• The Journal of Internal Korean Medicine
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• v.29 no.2
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• pp.348-358
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• 2008

Objective : The aim of this experimental study was to investigate the anti-diarrhea effects of Jisa-tang using mice and guinea pigs. Methods : We feed Jisa-tang to mice and guinea pigs to investigate its effects for anti-diarrhea action. We observed its actions on gastrointestinal smooth muscles, on the transportability of small and large intestines, on diarrhea induced by castor oil and magnesium sulfate, and on enteropooling by castor oil and prostaglandin $E_2(PGE_2)$. Results : 1. Jisa-tang showed alleviation, depending on the density, only on the contraction of mice's gastrointestinal smooth muscles induced by histamine. 2. The transportability of the small intestine was not significantly constrained by Jisa-tang. However, the enhancement of pyridostigmine-induced transportability of he small intestine was significantly constrained in the group administered 900mg/kg of Jisa-tang (p<0.05). 3. The transportability of large intestine was significantly constrained in the group administered 1,800mg/kg of Jisa-tang. 4. Jisa-tang showed significant anti-diarrhea effects on diarrhea induced by castor oil and by $MgSO_4$ in the group administered 1,800mg/kg of Jisa-tang. 5. Significant reduction of effects of enteropooling induced by caster oil and by prostaglandin $E_2$ were observed only in the group administered 1,800mg/kg of Jisa-tang. Conclusions : We conclude that Jisa-tang has advantageous effects on drug-induced diarrhea and will contribute to the development of diarrhea treatment through further related studies.

• Asian-Australasian Journal of Animal Sciences
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• v.21 no.4
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• pp.603-615
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• 2008

Dietary fiber is an inevitable component in pig diets. In non-ruminants, it may influence many physiological processes in the gastrointestinal tract (GIT) such as transit time as well as nutrient digestion and absorption. Moreover, dietary fiber is also the main substrate of intestinal bacteria. The bacterial community structure is largely susceptible to changes in the fiber content of a pig's diet. Indeed, bacterial composition in the lower GIT will adapt to the supply of high levels of dietary fiber by increased growth of bacteria with cellulolytic, pectinolytic and hemicellulolytic activities such as Ruminococcus spp., Bacteroides spp. and Clostridium spp. Furthermore, there is growing evidence for growth promotion of beneficial bacteria, such as lactobacilli and bifidobacteria, by certain types of dietary fiber in the small intestine of pigs. Studies in rats have shown that both phosphorus (P) and calcium (Ca) play an important role in the fermentative activity and growth of the intestinal microbiota. This can be attributed to the significance of P for the bacterial cell metabolism and to the buffering functions of Ca-phosphate in intestinal digesta. Moreover, under P deficient conditions, ruminal NDF degradation as well as VFA and bacterial ATP production are reduced. Similar studies in pigs are scarce but there is some evidence that dietary fiber may influence the ileal and fecal P digestibility as well as P disappearance in the large intestine, probably due to microbial P requirement for fermentation. On the other hand, fermentation of dietary fiber may improve the availability of minerals such as P and Ca which can be subsequently absorbed and/or utilized by the microbiota of the pig's large intestine.

• Journal of Haehwa Medicine
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• v.13 no.1
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• pp.225-241
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• 2004

Objectives & Methods: We investigated 45 books to study etiology, pathology and acupuncture & Moxibustion treatment of diarrhea. Result and Conclusion 1. The pathogenic factors of diarrhea are external sensation(外邪感受), jungjishiljo(情志失調), weakness of the spleen and stomach(脾胃虛弱), improper diet(飮食不節), sinyanghueson(腎陽虧損), sueumyujang(水飮留腸), liver Gi invades the sp1een(肝氣乘脾), uhhyuljeche(瘀血阻滯). 2. The etiological cause of diarrhea are closely related to the malfunction of the spleen & stomach(脾胃) and the related jang and bu(臟腑)'s pathological alternation such as spleen & stomach(脾胃), large intestine(大腸), small intestine(小腸), liver(肝), sp1een(脾), and kidney(腎). 3. Acupuncture and moxibustion treatment application of diarrhea with the meridian system are in the following order from the most often mentioned meridian system to the least, urinary bladder meridian(膀胱經), spleen meridian(脾經), stomach meridian(胃經), conception channel meridian(任脈經), liver mehdian(肝經), governor channel meridian(督脈經), large intestine meridian(大腸經), lung meridian(肺經), triple-warmer meridian(三焦經), gall bladder meridian(膽經), Pericardium meridian(心包經). 4. Acupuncture and moxibustion treatment application of diarrhea with meridian point are in the following order from the most often mentioned meridian point to the least, Cheonchu(天樞) sixteen times, Sin-gwol(神厥) fifteen times, Joksamni(足三理), Gwanwon(關元) each twelve times, Daejangsu(大腸兪) eleven times, Taechung(太衝), Bisu(脾兪), Sojangsu(小腸兪) each ten times,Sinsu(腎兪) nine times, CC12(中脘) eight times, Samchosu(三焦兪), gokcheon(曲泉), Harweom(下廉) each seven times, Samgan(三間), Sameungyo(三陰交), Yisa(意舍), Jungnyo, Gyeungmun(京門) each six times, Gyeonggol(京骨), Jangmun(章門) each five times, Sangnyeom(上廉), Hapgok(合谷), Yangmun(梁門), Sanggu(商丘), Yanggang(陽綱), Hoeyang(會陽), Gihyeol(氣穴), Taegye(太谿), Gihae(氣海) each four times.

• Journal of Life Science
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• v.15 no.5 s.72
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• pp.707-714
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• 2005

The conventional histochemical staining were used to study mucosubstances properties of intestinal striated border and goblet cells in four teleostean species, i. e., Sebastes schlegeli, Halichoeres poecilopterus, Bryzoichthys lysimus, and Takifugu pardalis. The following methods were used; PAS, AB pH 2.5, AB pH 1.0, AB pH 2.5-PAS, AF pH 1.7-AB pH 2.5 and HID-AB pH 2.5 stains. The mucosubstances of striated border in the proximal intestine and rectum of Sebastes schlegeli contained with neutral mucin, middle and distal intestine contained with neutral mucin and acid mucin. The striated border of all the intestines of Halichoeres poecilopterus contained with neutral mucin and acid mucin, and those of Bryzoichthys lysimus and Tnkifugu pardalis contained with neutral mucin only. The amounts of neutral mucin were moderate to considerable in Sebastes schlegeli and Halichoeres poecilopterus, minimal to small in Bryzoichthys lysimus and Tnkifugu pardalis. The amounts and properties in mucosubstances of intestinal goblet cells showed differences in species and regions. The intestinal goblet cells of Bryzoichthys lysimus, and Tnkifugu pardalis contained neutral mucin only while Sehastes schlegeli and Halichoeres poecilopterus contained mixture of neutral mucin, sulfomucin and sialomucin. The amounts of neutral mucin were considerable to large in distal intestine and rectum of Tnkifugu pardalis, while moderate to considerable in all intestines of Sehastes schlegeli, all the intestines except for middle intestine of Bryzoichthys lysimus, and proximal and middle intestine of Tnkifugu pardalis. Also it was minimal to small in middle intestine of Halichoeres poecilopterus. The intestinal goblet cells of Sehastes schlegeli contained mixture of minimal amounts of strong sulfmucin, weak sulfomucin and minimal to small amounts of sialomucin, and those of Halichoeres poecilopterus except for rectum contained mixture of minimal to small amounts of strong sulfomucin and sialomucin.

• Korean Journal of Veterinary Research
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• v.51 no.4
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• pp.289-295
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• 2011

Toxocara (T.) canis and Trichuris (T.) vulpis are very important canine parasitic nematodes. T. canis parasitize in small intestine and T. vulpis parasitize in large intestine. In order to control of these nematodes, ivermectin and pyrantel pamoate compound was applied to the dogs infected with these parasites naturally and artificially. This drug was composed of $68.0{\mu}g$ of ivermectin and 57.0 mg of pyrantel pamoate for small animal, $136.0{\mu}g$ of ivermectin and 114.0 mg of pyrantel pamoate for middle animal, and $272.0{\mu}g$ of ivermectin and 227.0 mg of pyrantel pamoate for large animal. Ivermectin in this drug is activity to nematodes and ectoparisites. Pyrantel pamoate in this drug is also activity to nematodes. In this experiment, this drug had a good efficacy against T. canis and T. vulpis in the infected dogs.

• Journal of Veterinary Clinics
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• v.18 no.1
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• pp.78-81
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• 2001

A 12-year old female Pointer was referred to the Veterinary Teaching Hospital, College of Veterinary Medicine, Kyungpook National University for evaluation of emaciation. The owner had noted a dysuria and dyschesia 2 months before admitting to the hospital. The patient showed anorexia, depression and mild anemia. Radiographic findings indicated the mass below the urinary bladder, which pushed the intestine up to the spine. The patient was necropsied and grossly, two large masses were found on the heart and cranial thorax. Congestive nodules of 0.5-1.5 cm in diameter were scattered on both sides of the lungs. The left ventricular wall was hypertrophied and adult heartworms were found in right atrium. A large mass, filled with blood, 9-10 cm in diameter, originated from the rectum, compressed urethra. The gall bladder was filled with bile juice and the spleen was mild atrophied. The cortex of the kidney and the intestine were congested. On microscopic observation, there were neoplastic cells forming irregular vascular channels in the lung, kidney and heart. The vascular channels contain variable amount of blood. In the lung, the cells were almost elongated and the nuclei of neoplastic cells were round or ovoid and hyperchromatized. Based on the observation, the case was diagnosed as a hemangiosarcoma.

• The Journal of Korean Medicine
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• v.28 no.3 s.71
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• pp.232-243
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• 2007

Objective : This study researched the application of Sa-am acupuncture for the treatment of hiccup. Methods : We investigated the literature for Sa-am acupuncture treatment and traditional acupuncture treatment for hiccup. Result & Conclusion : In traditional oriental medicine, hiccup is considered to be caused by uprising stomach gi, whereas, in Sa-am acupuncture, it is considered to be caused by weakness and impurity of lung gi. In Sa-am acupuncture, hiccup is divided into five classes; reverse hiccup (treated with large intestine tonification), wind hiccup (treated with liver tonification), fire hiccup (treated with heart tonification), damp hiccup (treated with spleen tonification) and cold hiccup (treated with kidney tonification). In traditional oriental medicine, hiccup is treated by way of lowering the uprising stomach gi, while, in Sa-am acupuncture, hiccup is treated by way of removing whichever of the original cause of hiccups (impurity of large intestine, damage to liver, dry heat of heart, impairment of spleen, exhaustion of kidney) caused the weakness and the impurity of lung gi. In Sa-am acupuncture, the therapeutic mode for all the five causes of hiccups is tonification mode.

• Asian-Australasian Journal of Animal Sciences
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• v.13 no.11
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• pp.1499-1507
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• 2000

This trial was to compare the digestive function of laboratory animals, which included omnivores (rats) and herbivores (rabbits, guinea pigs and hamsters). Ten weanling rats, rabbits, guinea pigs and hamster were randomly allocated in individual metabolic cages for a performance and a digestibility trial. Results showed that guinea pigs were significantly best in digestion of dietary crude protein and fiber. Rabbits, however, had the poorest nutrient digestion among the herbivores. Crude fiber digested significantly less by rats than by the herbivores (p<0.05). The digesta retention in the GI tract was longest in rabbits followed by guinea pigs, rats and hamsters. The relative length of the large intestine was significantly shorter in rats as compared to guinea pigs or hamsters. Both the weight and length ratio of the caecum or colon-rectum to the large intestine reflected the major site for fermentation that was the caecum in rabbits and the colon-rectum in guinea pigs. 10% of crude fiber diet did not result in damaged mucosa in any of the experimental animals in this trial.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.10 no.1
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• pp.139-158
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• 1997

A Literature study on the external treatment of nose diseases, the results are as follows; 1. Nose was called "Cheun-bin(天牝)", was outer orifice of the lung, was the gate of vital energe(氣), The main function of nose is divided three pacts. One is the respiration, another is the sense of smell, the other is the sounding consonance. 2. Nose is concerned with The Lung(肺), The Spleen(脾), The Heart(心), The Stomach(胃), The Large intestine(大腸), The Bladder(膀胱) in the organs, is concerned with Lung Meridean, Large intestine Meridean, Stomach Meridean, Heart Meridean, Spleen Meridean, Governor Vessel Meridean etc. 3. The method on the external treatment of nose diseases is classified with obstructive method, pouring method, blowing method, attaching method, plaster method, rubbing method, cleansing method, poulticing method. In frequency of practical use, Obstructive method is used 276 cases, Blowing method is used 123 cases, Attaching method is used 103 cases, Plaster method is used 76 cases. 4. In frequency of the medicinal works on the external treatment of nose diseases, Herba Asari(細辛) is used 134 cases, Pedicellus Melo(瓜 ) is used 85 cases, Radix Aconiti Praeparata(附子) is used 52 cases, Herba Agastachis(麝香) is used 51 cases, Semen Armeniacae Amarurn(杏仁) is used 44 cases etc. In frequency of a prescription on the external treatment of nose diseases, Tongcho-san(通草散) is used 9 cases, $Sesin-go{\cdot}Sinyi-go{\cdot}Changpo-san$ are used 8 cases, $Kwache-san{\cdot}Wungwhang-san$ are used 7 cases etc.

• The Journal of Pediatrics of Korean Medicine
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• v.35 no.1
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• pp.30-39
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• 2021

Objective The purpose of this study is to learn the anti-inflammatory effect of Douchi on ulcerative colitis (UC). Methods Three-month-old mice were divided into 4 groups as follows: control group (Ctrl), UC induced group (UCEG), Pentasa treated group after inducing UC (OPTG), and Douchi treated group after inducing UC (FGTG). NF-κB, p-IκB, iNOS, COX-2 were observed by immunohistochemistry and Masson trichrome, PAS, and Phloxine-tartrazine staining were used to observe histochemical changes. Results Inflammation indicators of the large intestine were significantly lower in FGTG than in the UCEG and OPTG. Also, indicators involved in pulmonary alveolar formation were significantly higher in the FGTG than in the UCEG and OPTG. Conclusions The result of this study suggests that Douchi extract was effective in ulcerative colitis and helped in the formation of alveolar. This result suggests that the lungs and colon are correlated.