• Journal of the Korea Society of Computer and Information
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• v.16 no.1
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• pp.143-151
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• 2011

Plaintext and key are independent in the existing block cipher. Also, encryption/decryption is performed by using structural features. Therefore, the external environment of suggested mixed cryptographic algorithm is identical with the existing ones, but internally, features of the existing block cipher were meant to be removed by making plaintext and key into dependent functions. Also, to decrease the loads on the authentication process, authentication add-on with dependent characteristic was included to increase the use of symmetric cryptographic algorithm. Through the simulation where the proposed cryptosystem was implemented in the chip level, we show that our system using the shorter key length than the length of the plaintext is two times faster than the existing systems.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2313-2318
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• 2014

Peroxisome proliferator-activated receptor gamma (PPAR-${\gamma}$), a ligand-dependent nuclear transcription factor, has been found to widely exist in tumor tissues and plays an important role in affecting tumor cell growth. In this study, we investigated the effect of PPAR-${\gamma}$ on aspects of the cervical cancer malignant phenotype, such as cell proliferation and apoptosis. Cell growth assay, Western blotting, Annexin V and flow cytometry analysis consistently showed that treatment with troglitazone (TGZ, a PPAR-${\gamma}$ agonist) led to dose-dependent inhibition of cervical cancer cell growth through apoptosis, whereas T0070907 (another PPAR-${\gamma}$ antagonist) had no effect on Hela cell proliferation and apoptosis. Furthermore, we also detected the protein expression of p53, p21 and Mdm2 to explain the underlying mechanism of PPAR-${\gamma}$ on cellular apoptosis. Our work, finally, demonstrated the existence of the TGZ-PPAR-${\gamma}$-p53 signaling pathway to be a critical regulator of cell apoptosis. These results suggested that PPAR-${\gamma}$ may be a potential therapeutic target for cervical cancer.

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.5
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• pp.682-685
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• 2005

Large White, an introduced European pig breed, and Meishan, a Chinese indigenous pig breed, were hybridized directly and reciprocally and a total of 260 pigs, including purebreds, Large White and Meishan, and their hybrids, White${\times}$Meishan (LM) and Meishan${\times}$Large White (ML) pigs, were bred in our laboratory. The mRNA differential display PCR (DD-PCR) was used to detect the age-dependent changes of differential gene expression in backfat tissue between hybrids and parents. Some measures were taken to reduce the false positives in our experiment. Among the total of 2,686 bands obtained, 1,952 bands (about 72.67%) were reproducible and eight patterns (fifteen kinds) of gene expression were observed. The percentage of differentially expressed genes between hybrids and parents is 56.86% at the age of four months and 57.71% at the age of six months. This indicated that the differences of gene expression between hybrids and their parents were very obvious. U-test was used to compare the patterns of gene expression between the age of four and six months, and results showed that bands occurring in only one hybrid and bands displayed in one hybrid and one parent were significantly different at p<0.05, and bands visualized in only two hybrids were significantly different at p<0.01. These indicated that differential gene expression between hybrids and parents changed at different ages.

• Bulletin of the Korean Mathematical Society
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• v.54 no.4
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• pp.1195-1219
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• 2017

In this paper, the limit behavior of solution for the $Schr{\ddot{o}}dinger$ equation with random dispersion and time-dependent nonlinear loss/gain: $idu+{\frac{1}{{\varepsilon}}}m({\frac{t}{{\varepsilon}^2}}){\partial}_{xx}udt+{\mid}u{\mid}^{2{\sigma}}udt+i{\varepsilon}a(t){\mid}u{\mid}^{2{\sigma}_0}udt=0$ is studied. Combining stochastic Strichartz-type estimates with $L^2$ norm estimates, we first derive the global existence for $L^2$ and $H^1$ solution of the stochastic $Schr{\ddot{o}}dinger$ equation with white noise dispersion and time-dependent loss/gain: $idu+{\Delta}u{\circ}d{\beta}+{\mid}u{\mid}^{2{\sigma}}udt+ia(t){\mid}u{\mid}^{2{\sigma}_0}udt=0$. Secondly, we prove rigorously the global diffusion-approximation limit of the solution for the former as ${\varepsilon}{\rightarrow}0$ in one-dimensional $L^2$ subcritical and critical cases.

• Archives of Pharmacal Research
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• v.28 no.6
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• pp.709-715
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• 2005

The purpose of this study was to investigate the effect of atropine on peripheral vasodilation and the mechanisms involved. The isometric tension of rat mesenteric artery rings was recorded in vitro on a myograph. The results showed that atropine, at concentrations greater than 1$\mu$M, relaxed the noradrenalin (NA)-precontracted rat mesenteric artery in a concentration-dependent manner. Atropine-induced vasodilatation was mediated, in part, by an endothelium-dependent mechanism, to which endothelium-derived hyperpolarizing factor may contribute. Atropine was able to shift the NA-induced concentration-response curve to the right, in a non-parallel manner, suggesting the mechanism of atropine was not mediated via the ${\alpha}_1$-adrenoreceptor. The $\beta$-adrenoreceptor and ATP sensitive potassium channel, a voltage dependent calcium channel, were not involved in the vasodilatation. However, atropine inhibited the contraction derived from NA and $CaCl_2$ in $Ca^{2+}$-free medium, in a concentration dependent manner, indicating the vasodilatation was related to the inhibition of extracellular $Ca^{2+}$ influx through the receptor-operated calcium channels and intracellular $Ca^{2+}$ release from the $Ca^{2+}$ store. Atropine had no effect on the caffeine-induced contraction in the artery segments, indicating the inhibition of intracellular $Ca^{2+}$ release as a result of atropine most likely occurs via the IP3 pathway rather than the ryanodine receptors. Our results suggest that atropine-induced vasodilatation is mainly from artery smooth muscle cells due to inhibition of the receptor-mediated $Ca^{2+}$-influx and $Ca^{2+}$-release, and partly from the endothelium mediated by EDHF.

• Journal of the Korea Institute of Military Science and Technology
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• v.21 no.5
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• pp.658-664
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• 2018

In this paper, we propose a group key management scheme for very high confidential information in tactical wireless networks. For the proposed scheme, we consider the tactical networks that has a hierarchical topology and the nature of high confidential information. The leader node, which may have higher probability of good channel state than others, provides some data to all the network member in order to generate a geographical group key and it transmits the encrypted information with minimum transmission power level to others. By this scheme, the security and reliability for sharing confidential information is ensured. The performance of the proposed scheme is validated by mathematical analysis. It shows that the proposed scheme makes nodes to share a high confidential information securely if the proper parameters for network design are selected.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.1
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• pp.382-403
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• 2020

Steganography is the art of concealing the existence of a secret data in a non-secret digital carrier called cover media. While the image of steganography methods is extensively researched, studies on other cover files remain limited. Videos are promising research items for steganography primitives. This study presents an improved approach to video steganography. The improvement is achieved by allowing senders and receivers exchanging secret data without embedding the hidden data in the cover file as in traditional steganography methods. The method is based mainly on searching for exact matches between the secret text and the video frames RGB channel pixel values. Accordingly, a random key-dependent data is generated, and Elliptic Curve Public Key Cryptography is used. The proposed method has an unlimited embedding capacity. The results show that the improved method is secure against traditional steganography attacks since the cover file has no embedded data. Compared to other existing Steganography video systems, the proposed system shows that the method proposed is unlimited in its embedding capacity, system invisibility, and robustness. The system achieves high precision for data recovery in the receiver. The performance of the proposed method is found to be acceptable across different sizes of video files.

• Geomechanics and Engineering
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• v.20 no.6
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• pp.517-525
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• 2020

The long-term stability of rock engineering is significantly affected by the time-dependent deformation behavior of rock, which is an important mechanical property of rock for engineering design. Although the hard rocks show small creep deformation, it cannot be ignored under high-stress condition during deep excavation. The inner mechanism of creep is complicated, therefore, it is necessary to investigate the relationship between microscopic creep mechanism and the macro creep behavior of rock. Microscopic numerical modeling of sandstone creep was performed in the investigation. A numerical sandstone sample was generated and Parallel Bond contact and Burger's contact model were assigned to the contacts between particles in DEM simulation. Sensitivity analysis of the microscopic creep parameters was conducted to explore how microscopic parameters affect the macroscopic creep deformation. The results show that the microscopic creep parameters have linear correlations with the corresponding macroscopic creep parameters, whereas the friction coefficient shows power function with peak strength and Young's modulus, respectively. Moreover, the microscopic parameters were calibrated. The creep modeling curve is in good agreement with the verification test result. Finally, the creep curves under one-step loading and multi-step loading were compared. This investigation can act as a helpful reference for modeling rock creep behavior from a microscopic mechanism perspective.

• BMB Reports
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• v.41 no.5
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• pp.376-381
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• 2008

The discovery of RNA silencing inhibition by virus encoded suppressors or low temperature leads to concerns about the stability of transgenic resistance. RNA-dependent RNA polymerase (RdRp) has been previously characterized to be essential for transgene-mediated RNA silencing. Here we showed that low temperature led to the inhibition of RNA silencing, the loss of viral resistance and the reduced expression of host RdRp homolog (NtRdRP1) in transgenic T4 progeny with untranslatable potato virus Y coat protein (PVY-CP) gene. Moreover, RNA silencing and the associated resistance were differently inhibited by potato virus X (PVX) and tobacco mosaic virus (TMV) infections. The increased expression of NtRdRP1 in both PVX and TMV infected plants indicated its general role in response to viral pathogens. Collectively, we propose that biotic and abiotic stress factors affect RNA silencing-mediated resistance in transgenic tobacco plants and that their effects target different steps of RNA silencing.

• Journal of Veterinary Science
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• v.24 no.5
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• pp.55.1-55.12
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• 2023

Background: Peste des petits ruminants (PPR), caused by the PPR virus (PPRV), is an acute and fatal contagious disease that mainly infects goats, sheep, and other artiodactyls. Peripheral blood mononuclear cells (PBMCs) are considered the primary innate immune cells. Objectives: PBMCs derived from goats were infected with PPRV and analyzed to detect the relationship between PPRV replication and apoptosis or the inflammatory response. Methods: Quantitative real-time polymerase chain reaction was used to identify PPRV replication and cytokines expression. Flow cytometry was conducted to detect apoptosis and the differentiation of CD4⁺ and CD8⁺ T cells after PPRV infection. Results: PPRV stimulated the differentiation of CD4⁺ and CD8⁺ T cells. In addition, PPRV induced apoptosis in goat PBMCs. Furthermore, apoptosis and the inflammatory response induced by PPRV could be suppressed by Z-VAD-FMK and Z-YVAD-FMK, respectively. Moreover, the virus titer of PPRV was attenuated by inhibiting caspase-1-dependent apoptosis and inflammation. Conclusions: This study showed that apoptosis and the inflammatory response play an essential role in PPR viral replication in vitro, providing a new mechanism related to the cell host response.