• Journal of the Computational Structural Engineering Institute of Korea
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• v.25 no.4
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• pp.363-372
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• 2012

In this study, a new information-based hybrid modeling framework is proposed. In the hybrid framework, a conventional mathematical model is complemented by the informational methods. The basic premise of the proposed hybrid methodology is that not all features of system response are amenable to mathematical modeling, hence considering informational alternatives. This may be because (i) the underlying theory is not available or not sufficiently developed, or (ii) the existing theory is too complex and therefore not suitable for modeling within building frame analysis. The role of informational methods is to model aspects that the mathematical model leaves out. Autoprogressive algorithm and self-learning simulation extract the missing aspects from a system response. In a hybrid framework, experimental data is an integral part of modeling, rather than being used strictly for validation processes. The potential of the hybrid methodology is illustrated through modeling complex hysteretic behavior of beam-to-column connections.

• Molecules and Cells
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• v.41 no.5
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• pp.486-494
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• 2018

Recently, we have reported that animals with telomerase reverse transcriptase (TERT) overexpression exhibit reduced social interaction, decreased preference for novel social interaction and poor nest-building behaviors-symptoms that mirror those observed in human autism spectrum disorders (ASD). Overexpression of TERT also alters the excitatory/inhibitory (E/I) ratio in the medial prefrontal cortex. However, the effects of TERT overexpression on hippocampal-dependent learning and synaptic efficacy have not been investigated. In the present study, we employed electrophysiological approaches in combination with behavioral analysis to examine hippocampal function of TERT transgenic (TERT-tg) mice and FVB controls. We found that TERT overexpression results in enhanced hippocampal excitation with no changes in inhibition and significantly impairs long-term synaptic plasticity. Interestingly, the expression levels of phosphorylated CREB and phosphorylated $CaMKII{\alpha}$ were significantly decreased while the expression level of $CaMKII{\alpha}$ was slightly increased in the hippocampus of TERT-overexpressing mice. Our observations highlight the importance of TERT in normal synaptic function and behavior and provide additional information on a novel animal model of ASD associated with TERT overexpression.

• Journal of Korean society of Dental Hygiene
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• v.17 no.5
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• pp.757-767
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• 2017

Objectives: The purpose of this study is to identify the associated factors with subjective oral symptoms experience of obesity adolescents. Methods: The study subjects were targeting 8,139 obesity adolescents and 55,601 non-Obesity adolescents who completed 2016 Korean Youth Risk Behavior Web-based survey. Dependent variables were subjective oral symptoms experiences of fracture teeth, pain, throbbing pain, periodontal pain & bleeding, mucosal disease and bad breath. Independent variables were demographic characteristics of the subjects, oral health behaviors, health behaviors and eating habits. Results: Obesity adolescents were 12.8% with 61.9% subjective oral symptoms experience. Regarding the related factors of subjective oral symptoms experience of obesity adolescents, the factors were identified to be significantly higher in high school (OR=1.72) compared to middle school, learning achievement was higher in middle (OR=1.09) and lower (OR=1.31) compared to high, economic status was higher in lower (OR=1.09) compared to high, sealant experience (OR=1.10) and scaling experiences (OR=1.12) responded no were higher compared to responded yes, smoking experiences responded yes(OR=1.08) were higher compared to responded no, sweet drink (OR=1.14) and fastfood (OR=1.13) consumption were higher in consumption compared to non-consumption and females (OR=0.46) were higher than males. Oral symptoms experience were lower that father and mother's level of education were under high school graduation (OR=0.86) compared to unknown, economic status was in case of middle (OR=0.93) compared to high, tooth brushing was lower in under 1 time (OR=0.76), 2 times (OR=0.61) compared to more than 3 times, vigorous physical activities responded no (OR=0.75) were lower, compared to yes, vegetable consumption was lower in non-consumption (OR=0.68) compared to consumption. Conclusions: Subjective oral symptoms experiences were identified higher in obesity adolescents than non-obesity adolescents. It would be useful to use the results of this study to reduce oral symptoms and necessary to develop a program system considering characteristics of obesity adolescents.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2009.05a
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• pp.408-411
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• 2009

In this paper, conventional PI, fuzzy neural network(FNN) and adaptive teaming mechanism(ALM)-FNN for rotor field oriented controlled(RFOC) induction motor are studied comparatively. The widely used control theory based design of PI family controllers fails to perform satisfactorily under parameter variation nonlinear or load disturbance. In high performance applications, it is useful to automatically extract the complex relation that represent the drive behaviour. The use of learning through example algorithms can be a powerful tool for automatic modelling variable speed drives. They can automatically extract a functional relationship representative of the drive behavior. These methods present some advantages over the classical ones since they do not rely on the precise knowledge of mathematical models and parameters. Comparative study of PI, FNN and ALM-FNN are carried out from various aspects which is dynamic performance, steady-state accuracy, parameter robustness and complementation etc. To have a clear view of the three techniques, a RFOC system based on a three level neutral point clamped inverter-fed induction motor drive is established in this paper. Each of the three control technique: PI, FNN and ALM-FNN, are used in the outer loops for rotor speed. The merit and drawbacks of each method are summarized in the conclusion part, which may a guideline for industry application.

• The Journal of Korean Society for School & Community Health Education
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• v.6
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• pp.1-16
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• 2005

This study was conducted to the middle and high school students in some Seoul and Kyunki areas to identify the smoking behavior characteristics among adolescences. A self-administered survey was conducted to the 2nd grad students in 4 middle schools and 6 high schools and the survey Questionnaire included general characteristics, smoking and drug use history, the close people's smoking and drug use, smoking and drug abuse prevention education, smoking intention, and smoking attitude. A total of 2,452 youths finished the survey (1,182 middle school students and 1,270 high school students). Current smoking students were 14.6%, the ex-smokers were 5.5%, and the never smokers were 85.4%. Majority of students smoked less than 5 bars of cigarettes and their first smoking experiences were related to their family members (siblings, parents, and relatives), friends, advertisement in order. Other GYTS countries reported the similar sources of the smoking start and friend was prior smoking start factor to the other sources. The students who wanted to Quit smoking were 6.7% and the students who ever had tried to Quit smoking were 9.1%. The major reasons of Quitting smoking were for their health and for their financial burden. Approximately 60% learned about smoking and drug abuse in their regular school classes, 8.4% were in the special school activities, and 7.9% were in the class closing time sometimes in order. The students who learned in any regular class were smaller in the high school students than in the middle school students. The learning experiences in school of other GYTS countries were similar to that of Korea. In conclusion, students' smoking was affected not only by the preventive activities in school but also by the close people's behaviors and care in this study; therefore, the active partnership between school and family must be a strong strategy for youth's smoking prevention.

• Journal of the Korean Society for Library and Information Science
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• v.49 no.4
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• pp.99-124
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• 2015

As the improvement of digital technologies increases the use of images from various fields, the domain of image retrieval has evolved and become a growing topic of research in the Library and Information Science field. The purpose of this study is to identify the knowledge structure of the image retrieval domain by using the author co-citation analysis and author bibliographic coupling as analytical tools in order to understand the domain's past and present. The data set for this study is 245 articles with 8,031 cited articles in the field of image retrieval from 1998 to 2013, from the Web of Science citation database. According to the results of author co-citation analysis for the past of the image retrieval domain, our findings demonstrate that the intellectual structure of image retrieval in the LIS field consists of predominantly user-oriented approaches, but also includes some areas influenced by the CBIR area. More specifically, the user-oriented approach contains six specific areas which include image needs, information seeking, image needs and search behavior, image indexing and access, indexing of image collection, and web image search. On the other hand, for CBIR approaches, it contains feature-based image indexing, shape-based indexing, and IR & CBIR. The recent trends of image retrieval based on the results from author bibliographic coupling analysis show that the domain is expanding to emerging areas of medical images, multimedia, ontology- and tag-based indexing which thus reflects a new paradigm of information environment.

• Education of Primary School Mathematics
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• v.22 no.4
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• pp.223-237
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• 2019

There is a close interaction between the linguistic-syntactic representation system and the affective representation system that appear in the mathematical process. On the other hand, since the mathematical conceptual system is fundamentally metaphoric, the analysis of the mathematical concept structure through linguistic representation can help to identify the source of cognitive and affective obstacles that interfere with mathematics learning. In this study, we analyzed the problem-solving protocols of mathematical gifted children from the perspective of cognitive language and meta-affect to identify the relationship between the functional characteristics of the text and metaphor they use and the functional characteristics of meta-affect. As a result, the behavior of the cognitive and affective characteristics of mathematically gifted children differed according to the success of problem solving. In the case of unsuccessful problem-solving, the use of metaphor as an internal representation system was relatively more frequent than in the successful case. In addition, while the cognitive linguistic aspects of metaphors play an important role in problem-solving, meta-affective attributes are closely related to the external representation of metaphors.

• Research in Community and Public Health Nursing
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• v.32 no.3
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• pp.404-414
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• 2021

Purpose: Health behaviors for metabolic syndrome (MetS) prevention should be emphasized from early adulthood. There is little information on psychosocial factors associated with health behaviors for MetS prevention. The aim of this study was to determine whether there would be a mediating effect of perceived stress on the association between social support and health behaviors for MetS prevention among university students. Methods: This cross-sectional and correlation study was conducted with 502 university students in South Korea. Social support, perceived stress, and lifestyle evaluation for metabolic syndrome scales were used. Online questionnaire survey was conducted between November and December 2019. The mediating effect of social support on health behaviors for MetS prevention was analyzed using PROCESS macro program with bootstrapping method to test our hypotheses. Results: Social support directly influenced perceived stress (β=-.35, p<.001) and health behaviors for MetS prevention (β=.14, p=.002). Health behaviors for MetS prevention was indirectly influenced by perceived stress (β=-.25, p<.001). The size of indirect effect of social support on health behaviors for MetS prevention was 0.06. Conclusions: The association of social support and health behaviors for MetS prevention was partially mediated by perceived stress among university students. Therefore, a university-based nursing intervention should comprise social support strategies with stress management to promote health behaviors for MetS prevention.

• International Journal of Computer Science & Network Security
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• v.21 no.8
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• pp.353-359
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• 2021

Information technology and the need for timely and effective communication during the Covid-19 have made most governments adopt technological approaches to provide their services. E-government services have been adopted by most governments especially in developed countries to quickly and effectively share information. This study discusses the reasons why governments in the Gulf region should develop a new model for information technology knowledge management practices. To achieve this, the author identified possible benefits of adopting information technology knowledge management practices and why most governments in the Gulf find it hard to adopt them. Knowledge management allows for learning, transfer as well as sharing of information between government organizations and citizens and with the development of technology, the effectiveness of electronic services can easily be achieved. Also, effective adoption of information technology can improve knowledge management with the help of techniques that enhance capture, storage, retrieval as well as sharing of information. The author used systematic literature review to select 28 journals and articles published post 2019. IEEE, Google Scholar and Science Direct were used to select potential studies from which 722 journals and articles were selected. Through screening and eligibility assessment, 21 articles were retained while the back and forward search had 7 more articles which were also included in the study. Using information gathered from these articles and journals a new conceptual model was developed to help improve information technology knowledge management for governments in the Gulf region to effectively deliver e-services during Covid-19. This model was developed based on the process of KM, Theory of Planned Behavior and Unified Theory of Acceptance and Use of Technology. Based on the developed model. From UTAUT model, performance expectancy, effort expectancy as well as social influence had a great impact.

• Journal of Veterinary Science
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• v.22 no.1
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• pp.7.1-7.13
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• 2021

Background: Niemann-Pick disease type C (NPC) is caused by the mutation of NPC genes, which leads to the abnormal accumulation of unesterified cholesterol and glycolipids in lysosomes. This autosomal recessive disease is characterized by liver dysfunction, hepatosplenomegaly, and progressive neurodegeneration. Recently, the application of induced neural stem cells (iNSCs), converted from fibroblasts using specific transcription factors, to repair degenerated lesions has been considered a novel therapy. Objectives: The therapeutic effects on NPC by human iNSCs generated by our research group have not yet been studied in vivo; in this study, we investigate those effects. Methods: We used an NPC mouse model to efficiently evaluate the therapeutic effect of iNSCs, because neurodegeneration progress is rapid in NPC. In addition, application of human iNSCs from NPC patient-derived fibroblasts in an NPC model in vivo can give insight into the clinical usefulness of iNSC treatment. The iNSCs, generated from NPC patientderived fibroblasts using the SOX2 and HMGA2 reprogramming factors, were transplanted by intracerebral injection into NPC mice. Results: Transplantation of iNSCs showed positive results in survival and body weight change in vivo. Additionally, iNSC-treated mice showed improved learning and memory in behavior test results. Furthermore, through magnetic resonance imaging and histopathological assessments, we observed delayed neurodegeneration in NPC mouse brains. Conclusions: iNSCs converted from patient-derived fibroblasts can become another choice of treatment for neurodegenerative diseases such as NPC.