• Journal of Preventive Medicine and Public Health
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• 제30권4호
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• pp.852-869
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• 1997

This study was conducted to develop and evaluate the reliability and the validity of a questionnaire in order to determine the applicability as a screening tool for estimating environmental exposure and health effects related to air pollution. The questionnaire was developed with adopting some items of others such as ISAAC or ATS-DLD. And then we performed test-retest to 89 middle school students and their mothers at interval of three months. Cohen's Kappa values, weighted Kappa values, Spearman's correlation coefficients, and Pearson's correlation coefficients for each item were computed as reliability coefficients. The validity coefficients and validity coefficient bounds were also obtained by simply using these reliability coefficients. As results, Kappa ranged broadly from 0.10 to 0.61 of the items 'diet', $0.52\sim0.79$ of the environmental tobacco smoke, $0.39\sim0.44$ of the functional categories of surrounding environment, and $0.39\sim0.44$ of the using transportation systems; these items were regarded as confounding factors. For items related to health outcomes, Kappa ranged from -0.02 to 0.37 in the respiratory system of past medical history, and from 0.11 to 0.55 in the current health status. But Kappa of the others were over 0.60. In conclusion, if some items can be corrected or modified, the questionnaire developed in this study can be used as a tool for evaluating environmental exposure and health effects associated with air pollution.

• 한국지진공학회논문집
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• 제10권1호
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• pp.33-39
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• 2006

본 연구는 경주부근에서 일어난 3개의 지진 (1999년 4월 24일, 규모 3.3, 6개 관측소; 1999년 6월 2일, 규모 4.0, 14개 관측소; 1999년 9월 12일, 규모 3.2, 7개 관측소)으로부터 27개의 관측된 지반진동 자료를 이용하여 지진원 및 지진파감쇄특성 변수값을 분석하였다. 본 연구에서는 구하고자 하는 모든 값을 동시에 비선형적으로 분석하기 위해 LM (Levenberg -Marquardt) 역산방법을 적용하였고 전단파 에너지를 이용하였다. 3개지진의 평균 응력강하값은 약48-bar이고 본 연구에 이용된 모든 관측소 부지부근 지진파감쇄 ${\kappa}$값의 평균은 0.0312-sec로 분석되었다. 또한 광역 지진파감쇄값인 Qo 과 ${\eta}$값은 각각 417 및 0.83으로 분석되었다. 특히 지진파감쇄 ${\kappa}$값은 미국 동부지역 대푯값 보다 훨씬 크고 미국 서부지역 대푯값 보다 약간 작은 값을 보여주고 있어 관측소 부지증폭 특성에 대한 분석자료가 있으면 보다 의미있는 결과를 얻을 수 있다고 판단된다. 본 연구에서 분석된 지진원 및 지진파감쇄 특성 변수값들은 지배방정식의 차이 등으로 인해 기존의 연구결과와 일부 파라메타값에 있어서 다소 커다란 차이를 보여주고 있다.

• Journal of Nutrition and Health
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• 제42권3호
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• pp.246-255
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• 2009

식품섭취빈도조사지는 식품 목록 종류의 구성방식에 띠라 식품을 기초로 한 조사지와 음식을 기초로 한 두가지 형태로 나누는데, 식품을 기초로 한 조사지는 유지류와 양념류의 영양소를 반영하지 못한다는 문제점이 지적되고 있다. 이 연구는 유지류와 양념류가 대상자 영양소 섭취량과 섭취 분포에 미치는 영향을 파악하고자, 한 농촌지역에서 식생활 요인 평가를 위해 개발하여 사용되고 있는 음식을 기초로 한 식품 빈도조사지를 이용하여, 1) 전체 영양소 섭취량, 2) 유지류를 제외한 영양소 섭취량, 3) 유지류와 양념류를 제외한 영양소 섭취량, 위의 3가지 형태의 영양소 섭취량을 산출하여 영양소 섭취량의 비교와 상관성, 영양소 섭취 분포 일치도를 분석하였다. 그 결과, 총 영양소 섭취량과 유지류를 제외한 영양소 섭취량을 비교하였을 때, 유지류를 제외한 경우, 열량, 식물성지방, 비타민 E 섭취량이 유의하게 낮아졌고, 단순 카파지수는 각각 0.95 (${\kappa}{\omega}$ = 0.98), 0.64 (${\kappa}{\omega}$ = 0.81), 0.59 (${\kappa}{\omega}$ = 0.79) 였다. 유지류와 양념류를 모두 제외한 영양소 섭취량과 총 영양소 섭취량과 비교하면, 유지류와 양념류를 모두 제외하였을 때, 유지류와 양념류에 포함되어 있지 않은 영양소인 동물성 단백질, 동물성 지방, 레티놀을 제외한 대부분의 영양소의 섭취량이 유의하게 낮았고, 그 중 식물성 지방 (K = 0.64, ${\kappa}{\omega}$ = 0.81), 비타민 E (K = 0.59, ${\kappa}{\omega}$ = 0.79), 나트륨 (K = 0.61, ${\kappa}{\omega}$ = 0.80)의 단순 카파지수는 0.8 이하로 다른 영양소에 비해 상대적으로 낮았다. 영양소 섭취 분포 일치도는 열량 보정 후에 조정 전보다 더 낮아졌다. 이상의 연구 결과, 유지류와 양념류를 포함하지 않은 경우 식물성 지방, 비타민 E, 나트륨의 섭취량을 저 평가하였고, 대상자의 영양소 섭취 수준의 분포에 영향을 미쳤다. 따라서, 유지류나 양념류의 조사가 없는 식품기반 식품섭취빈도 조사를 이용하여 질병과의 연관성을 분석할 경우 결과에 대한 해석에 주의해야 한다.

• Biomolecules & Therapeutics
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• 제22권4호
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• pp.334-340
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• 2014

In this study, 23 oleanane-type triterpenoid saponins were isolated from a methanol extract of the roots of Pulsatilla koreana. The NF-${\kappa}B$ inhibitory activity of the isolated compounds was measured in $TNF{\alpha}$-treated HepG2 cells using a luciferase reporter system. Compounds 19-23 inhibited $TNF{\alpha}$-stimulated NF-${\kappa}B$ activation in a dose-dependent manner, with $IC_{50}$ values ranging from $0.75-8.30{\mu}M$. Compounds 19 and 20 also inhibited the $TNF{\alpha}$-induced expression of iNOS and ICAM-1 mRNA. Moreover, effect of the isolated compounds on PPARs transcriptional activity was assessed. Compounds 7-11 and 19-23 activated PPARs the transcriptional activity significantly in a dose-dependent manner, with $EC_{50}$ values ranging from $0.9-10.8{\mu}M$. These results suggest the presence of potent anti-inflammatory components in P. koreana, and will facilitate the development of novel anti-inflammatory agents.

• 상하수도학회지
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• 제25권5호
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• pp.635-642
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• 2011

Hydraulic efficiency was a vital component in evaluating the disinfection capability of clearwell. Current practice evaluates these system based on the tracer test only. In this paper, CFD(Computational Fluid Dynamics) was applied on the clearwell for alternating or supplementing the tracer test. The baffle factor derived from the CFD modeling closely matched the values obtained from full scale tracer testing. And, for suggesting proper numerical model in clearwell; the turbulence model, discretization scheme, convergence criteria were investigated through separate simulation runs. The model validation was conducted by comparing the simulated data with experimental data. In the turbulence model, the realizable ${\kappa}-{\varepsilon}$ model and the standard ${\kappa}-{\varepsilon}$ model were found to be more appropriate than RNG ${\kappa}-{\varepsilon}$ model. The residuals of convergence criteria should be used as not $10^{-3}$ but $10^{-4}$ or $10^{-5}$. In discretization scheme, the difference of simulated values in 1st, 2nd, 3rd upwind scheme was found to be insignificant. Moreover, the result of this study suggest that CFD modeling can be a reliable alternative to tracer testing for evaluating the hydraulic efficiency.

• Bulletin of the Korean Chemical Society
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• 제32권12호
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• pp.4397-4402
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• 2011

The NF-${\kappa}B$ system of transcription factors plays a crucial role in inflammatory diseases, making it an important drug target. We combined quantitative structure activity relationships for predicting the activity of new compounds and quantitative dynamic models for the NF-${\kappa}B$ network with intracellular concentration models. GFA-MLR QSAR analysis was employed to determine the optimal QSAR equation. To validate the predictability of the $IKK{\beta}$ QSAR model for an external set of inhibitors, a set of ordinary differential equations and mass action kinetics were used for modeling the NF-${\kappa}B$ dynamic system. The reaction parameters were obtained from previously reported research. In the IKKb QSAR model, good cross-validated $q^2$ (0.782) and conventional $r^2$ (0.808) values demonstrated the correlation between the descriptors and each of their activities and reliably predicted the $IKK{\beta}$ activities. Using a developed simulation model of the NF-${\kappa}B$ signaling pathway, we demonstrated differences in $I{\kappa}B$ mRNA expression between normal and different inhibitory states. When the inhibition efficiency increased, inhibitor 1 (PS-1145) led to long-term oscillations. The combined computational modeling and NF-${\kappa}B$ dynamic simulations can be used to understand the inhibition mechanisms and thereby result in the design of mechanism-based inhibitors.

• 한방안이비인후피부과학회지
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• 제30권4호
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• pp.97-103
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• 2017

Objectives : To identify whether pattern identification using nasal endoscopy for rhinitis can be applied as a tool for evaluating rhinitis in routine care setting, we performed a inter-rater reliability study on this pattern identification. Methods : Two Korean medicine doctors assessed 290 left/right nasal endoscopy photograph cases of rhinitis patients with pattern identification using nasal endoscopy. This pattern identification consist of four assessment items, nasal membrane color(pale/hyperemia), nasal membrane humidity(dryness/dampness), rhinorrhea(watery/yellow), and turbinate membrane edema(atrophic/edematous). Cohen's kappa statistic and Percentage agreement were used to evaluate the inter-rater reliability. Results : Inter-rater percentage agreement and Kappa coefficient for left nasal endoscopy photograph cases was from 'slight' to 'moderate'(% agreement: 40.00-67.59%/Kappa: 0.06-0.407). Only the agreement of 'rhinorrhea (watery/yellow)' item was moderate(% agreement: 67.59%/Kappa: 0.407). Inter-rater percentage agreement and Kappa coefficient for right nasal endoscopy photograph cases was also from 'slight' to 'moderate'(% agreement: 42.41-68.97%/Kappa: 0.109-0.465). Only the agreement of 'rhinorrhea(watery/yellow)' item was moderate(% agreement: 68.97%/Kappa: 0.465). Conclusions : It is necessary to resolve problems such as cut-off value setting, bipolar evaluation values(pale/hyperemia, dryness/dampness, watery/yellow, atrophic/edematous) and weighting items. Further rigorous studies that overcome the limitations of the current research are warranted.

• 대한물리의학회지
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• 제5권3호
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• pp.477-485
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• 2010

Purpose : The clinical scale to assess spasticity of muscle was wildly used the modified Ashworth scale (MAS). But reliability of the MAS has been controverted for ambiguity among the grades. The purpose of this study was to establish the inter-rater reliability of the modified MAS (MMAS) translated into Korean in stroke patients. Methods : Twenty-five patients (sixteen men and nine women) with hemiplegia (ten right and fifteen left) were measured by two raters who were physical therapist in the rehabilitation hospital. The raters assessed spasticity of shoulder adductor, elbow flexor, wrist flexor, hip adductor, knee extensor, and ankle plantar flexor in the same patients according to ratings criteria of the MAS and the MMAS. Results : For the inter-rater reliability of the MAS, two raters agreed on 57.3% and the Kappa values were moderate ($\kappa$=0.41) between two rater. The inter-rater reliability of the MAS was fair for the wrist flexor and the hip adductor and moderate for the other muscles. The intra-rater reliability was good for the shoulder adductor and the knee extensor and moderate for the other muscles. For the inter-rater reliability of the MMAS, two raters agreed on 84.7% and the Kappa values were good ($\kappa$=0.78) between two rater. The inter-rater reliability of the MMAS was moderate for the hip adductor, and good for the shoulder adductor and the wrist flexor, and very good for the other muscles. The intra-rater reliability was good for the wrist flexor and the hip adductor and very good for the other muscles. Conclusion : This study suggests that the MMAS translated into Korean is reliable test scale for the spasticity with stroke patients in the clinical field.

• 치위생과학회지
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• 제15권3호
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• pp.377-382
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• 2015

본 연구는 노인 64명을 대상으로 Qraycam을 이용한 이미지로 치면세균막 지수를 측정하여 착색 검사와의 신뢰도를 평가하고자 하였으며, 수집된 자료를 분석하여 다음과 같은 결과를 얻었다. 측정 방법, 측정 부위, 지수유형별에 따른 치면세균막 지수의 각 측정값 사이에 높은 일치도가 나타났다. 측정 방법에 따른 전치부 순면의 Quigley-Hein index와 PCR의 평균은 유의한 차이가 없었으며, 측정 부위에 따른 Quigley-Hein index와 PCR의 평균은 통계적으로 유의한 차이가 있었다(p<0.001). Qraycam 검사와 착색 검사의 지수유형별 kappa계수를 확인한 결과 kappa값의 평균은 Quigley-Hein index 0.90, PCR 0.84로 전체적으로 높은 일치도를 보였다. Qraycam과 착색 검사의 전치부 순면 및 전체 치아를 Quigley-Hein index와 PCR로 측정하였을 때, 변수 간 ICC는 1에 가까운 결과를 보였다. 본 연구 결과 측정방법, 측정 부위, 지수유형별에 따른 치면세균막 지수의 일치도 평가에서 모든 측정값의 일치도가 높게 나타났다. 따라서 Qraycam은 치면세균막 검사 시 screening 도구로서 충분한 신뢰도가 있음을 확인하였다.

• Communications for Statistical Applications and Methods
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• 제10권2호
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• pp.341-352
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• 2003

Collecting data through experiment, the observers are an import source of measurement error and the inference on the measure of agreement, say kappa, is necessary. The models commonly used are complicated general mixture model, which have many nuisance parameters. Orthogonalization of parameters reduce the effect of nuisance parameter. Orthogonalization of estimating function gives the same effect as the parameter orthogonalization. In this study, the method for orthogonalization of estimating equation is studied and applied to the Beta-binomial model to examine the properties of the estimate of kappa. As a result, the likelihood function is insensitive to the change of the nuisance parameter and bias is smaller than the result of m.1.e. when kappa has extreme values