• Journal of the Computational Structural Engineering Institute of Korea
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• v.12 no.4
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• pp.537-549
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• 1999

선형탄성 파괴해석은 균열을 갖는 변형률 경화재료의 파괴거동을 예측하는데 불충분하기 때문에 최근에는 균열 선단 부에서 대규모 소성 역을 갖는 균열 체에 적용할 수 있는 많은 파괴역학개념이 제안되고 있다. 따라서, 본 연구에서는 대규모항복 조건하의 연성파괴를 보이는 평판을 정확하게 해석할 수 있는 새로운 유한요소모델을 제시하고자 한다. 균열 선단 부의 응력 장을 정의하는데 가장 지배적인 파괴매개변수인 J-적분 값과 소성 역의 크기 및 형상을 J-적분법과 등가영역적분법을 통해 파괴거동을 설명할 수 있도록 증분소성이론에 기초를 둔 p-version 유한요소해석이 채택되었다. 제안된 유한요소모델에 의한 수치해석결과는 이론 해와 h-version 유한요소해석과 비교되었다.

• Journal of the Korean Society of Safety
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• v.10 no.3
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• pp.3-10
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• 1995

For most engineering materials are influenced by the dominant mechanism resisting crack extention under large scale yielding conditions. Continuum mechanics analysis shows that fracture toughness, in addition to depending on young's modulus, flow stress strain hardening exponent, and yield strain, should be nearly proportoinal to the effective fracture ductility obtained for the stress state characteristic for region ahead of the crack; plane stress or plane strain. It's known that, in most ductile materials, crack propagation of the material strongly governed by the $J_{IC}$ value, which is still difficult to determine for it's complicate and treble-some determinative process. This paper, on the assumption that, initiation of crack tip strain field reaches on the relationships between the critical value of J-integral ($J_{IC}$) and the local fracture strain(${\varepsilon}_c$) in uniaxial tensile test in the region of maximun reduction areas was described.

• Structural Engineering and Mechanics
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• v.27 no.4
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• pp.425-438
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• 2007

Large changes in stiffness associated with cracking and yielding of reinforced concrete sections may be expected to occur during the dynamic response of reinforced concrete frames to earthquake ground shaking. These changes in stiffness in stories that experience cracking might be expected to cause relatively large peak interstory drift ratios. If so, accounting for such changes would add complexity to seismic design procedures. This study evaluates changes in an index parameter to establish whether this effect is significant. The index, known as the coefficient of distortion (COD), is defined as the ratio of peak interstory drift ratio and peak roof drift ratio. The sensitivity of the COD is evaluated statistically for five- and nine-story reinforced concrete frames having either uniform story heights or a tall first story. A suite of ten ground motion records was used; this suite was scaled to five intensity levels to cause varied degrees of damage to the concrete frame elements. Ground motion intensity was found to cause relatively small changes in mean CODs; the changes were most pronounced for changes in suite scale factor from 0.5 to 1 and from 1 to 4. While these changes were statistically significant in several cases, the magnitude of the change was sufficiently small that values of COD may be suggested for use in preliminary design that are independent of shaking intensity. Consequently, design limits on interstory drift ratio may be implemented by limiting the peak roof drift in preliminary design.

• Journal of Microbiology and Biotechnology
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• v.23 no.9
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• pp.1327-1338
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• 2013

The humanized anti-hepatocyte growth factor (HGF) monoclonal antibody (mAb) YYB-101 is a promising therapeutic candidate for treating various cancers. In this study, we developed a bioprocess for large-scale production of YYB-101 and evaluated its therapeutic potential for tumor treatment using a xenograft mouse model. By screening diverse chemically defined basal media formulations and by assessing the effects of various feed supplements and feeding schedules on cell growth and antibody production, we established an optimal medium and feeding method to produce 757 mg/l of YYB-101 in flask cultures, representing a 7.5-fold increase in titer compared with that obtained under non-optimized conditions. The optimal dissolved oxygen concentration for antibody production was 70% $pO_2$. A pH shift from 7.2 to 7.0, rather than controlled pH of either 7.0 or 7.2, resulted in productivity improvement in 5 L and 200 L bioreactors, yielding 737 and 830 mg/ml of YYB-101, respectively. The YYB-101 mAb highly purified by affinity chromatography using a Protein A column and two-step ion exchange chromatography effectively neutralized HGF in a cell-based assay and showed potent tumor suppression activity in a mouse xenograft model established with human glioblastoma cells.

• Earthquakes and Structures
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• v.5 no.6
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• pp.703-731
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• 2013

In order to verify the applicability of buckling restrained braces (BRB's) and fiber reinforced polymer (FRP) sheets to the seismic strengthening of a low-rise RC building having the irregularities of a soft/weak story and torsion at the ground story, a series of earthquake simulation tests were conducted on a 1:5 scale RC building model before, and after, the strengthening, and these test results are compared and analyzed, to check the effectiveness of the strengthening. Based on the investigations, the following conclusions are made: (1) The BRB's revealed significant slips at the joint with the existing RC beam, up-lifts of columns from RC foundations and displacements due to the flexibility of foundations, and final failure due to the buckling and fracture of base joint angles. The lateral stiffness appeared to be, thereby, as low as one seventh of the intended value, which led to a large yield displacement and, therefore, the BRB's could not dissipate seismic input energy as desired within the range of anticipated displacements. (2) Although the strengthened model did not behave as desired, great enhancement in earthquake resistance was achieved through an approximate 50% increase in the lateral resistance of the wall, due to the axial constraint by the peripheral BRB frames. Finally, (3) whereas in the original model, base torsion was resisted by both the inner core walls and the peripheral frames, the strengthened model resisted most of the base torsion with the peripheral frames, after yielding of the inner core walls, and represented dual values of torsion stiffness, depending on the yielding of core walls.

• Journal of the Korean Geotechnical Society
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• v.21 no.5
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• pp.51-58
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• 2005

In this study, the large scale model tests were executed to estimate the Load Sharing Ratio (LSR) of raft in a piled footing under various conditions. The conditions such as the subsoil type, pile length, pile spacing, away type and pile installation method etc. were varied in the pile loading tests about the free-standing group piles and a piled footing. As a result of this study, it was found that there was no difference in the load-settlement curves, resulting from the pile installation method and subsoil type. The piles supported most of the external load until a yielding load of the piled footing, but the raft supported a considerable load after a yielding load. As the relative density of sands increased, the LSR decreased. As the pile spacing was wider and the pile length increased, there was a tendancy for the LSR to increase. But it was also found that the LSR was not affected by the pile installation method and the subsoil type.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.4
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• pp.409-416
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• 2009

Standard procedures for a fracture toughness testing require very severe restrictions for the specimen geometry to eliminate a size effect on the measured properties. Therefore, the used standard fracture toughness data results in the integrity assessment being irrationally conservative. However, a realistic fracture in general structures, such as in nuclear power plants, may develop under the low constraint condition of a large scale yielding with a shallow surface crack. In this paper, cleavage fracture toughness tests have been made on side-grooved PCVN (precracked charpy V-notch) type specimens (10 by 10 by 55 mm) with various crack depths. The constraint effects on the crack depth ratios were evaluated quantitatively by the developed scaling method using the 3-D finite element method. After the fracture toughness correction from scaling model, the statistical size effects were also corrected according to the standard ASTM E 1921 procedure. The results were evaluated through a comparison with the $T_0$ of the standard CT specimen. The corrected $T_0$ for all of the PCVN specimens showed a good agreement to within $5.4^{\circ}C$ regardless of the crack depth, while the averaged PCVN $T_0$ was $13.4^{\circ}C$ higher than the real CT test results.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.30 no.6 s.249
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• pp.653-661
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• 2006

Metallic sandwich plates with various inner cores have important new features with not only ultra-light material characteristics and load bearing function but also multifunctional characteristics. Because of production possibility on the large scale and a good geometric precision, sandwich plates with inner dimpled shell structure from a single material have advantages as compared with other solid sandwich plates. Inner dimpled shell structures can be fabricated with press or roll forming process, and then bonded with two face sheets by multi-point resistance welding or adhesive bonding. Elasto-plastic bending behavior of sandwich plates have been predicted analytically and measured. The measurements have shown that elastic perfectly plastic approximation can be conveniently employed with less than 10% error in elastic stiffness, collapse load, and energy absorption. The dominant collapse modes are face buckling and bonding failure after yielding. Sandwich plates with inner dimpled shell structure can absorb more energy than other types of sandwich plates during the bending behavior.

• Journal of Korean Society of Steel Construction
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• v.14 no.1
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• pp.59-67
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• 2002

The ultimate strength testing of a two-story, single-bay, and sway allowed space steel frame was performed. Considering a majority of large-scale frame tests in the past, only two-dimensional frames were experimentally studied. Therefore, three-dimensional experiment is needed to extend the knowledge of this field. The steel frame subjected to non-proportional vertical and horizontal load was tested. The load-displacement curve of the test frame is provided. The experiment results are useful for verification of the three-dimensional numerical analysis. The results obtained from 3D non-linear analysis using ABAQUS were compared with experimental data.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.315.1-315.1
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• 2014

The use of cellulose papers has recently attracted much attention in various device applications owing to their natural advantageous properties of earth's abundance, bio-friendly, large-scale production, and flexibility. Conventional metal oxides with novel structures of nanorods, nanospindles, nanowires and nanobelts are being developed for emerging electronic and chemical sensing applications. In this work, both ZnO (n-type) nanorod arrays (NRAs) and CuO (p-type) nanospindles (NSs) were synthesized on cellulose papers and the p-n junction property was investigated using the electrode of indium tin oxide coated polyethylene terephthalate film. To synthesize ZnO and CuO nanostructures on cellulose paper, a simple and facile hydrothermal method was utilized. First, the CuO NSs were synthesized on cellulose paper by a simple soaking process, yielding the well adhered CuO NSs on cellulose paper. After that, the ZnO NRAs were grown on CuO NSs/cellulose paper via a facile hydrothermal route. The as-grown ZnO/CuO NSs on cellulose paper exhibited good crystalline and optical properties. The fabricated p-n junction device showed the I-V characteristics with a rectifying behaviour.