• Journal of the Korea Safety Management & Science
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• v.6 no.4
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• pp.47-59
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• 2004

Safety in the laboratory has been a growing interest due to recent recurrences of the fatal accidents such as physical or chemical explosions. It is not easy to determine the extent to what the industrial safety and health law should be applicable to the laboratory. Most laboratory workers are not sufficiently trained and recognized for the generic features of safety and health. The actual conditions of safety and health in the laboratory are not familar with laboratory workers. Safety and health in the laboratory is unfortunately in the dead ground. Therefore, it is most imperative to secure safety in the laboratory. This study proposes a method to improve safety in the laboratory.

• Proceedings of the Safety Management and Science Conference
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• 2004.11a
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• pp.289-299
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• 2004

Safety in the laboratory has been a growing interest due to recent recurrences of the fatal accidents such as physical or chemical explosions. It is not easy to determine, to what extents the industrial safety and health law should apply the laboratory. Most laboratory workers are not sufficiently trained and recognized for the generic features of safety and health. The actual conditions of safety and health in the laboratory are not appropriate for laboratory workers. Safety and health in the laboratory is unfortunately in the dead ground. Therefore, it is most imperative to secure safety in the laboratory. This study proposes a method to improve safety in the laboratory.

• Journal of Microbiology and Biotechnology
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• v.27 no.7
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• pp.1276-1280
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• 2017

The mcr-1 gene is a new "superbug" gene discoverd in China in 2016 that makes bacteria highly resistant to the last-resort class of antibiotics. The mcr-1 gene raised serious concern about its possible global dissemination and spread. Here, we report a potential anti-resistant strategy using the CRISPR/Cas9-mediated approach that can efficiently induce mcr-1 gene knockout in Escherichia coli. Our findings suggested that using the CRISPR/Cas9 system to knock out the resistance gene mcr-1 might be a potential anti-resistant strategy. Bovine myeloid antimicrobial peptide-27 could help deliver plasmid pCas::mcr targeting specific DNA sequences of the mcr-1 gene into microbial populations.

• Journal of the Ergonomics Society of Korea
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• v.35 no.2
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• pp.97-109
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• 2016

Objective: The aim of this study is to identify the domestic and foreign laboratory safety management system and to suggest domestic laboratory safety management policy priority. Background: Various types of accidents are occurred in research laboratories according to a variety of laboratory safety risks. However, there are only lists of incidents without any precise accident analysis. Method: We analyzed statistically the survey on current status of laboratory safety management of universities, research institutes, and industrial research institutions carried out by Ministry of Science, ICT and Future Planning in Korea. We also investigated laboratory safety management systems and safety organization carried out mainly in overseas countries such as USA, Japan, Switzerland and France. In addition, we analyze the UCLA College laboratory explosion occurred in the US in 2010. Results: More than 75 percent of 2015 domestic laboratory accidents were occurred in the field of operation management and chemistry research. Also, approximately 55% of accidents took place due to careless use mechanical instruments & dangerous chemicals. In addition, common difficulties of lab safety act applicable organizations are overlapping and comprehensive application of legal requirements. Conclusion: There is a need for laboratory safety professional organizations. Also, the high frequency of use of hazardous substances in the high-risk, such as the chemical field must be strengthened the laboratory safety management. In addition, it is needed to minimize the problems of the research organizations through close cooperation between related ministries and government support policy such as professional development program. Application: The result of this analysis might help to present a differentiated safety management policy and advanced safety management system in laboratory.

• International Journal of Safety
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• v.6 no.2
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• pp.33-37
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• 2007

In recent days, the accidents have happened at experimental laboratories in universities or institutes. In order to improve safety assurance of workers in laboratories, it is required to carry out systematic study concerned with evaluation of safety and health level. The safety and health inspection checklists were developed and conducted the case study. The case study was carried out laboratory safety inspection with 5 inspectors by the checklists to become aware of safety and health level. From the evaluation results of the inspection, we could be made quantification of laboratory through evaluation of safety and health level in laboratory. It was found that was recognized present states of the laboratory and established a plan for improvements in laboratory safety facilities from the case study. The safety inspection checklists can be used as basic data to establish evaluation criteria of safety and health level.

• Nuclear Engineering and Technology
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• v.53 no.9
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• pp.2977-2981
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• 2021

Corrosion fatigue crack growth (FCG) behavior of 316LN stainless steel was investigated in high-temperature pressurized water at different temperatures, load ratios (R = K_max/K_min) and rise times (t_R). The environmental assisted effect on FCG rate was observed when both the R and t_R exceeded their critical values. The FCG rate showed a linear relation with stress intensity factor range (ΔK) in double logarithmic coordinate. The environmental assisted effect on FCG rate depended on the ΔK and quantitative relations were proposed. Possible mechanisms of environmental assisted FCG rate under different testing conditions are also discussed.

• 한국가스학회:학술대회논문집
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• 2005.10a
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• pp.157-162
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• 2005

• Journal of the Korea Safety Management & Science
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• v.17 no.3
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• pp.89-96
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• 2015

The study was conducted with statical analysis of data (828 data in 2010, 752 data in 2012, 648 data in 2014) in order to evaluate laboratory awareness difference of research employees working in different types of universities. Results of the study were as follows: First, university institutes in the order of polytechnic colleges, university, and junior college showed the highest laboratory safety awareness in 'awareness and education of laboratorial safety regulation' and 'awareness in laboratory risk factors'. Second, the difference in safety awareness of universities by year(years that conducted current status survey) was the highest in year 2014, then in 2010, and in 2008. Third, the difference of research employees working for laboratory safety management by year(years that conducted current status) showed that university had the highest laboratory safety awareness in year 2010, but it changed to polytechnic colleges in year 2012 and 2014. Through this study, we could recognize the difference in safety awareness of research employees working in university institutes.

• Nuclear Engineering and Technology
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• v.53 no.8
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• pp.2600-2609
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• 2021

Low cycle fatigue behaviors of SA508-3 low-alloy steel were investigated in room-temperature air, high-temperature air and in light water reactor (LWR) water environments. The fatigue mean curve and design curve for the low-alloy steel are developed based on the fatigue data in room-temperature and high-temperature air. The environmental fatigue model for low-alloy steel is developed by the environmental fatigue correction factor (F_en) methodology based on the fatigue data in LWR water environments with the consideration of effects of strain rate, temperature, and dissolved oxygen concentration on the fatigue life.

• Nuclear Engineering and Technology
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• v.53 no.1
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• pp.103-110
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• 2021

In the development of a Risk Monitor probabilistic safety assessment (PSA) model from the basic PSA model of a nuclear power plant, the modeling of common-cause failure (CCF) is very important. At present, some approximate modeling methods are widely used, but there lacks criterion of modeling accuracy and error analysis. In this paper, aiming at ensuring the accuracy of risk assessment and minimizing the Risk Monitor PSA models size, we present three basic issues of CCF model resulted from the changes of a nuclear power plant configuration, put forward corresponding modeling methods, and derive accuracy criteria of CCF modeling based on minimum cut sets and risk indicators according to the requirements of risk monitoring. Finally, a nuclear power plant Risk Monitor PSA model is taken as an example to demonstrate the effectiveness of the proposed modeling method and accuracy criteria, and the application scope of the idea of this paper is also discussed.