• 동의생리병리학회지
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• 제17권2호
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• pp.416-422
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• 2003

Jaeumgenby-tang(JGT) have been used in oriental medicine for many centuries as a therapeutic agent of vertigo caused by deficiency of qi(氣) and blood(血). Effect of Aurantii Fructus(AF) take off the phlegm by promoting the circulation of qi, Gastrodae Rhizoma(GR) has effects treating for headache, vertigo by calming the liver and suppressing hyperactivity of the liver-yang(陽). And, We reported that JGT adding AFㆍGR extract(JGTAG) was significantly increased regional cerebral blood f1ow(rCBF) by dilating pial arterial diameter(PAD). Therefor we designed to investigate whether JGTAG is mediated by adrenergic β-receptor, cyclooxygenase or guanylate cyclase in normal rats. The changes of rCBF and mean arterial blood pressure(MABP) were determinated by laser-doppler flowmetry(LDF), and the change of PAD was determinated by video microscope and width analyzer. The results were as follows in normal rats; Pretreatment with propranolol(1mg/kg, i.v.) was significantly inhibited JGTAG induced increase of rCBF, PAD and MABP, and pretreatment with indomethacin(1 mg/kg, i.v.) was significantly inhibited too. But pretreatment with methylene blue(10μg/kg, i.v.) were accelerated JGTAG induced increase of rCBF and MABP, but pretreatment with methylene blue was inhibited JGTAG induced increase of PAD. This results suggest that the mechanism of JGTAG is mediated by adrenergic β-receptor and cyclooxygenase.

• 오토저널
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• 제6권2호
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• pp.14-19
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• 1984

종래에 많이 사용된 각양의 계측 방법을 일일이 설명하는 것은 본 해설의 목적이 아니기 때문에 개략적으로 분류하여 설명하면 다음과 같다. 1) 시간 평균유속은 주로 프로브(probe)를 경유하여 동압과 정압의 측정에 의하여 수행되어 왔다. 연소반응이 있으면 밀도의 변화가 있게 되는데 밀도는 후술하는 농도의 계측과 온도의 계측에 의하여 정해져 동압과 정압으로부터 유속으로 변환된다. 시간분해능이 높은 비접촉식(직접 프 로브를 측정부에 삽입하지 않는 방법) 유속측정이 가능한 방법으로는 레이저 도플러 유속계 (Laser Doppler Velocimetry, 이하 LDV로 표현)를 들 수 있다. LDV는 압력측정에 의한 유속 산출법에서와 같은 온도 및 농도 등의 부수적인 계측이 필요없이, 직접 유속을 검출할 수 있으며 또한 검정이 필요없는 절대유속 측정이 가능하며 현재 연소반응이 있는 흐름에 대한 대부분의 연구에 적용되고 있는 실정이다. 2) 시간평균 화학종 농도측정에 가장 많이 쓰이는 방법은, 연소가스를 채취하여 가스 크로마토 그라프(Gas Chromatograph)로 분석하는 것을 들 수 있다. 한편, 시간 분해능이 높은 화학종 농 도의 계측은 레이저를 사용하여 각 화학종의 발광, 산란 및 흡수성을 이용, 측정한다. 3) 온도측정은 대부분 열전대를 사용하고 있다. 그러나 이 방법은 직접 프로브를 삽입해야 하므로 사용한계의 범위가 지극히 좁으며, 연소반응이 일어나므로 프로브 자체의 촉매반응 및 복사 열전달에 의한 보정 등이 사용상 큰 문제로 제기된다. 그러나 최근 레이저 이용기술의 발달로 (2)항에서의 농도 계측과 같이 반응기체의 온도 및 성분의 동시측정이 가능한 방법도 점차 현 실화 되어가고 있다. 그 대표적인 예로 CARS법(Coherent Anti-Stokes Raman Spectroscopy)을 들 수 있다. 이상으로부터 연소반응이 일어나는 흐름에서의 각종 계측에서는, 비접촉 측정의 가능성과 시간 공간 분해능의 특징으로 미루어 앞으로는 레이저를 이용한 계측 방법이 그 주류를 이룰 것으로 사료된다. 우선 본 해설은 기체의 온도 및 농도의 광학적 측정방법중 Raman산란광 검출법에 대하여 실제로 측정하는 입장에서 간단히 소개한다.

• 한국소음진동공학회논문집
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• 제16권1호
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• pp.40-49
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• 2006

A novel disturbance measurement method, model based disturbance observer (MBDO) for optical disk drives (ODDs), is proposed and the disturbance analysis using the proposed method is performed under various conditions. In ODDs, the quantitative and qualitative analysis for the generated disturbance during normal operation is very important to successful servo loop design. However, the disturbance measurement is difficult, and high precision measurement is necessary. Furthermore, the conventional disturbance measurement method using a LDV (laser Doppler vibrometer) has many difficulties in eccentricity direction due to the vertical movement of an optical disk. To solve this problem, the MBDO is proposed. First, the relationship between the servo loop for ODDs and the generated disturbance are briefly reviewed. Second, the principle of the MBDO is introduced, and the disturbance measurement results, which are measured by the MBDO and a LDV, are compared. In these experiments, test DVD-ROM disks are used to generate quantitative/qualitative disturbance. Then, the disturbance analysis under various conditions is performed using waterfall technique. This technique clearly shows the disturbance trend from the inner part of an optical disk to the outer part of it. Finally, the various disturbances measurement results are summarized and some remarks for it are commented.

• 한국자동차공학회논문집
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• 제12권5호
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• pp.19-24
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• 2004

Entrainment of ambient gas into a transient diesel spray is a crucial factor affecting the following preparation of combustible mixture. In this study, the entrainment characteristics of ambient gas for a non-evaporating transient diesel were investigated using a common-rail injection system. The effects of ambient gas density and nozzle hole geometry were assessed with entrainment coefficient. Laser Doppler Velocimetry (LDV) technique was introduced to measure the entrainment speed of ambient gas into a spray. There appeared a region where the entrainment coefficients remained almost constant while injection rates were still changing. The effect of common-rail pressure, which altered the slope of injection rate curve, was hardly noticed at this region. Entrainment coefficient increased with ambient gas density, that is, the effect of ambient gas density was greater than that of turbulent jet whose entrainment coefficient remained constant. The non-dimensional distance was defined to reflect the effect of nozzle hole diameter and ambient gas density together. The mean value of entrainment coefficient was found to increase with non-dimensional distance from the nozzle tip, which would be suggested as the guideline for the nozzle design.

• 대한조선학회논문집
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• 제56권5호
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• pp.410-417
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• 2019

An axisymmetric submerged body(L=5.6m, Diam=0.53m) is installed in Large Cavitation Tunnel (LCT) of KRISO and the nominal and total velocities without and with the propeller in operation, respectively, are measured using Laser Doppler Velocimeter (LDV). The flow field is nearly axisymmetric except the wake of the supporting strut, and is considered ideal to study the hydrodynamic interaction between the propeller and the oncoming axisymmetric sheared flow. The measured velocity data are then provided to compute the propeller-induced velocity to get the effective velocity, which is defined by subtracting the propeller-induced velocity from the total velocity. We adopted, in computing the induced velocity, two different methods including the vortex lattice method and the vortex tube actuator model to evaluate the resultant effective velocity distribution. To secure a fundamental base of experimental data necessary for the research on the effective wake, we measured the drag of the submerged body, the nominal and total velocity distributions at various axial locations for three different tunnel water speeds.

• The Korean Journal of Physiology and Pharmacology
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• 제21권6호
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• pp.643-650
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• 2017

Vascular dementia (VaD) is a group of heterogeneous diseases with the common feature of cerebral hypoperfusion. To identify key factors contributing to VaD pathophysiology, we performed a detailed comparison of Wistar and Sprague-Dawley (SD) rats subjected to permanent bilateral common carotid artery occlusion (BCCAo). Eight-week old male Wistar and SD rats underwent BCCAo, followed by a reference memory test using a five-radial arm maze with tactile cues. Continuous monitoring of cerebral blood flow (CBF) was performed with a laser Doppler perfusion imaging (LDPI) system. A separate cohort of animals was sacrificed for evaluation of the brain vasculature and white matter damage after BCCAo. We found reference memory impairment in Wistar rats, but not in SD rats. Moreover, our LDPI system revealed that Wistar rats had significant hypoperfusion in the brain region supplied by the posterior cerebral artery (PCA). Furthermore, Wistar rats showed more profound CBF reduction in the forebrain region than did SD rats. Post-mortem analysis of brain vasculature demonstrated greater PCA plasticity at all time points after BCCAo in Wistar rats. Finally, we confirmed white matter rarefaction that was only observed in Wistar rats. Our studies show a comprehensive and dynamic CBF status after BCCAo in Wistar rats in addition to severe PCA dolichoectasia, which correlated well with white matter lesion and memory decline.

• 대한기계학회논문집B
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• 제22권2호
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• pp.139-152
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• 1998

In the present study, the flow characteristics of developing laminar oscillatory flows in a square -sectional 180 deg. curved duct are investigated experimentally. The experimental study using air in a square-sectional 180 deg. curved duct is carried out to measure velocity distributions with a data acquisition and LDV (Laser Doppler Velocimetry) processing system. In this system, Rotating Machinery Resolver (RMR) and PHASE program are used to obtain the results of unsteady flows. The major flow characteristics of developing oscillatory flows are found by analyzing velocity curves, mean velocity profiles, time-averaged velocity distribution of secondary flow, wall shear stress distributions, and entrance lengths. In a lower dimensionless angular frequency, the axial velocity distribution of laminar oscillatory flow in a curved duct shows a convex shape in a central part and axial symmetry. The maximum value of wall shear stress in a lower dimensionless angular frequency is located in an outside wall, but according to increasing the dimensionless angular frequency, the maximum of wall shear stress is moved to inner wall. The entrance lengths of laminar oscillatory flows in a square-sectional 180 deg. curved duct is obtained to 90 deg. of bended angle of duct in this experimental conditions.

• 대한기계학회논문집B
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• 제35권11호
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• pp.1147-1156
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• 2011

CLECDiS 는 면적변화형 정전용량 센서의 단점을 극복하고 나노미터 수준의 분해능으로 밀리미터 이상의 큰 변위를 측정하도록 개발된 접촉식 변위센서이다. 그러나 접촉구동 특성으로 인하여 표면평탄도와 마찰에 의해 작은 접촉상태의 변화에도 출력 신호는 크게 왜곡될 수 있어 실제 이를 활용하기 위해서는 전극간 접촉상태를 안정적으로 유지하는 것이 중요하다. 이에 본 연구에서는 전극간 접촉상태의 변화에 따른 신호의 왜곡 특성을 실제 출력 신호와 비교하여 분석하고, 접촉면 내 압력 분포와 센서의 운동 오차 측정을 통해 접촉상태의 변화를 파악하였다. 이를 통하여 센서의 운동 오차와 마찰력의 영향을 최소화하기 위한 접촉 유지 기구를 설계하고 제작하였으며 이를 이용한 구동실험을 통해 보다 안정적인 센서 출력 신호를 획득하였다.

• 대한인간공학회지
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• 제32권4호
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• pp.345-353
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• 2013

Objective: This research measured physiological and psychological effects of Vibroacoustic stimulation(VA) to scapular and sacrum of supine position on the mattress. Background: When vibroacoustic stimulation applies to human body, it has a positive influence on physiological and psychological effects by stimulating the organs, tissues and cells of whole body. Method: This experiment was conducted to 10 normal males in two conditions: no stimulation and vibroacoustic stimulation. No stimulation experiment was executed as a supine position for 30 minutes without any vibrational stimulus, while vibroacoustic stimulation was transmitted by the vibrational speaker, which uses 40Hz frequency. Subjects had a laser Doppler flowmeter probe in scapular, sacrum, and also had 8 channel electroencephalogram(EEG) measurement sensor in the scalp. Blood pressure and skin temperature were measured in two conditions with an underlying posture for 30 minutes. Additionally, blood flow rate and EEG were measured before and after for two minutes on two conditions. Results: According to the vibroacoustic stimulation, blood flow rate and skin temperature were increased, while blood pressure was decreased. When using vibroacoustic stimulation compared to no stimulation, blood flow rate went approximately two times higher, and skin temperature also higher 3~4 times. Furthermore, the relative alpha power of brain wave was significantly increased when we applied to vibroacoustic stimulation. Conclusion: This experiment tested the VAT embedded in mattress in two conditions. According to this experiment, VAT decreases blood pressure, improves not only a physiological effect on blood flow rate as well as skin temperature, but also psychological functions by increasing relative alpha power. Application: The results of the publishing trend analysis might help physiological and psychological effects of vibroacoustic stimulation.

• The Journal of Advanced Prosthodontics
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• 제2권1호
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• pp.7-13
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• 2010

Although most researchers agree that platelet-rich plasma (PRP) is a good source of autogenous growth factors, its effect on bone regeneration is still controversial. The purpose of this study was to evaluate whether increasing angiogenic factors in the human PRP to enhance new bone formation through rapid angiogenesis. MATERIAL AND METHODS. In vitro, the human platelets were activated with application of shear stress, $20\;{\mu}g/ml$ collagen, 2 mM $CaCl_2$ and 10U thrombin/$1\;{\times}\;10^9$ platelets. Level of vascular endothelial growth factor (VEGF) and platelet microparticle (PMP) in the activated platelets were checked. In the animal study, human angiogenic factors-enriched PRP was tested in 28 athymic rat's cranial critical bone defects with $\beta$-TCP. Angiogenesis and osteogenesis were evaluated by laser Doppler perfusion imaging, histology, dual energy X-ray densinometry, and micro-computed tomography. RESULTS. In vitro, this human angiogenic factors-enriched PRP resulted in better cellular proliferation and osteogenic differentiation. In vivo, increasing angiogenic potential of the PRP showed significantly higher blood perfusion around the defect and enhanced new bone formation around acellular bone graft material. CONCLUSION. Angiogenic factor-enriched PRP leads to faster and more extensive new bone formation in the critical size bone defect. The results implicate that rapid angiogenesis in the initial healing period by PRP could be supposed as a way to overcome short term effect of the rapid angiogenesis.