• 한국통신학회논문지
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• 제31권10C호
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• pp.1011-1022
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• 2006

최근 유무선 네트워크는 IP 코어망을 중심으로 가입자망의 형태를 가지는 BcN(Broadband convergence Network)로 진화되고 있으며, 이와 함께 인간 외부환경의 감지를 수행할 유비쿼터스 센서네트워크(USN : Ubiquitous Sensor Network)가 새로이 연구되어 오고 있다. 감지하는 대부분의 데이터의 경우에 악의를 가진 노드에게 노출되거나 위변조 되어서는 안될 정보들이기 때문에 센서네트워트에서 에너지 효율을 고려한 정보보호 기법을 요구한다. 본 논문에서는 임의의 센서노드부터 싱크까지의 에너지 효율적이고 안전한 데이터 전달을 위한 정보보호기법으로, 단순한 해쉬함수의 계산을 중심으로 에너지 소모를 줄이는 키관리기법을 제안하였다. 제안하는 키관리기법의 보안성 분석을 위하여 만족해야 하는 보안성에 대해 정의 증명하였으며, 에너지효율성을 측정하였다. 각 기법은 기존의 관련연구와 비교 분석하여 본 논문에서 제안한 기법이 우수함을 증명하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2699-2705
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• 2014

This study was to undertaken to investigate the impacts of AhR, CYP1A1, GSTM1 genetic polymorphisms on the R273G mutation in exon 8 of the tumor suppressor p53 gene (TP53) among polycyclic aromatic hydrocarbons (PAHs) exposed to coke-oven workers. One hundred thirteen workers exposed to PAH and 82 control workers were recruited. We genotyped for polymorphisms in the AhR, CYP1A1, GSTM1, and TP53 R273G mutation in blood by PCR methods, and determined the levels of 1-hydroxypyrene as PAH exposure marker in urine using the high pressure liquid chromatography assay. We found that the distribution of alcohol users and the urinary excretion of 1-OHP in the exposed workers were significantly higher than that of the control workers (p=0.004, p<0.001, respectively). Significant differences were observed in the p53 genotype distributions of smoking subjects (p=0.01, 95%CI: 1.23-6.01) and PAH exposure (p=0.008, 95%CI: 1.24-4.48), respectively. Further, significant differences were observed in the p53 exon 8 mutations for the genetic polymorphisms of Lys/Arg for AhR (p=0.02, 95%CI: 0.70-15.86), Val/Val for CYP1A1 (p=0.04, 95%CI: 0.98-19.09) and null for GSTM1 (p=0.02, 95%CI: 1.19-6.26), respectively. Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers.

• Nuclear Engineering and Technology
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• 제53권6호
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• pp.1942-1946
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• 2021

Gadolinium oxysulfide (GOS) is regarded as a novel scintillator for the realization of ultra-high spatial resolution in neutron imaging. Monte Carlo simulations of GOS scintillator show that the capability of its spatial resolution is towards the micron level. Through the time-of-flight method, the light output of a GOS scintillator was measured to be 217 photons per captured neutron, ~100 times lower than that of a ZnS/LiF:Ag scintillator. A detector prototype has been developed to evaluate the imaging solution with the GOS scintillator by neutron beam tests. The measured spatial resolution is ~36 ㎛ (28 line pairs/mm) at the modulation transfer function (MTF) of 10%, mainly limited by the low experimental collimation ratio of the beamline. The weak light output of the GOS scintillator requires an enormous increase in the neutron flux to reduce the exposure time for practical applications.

• Asian Pacific Journal of Cancer Prevention
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• 제15권9호
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• pp.3981-3986
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• 2014

Ganoderma lucidum polysaccharides (GLP) extracted from Ganoderma lucidum have been shown to induce cell death in some kinds of cancer cells. This study investigated the cytotoxic and apoptotic effect of GLP on HCT-116 human colon cancer cells and the molecular mechanisms involved. Cell proliferation, cell migration, lactate dehydrogenase (LDH) levels and intracellular free calcium levels ($[Ca^{2+}]i$) were determined by MTT, wound-healing, LDH release and fluorescence assays, respectively. Cell apoptosis was observed by scanning and transmission electron microscopy. For the mechanism studies, caspase-8 activation, and Fas and caspase-3 expression were evaluated. Treatment of HCT-116 cells with various concentrations of GLP (0.625-5 mg/mL) resulted in a significant decrease in cell viability (P< 0.01). This study showed that the antitumor activity of GLP was related to cell migration inhibition, cell morphology changes, intracellular $Ca^{2+}$ elevation and LDH release. Also, increase in the levels of caspase-8 activity was involved in GLP-induced apoptosis. Western blotting indicated that Fas and caspase-3 protein expression was up-regulated after exposure to GLP. This investigation demonstrated for the first time that GLP shows prominent anticancer activities against the HCT-116 human colon cancer cell line through triggering intracellular calcium release and the death receptor pathway.

• 디지털융복합연구
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• 제13권10호
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• pp.343-351
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• 2015

현재 M2M 환경은 다양한 서비스가 기관 및 기업이나 일상생활로 확대되면서 관련 기술의 보안 취약성 발생 가능성이 이슈화되고 있다. 본 논문은 이러한 보안 취약성 문제를 해결하기 위해 M2M 환경의 디바이스 키 보호를 위한 암호 알고리즘 응용 기법을 제안한다. 제안 기법은 타원곡선 암호 기반으로 초기 키 교환과 서명 교환을 통해 보안 세션을 생성하였고, 화이트박스 암호는 보안 세션 키를 이용하여 화이트박스 테이블을 생성하는 암호화에 응용하였다. 암호 알고리즘 적용 결과, 타원곡선 암호는 통신 세션에 대한 경량 화된 상호인증, 세션 키 보호를 제공하고, 화이트 박스 암호는 기존 암호 알고리즘과는 다른 방식으로 암호화에 사용되는 세션 키 보호를 보장하였다. 제안하는 프로토콜은 데이터변조 및 노출, 중간자 공격, 데이터 위조 및 변조 공격에 대해 안전한 장점이 있다.

• Plant Biotechnology Reports
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• 제4권3호
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• pp.213-222
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• 2010

Within their natural habitat, crops are often subjected to drought and heat stress, which suppress crop growth and decrease crop production. Causing overaccumulation of glycinebetaine (GB) has been used to enhance the crop yield under stress. Here, we investigated the response of wheat (Triticum aestivum L.) photosynthesis to drought, heat stress and their combination with a transgenic wheat line (T6) overaccumulating GB and its wild-type (WT) Shi4185. Drought stress (DS) was imposed by controlling irrigation until the relative water content (RWC) of the flag leaves decreased to between 78 and 82%. Heat stress (HS) was applied by exposing wheat plants to $40^{\circ}C$ for 4 h. A combination of drought and heat stress was applied by subjecting the drought-stressed plants to a heat stress as above. The results indicated that all stresses decreased photosynthesis, but the combination of drought and heat stress exacerbated the negative effects on photosynthesis more than exposure to drought or heat stress alone. Drought stress decreased the transpiration rate (Tr), stomatal conductance (Gs) and intercellular $CO_2$ concentration (Ci), while heat stress increased all of these; the deprivation of water was greater under drought stress than heat stress, but heat stress decreased the antioxidant enzyme activity to a greater extent. Overaccumulated GB could alleviate the decrease of photosynthesis caused by all stresses tested. These suggest that GB induces an increase of osmotic adjustments for drought tolerance, while its improvement of the antioxidative defense system including antioxidative enzymes and antioxidants may be more important for heat tolerance.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2013년도 춘계학술대회
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• pp.856-858
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• 2013

USN(Ubiquitous Sensor Network) 환경에서 센싱(sensing)된 데이터는 개인의 프라이버시 및 기업의 비밀 정보와 관련되어 있지만 일반 네트워크에 비해 보안에 취약한 특성을 가지고 있다. 즉, USN은 센서 정보의 도청, 비정상적인 패킷의 유통, 메시지의 재사용, 데이터 위변조 공격, 서비스 거부 공격 등에 쉽게 노출되는 취약점을 가지고 있다. 따라서 USN 환경에서 센서 노드들의 사이의 안전한 통신을 위해서는 반드시 키가 필요하다. 본 논문에서는 센서 네트워크의 특성을 고려한 ECDH 알고리즘을 이용하여 클러스터 기반 키 분배 프로토콜인 KDPC(Key Distributed Protocol based on Cluster)을 설계한다. 그 결과, 데이터 위변조 공격을 탐지하고, 센싱된 데이터의 노출을 방지함으로써 안전한 USN 환경을 제공할 수 있다.

• 한국통신학회논문지
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• 제35권3B호
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• pp.462-473
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• 2010

RFID(Radio-Frequency IDentification) 시스템은 개인 정보의 노출 및 위치 추적과 같은 보안상 문제점을 가지고 있다. 이러한 문제점을 해결하기 위해 해쉬함수와 같은 암호학적 접근방법들은 안전성을 증명하고 있지만 태그의 연산능력과 저장 공간의 한계로 인해 현실적으로 적용하기 어렵다. 최근의 경량 인증기법들은 단순 연산자만을 사용하여 높은 효율성을 보장하지만 안전성에 관한 주장이 충분하지 못하다. 본 논문에서는 안전한 RFID 인증을 위해서 대칭키 방식의 AES(Advanced Encryption Standard)를 이용하며 대칭키 방식에서의 고정된 키를 사용하던 문제를 단계적인 키 변환을 통해 해결한다. 프로토콜에서 태그와 서버의 동일한 대칭키는 태그, 리더, 백-엔드-서버에서 각각 생성된 난수를 이용하여 차례로 변환되며 태그와 리더의 출력 값을 항상 변경한다. 이와 같이 단계적으로 변환된 키를 이용할 경우 태그 정보의 노출 문제를 해결하며 도청, 재전송, 위치추적 및 스푸핑과 같은 공격에도 안전한 상호 인증이 이루어진다.

• Journal of Microbiology and Biotechnology
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• 제20권12호
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• pp.1630-1636
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• 2010

During the fermentation process of Saccharomyces cerevisiae, yeast cells must rapidly respond to a wide variety of external stresses in order to survive the constantly changing environment, including ethanol stress. The accumulation of ethanol can severely inhibit cell growth activity and productivity. Thus, the response to changing ethanol concentrations is one of the most important stress reactions in S. cerevisiae and worthy of thorough investigation. Therefore, this study examined the relationship between ethanol tolerance in S. cerevisiae and a unique protein called alcohol sensitive RING/PHD finger 1 protein (Asr1p). A real-time PCR showed that upon exposure to 8% ethanol, the expression of Asr1 was continuously enhanced, reaching a peak 2 h after stimulation. This result was confirmed by monitoring the fluorescence levels using a strain with a green fluorescent protein tagged to the C-terminal of Asr1p. The fluorescent microscopy also revealed a change in the subcellular localization before and after stimulation. Furthermore, the disruption of the Asr1 gene resulted in hypersensitivity on the medium containing ethanol, when compared with the wild-type strain. Thus, when taken together, the present results suggest that Asr1 is involved in the response to ethanol stress in the yeast S. cerevisiae.

• Computers and Concrete
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• 제24권3호
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• pp.249-258
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• 2019

In order to investigate the strength recovery of fire-damaged concrete after post-fire curing, concrete specimens were heating at $2^{\circ}C/min$ or $5^{\circ}C/min$ to 400, 600 and $800^{\circ}C$, and these exposed specimens were soaked in the water for 24 hours and following by 29-day post-fire curing. The compressive strength and split tensile strength of the high-temperature-exposed specimens before and after post-fire curing were tested. The proportion of split aggregate in the split surfaces was analyzed to evaluate the mortar-aggregate interfacial strength. After the post-fire curing process, the split tensile strength of specimens exposed to all temperatures was recovered significantly, while the recovery of compressive strength was only obvious within the specimens exposed to $600^{\circ}C$. The tensile strength is more sensitive to the mortar-aggregate interfacial cracks, which caused that the split tensile strength decreased more after high-temperature exposure and recovery more after post-fire curing than the compressive strength. The mortar-aggregate interfacial strength also showed remarkable recovery after post-fire curing, and it contributed to the recovery of split tensile strength.