• Biomolecules & Therapeutics
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• v.28 no.4
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• pp.320-327
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• 2020

In current study, we aimed to investigate whether the gentiopicroside (GPS) derived from Gentiana manshurica Kitagawa could block the progression of alcoholic hepatic steatosis to fibrosis induced by chronic ethanol intake. C57BL/6 mice were fed an ethanol-containing Lieber-DeCarli diet for 4 weeks. LX-2 human hepatic stellate cells were treated with GPS 1 h prior to transforming growth factor-β (TGF-β) stimulation, and murine hepatocyte AML12 cells were pretreated by GPS 1 h prior to ethanol treatment. GPS inhibited the expression of type I collagen (collagen I), α-smooth muscle actin (α-SMA) and tissue inhibitor of metal protease 1 in ethanol-fed mouse livers with mild fibrosis. In addition, the imbalanced lipid metabolism induced by chronic ethanol-feeding was ameliorated by GPS pretreatment, characterized by the modulation of lipid accumulation. Consistently, GPS inhibited the expression of collagen I and α-SMA in LX-2 cells stimulated by TGF-β. Inhibition of lipid synthesis and promotion of oxidation by GPS were also confirmed in ethanol-treated AML12 cells. GPS could prevent hepatic steatosis advancing to the inception of a mild fibrosis caused by chronic alcohol exposure, suggesting GPS might be a promising therapy for targeting the early stage of alcoholic liver disease.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.5
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• pp.47-53
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• 2020

The purpose of this study was to increase product reliability by improving the durability of the breech block for a 30mm Automatic Gun. The breech block is a key component of a gun that functions as chambering, closing, and extracting. The breech block requires high reliability, which needs to be improved because cracks of a breech block can occur early in operation. Cause analysis confirmed that the crack is caused by repeated impacts. Therefore, the following improvement measures were studied, and the effects were demonstrated using a firing test. The energy of impact absorption was increased by changing the material, and the stress concentration was mitigated by increasing the value of R. In addition, the fatigue life was increased by adding Shot-peening, deleting chromium plating, and changing the forging method. The firing test did not show firing trouble for up to 5,000 rounds. The start timing of the crack was delayed, and the depth was small. Therefore, the improved product was more durable than the existing product. This study can be used as a useful reference when assessing the improvement of the durability of similar products, life study, and criteria for crack acceptance.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.11
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• pp.66-76
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• 2009

The motion estimation in video encoding system occupies the biggest part. So, we require the motion estimator with efficient structure for real-time operation. And for motion estimator's implementation, it is desired to design hardware module of an exclusive use that perform the encoding process at high speed. This paper proposes motion estimation detection block(MED), 41 SADs(Sum of Absolute Difference) calculation block, minimum SAD calculation and motion vector generation block based on parallel processing. The parallel processing can reduce effectively the amount of the operation. The minimum SAD calculation and MED block uses the pre-computation technique for reducing switching activity of the input signal. It results in high-speed operation. The MED and 41 SADs calculation blocks are composed of adder tree which causes the problem of critical path. So, the structure of adder tree has changed the most commonly used ripple carry adder(RCA) with carry skip adder(CSA). It enables adder tree to operate at high speed. In addition, as we enabled to easily control key variables such as control signal of search range from the outside, the efficiency of hardware structure increased. Simulation and FPGA verification results show that the delay of MED block generating the critical path at the motion estimator is reduced about 19.89% than the conventional strukcture.

• Asian-Australasian Journal of Animal Sciences
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• v.29 no.12
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• pp.1761-1767
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• 2016

Two experiments were conducted to evaluate effects of coated compound proteases (CC protease) on apparent total tract digestibility (ATTD) of nitrogen (N) and energy, and apparent ileal digestibility (AID) of amino acids (AA) and nutrients in diets for pigs. In Exp. 1, 12 crossbred barrows (initial body weight: $20.79{\pm}1.94kg$) were housed in individual metabolism crates and allotted into 2 treatments with 6 piglets per treatment according to weight in a randomized complete block design. The 2 diets were corn-soybean meal basal diets with (0.2 g/kg) or without CC protease supplementation. The CC protease supplementation increased (p<0.05) the digestible and metabolizable N and energy values and the digestibility and retention rate of N in the diet. The ATTD of energy and nutrients had been improved (p<0.05) in the diet supplemented with CC protease. In Exp. 2, 12 crossbred barrows (initial body weight: $20.79{\pm}1.94kg$), fitted with T-cannulas at the distal ileum, were blocked by body weight into 2 groups with 6 pigs each. The diets were the same as those in Exp. 1. The CC protease increased (p<0.05) the AID of crude protein and some essential AA including arginine, isoleucine and leucine. The AID and ATTD of energy and nutrients had been improved (p<0.05) by supplemental CC protease, but the hindgut digestibility of nutrients was unaffected. Overall, the CC protease improved the ATTD of N and energy and AID of some indispensible AA and nutrients in the corn-soybean meal diet for pigs. Therefore, the CC protease supplement could improve the utilization of protein in the corn-soybean meal diet and thus contribute to lower N excretion to the environment.

• World Technopolis Review
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• v.2 no.2
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• pp.81-95
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• 2013

This paper seeks to build on previous work conducted by Porter, Devol, Florida, Bahrami and Evans, Wennberg and Lindqvist, and others contained in the literature, to construct a new way of looking at innovation cluster development. It seeks to describe the key elements contained in the research that serve as building blocks for innovation clustering, adding analysis dimensions that aim to further illuminate understanding of this process. It compares those building block characteristics to the innovation topography of U.S. urban centers, to shed light on a new framework through which urban innovation cluster formation can be considered. It identifies three building block analysis categories: 1) Technological Capability and Capacity (TCC); 2) Intellectual Propulsion Capacity (IPC); and 3) Structural Creative Inspiration (SCI). These three pillars form the architecture for creation of a Strategic Innovation Network (SIN), upon which clustering can be systematically analysed and built. The purpose of the SIN is to optimally organize and connect all available resources that include physical, financial, and human, such that innovation clustering is inspired, encouraged, nurtured, and ultimately constructed as fully functioning socio-economic organisms that provide both local and regional benefits. It is designed to aid both private enterprise and public policy leaders in their strategic planning considerations, and to enhance urban economic development opportunities.

• Journal of Korea Society of Digital Industry and Information Management
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• v.12 no.3
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• pp.125-132
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• 2016

The European Telecommunication Standards Institute (ETSI) Technical Committee (TC) Reconfigurable Radio Systems (RRS) is standardizing the multi-mode Mobile Device (MD). The configuration of multi-mode MD is determined by the downloaded mobile communication standard software. In this paper, we introduce the Radio Library concept for multi-mode MD which is one of the key components of RRS standard. This paper also introduces the Standard Functional Block which is a part of Radio Library. A method for selecting efficiency SFBs for multi-mode MD is presented and a Radio Library is generated based on the selected SFBs. This paper also shows sample Standard Functional Block Set which included in Radio Library. In order to verify the compatibility of the generated Radio Library which was made by C language, we implement the LTE Rel-10 and Wi-Fi(802.11b) to show the efficiency of generating a mobile communication standard software based on the Radio Library. Then using the Prograph Visual Programming MartenTM 1.6.4, we compiled our LTE Rel-10 and Wi-Fi(802.11b) source code.

• Journal of Engineering Education Research
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• v.21 no.1
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• pp.77-89
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• 2018

The chromosomes of all the world are the same in all 24 pairs, but the key, skin color and appearance are different. Also, it is the resistance of adult disease, diabetes, cancer. In 1953, Watson, Crick of Cambridge University experimentally discovered a DNA double helix structure, and in 1962, They laureates the Nobel Prize. In 1964, Temin, University of Wisconsin, USA, experimentally identified the ability to copy gene information from RNA to DNA and received the Nobel Prize in 1975. In this paper, we analyzed 24 pairs of DNA chromosomes using mathematical matrices based on the combination order sequence of four groups, and designed the Taegeuk pattern genetic code for the first time in the world. In the case of normal persons, the middle Yin-Yang taegeuk is designed as a block circulant Jacket matrix in DNA, and the left-right and upper-lower pairs of east-west and north-south rulings are designed as pair complementary matrices. If (C U: A G) chromosomes are unbalanced, that is, people with disease or inheritance become squashed squirming patterns. In 2017, Professor Michel Young was awarded a Nobel by presenting a biological clock and experimentally explained the bio-imbalance through a yellow fruit fly experiment.This study proved mathematical matrices for balanced and unbalanced RNA.

• International Journal of Control, Automation, and Systems
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• v.1 no.4
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• pp.495-502
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• 2003

This paper focuses on the implementation of an efficient tracking method of a moving object using optimal representative blocks by way of a pan-tilt camera. The key idea is derived from the fact that when the image size of a moving object is shrunk in an image frame according to the distance between the mobile robot camera and the object in motion, the tracking performance of a moving object can be improved by reducing the size of representative blocks according to the object image size. Motion estimations using Edge Detection (ED) and Block-Matching Algorithm (BMA) are regularly employed to track objects by vision sensors. However, these methods often neglect the real-time vision data since these schemes suffer from heavy computational load. In this paper, a representative block able to significantly reduce the amount of data to be computed, is defined and optimized by changing the size of representative blocks according to the size of the object in the image frame in order to improve tracking performance. The proposed algorithm is verified experimentally by using a two degree-of- freedom active camera mounted on a mobile robot.

• Journal of Korea Multimedia Society
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• v.17 no.12
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• pp.1402-1411
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• 2014

Buyer-seller watermarking protocol is defined as the practice of imperceptible altering a digital content to embed a message using watermarking in the encryption domain. This protocol is acknowledged as one kind of copyright protection techniques in electronic commerce. Buyer-seller watermarking protocol is fundamentally based on public-key cryptosystem that is operating using the algebraic property of an integer. However, in general usage, digital contents which are handled in watermarking scheme mostly exist as real numbers in frequency domain through DCT, DFT, DWT, etc. Therefore, in order to use the watermarking scheme in a cryptographic protocol, digital contents that exist as real number must be transformed into integer type through preprocessing beforehand. In this paper, we presented a new watermarking scheme in an encrypted domain in an image that is based on the block-DCT framework and homomorphic encryption method for buyer-seller watermarking protocol. We applied integral-processing in order to modify the decimal layer. And we designed a direction-adaptive watermarking scheme by analyzing distribution property of the frequency coefficients in a block using JND threshold. From the experimental results, the proposed scheme was confirmed to have a good robustness and invisibility.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.4
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• pp.551-558
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• 2003

An efficient and reliable subspace iteration algorithm using the block algorithm is proposed. The block algorithm is the method dividing eigenpairs into several blocks when a lot of eigenpairs are required. One of the key for the faster convergence is carefully selected initial vectors. As the initial vectors, the proposed method uses the modified Ritz vectors for guaranteering all the required eigenpairs and the quasi-static Ritz vectors for accelerating convergency of high frequency eigenvectors. Applying the quasi-static Ritz vectors, a shift is always required, and the proper shift based on the geometric average is proposed. To maximize efficiency, this paper estimates the proper number of blocks based on the theoretical amount of calculation in the subspace iteration. And it also considers the problems generated in the process of combining various algorithms and the solutions to the problems. Several numerical experiments show that the proposed subspace iteration algorithm is very efficient, reliable ,and accurate.