• Journal of Acupuncture Research
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• v.20 no.3
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• pp.117-130
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• 2003

To study the analgesic and effect and its mechanism of eletroacupunture(EA) on the chronic inflammatory pain 50 rats were induced with arthralgesia by injecting complete freund's adjuvant(CFA). Two weeks after the injection of CFA, EA stimulation(2Hz, 0.07mA, 0.3ms) was delivered to Jogsamni($ST_{36}$) for 20 minutes. Analgesic effect was evaluated by using the tail flick latency(TFL) and the analgesic mechanism was observed by applying TFL with the pretreatment with naloxone and yohimbine. The results were as follows ; 1. TFL level for the model of adjuvant-induced arthritis decreased as time went by and it induced the hyperalgesia. 2. EA stimulation delivered to Jogsamni($ST_{36}$) for 20 minutes in the rat model of adjuvant-induced arthritis brought analgesic effect and its effect had lasted for 40 minutes after the stimulation. 3. The analgesic effect of Jogsamni($ST_{36}$) EA in the rat model of adjuvant-induced arthritis was blocked by pretreatment with naloxone(2mg/kg,i.p). This result suggests that the EA effect on the chronic inflammatory pain can be related to the endogenous opioid mechanism. 4. The analgesic effect of Jogsamni($ST_{36}$) EA in the rat model of adjuvant-induced arthritis was blocked by pretreatment with naloxone(2mg/kg,i.p). This result suggests that the EA effect on the chronic inflammatory pain can be related to the ${\alpha}_2$-adrenergic mechanism.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.11
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• pp.11-18
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• 2014

Most of the energy efficient MAC protocols for wireless sensor networks (WSNs) are based on duty cycling in a single channel and show competitive performances in a small number of traffic flows; however, under concurrent multiple flows, they result in significant performance degradation due to contention and collision. We propose a multi-channel pipelining (MCP) method for convergecast WSN in order to address these problems. In MCP, a staggered dynamic phase shift (SDPS) algorithms devised to minimize end-to-end latency by dynamically staggering wake-up schedule of nodes on a multi-hop path. Also, a phase-locking identification (PLI) algorithm is proposed to optimize energy efficiency. Based on these algorithms, multiple flows can be dynamically pipelined in one of multiple channels and successively handled by sink switched to each channel. We present an analytical model to compute the duty cycle and the latency of MCP and validate the model by simulation. Simulation evaluation shows that our proposal is superior to existing protocols: X-MAC and DPS-MAC in terms of duty cycle, end-to-end latency, delivery ratio, and aggregate throughput.

• Journal of Acupuncture Research
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• v.28 no.1
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• pp.37-44
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• 2011

배경 및 목적 : 봉독약침요법(bee venom pharmacopuncture, BVP)은 rheumatoid arthritis(RA)의 치료에 활용되고 있으나, RA로 인한 염증성 통증에 대한 봉독약침의 진통효과와 specific mechanism은 아직까지 명확하게 밝혀지지 않았다. 이에 본 연구에서는 RA animal model로서 collagen-induced arthritis(CIA) rat model에서 봉독약침의 a1-adrenergic, 5HT-3 그리고 muscarinic cholinergic mechanism을 확인하고자 한다. 방법 : CIA를 유도하기 위하여 male Sprague-Dawley rat에 freund's incomplete adjuvant에 유화(乳化)시킨 bovine type II collagen을 주입하고 14일 후 booster injection 시행하였다. 진통효과는 tail flick latency (TFL)로 평가하였다. 결과 : 관절염의 유도 이후 염증성 통증 역치는 시간이 지나면서 낮아지며, 5주 이후로는 통증 역치에 큰 변화가 없이 유지되었다. 첫 번째 immunization으로부터 5주 경과 후 족삼리($ST_{36}$)에 봉독약침처치(0.25 mg/ kg)를 시행하여 유의한 진통효과를 관찰하였다. 또한 봉독약침의 진통효과는 ondansetron(5HT-3 receptor antagonist, 0.5mg/kg, i.p.), atropine(muscarinic cholinergic receptor antagonist, 1mg/kg, i.p.)의 전처치에 의하여 억제되었으나, prazosin(a1-adrenergic receptor antagonist, 1mg/kg, i.p.)의 전처치에 의해서는 억제되지 않았다. 결론 : 봉독약침은 CIA로 인한 염증성 통증에 유의한 진통효과를 나타내며 그 analgesic mechanism은 5HT-3와 muscarinic cholinergic receptor에 의하여 매개되며 a1-adrenergic receptor에 의하여 매개되지는 않았다.

• Journal of the Korea Computer Graphics Society
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• v.4 no.1
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• pp.89-100
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• 1998

A multi-user virtual reality system supports shared environments for concurrent accesses by multiple users. The performance of these systems depends heavily on the network environments. This paper experiments an effective network model for shared virtual environments. This model has a middle layer called groups placed between the server and its clients, and the tasks of server are distributed to these groups. Using groups solves some of the problems of existing systems such as lack of scalability, message overheads, and latency due to message passing among locally communicating entities in the virtual environment. Some experiments show lower overhead than existing distributed virtual environment systems in WAN as well as LAN environments. This model also supports a method that can be used to construct application specific network environments using message handler which allows user-defined message formats.

• Journal of the Korea Convergence Society
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• v.8 no.7
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• pp.29-37
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• 2017

Compared to the commercial networks, R&E networks have the strength such as flexible network engineering and design. Based on those features of R&E networks, we propose our storage cloud service model which supports general-purpose network users in a central region and experimental network users in distributed regions simultaneously. We prototype our service model utilizing multiple proxy controllers of OpenStack Swift service in order to deploy several regions via experimental backbone networks. Our experiments on the influence of the network latency and the size of data to be transmitted show that the bigger size of data is preferable to the smaller size of data in an experimental backbone network where the network latency increases within 10ms because the rate of throughput decline in the bigger object is comparatively small. It means that our service model is appropriate for experimental network users who directly access the service in order to move intermittently high volume of data as well as normal users in the central region who access the service frequently.

• The Korean Journal of Physiology
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• v.26 no.2
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• pp.143-150
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• 1992

The purpose of this study is to obtain the effective concentration of capsaicin to relieve pain with no change in the number of C-fibers and its effective duration for pain relief. Capsaicin has been used extremely as a experimental tool and as topical medications for acute or chronic tissue injuries and partial nerve injury is the main cause of causalgiform pain disorders in humans. Here, the left sciatic nerve was ligated unilaterally at the high level of the thigh to prepare an animal model of this pain condition. The rat developed guarding behavior of the ipsilateral hind paw within a few hours after the operation and this behavior was maintained for several months thereafter, suggesting the possibility of spontaneous pain. These animals were divided into two groups(4-week & 8-week) and each group was subdivided into five groups by different concentration (0.05, 0.1, 0.5, 1.0 & 2.0%). Each capsaicin concentration was treated locally on the spinal cord-side of the ligated nerve and the foot withdrawal latency was measured. Thereafter, the dorsal roots of L5 were removed from both sides immediately after in tracardial perfusion for the counting of C-fibers by the histological procedure. There were no significant differences in the foot-withdrawal latency and the number of C-fibers between the left side treated with 0.05% capsaicin and the right side treated with the vehicle. However, latencies of the left sides treated with 0.1, 0.5, and 1.0% capsaicin increased significantly throughout 4-6 weeks with almost no change in the number of C-fibers, and the latencies showed the trends to approach slowly to those of the conditions after operation. The latency of subgroup treated with 2.0% increased by approximate 10% more than that of the right side throughout 8 weeks, and the number of C-fibers decreased by about 30% or more These results suggest that the elevated latency with capsaicin(0.1-1.0%) treatment is due to the inhibition of impulse transmission throughout the primary afferent fiber and the data from 2.0% are due to partial destruction of C-fibers. Therefore, capsaicin concentrations from 0.1% to 1.0% are probably very effective for the treatment of causalgiform pain with almost no destruction of C-fibers.

• Journal of Information Processing Systems
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• v.18 no.1
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• pp.159-172
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• 2022

The role of the interconnect network, which connects computing nodes to each other, is important in high-performance computing (HPC) systems. In recent years, the peripheral component interconnect express (PCIe) has become a promising interface as an interconnection network for high-performance and cost-effective HPC systems having the features of non-transparent bridge (NTB) technologies. OpenSHMEM is a programming model for distributed shared memory that supports a partitioned global address space (PGAS). Currently, little work has been done to develop the OpenSHMEM library for PCIe-interconnected HPC systems. This paper introduces a prototype implementation of the OpenSHMEM library through a switchless interconnect network using PCIe NTB to provide a PGAS programming model. In particular, multi-interrupt, multi-thread-based data transfer over the OpenSHMEM shared memory model is applied at the implementation level to reduce the latency and increase the throughput of the switchless ring network system. The implemented OpenSHMEM programming model over the PCIe NTB switchless interconnection network provides a feasible, cost-effective HPC system with a PGAS programming model.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.6B
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• pp.316-324
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• 2007

In this paper we proposed an energy consumption model for IR-UWB wireless sensor networks. The model takes the advantages of PHY-MAC cross layer design, and we used slotted and un-slotted sleeping protocols to compare the energy consumption. We addressed different system design issues that are responsible to energy consumption and proposed an optimum model for the system design. We expect the slotted sleeping will consume less energy for bursty load than that of the un-slotted one. But if we consider latency, the un-slotted sleeping model performs better than the slotted sleeping case.

• Proceedings of the Korea Information Processing Society Conference
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• 2022.05a
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• pp.517-519
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• 2022

In 5G network environment, proactive mobility management is essential as 5G mobile networks provide new services with ultra-low latency through dense deployment of small cells. The importance of a system that actively controls device handover is emerging and it is essential to predict mobile trajectory during handover. Sequence-to-sequence model is a kind of deep learning model where it converts sequences from one domain to sequences in another domain, and mainly used in natural language processing. In this paper, we developed a system for predicting mobile trajectory in a wireless network environment using sequence-to-sequence model. Handover speed can be increased by utilize our sequence-to-sequence model in actual mobile network environment.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.8
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• pp.49-58
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• 2016

In designing heterogeneous architecture based application-specific network-on-chips (NoCs), the opportunities of performance improvement would be expanded when applying asynchronous on-chip communication protocol. This is because the wire latency can be configured independently considering the wirelength of each link. In this paper, we develop the delay model of link-wire-length in asynchronous NoC and propose simulated annealing (SA) based floorplan-aware topology generation algorithm to optimize link-wirelengths. Incorporating the generated topology and the associated latency values across all links, we evaluate the performance using the floorplan-annotated sdf (standard delay format) file and RTL-synthesized gate-level netlist. Compared to TopGen, one of general topology generation algorithms, the experimental results show the reduction in latency by 13.7% and in execution time by 11.8% in average with regards to four applications.