• Interdisciplinary Bio Central
• /
• v.4 no.3
• /
• pp.10.1-10.12
• /
• 2012

Introduction: We investigated frameshift suppressor tRNAs previously reported to use five-base anticodon-codon interactions in order to provide a collection of frameshift suppressor tRNAs to the synthetic biology community and to develop modular frameshift suppressor logic devices for use in synthetic biology applications. Results and Discussion: We adapted eleven previously described frameshift suppressor tRNAs to the BioBrick cloning format, and built three genetic logic circuits to detect frameshift suppression. The three circuits employed three different mechanisms: direct frameshift suppression of reporter gene mutations, frameshift suppression leading to positive feedback via quorum sensing, and enzymatic amplification of frameshift suppression signals. In the course of testing frameshift suppressor logic, we uncovered unexpected behavior in the frameshift suppressor tRNAs. The results led us to posit a four-base binding hypothesis for the frameshift suppressor tRNA interactions with mRNA as an alternative to the published five-base binding model. Conclusion and Prospects: The published five-base anticodon/codon rule explained only 17 of the 58 frameshift suppression experiments we conducted. Our deduced four-base binding rule successfully explained 56 out of our 58 frameshift suppression results. In the process of applying biological knowledge about frameshift suppressor tRNAs to the engineering application of frameshift suppressor logic, we discovered new biological knowledge. This knowledge leads to a redesign of the original engineering application and encourages new ones. Our study reinforces the concept that synthetic biology is often a winding path from science to engineering and back again; scientific investigations spark engineering applications, the implementation of which suggests new scientific investigations.

• Proceedings of the Korea Society of Information Technology Applications Conference
• /
• 2005.11a
• /
• pp.281-284
• /
• 2005

Kerberos is system that offer authorization in internet and authentication service. Can speak that put each server between client and user in distributed environment and is security system of symmetry height encryption base that offer authentication base mutually. Kerberos authentication is based entirely on the knowledge of passwords that are stored on the Kerberos Server. A user proves her identity to the Kerberos Server by demonstrating Knowledge of the key. The fact that the Kerberos Server has access to the user's decrypted password is a rwsult of the fact that Kerberos does not use public key cryptogrphy. It is a serious disadvantage of the Kerbercs System. The Server must be physically secure to prevent an attacker from stealing the Kerberos Server and learning all of the user passwords. Kerberos was designend so that the server can be stateless. The Kerberos Server simply answers requests from users and issues tickets. This study focused on designing a SIP procy for interworking with AAA server with respect to user authentication and Kerberos System. Kerberos is security system of encryption base that offer certification function mutually between client application element and server application element in distributed network environment. Kerberos provides service necessary to control whether is going to approve also so that certain client may access to certain server. This paper does Credit-Control Server's function in AAA system of Diameter base so that can include Accounting information that is connected to Rating inside certification information message in Rating process with Kerberos system.

• Journal of KIISE:Software and Applications
• /
• v.36 no.5
• /
• pp.411-419
• /
• 2009

In order to derive hidden Information (concept subsumption, concept satisfiability and realization) of OWL ontologies, a number of OWL reasoners have been introduced. Most of the reasoners were implemented to be based on tableau algorithm. However this approach has certain limitation. This paper presents architecture for Medusa. The Medusa is an extended DL-reasoner for SWRL(Semantic Web Rule Language) reasoning under well-founded semantics with ontologies specified in Description Logic. Description logic based ontology reasoners theoretically explore knowledge representation and its reasoning in concept languages. However these logics are not equipped with rule-based reasoning mechanisms for assertional knowledge base; specifically, rule and facts in logic programming, or interaction of rules and facts with terminology. In order to deal with the enriched reasoning, The Medusa provides combining DL-knowledge base and rule based reasoner. The described prototype uses $Prot{\acute{e}}g{\acute{e}}$ API[1] for controlling communication with the ontology reasoner.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.5 no.1
• /
• pp.173-182
• /
• 2001

In this paper, we discuss how ontology Plays roles in building a distributed and heterogeneous knowledge-base system. First, we discuss relationship between ontology and agent in the Knowledgeable Community which is a framework of knowledge sharing and reuse based on a multi-agent architecture. Ontology is a minimum requirement for each agent to join the Knowledgeable Community. Second we explain mediation by ontology to show how ontology is used in the Knowledgeable Community. A special agent called mediation analyzes undirected messages and infer candidates of recipient agents by consulting ontology and relationship between ontology and agents. Third we model ontology as combination of aspects each of which can represent a way of conceptualization. Aspects are combined either as combination aspect which means integration of aspects or category aspect which means choice of aspects. Since ontology by aspect allows heterogeneous and multiple descriptions for phenomenon in the world, it is appropriate for heterogeneous knowledge-base systems. We also show translation of messages as a wave of interpreting multiple aspects. A translation agent can translate a message with some aspect to one with another aspect by analyzing dependency of aspects. Mediation and translation of messages are important to build agents easily and naturally because less knowledge on other agents is requested for each agent.

• Korean Journal of Adult Nursing
• /
• v.23 no.5
• /
• pp.514-524
• /
• 2011

The Korean Society of Adult Nursing (KSAN) was founded in 1971. KSAN is dedicated to the development of nursing's knowledge base and specifically in the area of adult nursing. Other goals are knowledge dissemination, promotion of nursing research and education, and the encouragement and support of nurse researchers, nurse educators and nurse practitioners through forums fostering interactions. With more than 1,100 active members in 2011, this year we celebrate the 40th anniversary of KSAN by lookingback at our past, living our present, and pursuing the future. KSAN has six branches nationwide and is governed by an eleven board of directors. KSAN's conferences, held two or three times every year, offer members opportunities to share creative nursing ideas. The Korean Journal of Adult Nursing (KJAN), our bi-monthly Journal, provides innovative ideas in the field of adult nursing for our members through peer-reviewed articles. It was launched in 1989, listed in the Cumulative Index to Nursing and Allied Health Literature (CINAHL) in 2011, and strives to publish the best articles. Each issue of the Journal examines current problems and trends in nursing practice, education, and research. On the occasion of our 40th anniversary, we pledge to continue the development of our society in order to meet the needs of our members, and contribute to expand and extend the knowledge base of adult nursing.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2006.05a
• /
• pp.813-816
• /
• 2006

Today us the creation of knowledge and find, accumulation and use ability is living in the knowledge base society where the base of social advancement becomes. The social members as sleep and the production where is not the consumer of knowledge, own lead whole life studying as they sleep and, they are soft and an open accident, must equip the hazard which gets information and the knowledge which are new the whole life must endeavor. From the hazard which is adapted to like this social change the education for a technical find was necessary absolutely, the education against an updated technology became essential element from the If field which changes soddenly specially. From the dissertation which it sees if in the object facing each other from IT curriculum analyzes the merit and demerit of method and the WBI and against the hereafter developmental subject for an efficient education to sleep it researches the IT industry worker and it does.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2006.05a
• /
• pp.939-942
• /
• 2006

Currently, There is a conference system in one field of knowledge base system, the study against a conference of multimedia approach method is become accomplished actively. However, Case of the conference system which is studied from multimedia viewpoint, only it will bring the merit and demerit of the off-line conference of existing with on-line, it isn't considering to make knowledge plan of important conference content and method. This thesis proposes stand of Knowledge-base system architecture for it break from the method which composes a conference system from the multimedia side of existing and focus it will be able to contain existing systems to conference contents and method.

• The Korean Journal of Emergency Medical Services
• /
• v.12 no.2
• /
• pp.45-58
• /
• 2008

This study examined the knowledge and health education about First Aid of Physical Education College Students. The survey had been done from September to November, 2007. Total subjects in this study were 193. The collected data were analyzed by SPSS. The results of the study were as follows : 1. Among total 193, 74.6% were male, 25.4% were female, 1st grade were 38.9%, 2nd grade were 61.1%. 58% of the subjects had not been trained first aid education. 2. For needs assessment about first aid education contents, the needs for first aid was high(2.36) of the lecture, and assessment of emergency situation(2.65) was high of the practice. Legal problems of first aid was low of the lecture and practice. 3. An average the knowledge score of the subjects was 55.1088(${\pm}19.09$) when the knowledge score of subjects converted 100 points. 4. There were significant difference in the knowledge of first aid according to subject's gender(t=2.907, p= .004), grade(t=-7.167, p= .000), and experience of first aid education(t=5.174, p= .000). These results will provide the base data for the development of first aid education program for physical education college students.

• Journal of the Institute of Electronics and Information Engineers
• /
• v.50 no.4
• /
• pp.83-88
• /
• 2013

Many studies adopting brain functions to the engineering systems have been made for recent years as the brain Science has developed. If we investigate the parts which take part in memorizing and emotional process, we can know that Hippocampus of memorizing center and Amygdala of Emotional center closely cooperate each other. Actually Knowledge effects on Emotion and Emotion effects on Knowledge. During the human decision making, emotional factor has much important effects on Decision making process. For implementing more delicate intelligent system, the knowledge base coupled to emotional factor should be designed. Accordingly in this paper starting from the idea of cooperating system between Hippocampus and Amygdala,, we design Knowledge Emotion Binding System and propose Emotional changing mechanism by Memory retrieval and knowledge reasoning process.

• The Journal of Korean Academic Society of Nursing Education
• /
• v.12 no.1
• /
• pp.104-114
• /
• 2006

Genetic knowledge for oncology nurses is important in Korea because oncologists are incorporating genetic counseling and genetic testing into their practice. The purpose of this paper is to describe our method of developing the first academic cancer genetic risk assessment and counseling course for Korean nurses. A one-week (non-credit) cancer genetics counseling program was constructed for master's level Korean oncology nurses. The course emphasized basic genetic concepts and principles the genetics of cancer; hereditary cancer syndromes; family history assessments; pedigree construction; risk calculation; surveillance recommendations and treatment options ethical, legal, social, and psychological issues inherent in genetic testing. The goals of this program are to: 1) provide a comprehensive knowledge base for nurses who are currently expanding their scope of practice into the genetic counseling role 2) introduce this knowledge to nurses who want to use it in their practice; and 3) provide cancer genetic knowledge and resources to Korean nursing faculty who plan to incorporate this knowledge into existing master's courses. This academically-based course is recognized as valuable by nurses, nursing faculty, and physicians. With this new knowledge nurses can begin toexpand their role in delivering comprehensive cancer care services.