to help the community and public culture to reduce the social stigma surrounding this disease and causing suffering for the patients. The results of the present study can help us to have a better understanding of various aspects of patients' lived experiences.