• Journal of Chest Surgery
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• 제29권5호
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• pp.585-588
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• 1996

식도평활근종은 식도암에 비해 매우 드물지만 식도양성종양의 대부분을 차지한다. 식도질환의 수술 은 개흥을 통해 시행되 었으나 흥강경수슬의 발달과 함께 일부 식도수술을 흉강경을 이 용하여 수술을 하 게되었다. 저자들은 상부식도에 발생한 평활근종을 흥강경을 이용하여 절제하고 좋은 결과를 얻었다. 환자는 24세 남자로 내원 2개월전부터 발생한 흥골후방 불쾌감과 경미한 연하곤란을 호소하였다. 식도 위장관촬영과 식도경검사에서 상부식도에 점막의 변화없는 점 막하종양이 있었으며 흉부전산화단층 및 자기공명영상 촬영으로 종양의 위치,크기 및 주위조직으로의 침범과 종격동 림프절종대가 없음을 확인 하였다. 종양은 흥강경을 이용하여 제거하였고, 크기는 4$\times$2xlcm로 병리조직검사상 평활근종으로 진 단되었다. 환자는 수술후 10일째 이상없이 퇴원하였다.

• Clinical and Experimental Reproductive Medicine
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• 제29권4호
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• pp.337-343
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• 2002

Objectives: To investigate the distribution of $ER{\alpha}$, $ER{\beta}$, c-fos and c-jun in the uterine myoma and myometrium in oder to know how the tamoxifen cause the growth of myoma. Methods: Myoma and myometrial tissue were obtained from the postmenopausal women treated with tamoxifen in the patients with breast cancer and in the premenopausal patients, who were undergoing myoma of uterus from 1998 through 2000. The espression of each gene was quantitated with quantitative RT-PCR. Results: The expression of $ER{\alpha}$ was slightly increased in the myoma than the myometrium in the proliferative phase, and was slightly decreased in the myometrium than the myoma in the secretory phase. However it was not significant statistically. In the postmemopausal women treated with tamoxifen, $ER{\alpha}$ was expressed in all myoma and myome1rial tissues and the expression was not statistically significant. The expression ofER~ was slightly increased in the myome1rium than the leiomyoma in the proliferative and secretory phase, but it was not significant statistically. In the postmemopausal women treated with tamoxifen, the expression of ER~ was significantly incresed in the myome1rium than the leiomyoma. The expression of c-fos was significantly increased in the myome1rium than the leiomyoma in the proliferative and secretory phase. In the postmemopausal women treated with tamoxifen, the expression of c-fos was slightly increased in the leiomyoma than the myomelrium, however, it was not statistically significant. Conclusion: Tamoxifen may cause the growth of leiomyoma by $ER{\alpha}$ with AP-l pathway reducing the counteraction of 6$ER{\beta}$ to $ER{\alpha}$.