• 대한임상독성학회지
• /
• 제7권2호
• /
• pp.113-120
• /
• 2009

Purpose: Though caustic injury of the upper digestive tract can lead to severe sequelae, there are few clinical studies on this subject. This study was undertaken to evaluate the clinical characteristics, the endoscopic findings and the risk factors of the upper digestive lesions in patient with caustic ingestion injury. Methods: We retrospectively reviewed the medical records of 137 patients who ingested caustic materials and who visited to our emergency room from January, 2000 to June, 2009. Results: The most common ingested agent was sodium hypochlorite (44.5%), followed by acetic acid (19.7%), hydrochloric acid (11.7%) and lye (8.0%). Ingestion for suicidal attempt (62.0%) was more frequent than accidental ingestion (30.7%). Grade IIa injury was the most frequent finding on endoscopy of the esophagus and Grade 1 injury was the most frequent finding on endoscopy of the stomach. For the late sequelae, there were 9 cases (6.6%) of esophageal stricture and 2 cases (1.5%) of gastric outlet obstruction. The initial signs and symptoms did not correlate with the development of stricture, but leukocytosis, and grade III injury were related to the risk of developing stricture. Conclusion: Caustic injury of the upper gastrointestinal tract is frequently observed on early endoscopy and it can cause significant late sequelae such as stricture. Therefore, it is necessary to evaluate these patients with regular follow up endoscopic examinations for the management of late sequelae.

• Archives of Plastic Surgery
• /
• 제38권4호
• /
• pp.523-526
• /
• 2011

Purpose: The odontogenic sinus and fistulous tracts is the most common draining sinus and fistulous tract of the head and neck region. These are often misdiagnoses by clinicions who are not familiar with cutaneous sinus, since most of patients do not have dental symptoms. Here we present two cases of odontogenic cutaneous sinus tract which have been diagnosed after excision of epidermal cyst. Methods: Two patients who presented with an odontogenic sinus tract draining to the skin at our institusion during the two years were enrolled in this study. We reviewed all the medical records of the patients and literature about odontogenic cutaneous sinus tract. Results: Odontogenic cutaneous sinus tracts of our cases were healed after treatment of periapical odontitis and extraction of the carious tooth. Conclusion: The cutaneous sinus tract of dental origin is well documented condition. But its diagnosis is not always easy unless the clinicians consider the possibility of its dental origin. An understanding of the pathogenesis of odontogenic cutaneous sinus tract will lead to early correct diagnosis and proper treatment without unnecessary surgery.

• 한국축산식품학회지
• /
• 제43권5호
• /
• pp.859-876
• /
• 2023

It is known that animal-origin medicine could be one of effective treatment to remedy atopic dermatitis (AD) by controlling the cytokines. Cicadidae Periostracum (CP), the slough of Cryptotympana pustulata, has been frequently used for treating AD and skin affliction in traditional Korean Medicine. This study is aimed at investigating the ameliorating effects of CP on AD and its potential mechanism. The dinitrochlorobenzene sensitized mice were treated with CP for 2 weeks. The various biomarkers and the dermatitis scores presented that CP treatment can induce the visual and biological improvements of AD model. Pruritus, the most serious symptom of AD, which can cause repeated scratching behaviors and finally lead to lichenification, was reduced with CP treatment by regulating the inflammatory reactions. In addition, CP treatment diminished the number of mast cells that are known for causing inflammatory reactions. Moreover, it is proven that CP can decline secretion of interleukin-22, which means CP treatment has anti-inflammatory effects. CP treatment can correct the imbalance of helper T (Th)1 and Th2, downregulating thymic stromal lymphopoietin that leads to decrease of mRNA level of inflammatory cytokines. The crucial role of CP treatment is controlling of the Janus kinase 1/signal transducer and activator of transcription 3 pathway. In addition, CP treatment has the inhibitory effects on kallikrein related peptidase (KLK) 5 and KLK7. Taken together, CP treatment can ameliorate most symptoms and problems caused by AD disease, improving the AD patients' life quality.

• 대한지역사회영양학회지
• /
• 제28권3호
• /
• pp.181-191
• /
• 2023

Objectives: The incidence of inflammatory bowel disease (IBD) is increasing globally, and excessive added sugar consumption has been identified as one of the contributing factors. In the context of IBD, it is essential to explore functional sweeteners that can improve metabolic health and minimize the risk of IBD-related symptoms. This review article aims to shed light on the effects of natural mono- and di-saccharides as alternative sweeteners, specifically focusing on potential benefits for IBD. Methods: A comprehensive literature review was performed using PubMed and Google Scholar databases with articles published after the year 2000. The search terms 'IBD', 'added sugar', 'sweeteners', 'mono-saccharide', and 'di-saccharide' were combined to retrieve relevant articles. A total of 21 manuscripts, aligning with the objectives of the study, were selected. Papers focusing on artificial or high-intensity sweeteners were excluded to ensure relevant literature selection. Results: Multiple studies have emphasized the association between the high consumption of added sugars such as simple sugars and the increased risk of developing IBD. This is suggested to be attributed to the induction of pro-inflammatory cytokine productions and dysbiosis of the gut microbiota. Consequently, there is a growing demand for safe and functional sweeteners, in particular mono- and di-saccharides, that can serve as alternatives for IBD patients. Those functional sweeteners regulate inflammation, oxidative stress, and Intestinal barrier protection, and restore microbiome profiles in various IBD models including cells, animals, and humans. Conclusions: Understanding these mechanisms resolves the link between how sugar consumption and IBD, and highlights the beneficial effects of natural alternative sweeteners on IBD when they were administered by itself or as a replacement for simple sugar. Further, exploration of this relationship leads us to recognize the necessity of natural alternative sweeteners in dietary planning. This knowledge could potentially lead to more effective dietary strategies for individuals with IBD.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제27권2호
• /
• pp.167-173
• /
• 2001

Cystic lesion of the jaw are frequently encountered clinically. Although they rarely lead to development of tumors, they can result in resorption of the jaw bone or asymmetry of the face may occur. The purpose of this study is to find the clinical and histopathological pattern of cysts and to help better understanding for the diagnosis and treatment of jaw cysts. The hospital chart, out-patient chart, panorama X-ray, histopathological report and operation report of 246 patients were reviewed who had been diagnosed as cyst. Sex distribution, age distribution, classification, anatomic distribution, clinical sign & symptoms, treatment, post-operation complications, recurrence rate were studied. Then significant difference between the diameter of cyst with bone graft and none-bone graft was calculated with SAS program. The results were as follows. 1. Among the total patient of 246 cases, male were 163 case(67.0%), and female were 83 case(37.0%), male predominated by the ratio of 1.98. 2. By age group, the 20's accounted for the largest proportion of the cases(27.2%) and the 30' accounted for the 2nd largest proportion of the case(19.5%). 3. Radicular cyst and dentigerous cyst were most common cysts, irrespective of 166 case(67.5%) and 62 case(25.2%). 4. Clinical sign & symptoms were swelling(167case), pain(85case), pus discharge(53case), teeth discoloration(28case), indicating that most complaints were related to inflammation and facial asymmetry. 4.9% of the total cases were discovered accidentally. 5. The primary site of cysts were maxillary anterior area(43.9%), the others were, in descending order, mandibular posterior area(25.6%), maxillary posterior area(14.6%). 6. Enucleation with endodontic treatment was a main treatment method(133 case, 54.1%) and 38 cases(15.4%) were enucleation with extraction, and 37 cases(15.0%) were only enucleation, and 21 cases(8.5%) were enucleation with bone graft. 7. The average diameter of cysts with bone graft was significally greater than with non-bone graft(p<0.05). 8. Post-operation complications occurred in 10 case(4.1%), all of this were due to secondary infection.

• Journal of Dairy Science and Biotechnology
• /
• 제27권2호
• /
• pp.55-62
• /
• 2009

우유는 110여 종에 달하는 다양한 영양소를 골고루 함유하고 있어 성장기 어린이들에게 영양학적으로 완전에 가까운 식품으로 알려져 있다. 전세계 인구의 75% 정도가 유전적으로 유당을 소화시키는 능력이 부족한 이른바 유당불내증 때문에 우유 소비를 가로막는 최대 장애요인이 되고 있다. 우유의 섭취 부족으로 인하여 영양소의 결핍이 초래되어 골다공증, 고혈압, 결장암의 발병율이 증가하고 있는 추세이다. 식품 중에 함유된 유당이 체내에 흡수되려면 소장내에서 가수분해가 일어나야 한다. 유당을 분해하는 효소를 락타아제 또는 $\beta$-갈락토시다아제라 한다. 유당의 가수분해로 생성되는 포도당은 혈당이나 에너지원으로 이용되지만, 갈락토오스는 유아의 뇌조직 성분인 당지질의 합성에 이용된다. 임상적으로 유당불내증은 breath hydrogen production test로 진단할 수 있다. 유당불내증은 유럽인 25%, 히스패닉계, 인도인, 흑인 및 유대인 50~80%, 아시아인과 아메리카 인디언의 경우 거의 100% 생기는 것으로 보고되었다. 성인의 경우 유당을 가수분해할 수 있는 능력 즉, 락타아제 지속성(lactase persistence)이 북유럽 인들에게는 흔한 표현형 인 반면 그 외 지역에서는 락타아제 비지속성(lactase non-persistence) 또는 성인형 저유당분해 효소증(adult-type hypolactasia)이 가장 흔하게 나타난다. 유전자 분석 결과 인간의 락타아제 유전자의 5' 말단으로부터 13910째 염기의 다혈성(C/T-13910 single nucleotide polymorphism)이 락타아제 지속성과 관련이 있다는 사실이 밝혀졌다. 유당불내증을 완화하기 위해서는 1회분으로 한 컵 이하, 타 식품과 함께 마실 것, 탈지유보다는 전지유, 요구르트 유산균과 함께 마실 것 등이 권장되며 위배출지연도 유당불내증 개선에 효과적이다. 기존 유당불내증 진단법은 지나치게 많은 유당을 투여함으로써 유당불내증 비율이 과장되어 있으므로 정확한 진단법의 개발이 필요하다. 발효유 제품이나 저유당 제품을 개발하면 유당불내증으로 인한 유제품의 소비 부진을 크게 해소할 수 있을 것으로 판단된다.

• Clinics in Shoulder and Elbow
• /
• 제13권1호
• /
• pp.167-174
• /
• 2010

목적: 광범위 회전근 개 파열은 파열단의 내측 퇴축, 근위축 및 지방 변성과 함께 주변 조직과의 유착 등으로 해부학적 봉합이 불가능한 경우가 많다. 본 종설에서는 광범위 회전근 개 파열의 여러 가지 치료 방법 중 봉합술에 대하여 문헌 고찰과 함께 임상 결과 향상과 재파열율을 감소시키고 치유력을 높일 수 있는 방법을 알아보고자 한다. 대상 및 방법: 광범위 회전근 개 파열 봉합술의 선택은 환자의 나이, 동반 질환, 통증, 운동 범위 감소, 근력 약화 등의 임상 증상 및 재활 의지 등 환자와 관련된 요인과, 회전근 개 파열 기간, 크기, 퇴축 및 지방 변성 정도 등은 회전근 개와 관련된 요인을 고려하여 선택해야 한다. 결과: 조직의 가동성이 떨어져 해부학적 봉합이 어려운 광범위 회전근 개 파열은 주변 조직 유리술과 간격 활주 방법으로 가동성을 증가시켜 봉합할 수 있다. 주변 조직 유리술을 시행하고 회전근 개의 가동성을 증가시켜도 해부학적 봉합이 불가능한 광범위 회전근 개 파열은 부분 봉합, 변연 수렴 술식 및 상완 이두건 절제 및 고정술 등의 대체 술식을 고려할 수 있다. 광범위 회전근개 파열 환자에서 견봉하 감압술 및 회전근 개 봉합술에 관한 여러 보고는 통증 감소, 견관절 기능 및 근력 회복 등 만족할만한 임상 결과를 보고하고 있으나 장기 추시 결과 높은 재파열율이 관찰되고 있다. 결론: 광범위 회전근 개 파열의 치료는 아직까지 높은 재파열 발생율로 해결해야 할 과제가 많으나 광범위 파열의 병인, 진행 과정 및 임상 양상에 대한 이해와 재파열 예후 인자 분석 등을 통해 향상된 치료 성적을 얻을 수 있을 것으로 사료된다.

• 수면정신생리
• /
• 제26권1호
• /
• pp.33-43
• /
• 2019

목 적 : 양극성 장애 환자의 기능은 증상의 심각도, 약물 순응도, 수면의 질, 사회적 지지와 관련되어 있다고 알려져 있다. 본 연구에서는, 정신사회적 요인들과 인구학적 요인들이 양극성 장애 환자의 기능 상태와 갖는 연관성에 대해 알아보고자 하였다. 방 법 : 본 연구에서는 양극성 장애 환자 52명을 대상으로 하였다. 다음과 같은 임상적 척도들이 수행되었다: 한국판 personal and social performance scale (K-PSP), 한국판 Hamilton rating scale for depression (K-HDRS), 한국판 young mania rating scale (K-YMRS), 한국판 Pittsburgh sleep quality index (PSQI-K), 한국판 drug attitude inventory (K-DAI), mood disorders insight scale (MDIS), multidimensional scale of perceived social support (MSPSS). 연구 대상의 기능 상태와 임상적 변수들 간의 관계는 상관 분석을 사용하여 분석하였고, 이어 다중 선형 회귀분석을 시행하였다. 결 과 : 전체 K-PSP 점수의 평균은 $57.92{\pm}13.76$이었다. 전체 K-PSP 점수는 K-HDRS 점수와는 음의 상관관계를 나타냈다(r = -0.387, p = 0.005). 반면, K-YMRS 점수와 전체 K-PSP 점수는 통계적으로 의미 있는 관계가 도출되지 않았다(r = -0.205, p = 0.145). 전체 K-PSP 점수는 PSQI-K 총점(r = -0.378, p = 0.005) 및 전반적인 수면의 질(r = -0.353, p = 0.010)과 음의 상관관계를 나타냈다. 전체 K-PSP 점수는 KDAI 점수(r = 0.409, p = 0.003) 및 총 MSPSS 점수(r = 0.334, p = 0.015)와는 양의 상관관계를 보였다. 전체 K-PSP에 대하여 설명 가능한 변수들은 PSQI-K 중 전반적인 수면의 질과 MSPSS 중 가족에 의한 지지였다(adjusted $R^2=28.3%$). 결 론 : 본 연구에서는 우울 증상이 심할수록, 전반적인 수면의 질이 낮을수록, 약물에 대해 부정적으로 인식할수록, 사회적 지지가 적을수록 양극성 장애 환자의 기능 수준이 저하된다는 결과를 제시해주었다. 양극성 장애 환자의 기능 상태는 환자가 보고하는 전반적인 수면의 질과 가족에 의한 사회적 지지를 통해 예측 가능하므로, 환자의 수면 만족도를 증진시키고 가족에 의하여 적절한 지지를 제공하는 것이 양극성 장애 환자의 기능 회복과 사회적 복귀에 있어서 중요한 부분이라고 시사된다.

• 생명과학회지
• /
• 제21권5호
• /
• pp.734-738
• /
• 2011

율피를 기능성 화장품 소재로 활용하기 위하여 주름개선, 미백 및 수렴효과를 검증하였다. 주름개선 효과를 검증하기 위하여 elastase 저해활성과 collagenase 저해활성을 측정하였다. Elastase 저해활성을 측정한 결과 율피 아세톤 추출물 100 ug/ml에서 51.0%의 효과를 나타내었으며, collagenase 저해활성을 측정한 결과 아세톤 및 에탄올 추출물이 50 ug/ml 에서 96.4%, 94.3%의 저해활성을 나타내었다. 미백효과를 확인하기 위하여 tyrosinase 저해활성을 측정한 결과 아세톤 및 에탄올 추출물이 열수 추출물보다 높은 Tyrosinase 저해활성을 나타내었으나 대조군으로 사용한 Vitamin C와 비교시 약 50%의 효과를 나타내었다. 이상의 결과로 미루어 보아 율피 추출물의 주름개선 효과가 높음을 확인할 수 있었고, 주름개선 기능성 화장품 소재로서의 가능성을 확인하였다.

• 생물정신의학
• /
• 제4권2호
• /
• pp.198-210
• /
• 1997

To examine the double-faced thymoleptic(antidepressant and antimanic) effects of risperidone in mood disorders, this article reviews the psychotropic-induced mania, thymoleptic effects of antipsychotics, therapeutic effects of risperidone and risperidone(RIS)-induced mania(RIM) in mood disorders, risk factors of RIM, possible neurochemical mechanism of these thymoleptic effects, pathophysiological and clinical significance of thymoleptic effects, and suggestive clinical guideline of RIS in mood disorders. RIS appeared effective for bipolar disorder at a lower dose than that recommended for schizophrenia, especially in the cases of maintenance of mood stabilizers, and gradual titration from low doses. Manic induction/exacerbation can occur by chance during RIS treatment in mood disorders, schizoaffective disorders, and schizophrenias. The possible risk factors for RIM are refractory mood disorder, especially in bipolar I disorder with poor initial response ; refractory schizoaffective disorders, especially in bipolar type with poor initial response ; refractory chronic schizophrenias, especially with initial responses ; psychotic features ; higher initial doses ; rapid titration ; combined therapy with antidepressants in refractory depression ; and RIS monotherapy in mania/hypomania. RIS is a drug that preferentially block 5-HT2 receptors. The effects of low dose are due mainly to the blockade of 5-HT2 receptors. There are more gradual increase in D2 blockade with increasing dose and this D2 blocking properties become apparent at higher doses. This may be related to a modulation of dopaminergic transmission by 5-HT2 antagonism at lower doses with the direct action of RIS on DA receptors coming into play at higher dose. The serotonergic antagonistic effect may be important for its effects on depressive symptoms. This, together with adequate blo-ckade of D2 receptors, may not necessarily lead to destabilization of mood disorder, but rather to more therapeutic effects. Therefore, this dose-receptor affinity relationship with both antidepressant and antimanic effects according to treatment duration can explain a continuum of antidepressant effect, antimanic effect, behavioral stimulation, and manic/hypomanic induction/exacerbation. It was the recognition of a useful psychiatric side effects by a thoughtful observer with fertile minds that led to their ultimate utilization as psychotropic drugs, i.e., phenothiazine, MAOI, TCA, and lithium. And, in vivo pharmacological challenge by novel psychotropics, as a neurochemical probe, with more specific actions is a useful tool to select pharmacologically homogeneous subgroup of the same phenotypical(clinical) condition, to further study the unknown underlying pathogenesis of various mental illnesses. Finally, RIS may be a useful alternative or adjunctive drug for patients with mood disorders without psychotic features or refractory to treatment with standard antipsychotic drugs. The more conservative doses(tirated slowly from 1-3 mg/d) of RIS, and maintenance of mood stabilizer in the cases with risk factors of RIM are recommended in mood disorder.