• The Journal of Pediatrics of Korean Medicine
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• v.33 no.2
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• pp.22-31
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• 2019

Objective This study is to learn the effects of Hataedock method using Coptidis rhizoma and Glycyrrhiza uralensis mixed extract on inflammatory response in allergic rhinitis-induced obese NC/Nga mice. Materials and Methods The mice were fed with high fat-diet to be obese, and were divided into 3 groups as follows; allergic rhinitis-induced obese mice group with Hataedock method (CGT, n=10), no treatment group (Ctrl), allergic rhinitis elicited obese mice group (ARE). To induce allergic rhinitis, NC/Nga mice of 3 weeks age were sensitized on 7, 8 and 9 weeks by ovalbumin antigen in intraperitoneal space. After 7 days of final sensitization, allergic rhinitis was initially induced in mice through nasal cavities for 5 days. After 1-week, allergic rhinitis was induced again by the same method. Histological examination was used to identify distribution of IL-4, CD40, STAT6, $Fc{\varepsilon}RI$, substance P, MMP-9, NF-${\kappa}B$ p65, iNOS and COX-2. Results Hataedock method significantly reduced IL-4, STAT6 and CD40 response (p<0.05). In CGT, the inhibition of Th2 differentiation decreased inflammatory mediators such as $Fc{\varepsilon}RI$, substance P, MMP-9, NF-${\kappa}B$ p65, iNOS and COX-2 (all p<0.05). The immunological improvement led reduction of respiratory epithelial damage and mucin secretion in goblet cell. Conclusion The results of this study show that the Hataedock method suppresses the expression of allergic rhinitis by decreasing the inflammatory mediators through the regulation of Th2 differentiation even when the inflammation reaction is increased by obesity. Therefore, Hataedock may have potential preventive measure of allergic rhinitis accompanied by obese.

• Annals of Occupational and Environmental Medicine
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• v.35
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• pp.35.1-35.11
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• 2023

Background: Cardio-cerebrovascular diseases (CVDs) are the most common cause of death worldwide. Various CVD risk assessment tools have been developed. In South Korea, the Korea Occupational Safety & Health Agency (KOSHA) and the National Health Insurance Service (NHIS) have provided CVD risk assessments with health checkups. Since 2018, the KOSHA guide has stated that NHIS CVD risk assessment tool could be used as an alternative of KOSHA assessment tool for evaluating CVD risk of workers. The objective of this study was to determine the correlation and agreement between the KOSHA and the NHIS CVD risk assessment tools. Methods: Subjects of this study were 17,485 examinees aged 20 to 64 years who had undergone medical examinations from January 2021 to December 2021 at a general hospital. We classified subjects into low-risk, moderate-risk, high-risk, and highest-risk groups according to KOSHA and NHIS's CVD risk assessment tools. We then compared them with cross-analysis, Spearman correlation analysis, and linearly weighted kappa coefficient. Results: The correlation between KOSHA and NHIS tools was statistically significant (p-value < 0.001), with a correlation coefficient of 0.403 and a kappa coefficient of 0.203. When we compared risk group distribution using KOSHA and NHIS tools, CVD risk of 6,498 (37.1%) participants showed a concordance. Compared to the NHIS tool, the KOSHA tool classified 9,908 (56.7%) participants into a lower risk category and 1,079 (6.2%) participants into a higher risk category. Conclusions: In this study, KOSHA and NHIS tools showed a moderate correlation with a fair agreement. The NHIS tool showed a tendency to classify participants to higher CVD risk group than the KOSHA tool. To prevent CVD more effectively, a higher estimation tool among verified CVD risk assessment methods should be selected and managements such as early intervention and treatment of risk factors should be performed targeting the high-risk group.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.31 no.3
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• pp.115-128
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• 2019

In this study, a probabilistic model for the estimation of yearly workable wave condition period for offshore operations is developed. In doing so, we first hindcast the significant wave heights and peak periods off the Ulsan every hour from 2003.1.1 to 2017.12.31 based on the meteorological data by JMA (Japan Meterological Agency) and NOAA (National Oceanic and Atmospheric Administration), and SWAN. Then, we proceed to derive the long term significant wave height distribution from the simulated time series using a least square method. It was shown that the agreements are more remarkable in the distribution in line with the Modified Glukhovskiy Distribution than in the three parameters Weibull distribution which has been preferred in the literature. In an effort to develop a more comprehensive probabilistic model for the estimation of yearly workable wave condition period for offshore operations, wave height distribution over the 15 years with individual waves occurring within the unit simulation period (1 hour) being fully taken into account is also derived based on the Borgman Convolution Integral. It is shown that the coefficients of the Modified Glukhovskiy distribution are $A_p=15.92$, $H_p=4.374m$, ${\kappa}_p=1.824$, and the yearly workable wave condition period for offshore work is estimated to be 319 days when a threshold wave height for offshore work is $H_S=1.5m$. In search of a way to validate the probabilistic model derived in this study, we also carry out the wave by wave analysis of the entire time series of numerically simulated significant wave heights over the 15 years to collect every duration periods of waves the height of which are surpassing the threshold height which has been reported to be $H_S=1.5m$ in the field practice in South Korea. It turns out that the average duration period is 45.5 days from 2003 to 2017, which is very close to 46 days from the probabilistic model derived in this study.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2579-2584
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• 2007

A digital micro holographic particle tracking velocimetry (HPTV) system consisting of a high-speed camera and a single laser with acoustic optical modulator (AOM) chopper was established. The digital micro HPTV system was applied to water flow in a micro curved-tube for measuring instantaneous 3-D velocity field data consecutively. The micro curved-tube is using to reproduce the dorsal aorta or utilize in various lap-on-a-chip. The temporal evolution of a three-dimensional water flow in the micro curved-tube (the curvature, ${\kappa}$=1/${\phi}$, 2/${\phi}$, 4/${\phi}$, 8/${\phi}$) of 100 ${\mu}m$ and 300 ${\mu}m$ inner diameters was obtained and mean velocity field distribution was obtained by statistical-averaging the instantaneous velocity fields.

• Transactions of the Korean Society of Mechanical Engineers
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• v.5 no.2
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• pp.88-93
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• 1981

The three force components of shear spinning are calculated by a newly proposed deformation model. The spinning process is understooed as shearing deformation arter uniaxial yuelding by ending, and shear stress .tau.$\sub$rz/ becomes .kappa. the yueld limit in pure shear, in the deformation zone. The tangential forces are calculated and then the feed forces and normal foeces are obtained by assuming a nuiform distribution of roller pressure on the contact surface. An optimum contact area is obtaned by minimizing the bending energy required to obtain the assumed deformation mechanism. The calculated forces are compared with experimental data form published literature and present experiments. Good agreement cetween calculated and experimental values for working forces is obtained over a wide range of process variables.

• 한국연소학회:학술대회논문집
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• 1999.10a
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• pp.139-148
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• 1999

In oder to analyze the effect of operating conditions on pulverized coal combustion, a numerical study is conducted at the pulverized coal combustor. Eulerian approach is used for the gas phase, whereas Lagrangian approach is used for the particle phase. Turbulence is modeled using standard ${\kappa}-{\varepsilon}$ model. The description of species transport and combustion chemistry is based on the mixture fraction/probability density function(PDF) approach. Radiation is modeled using P-l model. The turbulent dispersion of particles is modeled using discrete random walk model. Swirl number of secondary air affects the flame front, particle residence time and carbon conversion. Primary/Secondary air mass ratio also affects the flame front but little affects the carbon conversion and particle residence time. Air-fuel ratio only affects the flame front due to lack of oxygen. Radiation strongly affects the flame front and gas temperature distribution because pulverized coal flame of high temperature is considered.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.2168-2173
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• 2003

Pressure balancing valve is one of important control devices, which is fully automatic and no manual controls, regulating or adjustments are needed. It is typically used to maintain constant temperature of working fluid in power and chemical plants and domestic water supply systems. Pressure balancing valve is composed of body, cylinder and balancing piston. Therefore, the balancing piston shapes are important design parameters for a pressure balancing valve. In this study, numerical and experimental analyses are carried out with two different balancing piston shapes. Especially, the distribution of static pressure is investigated to calculate the flow coefficient($C_v$). The governing equations are derived from making using of three-dimensional Navier-Stokes equations with standard ${\kappa}-{\varepsilon}$ turbulence model and SIMPLE algorithm. Using commercial code, PHOEIC, the pressure and flow fields in pressure balancing valve are depicted.

• Journal of Power System Engineering
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• v.10 no.2
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• pp.16-21
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• 2006

On this study, numerical analysis was performed for the 3 dimensional flow field of gas and particle phase for axial inlet cyclone, a part of dust collector. We applied FVM to visualize the gas phase. The flow was solved using ${\kappa}-{\varepsilon}$ turbulence model. The major parameters considered in this study were helical guide vane, inner diameter, length. Particle trajectory calculations were performed for the particle sizes of $5{\mu}m{\sim}75{\mu}m$. The distribution curve of particle sizes was made of Rosin-Rammler function. The simulation results show various gas flows, particle trajectories on numerical models.

• The Journal of Korean Medicine
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• v.23 no.4
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• pp.169-185
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• 2002

Objectives: This study was carried out to investigate 1he effects of Sasammaickmoondong-tang(SME) on colonic mucosal lesions induced by indomethacin in mouse. Methods: The normal group is 1hat no inflammation elicitated mouse. Control group is that gastro-inflammation elicitated mouse. Sample group is that SME administered mouse after gastro-inflammation elicitation. Results: In the common morphology and histochemical change, control group was observed various injury-mucous surface cell, micro-villi, paneth cell, surface epithelial cell, goblet cell-by hemorrhagic erosion, while sample group was as same as normal group. In the immunohistochemical change, 1he distributions of COX-1, Bcl-2, and BrdU treated with SME noticeably increased than control group(P<0.05). The distributions of TUNEL, $NF-{\kappa}B$, COX-2, $IL-2R-\alpha$, NK-1.1, ICAM-1, and CD11b/18 treated with SME noticeably decreased than control group(P<0.05). And the distribution of SBA was as same as normal group. Conclusions: According to the above results, it is supposed that Sasammaickmoondong-tang is applicable to colonic mucosal lesions.

• Journal of the Korean Applied Science and Technology
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• v.29 no.1
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• pp.33-39
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• 2012

A numerical simulation of plume from a stack into atmospheric cross flow is investigated using a two-dimension model. The simulation is based on the ${\kappa}{\sim}{\varepsilon}$ turbulence model and a finite volume method. In this paper, it mostly researches how the wind velocity affects the flue gas diffusion from an 80 m high stack. Wind velocity is one of the most important factors for flue gas diffusion. The plume shape size, the injection height, the NO pollutant distribution and the concentration at the near ground are presented with two kinds of wind velocities, 1 m/s and 5 m/s. It is found that large wind velocity is better for flue gas diffusion, it generates less downwash. Although the rise height is lower, the pollutant dilutes faster and more sufficient.