• Journal of Korean Medicine Rehabilitation
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• v.23 no.3
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• pp.55-68
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• 2013

Objectives This study was to investigate the effects of Yuhyangjeongtong-san on the carrageenin-induced acute inflammation and adjuvant-induced arthritis in rats. Methods Acute inflammation was induced by injection of 2% carrageenin 0.15 ml into right hind foot of rats. Control group was carrageenin injected and taken distilled water, treated group was carrageenin injected and taken Yuhyangjeongtong-san by orally once. 2 hours after injection, plantar temperature and paw volume were measured. 3 hours after, counts of white blood cell (WBC) were performed. Arthritis was induced by injection of complete freund's adjuvant (CFA) into base of tail. Control group was CFA injected and taken distilled water, treated group was CFA injected and taken Yuhyangjeongtong-san by orally for 10 days. 0,5,10 day, body weight, thickness of ankle joint and paw edema were measured. 10 day, counts of WBC, $interleukin-1{\beta}$ ($IL-1{\beta}$) and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) level were analysed. Histochemical study of NADPH-d and immunohistochemical study of c-fos were performed. Results In the carrageenin-induced acute inflammation, neutrophils of treated group were significantly decreased compared with control group. In the adjuvant-induced arthritis, paw edema, total counts of WBC and TNF-${\alpha}$ level in paw exudates were significantly decreased compared with control group, and the number of c-fos positive neurons of treated group was significantly decreased compared with control group. Conclusions On the basis of these results, we concluded that Yuhyangjeongtong-san have anti-arthritic and anti-inflammatory effects.

• Journal of the Korean association of regional geographers
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• v.8 no.4
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• pp.468-479
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• 2002

This study attempts to characterize Taebaek mountainous region as a natural unit, relating to morphoclimatic milieu and landform development patterns of the mountains of each lithologic type. In the case of granitic mountains of Nothern parts of this region, the slopes presents more or less steep or irregular profile because of abundant microforms of exposed bedrocks and blocks. The development of such landscape is essentially due to differential weathering, associated with difference of joint density. In the case of gneissic mountains, the slopes are well regularized straight steep ones, due not only to generalized superficial weathering but also to massmovement of weathered materials. In the Middle parts of this region, especially in Taegwallyong area, with frequent alternations both of freezing-thawing and of snow accumulation-melting, the roles played by cryo-nival processes proved to be important in weathering of granite as well as in morpho-pedogenesis. In this area, weathered mantle, developed by cryogenic activity under humid condition of nival environment, covered almost all over the slopes. Although Southern parts of this region consist of limestone, on the mountainous volume, distribution of Karst forms are limited while predominate none karst forms such as cockpit type peaks, V-shaped type valleys dissecting steep slopes covered with thin deposits in thickness containing rock debris.

• Transactions of Materials Processing
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• v.29 no.5
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• pp.257-264
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• 2020

This paper is concerned with the influence of the plastic property of the rivet on the numerical prediction of the Self-Piercing Rivet (SPR) Joining. In order to predict the plastic property of the rivet, a ring compression specimen was directly fabricated from the rivet used for the mechanical joining of dissimilar materials, and the FE analysis together with the ring compression test was iteratively carried out by changing the plastic property of the rivet. For reliable FE analysis, a friction coefficient was estimated based on a friction calibration curve, measuring the reductions in inner diameter and height of the ring specimen after the compression test. From each simulation result, the force-displacement curves were then compared from each other so as to obtain the rivet plastic property that shows good agreement with the experimental result. The SPR joining between GA590 1.0t and Al5052 2.0t was conducted, and the numerical prediction was performed with the use of the plastic property evaluated based on the inverse analysis and the one referred from Mori et al. [11]. Comparison of the experiment and the numerical predictions in terms of the interlock and bottom thickness revealed that the reliable evaluation of the plastic property of the rivet is necessary for the trustworthy numerical prediction of the SPR joining.

• Biomolecules & Therapeutics
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• v.21 no.4
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• pp.290-298
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• 2013

This study examined the effects of calcium (Ca) gluconate on collagen-induced DBA mouse rheumatoid arthritis (CIA). A single daily dose of 200, 100 or 50 mg/kg Ca gluconate was administered orally to male DBA/1J mice for 40 days after initial collagen immunization. To ascertain the effects administering the collagen booster, CIA-related features (including body weight, poly-arthritis, knee and paw thickness, and paw weight increase) were measured from histopathological changes in the spleen, left popliteal lymph node, third digit and the knee joint regions. CIA-related bone and cartilage damage improved significantly in the Ca gluconate-administered CIA mice. Additionally, myeloperoxidase (MPO) levels in the paw were reduced in Ca gluconate-treated CIA mice compared to CIA control groups. The level of malondialdehyde (MDA), an indicator of oxidative stress, decreased in a dose-dependent manner in the Ca gluconate group. Finally, the production of IL-6 and TNF-${\alpha}$, involved in rheumatoid arthritis pathogenesis, were suppressed by treatment with Ca gluconate. Taken together, these results suggest that Ca gluconate is a promising candidate anti-rheumatoid arthritis agent, exerting anti-inflammatory, anti-oxidative and immunomodulatory effects in CIA mice.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.5
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• pp.483-487
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• 2014

In this study, joining methods with SiC powder as the joining adhesives were studied in order to avoid the residual stresses coming from CTE (Coefficient of Thermal Expansion) mismatch between substrate and joining layer. The shear strength and microstructure of joined material between SiC substrates are investigated. The commercial Hexoloy-SA (Saint-Gobain Ceramics, USA) used in this work as substrate material. The fine ${\beta}$-SiC nano-powder which the average particle size is below 30 nm, $Al_2O_3$, $Y_2O_3$, and $SiO_2$ were used as joining adhesives. The specimens were joined with 20MPa and $1400-1900^{\circ}C$ by hot pressing in argon atmosphere. The shear test was performed to investigate the bonding strength. The cross-section of the joint was characterized by using an optical microscope and scanning electron microscopy (SEM).

• International Journal of Highway Engineering
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• v.6 no.1 s.19
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• pp.25-36
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• 2004

The total length of paved roads in Korea is 67,265 Km, and among these roads, about 40% of the national highways and 98% of local roads are paved with asphalt concrete. The major distress to asphalt pavement is rutting and fatigue crack. The permanent deformation including rutting accounts for about 75% of this distress. UTW(Ultra-Thin Whitetopping), which is known for its high-quality performance in asphalt pavement with rutting and cracking, seems to reduce maintenance costs significantly if it is used as the maintenance/repair method for domestic asphalt pavement. In the research, static load test was conducted to establish a behavior of Whitetopping under traffic and environmental condition. It showed that the effect of the thickness of the concrete layer and the temperature change was significant. In addition, the tensile strain as the wheel load position was close to interior and edge of concrete slab were increased up to 75% of maximum tensile strain. It showed that joint spacing must be considered in UTW design procedure.

• International Journal of Highway Engineering
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• v.11 no.3
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• pp.151-161
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• 2009

This study was conducted to investigate the characteristics of the curling behavior of long-span pavement slabs under environmental loads. By developing and using finite element models of the long-span pavement slabs, the stress distribution and the effects of slab length, slab thickness, stiffness of underlying layers, and the restraints of the slab ends on the curling behavior were analyzed. In addition, the field experiments were performed with the actual long-span pavement slab to obtain the curling behavior of the real structure under environmental loads. As a result of this study, it was found that the vertical displacements of the long-span pavement slab along the centerline due to the curling behavior were zero except for the areas near the slab ends, and the curling stresses were maximum and constant where the displacements were zero. The slab length and the stiffness of underlying layers did not affect the maximum curling stresses. The restraints at the slab ends made the curling stresses occur near the slab ends, but did not much affect the maximum curling stresses.

• Journal of Korean Society of Steel Construction
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• v.14 no.4
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• pp.481-487
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• 2002

Currently, the load transfer's mechanism from a beam to a column has yet to ve clarified in a concrete filled steel tubular (CFT) structure with a connection type of an exterior diaphragm. The loads for each floor are transferred to the concrete core from a steel beam through ha contacted face between an in-filled concrete and the interior surface of a steel tube. Thus, a Push-Out test was performed to investigate the load transfer mechanism. A total of 30 samples were tested to confirm the bond stress and/or axial load distribution between a steel tube and in-filled concrete for CFT column. The main parameters considered for this study included concrete type, steel tube-shape/length, and the effect of a weld joint wit ha backing strip for a column splice. Test results were summarized to confirm load transfer behavior between a concrete and steel tube for each experimental parameter, using the analytical approach to verify experimental results.

• Journal of the Korea institute for structural maintenance and inspection
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• v.15 no.2
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• pp.179-188
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• 2011

Steel structures have been allowed to have fatigue damage tolerance in fact. If it would be assessed whether fatigue crack is growing or not and How fast fatigue crack is propagating, we should make a rational decision on methods and a period of reinforcement in the maintenance. In this study, fatigue crack growth tests on two kinds of through-thickness cracked steel plates and a out-of-plane gusset welded joint were conducted to evaluate fatigue crack growth rate using the COD(Crack Opening Displacement), and COD measurement using strain gauges was examined to offer a practical method. As a result, we proposed a reasonable assessing method for fatigue crack growth rate using the COD and it was experimentally proved practical to estimate the COD through measuring strains.

• Journal of the Korea institute for structural maintenance and inspection
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• v.19 no.3
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• pp.122-129
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• 2015

In this study, a prediction model for the effective compressive strength of corner columns with intervening normal strength concrete slabs was developed. A structural analogy between high-strength concrete column-normal strength concrete slab joint and brick masonry was used to develop the prediction model. In addition, the aspect ratio of slab thickness to column dimension was considered in the models. The reliability of the new prediction model was evaluated by comparison with experimental results and its superiority was demonstrated by comparison with previous models proposed by design codes and other researchers. As a result, with average test-to-predicted ratios of 1.09, a standard deviation of 0.15, the newly developed equation provided superior predictions in terms of accuracy and consistency over all of the existing effective strength prediction approaches including KCI structural concrete design code (2012).