• Journal of the Korea Convergence Society
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• v.10 no.9
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• pp.193-198
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• 2019

This study analyzed the changes of vowel formant, voice intensity, and fundamental frequency of vowels for 11 months using acoustochemical spectrogram analysis of women diagnosed with amyotrophic lateral sclerosis (ALS). The test word was a vowel /a, i, u/ and a diphthong /h + ja + da/, /h + wi + da/, and /h +ɰi+ da/. Speech data were collected through the word reading task presented on the monitor using 'Alvin' program, and the recording environment was set to 5,500 Hz for the nyquist frequency and 11,000 Hz for the sampling rate. The records were analyzed by using spectrograms to vowel formants, voice intensity, and fundamental frequency. As a result of analysis, the fundamental frequency and intensity of the ALS process were decreased and the formant slope of the diphthong was decreased rather than the formant change in the vowel. This result suggests that the vowel distortion of ALS due to disease progression is due to the decrease of tongue and jaw co morbidity.

• Biomolecules & Therapeutics
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• v.29 no.5
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• pp.498-505
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• 2021

Amyotrophic lateral sclerosis (ALS) is a lethal neurological disorder characterized by the deterioration of motor neurons. The aim of this study was to investigate alteration of cationic amino acid transporter (CAT-1) activity in the transport of lysine and the pretreatment effect of lysine on pro-inflammatory states in an amyotrophic lateral sclerosis cell line. The mRNA expression of cationic amino acid transporter 1 was lower in NSC-34/hSOD1^G93A (MT) than the control cell line (WT), lysine transport is mediated by CAT-1 in NSC-34 cell lines. The uptake of [³H]L-lysine was Na⁺-independent, voltage-sensitive, and strongly inhibited by inhibitors and substrates of cationic amino acid transporter 1 (system y⁺). The transport process involved two saturable processes in both cell lines. In the MT cell line, at a high-affinity site, the affinity was 9.4-fold higher and capacity 24-fold lower than that in the WT; at a low-affinity site, the capacity was 2.3-fold lower than that in the WT cell line. Donepezil and verapamil competitively inhibited [³H]L-lysine uptake in the NSC-34 cell lines. Pretreatment with pro-inflammatory cytokines decreased the uptake of [³H]L-lysine and mRNA expression levels in both cell lines; however, the addition of L-lysine restored the transport activity in the MT cell lines. L-Lysine exhibited neuroprotective effects against pro-inflammatory states in the ALS disease model cell lines. In conclusion, studying the alteration in the expression of transporters and characteristics of lysine transport in ALS can lead to the development of new therapies for neurodegenerative diseases.

• Journal of Veterinary Science
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• v.21 no.4
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• pp.67.1-67.11
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• 2020

Background: Tibial tuberosity transposition (TTT) causes caudalization of the patellar ligament insertion in canine medial patellar luxation, which can lead to increases in patellofemoral contact pressure. Objectives: The purpose of this study is to confirm the effect of patellofemoral contact mechanics after craniolateral and caudolateral transposition of tibial tuberosity in normal canine hindlimbs. Methods: Craniolateral and caudolateral transposition of tibial tuberosity was performed in 5 specimens, respectively. The pressure was measured in the specimen before TTT, and then in the same specimen after TTT. In this process, data was obtained in 10 specimens. The measurement results were output as visualization data through the manufacturer's software and numerical data through spreadsheet. Based on these 2 data and the anatomical structure of the patellofemoral joint (PFJ) surface, whole measurement area was analysed by dividing into medial, lateral and central area. Results: In craniolateralization of tibial tuberosity, total, medial, central contact pressure was decreased and lateral contact pressure was not statistically changed lateral contact pressure than normal PFJ. In caudolateralization of tibial tuberosity, total, lateral contact pressure was increased and medial contact pressure was not statistically changed than normal PFJ. Although not statistically significant changed, central contact pressure in caudolateralization of tibial tuberosity was increased in all 5 specimens. Conclusions: These results imply that traditional TTT, prone to caudal shift of patellar tendon, can increase retropatellar pressure may lead to various complications and diseases of the stifle joint.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 1997.04a
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• pp.54-61
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• 1997

Furthermore the rothor pole, with a solid type, manufactured by cold forging process at present should dmploy 3 press lines which consist of total 7 processes. Since A.S.B. treatment is prerequisite for the press line, the 3 times of A.S.B. treatment requires a long lead time, with little contribution to the reduction in cost. The author has investigated, through this researach, the possibility of a new forging method for a rotor pole production with (1) 2 pass instead of 3 press lines (2) only one A.S.B. treatment instead of 3 ones (3) solid type instead of sectional type, and (4) improvment of material property during process using a modified forging process and a specially designed die.

• Journal of Institute of Control, Robotics and Systems
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• v.11 no.11
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• pp.913-919
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• 2005

An advanced method of Relaxed Static Stability (RSS) is utilized for improving the aerodynamic performance of modem version supersonic jet fighter aircraft. The flight control system utilizes RSS criteria in both longitudinal and lateral-directional axes to achieve performance enhancements and improve stability. Standard CLDA (Control Law Design and Analysis) process is provided that reduce the development period of the flight control system. In addition, if this process is employed in developing flight control laws, it reduces the trial and error development and verification of control laws. This paper details the design process of developing a flight control law for the RSS aircraft, utilizing military specifications, linear and nonlinea, analysis using XMATH and ATLAS(Aircraft, Tim Linear and Simulation), handling quality tests using the HQS (Handling Quality Simulator), and real flight test results to verify aircraft dynamic flight responses.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.30A no.1
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• pp.16-22
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• 1993

A via-hole process for reproducible and reliable GaAs MMIC fabrication is described. The via-hole etching process consists of two step dry etching. During the first etching step a BC $I_{3}$/C $I_{2}$/Ar gas mixure is used to achieve high etch rate and small lateral etching. In the second etching step. CC $L_{2}$ $F_{2}$ gas is used to achieve selective etching of the GaAs substrate with respect to the front side metal layer. Via holes are formed from the backside of a 100$\mu$m thick GaAs substrate that has been evaporated initially with 500.angs. thick chromium and subsequently a 2000.angs. thick gold layer. The fabricated via holes are electroplated with gold (~20$\mu$m thick) to form via connections. The results show that established via-hole process is satisfactory for GaAs MMIC fabrication.

• Journal of Magnetics
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• v.2 no.3
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• pp.67-71
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• 1997

A new hot-forming process has been studied to produce anisotropic Nd-Fe-B based magnets from melt-spun ribbons. The ribbon fragments were inserted in a Cu tube and hot-deformed together with one-stroke. At a height reduction ratio of 0.44, the melt-spun ribbons were densified into a magnet with a density of 7.14 g/cm3, and showed a (BH)max of 14.6 MGOe. With further deformation, the magnets were plastically deformed with Cu tubes in the lateral direction, and crystallographic anisotropy was introduced. The magnets with a height reduction ratio of 0.75 exhibited magnetic properties of (BH)max = 32.1 MGOe, Br = 11.7 kG, and iHc = 10.6 kOe. This process shows the possibility that the conventional hot-pressing and subsequent die-upsetting for anisotropic magnets can be simplified into a one-step process.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.26 no.5
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• pp.446-454
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• 2000

Condylar process of mandible is an important and fuctionally versatile part of the mandible. There were quite large amount of investigations on the functional and anatomical adaptation of the temporomandibular joint(TMJ) to the surrounding tissues. But controversies on the mechanism of functional adaptation of the joint still exist. In this research, we investigated changes in the TMJ by the lateral deviation of the maxillary incisor to shift the mandible right, and bone the undecalcified microscopic sections with fluorescent microscope and von Kossa staining with bright field microscope. Results were as follows: 1. Lateral deviation rendered shifting and tilting of the mandible, There were, compressions in the right joint and opening of the left joint space at early stage. At the same time, both condyles shifted slightly to anterior. 2. After $2{\sim}4$ weeks, left condyle showed anterior displacement and compressions in the joint space. Right condyle showed only slight shift to the anterior. 3. Regardless of the direction of the lateral shift, anterior bite plate compressed both condyle heads until 2 weeks. 4. There are bone resorptions in the anterior aspect of the condyle head and apposition of posterior border. Bone remodeling were observed between 3 and 4 weeks. 5. After 8 weeks of the experiment, there were little differences in condylar morphology between experimental and control group, though slight shifting and compression were still present in the experimental group. Lateral deviation of mandible evoked active remodeling of the TMJ until functional and anatomical reconstruction of TMJ position was achieved.

• Journal of the Earthquake Engineering Society of Korea
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• v.10 no.1 s.47
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• pp.9-16
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• 2006

The design practice of the lateral resisting system has been traditionally dependent on the experience and know-how of a structural engineer. And the method to reflect the evaluation results of building's capacity on design process doesn't exist. The proposal of a rational design of the lateral load resisting system is based on the available full capacity $(R_{ac})$ of a building and the minimum required capacity $(R_{code})$ suggested in the code. This study suggests thai nonlinear static analysis, which is the estimation of the lateral capacity with the pushover analysis, be included in the existing design procedure of the structure. After finishing the basic structural design, the lateral resisting capacity ol a building is estimated. At the phase of nonlinear static analysis, pushover analysis is peformed to define the fully yielded baseshear $(V_Y)$. When the design wind baseshear $(V_{wind})$ is bigger than the design seismic baseshear $(V_D)$, the value is checked to determine whether or not it is smaller than the $V_Y$. After confirming that it is smaller, the $R_{ac}$ of the structure is computed. If the $V_D$ is bigger at first, only the $R_{ac}$ is computed. When the value of the estimation shows remarkable differences with the $R_{code}$, repetition of the design modification is needed for those approximate to the $R_{code}$. Application of the proposed design procedure to 2-D steel braced RC buildings has proven to be efficient.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.3A
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• pp.149-160
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• 2012

Corrugated steel plates have several advantages such as high resistance for shear without stiffeners, minimization of welding process, and high fatigue resistance. To take advantage of these benefits, several researchers have attempted to use corrugated steel plate as a web of I-girders. The lateral-torsional buckling is the major design aspect of such I-girders. However, lateral-torsional buckling of the I-girder with corrugated steel webs still needs to be investigated especially for a real loading condition such as non-uniform bending. This paper investigated the lateral-torsional buckling strength of the I-girder with corrugated steel webs under linear moment gradient by using finite element analysis. From the results, it was found that the buckling behavior of the I-girder with corrugated steel webs differed depending on the number of periods of the corrugation. Also, a simple equation for the moment gradient correction factor of the I-girder with corrugated steel webs was suggested. The inelastic lateral-torsional buckling strength of the I-girder with corrugated steel webs was then discussed based on current design equations for ordinary I-girders and the results of finite element analysis.