• Toxicological Research
• /
• v.14 no.3
• /
• pp.379-384
• /
• 1998

Endocrine disruptor is an exogenous substance that changes endocrine function and causes adverse effects at the level of the organism, its progeny, and/or (sub)populations of the organisms. Purported adverse effects are cancers, declines in reproductive health, developmental learning disabilities in humans, and declining populations, altered morphology, physiology or behavior in wildlife. In these days, expert groups on chemicals in IPCS, IFCS and OECD are intensively discussing the identification of endocrine disruptors and the proper management of those chemicals. In this study, we screened the endocrine disrupting effects of lead using fertilized eggs of Oryzias latipes. In brief, the eggs were exposed to lead with different concentrations at Ringer's solution, and the mortality, the incidence of deformation, the body movement and the hatching success were determined after incubation. The histological analysis of normal and deformed larvae was also carried out. Compared to control, the mortality and the heart rate of eggs and/or larvae increased, but the hatching success and the tail movement decreased. The morphological observation showed the asymmetrical deformation of larvae and the distortion of spinal cord. The absorption of the liquid in yolk sac was hindered. The adverse effects of lead in the ontogeny of fertilized eggs of Oryzias latipes seemed to be stronger in pH5.6 than in pH7.5 solution. In summary, lead showed adverse effects on the ontogeny of fish fertilized eggs plays critical role in regulating biological systems and controlling developmental processes as an endocrine disruptor.

• The Journal of Korean Society for School & Community Health Education
• /
• v.8 no.2
• /
• pp.49-59
• /
• 2007

Objectives: This study was designed to understand the oral health fact of high school students, search for an education method and learning goal appropriate for the subjects, and utilize them as basic data to think of effective solutions for oral health care. Methods: The samples to achieve the purpose of this research are composed of 386 students in J industrial high school, OO city, Kyounggido, the number of male students 286, and female students 100. Data were statistically analyzed by frequency analysis, cross tabulation by using SPSS WIN Ver. 12.0. Results: First, The answers in terms of oral symptoms were in the order of 31.8% for gum hurt and bleeding, 31.4% for pain in teeth by drinking or eating hot and cold drinks or food, 27.1% for broken or cracked teeth, 25.7% for aching and throbbing teeth, 20.6% for unpleasant mouth smell, and 5.7% for pain of tongue and soft oral tissues. Second, In terms of behavior for oral health, 88.4% answered that they consume cariogenic snacks, while 29.2% of them, 2.5% of male and 6.3% of female enjoy consuming them but hardly brush their teeth after consumption. Third, In terms of timing for brushing teeth, the results show that 50.0% do so before breakfast, 47.9% after breakfast, 15.2% after lunch, 36.9% after dinner, 65.5% before going to sleep, and 3.5% after consuming snacks, whereas 64.2% answered that they are not aware of fluorine mouthwash. Fourth, In terms of oral health condition. proportion of children with one or more caries in permanent teeth was 71.0%, while 51.4% have $2{\sim}3$ cariogenic teeth, and 16.8% have more than 4 cariogenic teeth. Considering sex, female students have somewhat higher ratio showing 68.5% for male and 78.0% for female, but the ratio was 53.1% for male and 46.7% for female in case of $2{\sim}3$ cariogenic teeth, and 17.5% for male and 15.8% for female in case of more than 4 cariogenic teeth. 9.3% of students turned out to have decayed teeth. Fifth, In terms of oral hygiene condition, only 7.9% of them had excellent condition, and 38.4% need to improve. More specifically, 41.1% of male students and 30.6% of female students need to improve their oral hygiene condition. Conclusions: The study results suggest that School Dental health programs increase and need to be community-incorporated and comprehensive from elementary to high school.

• Archives of design research
• /
• no.18
• /
• pp.113-121
• /
• 1996

Persuasion is one of the attractive channels to enhance the relation between markerters and consumers and deliver the true communication on products to the consumers. This arctic tried to examine the symbolic meaning system as a way of maximizing the visual communicational effect of persuasion, the efforts of marketers who are trying to utilize the psychology of the mass that consume the symbol rather than products and the symbol system as a mean of propaganda were analyzed as well. People in modern age, in general, place more value on the emotional assoessibility than the efficiency of the product, As a result, the ways of expression of propaganda approaching the mass are in the process of gradual change, which was another theme this article tried to explore. Ames sied that the human preoeption has a tendency to perceive things in some organized pattern, which can be applied to even untransparable and meaningless image. Human beings don't perceive what there is but what, thery believe there to be, and his peroeption are channelized by the opportunity of the past, his peroeption are channelized by the opportunity of the past, his experience of the environment, and the history of learning. To say another word, people not only recognize the objective form but also accept the inside meaning of the visual object. Their reponse to the visual object, therefore, include personal cognition, judgment, and attitued. The communication in visual design reveals the culture, society, and art in a complex symbol, and make synthetic cultural interpretation possible. It's pretty attractive, effective, and reasonable method to use symbolic meaning system as a way of persuasion. It is because communication means whole process from receiving and delivering the information and message to making common meaning system, to measuring the effect of the behavior change.

• Korean Journal of Health Education and Promotion
• /
• v.16 no.1
• /
• pp.31-43
• /
• 1999

Increase of automobiles become today's environmental problem decreasing space for our children's playground. The traffic situation around us shows automobiles over filled the public roads and started to intrude even on the side walks. Children's traffic safety education for the awareness of the danger from traffic mishaps, and for the behavior to cope with preventives measure by continual learning programs in systematized method is very important need in current health education. For this research, the subject was represented by 243 students from 4th grade in D Elementary School located at Daechi-dong, Seoul. During total of 5 weeks (September 4, 1997 to September 30, 1997), lessons were taught to the subject. Lessons consist of traffic safety education and customized education program that were designed and developed specificially for the subject level. In this research, Case group of 3 classes and control group of 3classes were predetermined before subject's degree of knowledge, attitude, and practice was analized. The difference before and after the training of this education was observed to verify the effectively and to find the influential factors of this education program. On September 2-3, survey study was performed after the training. the results of this study were as follows: 1. The knowledge analysis from the comparison between before and after of the training shows case group and control group scored(8.36, 8.86) before the traning, but scored(10.36, 8.52) after the traning. the difference from the result of the case group is statistically significant(p〈0.001). 2. The attitude analysis from the comparison between before and after of the training shows case group and control group scored(48.23, 49.87) before the training, but scored (51.05, 48.45) after the traning. the difference from the result of the case group is statistically significant(p〈0.001) 3. The practice analysis from the comparison between before and after of the training shows case group and control group scored (27.42, 28.08) before the training, but scored(30.49, 28.25) after the training. The differece from the result of the case group is statistically significant (p〈0.001). 4. The correlation analysis of traffic safety education's influence on traffic safety knowledge, attitude, and practice before training shows the relationship between attitude and practice was satistically significant(p〈0.05). The result after the training shows the relationship between knowledge and attitude, attitude and practice, and knowledge and practice was all statistically significant(p〈0.001).

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.3
• /
• pp.291-300
• /
• 2018

This descriptive study was conducted to determine the influence of stress coping styles of nursing students on problem solving ability. Data were collected from 142 nursing students in the M-area from September 20, 2016, to November 30 and analyzed using SPSS WIN 21.0. The average degree of stress coping styles was $3.36{\pm}.30$ (5 point-scale), problem solving abilities was $3.42{\pm}.38$ (5 point-scale). Among the subdomains of stress coping styles, problem focusing was highest, with a score of $3.60{\pm}.42$. Additionally, among the subdomains of problem solving ability, clarification was highest, with a score of $3.50{\pm}.51$. The problem solving abilities of nursing students showed a positive correlation with stress coping styles (r=0.53, p<.001) and was positively correlated with problem focusing (r=0.66, p<.001), positive point of view (r=0.53, p<.001), and social support navigation (r=0.42, p<.001). In addition, the factor with the greatest effect among subdomains of stress coping styles was problem focusing (${\beta}=0.416$, p<.001) and positive point of view (${\beta}=0.257$, p=.002). These two factors were found to explain 54.3% of the variance in problem solving ability. Therefore, the results of this study indicate that application of teaching-learning methods has the potential to improve students' problem-solving ability through problem-oriented and positive stress coping behavior.

• Proceedings of the Korea Inteligent Information System Society Conference
• /
• 1999.03a
• /
• pp.175-186
• /
• 1999

Detecting the features of significant patterns from their own historical data is so much crucial to good performance specially in time-series forecasting. Recently, a new data filtering method (or multi-scale decomposition) such as wavelet analysis is considered more useful for handling the time-series that contain strong quasi-cyclical components than other methods. The reason is that wavelet analysis theoretically makes much better local information according to different time intervals from the filtered data. Wavelets can process information effectively at different scales. This implies inherent support for multiresolution analysis, which correlates with time series that exhibit self-similar behavior across different time scales. The specific local properties of wavelets can for example be particularly useful to describe signals with sharp spiky, discontinuous or fractal structure in financial markets based on chaos theory and also allows the removal of noise-dependent high frequencies, while conserving the signal bearing high frequency terms of the signal. To data, the existing studies related to wavelet analysis are increasingly being applied to many different fields. In this study, we focus on several wavelet thresholding criteria or techniques to support multi-signal decomposition methods for financial time series forecasting and apply to forecast Korean Won / U.S. Dollar currency market as a case study. One of the most important problems that has to be solved with the application of the filtering is the correct choice of the filter types and the filter parameters. If the threshold is too small or too large then the wavelet shrinkage estimator will tend to overfit or underfit the data. It is often selected arbitrarily or by adopting a certain theoretical or statistical criteria. Recently, new and versatile techniques have been introduced related to that problem. Our study is to analyze thresholding or filtering methods based on wavelet analysis that use multi-signal decomposition algorithms within the neural network architectures specially in complex financial markets. Secondly, through the comparison with different filtering techniques results we introduce the present different filtering criteria of wavelet analysis to support the neural network learning optimization and analyze the critical issues related to the optimal filter design problems in wavelet analysis. That is, those issues include finding the optimal filter parameter to extract significant input features for the forecasting model. Finally, from existing theory or experimental viewpoint concerning the criteria of wavelets thresholding parameters we propose the design of the optimal wavelet for representing a given signal useful in forecasting models, specially a well known neural network models.

• Journal of Music and Human Behavior
• /
• v.14 no.1
• /
• pp.85-108
• /
• 2017

The purpose of this study was to examine how a therapeutic drumming intervention would impact middle school students with regard to school violence prevention. Participants were all in the third-year class of a middle school in Korea. A school music teacher and a music therapist designed and implemented the program collaboratively, and mainly used dyadic, synchronized, and improvisational drumming based on the Social Emotional Learning core competencies. A total of 65 students participated in a weekly 45-minute program for 10 weeks. Ten participants out of 65 were selected for interviews and the rest of the 55 participants were asked to fill out an open-ended survey. Content analysis of the survey and interviews produced 492 meaningful statements, which were categorized into seven themes: somatic responses to drumming, emotional processing, group cohesion, empathy, relationship with peers, self-esteem, and self-regulation. The findings indicated that dyadic, synchronized, and improvisational drumming may promote prosocial behaviors in students of this age. The author discussed that drumming produces physical input directly from the instruments, which prompts students to identify and empathize with their own or others' emotions. This study therefore suggests that collaborative work between school music teachers and music therapists may positively impact middle school students' prosocial behaviors, as they pertain to school violence in Korea.

• Biomolecules & Therapeutics
• /
• v.15 no.1
• /
• pp.16-26
• /
• 2007

Tissue plasminogen activator (tPA) is a serine protease catalyzing the proteolytic conversion of plasminogen into plasmin, which is involved in thrombolysis. During last two decades, the role of tPA in brain physiology and pathology has been extensively investigated. tPA is expressed in brain regions such as cortex, hippocampus, amygdala and cerebellum, and major neural cell types such as neuron, astrocyte, microglia and endothelial cells express tPA in basal status. After strong neural stimulation such as seizure, tPA behaves as an immediate early gene increasing the expression level within an hour. Neural activity and/or postsynaptic stimulation increased the release of tPA from axonal terminal and presumably from dendritic compartment. Neuronal tPA regulates plastic changes in neuronal function and structure mediating key neurologic processes such as visual cortex plasticity, seizure spreading, cerebellar motor learning, long term potentiation and addictive or withdrawal behavior after morphine discontinuance. In addition to these physiological roles, tPA mediates excitotoxicity leading to the neurodegeneration in several pathological conditions including ischemic stroke. Increasing amount of evidence also suggest the role of tPA in neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis even though beneficial effects was also reported in case of Alzheimer's disease based on the observation of tPA-induced degradation of $A{\beta}$ aggregates. Target proteins of tPA action include extracellular matrix protein laminin, proteoglycans and NMDA receptor. In addition, several receptors (or binding partners) for tPA has been reported such as low-density lipoprotein receptor-related protein (LRP) and annexin II, even though intracellular signaling mechanism underlying tPA action is not clear yet. Interestingly, the action of tPA comprises both proteolytic and non-proteolytic mechanism. In case of microglial activation, tPA showed non-proteolytic cytokine-like function. The search for exact target proteins and receptor molecules for tPA along with the identification of the mechanism regulating tPA expression and release in the nervous system will enable us to better understand several key neurological processes like teaming and memory as well as to obtain therapeutic tools against neurodegenerative diseases.

• Steel and Composite Structures
• /
• v.34 no.5
• /
• pp.743-767
• /
• 2020

Due to the impressive flexural performance, enhanced compressive strength and more constrained crack propagation, Fibre-reinforced concrete (FRC) have been widely employed in the construction application. Majority of experimental studies have focused on the seismic behavior of FRC columns. Based on the valid experimental data obtained from the previous studies, the current study has evaluated the seismic response and compressive strength of FRC rectangular columns while following hybrid metaheuristic techniques. Due to the non-linearity of seismic data, Adaptive neuro-fuzzy inference system (ANFIS) has been incorporated with metaheuristic algorithms. 317 different datasets from FRC column tests has been applied as one database in order to determine the most influential factor on the ultimate strengths of FRC rectangular columns subjected to the simulated seismic loading. ANFIS has been used with the incorporation of Particle Swarm Optimization (PSO) and Genetic algorithm (GA). For the analysis of the attained results, Extreme learning machine (ELM) as an authentic prediction method has been concurrently used. The variable selection procedure is to choose the most dominant parameters affecting the ultimate strengths of FRC rectangular columns subjected to simulated seismic loading. Accordingly, the results have shown that ANFIS-PSO has successfully predicted the seismic lateral load with R² = 0.857 and 0.902 for the test and train phase, respectively, nominated as the lateral load prediction estimator. On the other hand, in case of compressive strength prediction, ELM is to predict the compressive strength with R² = 0.657 and 0.862 for test and train phase, respectively. The results have shown that the seismic lateral force trend is more predictable than the compressive strength of FRC rectangular columns, in which the best results belong to the lateral force prediction. Compressive strength prediction has illustrated a significant deviation above 40 Mpa which could be related to the considerable non-linearity and possible empirical shortcomings. Finally, employing ANFIS-GA and ANFIS-PSO techniques to evaluate the seismic response of FRC are a promising reliable approach to be replaced for high cost and time-consuming experimental tests.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.17 no.7
• /
• pp.144-153
• /
• 2016

This study examined the recent study trends through a systematic review of the effect of sensory integration intervention and the objective reason to show the areas where sensory integration intervention is effective. The databases, Medline and EMBASE, were searched for "Occupational therapy", "Sensory integration therapy", "Sensory processing", "Weighted vest", and "Wilbarger protocol". For the analysis studies, 14 studies on the effects of sensory integration intervention from 2010 to 2015 were analyzed and organized according to the principle of PICO. According to the result, there were 4 studies each of evidence levels I and e V, which was the largest number of studies (28.6%). The result from frequency analysis of the measurement used for measuring the effects of intervention showed that GAS and VABS-II were used in the 4 studies (11.8%). 71.4% of children with autism spectrum were the major subject group in the analysis studies and sensory integration intervention had an effect on the motor performance, sensory processing, behavior, learning-related education, and occupation performance area. This study result will be useful for establishing sensory integration as an interventional program in occupational therapy practice. In further studies, it will be important to verify the intervention effect of sensory integration in another rehabilitation area.