• Clinical and Experimental Pediatrics
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• 제55권6호
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• pp.206-211
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• 2012

Purpose: The increasing prevalence of breast feeding has led to concerns about vitamin D deficiency (VDD) and iron deficiency anemia (IDA) in children. We evaluated the prevalence of VDD in a population of Korean children with IDA and assessed the risk factors for VDD in these children. Methods: A total of 79 children who were diagnosed with IDA were prospectively surveyed from April 2010 to March 2011. Data were collected by questionnaire, medical assessment, and laboratory tests, including measurement of 25-hydroxyvitamin D (25OHD), hemoglobin, and wrist radiography. Results: The median age was 22 months and 30% of the subjects were female. Over a half of subjects (58%) had subnormal vitamin D level (25OHD<30 ng/mL), and VDD (25OHD<20 ng/mL) was present in 39% of children. There was no difference in serum hemoglobin level between IDA patients with VDD and those without VDD. Most subjects (89%) were currently or had recently been breastfed and almost all subjects (97%) who had VDD received breastfeeding. Children with VDD were more likely to be younger than 2 years, to have been breastfed, and to have been tested in winter or spring. Multivariable analysis indicated seasonal variation was a significant independent risk factor for VDD in our IDA patients. Conclusion: Our results demonstrated that VDD has a high prevalence in Korean children with IDA. Primary care physicians should be aware of the possibility of VDD in children with IDA and should supplement the vitamin D as well as iron.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권2호
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• pp.671-686
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• 2020

Due to the long training time and high training cost of traditional surgical training methods, the emerging virtual surgical training method has gradually replaced it as the mainstream. However, the virtual surgical system suffers from poor authenticity and high computational cost problems. For overcoming the deficiency of these problems, we propose an optimized model for the local compression deformation of soft tissue. This model uses a simulated annealing algorithm to optimize the parameters of the soft tissue model to improve the authenticity of the simulation. Meanwhile, although the soft tissue deformation is divided into local deformation region and non-deformation region, our proposed model only needs to calculate and update the deformation region, which can improve the simulation real-time performance. Besides, we define a compensation strategy for the "superelastic" effect which often occurs with the mass-spring model. To verify the validity of the model, we carry out a compression simulation experiment of abdomen and human foot and compare it with other models. The experimental results indicate the proposed model is realistic and effective in soft tissue compression simulation, and it outperforms other models in accuracy and real-time performance.

• Journal of the Korean Wood Science and Technology
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• 제44권6호
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• pp.913-922
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• 2016

This study attempted to measure molecular weight (MW) of melamine-urea-formaldehyde (MUF) resins prepared by two different synthesis methods: the one-step MUF resins were synthesized in one batch procedure, while the two-step MUF resins were prepared by a physical mixing of urea-formaldehyde (UF) resin with melamine-formaldehyde (MF) resin that had been synthesized in a separate procedure. The properties of medium density fiberboard (MDF) panels bonded with two types of MUF resins were also investigated. MWs of these MUF resins were measured using gel permeation chromatography (GPC). In addition, this study measured the MWs of one-step MUF resin during its synthesis procedure. The performance of two types of MUF resins was evaluated by determining properties of MDF panels prepared in laboratory. As the synthesis procedure progressed, both number average MW ($M_n$) and weight average MW ($M_w$) of one-step MUF resin gradually increased, while the polydispersity index (PDI) decreased. And low Mw species of the resin predominantly decreased as the synthesis step progressed. The one-step MUF resin showed greater $M_n$ and $M_w$ than those of the two-step ones even though the PDI values of both resins were very similar each other. As expected, the one-step MUF resin resulted in better properties of MDF panels than those of two-step resins. In particular, the one-step MUF resin provided better internal bond (IB) strength and thickness swelling (TS) with MDF panels than those of two-step ones, indicating better water resistance of the one-step resin. These results suggest that the preparation method of MUF resins have a great impact on the MW and final panel properties.

• 대한약침학회지
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• 제13권4호
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• pp.43-61
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• 2010

Objectives : This study was performed to analyse single dose toxicity of Sweet Bee Venom(Sweet BV) extracted from the bee venom in Beagle dogs. Methods : All experiments were conducted under the regulations of Good Laboratory Practice (GLP) at Biotoxtech Company, a non-clinical study authorized institution. Male and female Beagle dogs of 5-6 months old were chosen for the pilot study of single dose toxicity of Sweet BV which was administered at the level of 9.0 mg/kg body weight which is 1300 times higher than the clinical application dosage as the high dosage, followed by 3.0 and 1.0 mg/kg as midium and low dosage, respectively. Equal amount of excipient(normal saline) to the Sweet BV experiment groups was administered as the control group. Results : 1. No mortality was witnessed in all of the experiment groups. 2. Hyperemia and movement disorder were observed around the area of administration in all the experiment groups, and higher occurrence in the higher dosage treatment. 3. For weight measurement, Neither male nor female groups showed significant changes. 4. To verify abnormalities of organs and tissues, thigh muscle which treated with Sweet BV, brain, liver, lung, kidney, and spinal cords were removed and histologocal observation using H-E staining was conducted. In the histologocal observation of thigh muscle, cell infiltration, inflammation, degeneration, necrosis of muscle fiber, and fibrosis were found in both thigh tissue. And the changes depend on the dose of Sweet BV. But the other organs did not showed in any abnormality. 5. The maximum dose of Sweet BV in Beagle dogs were over 9 mg/kg in this study. Conclusions : The above findings of this study suggest that Sweet BV is a relatively safe treatment medium. Further studies on the toxicity of Sweet BV should be conducted to yield more concrete evidences.

• 한국지반공학회논문집
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• 제21권10호
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• pp.17-25
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• 2005

벤더엘리먼트 시험은 시험시편의 전단파속도를 직접 측정함으로써 최대전단탄성계수를 평가하기 위한 시험법으로, 다양한 실내시험장비에 간단히 부착되어 다양한 시험조건에서 시편의 최대전단탄성계수를 평가할 수 있는 유용한 시험기법으로 현재 널리 이용되고 있는 추세다. 본 연구에서는 포화가 가능하도록 개조된 Stokoe식 공진주/비틂전단 시험장비에 벤더엘리먼트 시험장비를 부착하여 동일한 시험시편에 대하여 다양한 조건에서 벤더엘리먼트 시험, 공진주 시험, 비틂전단 시험의 세 가지 시험을 동시에 수행함으로써 각 시험법에 의하여 평가되는 최대전단탄성계수를 비교하였으며, 벤더엘리먼트 시험기법을 검증해보고자 하였다. 또한 포화조건에서 Biot의 이론을 적용하여 각 시험기법의 하중주파수를 고려함으로써 보다 타당한 비교를 수행할 수 있었다.

• Clinical and Experimental Pediatrics
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• 제56권1호
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• pp.19-25
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• 2013

Purpose: Childhood obesity is associated with nonalcoholic fatty liver disease (NAFLD), and it has become one of the most common causes of childhood chronic liver diseases which significant as a cause of liver related mortality and morbidity in children in the United States. The development of simpler and easier clinical indices for medical practice is needed to identify advanced hepatic fibrosis in childhood NAFLD instead of invasive method like liver biopsy. FibroScan and aspartate aminotransferase (AST)-to-platelet ratio index (APRI) have been proposed as a simple and noninvasive predictor to evaluate hepatic fibrosis in several liver diseases. APRI could be a good alternative to detect pathologic change in childhood NAFLD. The purpose of this study is to validate the efficacy of APRI for assessing hepatic fibrosis in childhood NAFLD based on FibroScan. Methods: This study included 23 children with NAFLD who underwent FibroScan. Clinical, laboratory and radiological evaluation including APRI was performed. To confirm the result of this study, 6 patients received liver biopsy. Results: Factors associated with hepatic fibrosis (stiffness measurement >5.9 kPa Fibroscan) were triglyceride, AST, alanine aminotransferase, platelet count, APRI and collagen IV. In multivariate analysis, APRI were correlated with hepatic fibrosis (>5.9 kPa). In receiver operating characteristics curve, APRI of meaningful fibrosis (cutoff value, 0.4669; area under the receiver operating characteristics, 0.875) presented sensitivity of 94%, specificity of 66%, positive predictive value of 94%, and negative predictive value of 64%. Conclusion: APRI might be a noninvasive, simple, and readily available method for medical practice to predict hepatic fibrosis of childhood NAFLD.

• 대한약침학회지
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• 제12권4호
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• pp.5-32
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• 2009

Objectives: This study was performed to analyse single dose toxicity of pure melittin(Sweet Bee Venom-Sweet BV) extracted from the bee venom by utilizing protein isolation method of gel filtration. Methods: All experiments were conducted at Biotoxtech, a non-clinical studies authorized institution, under the regulations of Good Laboratory Practice (GLP). Six weeks old female Sprague-Dawley rats were chosen for the pilot study and determined 30㎎/㎏ which is 4285 times higher than the clinical application dosage as the high dosage, followed by 15 and 7.5㎎/㎏ as mid and lose dosage, respectively. Equal amount of excipient to the Sweet BV experiment groups was administered as the control group. Results: 1. No mortality was witnessed in all of the experiment groups. 2. Hyperemia and movement disorder were observed around the area of administration in all groups, and higher occurrence in the higher dosage groups. Hyperemia and movement disorder diminished with elapsed time. 3. For the weight measurement, male groups showed larger reduction in weight in accordance with higher dosage. Female groups didn't s how significant changes. 4. To verify abnormalities of organs and tissues, cerebellum, cerebrum, liver, lung, kidney, and spinal nerves were removed and conducted histological observation with H-E staining. No abnormalities were detected in any of organs and tissues. 5. One female rat in the 30㎎/㎏ group had amputated toe near the administered area and histopathological finding was hemorrhage with inflammation. This is presumed as a secondary infection after the administration of Sweet BV. Conclusion: Above findings suggest Sweet BV is relatively s safe treatment medium. Further studies on the subject should be conducted to yield more concrete evidences.

• 지질공학
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• 제25권2호
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• pp.281-290
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• 2015

남한 지역에서 수행된 검층밀도 자료를 수집하고 코어밀도 자료와 비교 분석하였다. 먼저 코어밀도와 검층밀도 자료의 비교로부터 검층밀도가 비이상적으로 낮은 현상이 얻어졌으며 이는 소선원 검층밀도 자료에서의 비이상적으로 낮은 밀도와 연관되어 있음이 밝혀졌다. 표준선원과 소선원 자료간의 큰 밀도 차이를 비롯하여 표준선원 검층밀도와 코어밀도 간의 상관성 비교에서 나타난 분포곡선의 형태, 평균값, 표준편차 등 모든 결과들이 소선원 밀도자료의 품질에 이상이 있음을 보였다. 소선원 밀도자료에서의 품질 이상은 검층밀도 결정에서 소선원 밀도검층기가 지니는 선원 특성과 연결되었으며 결론적으로 지금까지의 소선원 밀도자료는 정확성을 유지하기 위한 최소의 조건이 충족되지 못한 상태에서 얻어진 것으로 판단하였다. 끝으로 코어자료와 표준선원 자료를 사용하여 남한지역 주요 지층의 밀도 분포 특성이 결정되었다.

• Smart Structures and Systems
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• 제21권1호
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• pp.53-64
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• 2018

Nondestructive testing methods are required to assess the condition of civil structures and formulate their maintenance programs. Axial force identification is required for several structural members of truss bridges, pipe racks, and space roof trusses. An accurate evaluation of in situ axial forces supports the safety assessment of the entire truss. A considerable redistribution of internal forces may indicate structural damage. In this paper, a novel compressive force identification method for prismatic members implemented using static deflections is applied to steel beams. The procedure uses the Euler-Bernoulli beam model and estimates the compressive load by using the measured displacement along the beam's length. Knowledge of flexural rigidity of the member under investigation is required. In this study, the deflected shape of a compressed steel beam is subjected to an additional vertical load that was short-term measured in several laboratory tests by using fiber Bragg grating-differential settlement measurement (FBG-DSM) sensors at specific cross sections along the beam's length. The accuracy of midspan deflections offered by the FBG-DSM sensors provided excellent force estimations. Compressive load detection accuracy can be improved if substantial second-order effects are induced in the tests. In conclusion, the proposed method can be successfully applied to steel beams with low slenderness under real conditions.

• 대한화장품학회지
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• 제30권4호
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• pp.549-553
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• 2004

화장품중의 미생물을 검출하는데 소요되는 시간을 $48{\~}72{\;}h$에서 24 h 이내로 단축하고자 하는 목적으로 자동화 방법으로서 ATP bioluminescence 시스템과 impedance 시스템에 대한 비교 평가를 수행하였다. 인위적으로 저농도의 미생물로 오염시킨 에멀전 제형에 대하여 표준 한천 평판 배지법과 ATP bioluminescence 방법 및 impedance 측정 방법으로 분석을 실시한 결과에서 모두 유의한 검출 결과를 나타내었으며, 실제 적용 실험 결과에서도 각각 $95\%$ 이상의 좋은 상관관계를 나타내었다. 오염균으로는 표준 균주로서 Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli와 사내 현장 검출 균주인 Ralstonia mannitolilytica를 사용하였다. 본 검증 결과에 따라 화장품의 미생물 품질 관리 방법으로 ATP bioluminescence 방법 또는 impedance 측정 방법을 활용한 자동화 장비의 사용을 통해 신속한 품질 판정이 가능하게 되었다.