• Asian-Australasian Journal of Animal Sciences
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• 제24권2호
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• pp.285-294
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• 2011

The abatement of methane emission from ruminants is an important global issue due to its contribution to greenhouse gas with carbon dioxide. Methane is generated in the rumen by methanogens (archaea) that utilize metabolic hydrogen ($H_2$) to reduce carbon dioxide, and is a significant electron sink in the rumen ecosystem. Therefore, the competition for hydrogen used for methanogenesis with alternative reductions of rumen microbes should be an effective option to reduce rumen methanogenesis. Some methanogens parasitically survive on the surface of ciliate protozoa, so that defaunation or decrease in protozoa number might contribute to abate methanogenesis. The most important issue for mitigation of rumen methanogenesis with manipulators is to secure safety for animals and their products and the environment. In this respect, prophylactic effects of probiotics, prebiotics and miscellaneous compounds to mitigate rumen methanogenesis have been developed instead of antibiotics, ionophores such as monensin, and lasalocid in Japan. Nitrate suppresses rumen methanogenesis by its reducing reaction in the rumen. However, excess intake of nitrate causes intoxication due to nitrite accumulation, which induces methemoglobinemia. The nitrite accumulation is attributed to a relatively higher rate of nitrate reduction to nitrite than nitrite to ammonia via nitroxyl and hydroxylamine. The in vitro and in vivo trials have been conducted to clarify the prophylactic effects of L-cysteine, some strains of lactic acid bacteria and yeast and/or ${\beta}$1-4 galactooligosaccharide on nitrate-nitrite intoxication and methanogenesis. The administration of nitrate with ${\beta}$1-4 galacto-oligosaccharide, Candida kefyr, and Lactococcus lactis subsp. lactis were suggested to possibly control rumen methanogenesis and prevent nitrite formation in the rumen. For prebiotics, nisin which is a bacteriocin produced by Lactococcus lactis subsp. lactis has been demonstrated to abate rumen methanogenesis in the same manner as monensin. A protein resistant anti-microbe (PRA) has been isolated from Lactobacillus plantarum as a manipulator to mitigate rumen methanogenesis. Recently, hydrogen peroxide was identified as a part of the manipulating effect of PRA on rumen methanogenesis. The suppressing effects of secondary metabolites from plants such as saponin and tannin on rumen methanogenesis have been examined. Especially, yucca schidigera extract, sarsaponin (steroidal glycosides), can suppress rumen methanogenesis thereby improving protein utilization efficiency. The cashew nutshell liquid (CNSL), or cashew shell oil, which is a natural resin found in the honeycomb structure of the cashew nutshell has been found to mitigate rumen methanogenesis. In an attempt to seek manipulators in the section on methane belching from ruminants, the arrangement of an inventory of mitigation technologies available for the Clean Development Mechanism (CDM) and Joint Implementation (JI) in the Kyoto mechanism has been advancing to target ruminant livestock in Asian and Pacific regions.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2311-2314
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• 2012

Genetic polymorphisms of uridine diphosphate-glucuronosyltransferases 1A6 (UGT1A6) and 1A7 (UGT1A7) may lead to genetic instability and colorectal cancer carcinogenesis. Our objective was to measure the interaction between polymorphisms of these repair genes and tobacco smoking in colorectal cancer (CRC). A total of 68 individuals with CRC and 112 non-cancer controls were divided into non-smoker and smoker groups according to pack-years of smoking. Genetic polymorphisms of UGT1A6 and UGT1A7 were examined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). We found a weak association of UGT1A6 polymorphisms with CRC risk (crude odds ratio [OR], 1.65;95% confidence interval [95% CI], 0.9-3.1, P=0.107; adjusted OR 1.95%, 95% CI 1.0-3.8, P=0.051). The ORs for the UGT1A7 polymorphisms were statistically significant (crude OR: 26.40, 95% CI: 3.5-198.4, P=0.001; adjusted OR: 21.52, 95% CI: 2.8-164.1, P=0.003). The joint effect of tobacco exposure and UGTIA6 polymorphisms was significantly associated with colorectal cancer risk in non-smokers (crude OR, 2.11; 95% CI, 0.9-5.0, P=0.092; adjusted OR 2.63, 95% CI, 1.0-6.7, P=0.042). In conclusion, our findings suggest that UGT1A6 and UGT1A7 gene polymorphisms are associated with CRC risk in the Japanese population. In particualr, UGT1A6 polymorphisms may strongly increase CRC risk through the formation of carcinogens not associated with smoking.

• 대한관절경학회지
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• 제10권2호
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• pp.214-218
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• 2006

목적: 급성 또는 재발성 슬개골 탈구의 치료에 있어서 내측 슬개-대퇴 인대의 해부학적 위치를 고려하여 견인 봉합술을 이용한 관절경적 내측 관절막 중첩술을 새롭게 고안하였기에 소개하고자 한다. 수술 술기: 관절경하에서 내측 슬개-대퇴 인대가 위치하는 부위의 내측 관절막에 봉합사를 관절 밖에서 안으로 통과시킨다. 슬개골에 유도강선으로 3개의 터널을 뚫는데, 그 관절내 입구가 슬개골의 내측 변연 상부 1/2에 위치하도록 한다. 관절 내로 들어와 있는 봉합사를 슬개골의 터널을 통해 관절 밖으로 빼내고, 봉합사에 긴장을 준 상태에서 적절한 정도로 외측 지대 유리술을 시행한 후 봉합사를 결찰한다. 결론: 본 술기는 최근 중요시되고 있는 내측 슬개-대퇴 인대를 봉합함으로써 내측 관절막 중첩술의 효과를 극대화시키고 슬개골의 아탈구 및 경사를 교정할 수 있으며, 최소 침습적이고 비교적 쉽고 간단하여 급성 또는 재발성 슬개골 탈구의 치료에 있어서 효과적인 술식으로 생각된다.

• 대한관절경학회지
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• 제9권1호
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• pp.60-64
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• 2005

목적: 굴곡 구축과 신전제한이 발생한 중노동 작업자에서 발견된 주관절 주두 골극과 상완골 주두와 골곡 사이의 충돌을 발견하고 이 병변이 주관절 신전장애에 미치는 영향과 제거 효과를 파악하고자 하였다. 대상 및 방법: 무거운 물건을 들어올리는 중노동자에서 발생한 통증을 수반하는 신전제한을 갖은 주관절에 대하여 관절경을 시술하였다. 6명 7예를 대상으로 하였으며 환자의 평균 연령은 43 세였다. 내원 당시 동통을 동반한 관절운동 제한을 호소하였으며 평균 관절운동 범위는 굴곡구축 $17^{\circ}$, 후속 굴곡 $87^{\circ}$였다. 결과: 전 예에서 술 후 2개월 추시상 평균 굴곡구축 $2^{\circ}$($15^{\circ}$ 호전), 후속굴곡 $122^{\circ}$($35^{\circ}$ 호전)를 보였으며 술 후 1년 추시상 평균 굴곡구축 $3^{\circ}$($14^{\circ}$ 호전), 후속굴곡 $113^{\circ}$($26^{\circ}$ 호전)의 호전을 얻을 수 있었다. 얻어진 관절 운동 범위 내에서는 동통이 없는 상태를 보였으며, 합병증은 발견되지 않았다. 결론: 만성 반복성 외상에 의해 발생된 주관절 후방부의 퇴행성 강직에 대하여 충돌부위만을 선택적으로 제거하는 방식은 관절운동회복과 동통의 경감에 있어서 효과적이고 조기 재활이 가능한 술식으로 사료된다.

• 대한정형도수물리치료학회지
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• 제14권2호
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• pp.1-15
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• 2008

Purpose : This survey was to investigate on the effect of each region changed in trunk through sagittal plane after Trunk Flexion-Extension Exercise. Methods : 18 students of Gimcheon College participated in this study for the period of July 9-30, 2007. Analyzed factor were 1) degree of pain 2) presence of Gillet test and 3) difference of right-left for 7 landmark region in trunk applying I.B.S.-2000 after Trunk Flexion - Extension Exercise. We used the SPSS $PC^+$ program for classifying into analysis of frequency, $x^2$-test, t-test and Simple Linear Regression analysis test. Results: Followings are concluded For degree of pain, 13(72.2%) of students answered "No pain" after Trunk Flexion-Extension Exercise and in the result 4 more students decreased the pain. In the Gillet test, 14(77.8%) of students answered "positive" after Trunk Flexion-Extension Exercise and in the result 4 more students increased mobility of Sacroiliac joint. In the differences of right-left for 7 landmark region in trunk by B.M.I. scale, Slim type was decreased both Acromion(0.45mm), both Iliac crest(0.44mm), and both ASIS(0.31mm) to anterior plane, Normal type was decreased both inferior angle of Scapular(0.02mm), both L4-5(0.07mm), and both PSIS(0.09mm) to posterior plane Fatness type was decrease both Acromion(0.05mm), both ASIS(0.05mm) to anterior plane. In the differences of right-left for 7 landmark region in trunk for degree of pain No pain group was decreased both Acromion(0.17mm), both Nipple(0.25mm) to anterior plane and both PSIS(0.13mm) to posterior plane Pain group was decreased both Acromion(0.04mm), both Iliac creast(0.03mm) to anterior plane and both inferior angle of Scapular(0.18mm) both PSIS(0.13mm) to posterior plane. In the difference of right-left for 7 landmark region in trunk for each of the exercises, Both iliac crest(0.1mm), both ASIS(0.12mm) to anterior plane were decreased after Flexion Trunk Exercise. Both acromion(0.27mm) to anterior plane, both inferior angle of scapular(0.14mm) and both PSIS(0.12mm) to posterior plane were decreased after Extension Trunk Exercise. Each of the exercises, The both inferior angle of Scapular showed high scores($0.65{\pm}0.23$) at Trunk Extension Exercise group and there was statistical significance between Trunk Flexion Exercise group and Extension exercise group(t :-2.502, p < 0.05). 7. At Pre-exercise group, Both inferior angle of Scapular showed low scores($0.23{\pm}8.27$) at Trunk Extension Exercise group and there was statistical significance between Pre- Exercise group and Trunk Extension Exercise group(t :-2.5430, p<0.05). Conclusion : The simple linear regression analysis was presented at Acromion(-0.243), L4-5(-0.753), PSIS(0.576) and there was statistical significance in BMI scale(p<0.01).

• 정보보호학회논문지
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• 제27권2호
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• pp.281-292
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• 2017

지속적인 북한의 사이버 공격에 대응해서 사이버 무기체계와 핵심기술의 연구개발 추진을 요구받고 있는 상황이다. 본 논문은 사이버 무기체계에 소요되는 핵심기술을 도출하고, 도출된 핵심기술들의 실현시기에 대한 영향 요인을 분석하였다. 9개의 핵심기술군, 36개의 핵심기술이 도출되었으며, 도출된 핵심기술군을 합동사이버작전교범의 작전단계와 록히드마틴의 사이버 킬체인과 비교해 본 결과, 누락된 요소가 없이 매핑되고 있음을 확인하였다. 핵심기술의 실현시기에 대한 각 요인별 영향도를 회귀분석한 결과, 핵심기술의 실현시기는 최고선진국 기술수준, 한국 기술수준, 국방에서 민간으로의 기술이전 가능성, 민간에서 국방으로의 기술이전 가능성이 높을수록 더 빨라지고, 선진국의 기술이전 기피도가 높을수록 더 늦어지며, 경제적 파급효과와는 유의미한 상관관계가 없는 것으로 확인되었다. 본 연구는 사이버무기 체계를 정식 무기체계로 편입시킨 전력발전훈령 개정 및 합참사이버작전교범 제정에 맞춰 사이버 무기체계의 핵심기술을 도출하고 핵심기술 실현시기의 영향 요인을 확인한 것에 의의가 있다.

• 한국산학기술학회논문지
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• 제18권12호
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• pp.434-442
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• 2017

본 연구는 부산지역 교정환자를 대상으로 부정교합의 종류와 교정치료에 대한 인식이 삶의 질에 미치는 영향을 파악하고, 부정교합의 종류에 따른 맞춤형 교육프로그램을 개발하여 삶의 질 향상의 기초자료로 삼고자 한다. 2015년 12월부터 약 6개월간 설문조사하여 최종 472부를 분석하였다. 연구결과는 부정교합의 가족력은 I급은 없음, II급, III급은 있음으로 응답하였고, 교육 실천은 자주실천에서 부정교합의 종류에 따른 차이를 보였다(p=0.003). 교정치료의 만족감에서는 불편감은 I급은 기간, II급과 III급은 통증(p=0.035)이였고, 통증부위에서는 치아가 가장 많았으나 II급에서 가장 높아 차이를 보였다(p<0.001). 교정치료 만족도에 따른 삶의 질에서는 현재 만족도가 높을수록, 자신감이 보통인 경우 삶의 질이 높았으며, 교정치료 시작 계기에서는 발음문제(p=0.013), 저작 불편감(p<0.001), 턱관절 소리(p<0.001)가 있는 경우 삶의 질이 낮았다. 구강건강관련 삶의 질에 미치는 요인으로는 교정치료시기(p<0.001), 현재 만족감(p<0.001), 자신감 변화(p=0.003), 주관적 치아상태(p=0.008), 교합의 종류(p=0.019)순으로 영향을 미쳤다. 따라서 교정치료를 받는 환자들의 구강건강 상태를 면밀하게 분석하고 맞춤형 교정상담프로그램을 통하여 교정기간에도 삶의 질을 향상시킬 수 있어야 한다.

• Restorative Dentistry and Endodontics
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• 제27권5호
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• pp.502-514
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• 2002

The aim of this study was to evaluate the marginal adaptation of direct class II sandwich restoration with packable composites(P-60), resin modified glass ionomer cement(Fuji-II LC), flowable compomer(Dyract Flow), flowable composites(Filtek Flow) in comparison with total bond restorations. In addition, for sandwich restorations, influence of different sandwich techniques was also evaluated. Large butt-joint box typed class II cavites with cervical margins 1mm below the cemento-enamel junction were cut into 70 extracted human molars. The cavities(7 groups, n=10) were filled using a closed/open sandwich restoration or total bond restoration technique with materials according to the manufacturer's recommandation using the single-component bonding agent for each system. Teeth were thermocycled 500 times between 5$^{\circ}C$ and 55$^{\circ}C$ with 30-second dwell time. The teeth were then coated with nail polish 1mm short of the restoration, placed in a 2% methylene blue for 24 hours, and sectioned with diamond wheel. Sections were examined with a stereoscope to determine the extent of microleakage. Dentine /Cementum margins were analyzed for microleakage on scale of 0(no leakage) to 4(entire axial wall) and interface between materials, on scale of 0(no leakage) to 3(axial wall). Results were evaluated with Kruskal Wallis Test, corrected for ties, to determine whether there were statistically significant differences among the seven groups. Pairs of groups were analyzed using the Student-Newman-Keuls Method and Dunn s Method. The results were as follows : 1. All groups showed some micoleakage in cervical portion. But there were no microleakage in interface between materials. 2. Closed sandwich restorations with Fuji-II LC and Filtek Flow had significantly lower leakage rating than total restorations with only P-60. However, open sandwich restorations with Dyract Flow showed significantly higher (P<0.05) 3. Closed sandwich restorations had significantly lower leakage rating than total restorations. However open sandwich restoration s showed significantly higher (P<0.05). 4. Sandwich restorations with Fuji-II LC were iou$.$or leakage than only P-60. Filtek Flow, Dyract Flow. But there were no statistically differences among the materials. From the results above, it could be concluded, closed sandwich restorations was effective in reducing microleakage of class II restorations. The best results showing the least microleakage were for the closed sandwich technique with Fuji-II LC and Filtek Flow.

• 유통과학연구
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• 제13권6호
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• pp.97-104
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• 2015

Purpose - The distribution of agricultural products is changing due to recent shifts in environmental free trade. Specifically, the competitiveness of domestic agricultural products has weakened as a result of the Korea-China Financial Trade Agreement. Agricultural producers are faced with increasing difficulties and organized production centers are growing in importance daily. To overcome this crisis, agricultural producer organizations are vying for environment-friendly agricultural certifications, Good Agriculture Practices (GAP) and Hazard Analysis and Critical Control Point (HACCP). In particular, as consumer demand for higher safety grows, farmers are increasing their certification rates. Therefore, this certification system is expected to help strengthen the competitiveness of agricultural producer organizations. Research design/data/methodology - Organized production centers are classified by certification. A survey was conducted with 91 organizations using factor analysis and logistic regression analysis for the examination. The factor analysis results are as follows. Raw material procurement, education·specialization, marketing, joint business, organizing ability, business management, effectiveness, certification, and larger organizations were classified as the nine types of factors. These factors affect the organized production centers and are used in the logistic regression analysis. The purpose of such research and analysis is to suggest a direction for future production center policies. Results - The basic statistical results are as follows: analysis of the producer organizations of 91 sites, average number of members per site of 1,624, and average sales of 25,961 million won. Additionally, the average income per farmer is 175 million won, and the pooling system rate is 53.5%. The factor analysis results are as follows. Factor 1 consists of contract cultivation, ongoing shipment, selection subdivision, traceability, and major retailer management. Factor 2 consists of manual cultivation, specialty selection, education program, and R&D. Factor 3 consists of advertising, various dealers, various sales strategies, and a unified sales counter. Factor 4 consists of agricultural materials co-purchase, policy support, co-shipment, and incentives. Factor 5 consists of the co-selection and pooling system. Factor 6 consists of co-branding and operating by the organization's article. Factor 7 consists of the buy-sell ratio and rate of operation of the agriculture promotion center. Factor 8 consists of bargaining power in volume and participation rate of farmer certification. Factor 9 consists of increasing new subscribers. The logistic regression analysis results are as follows. Considering the results by type of certification, the environment-friendly agricultural certification type and the GAP certification type have a (+) influence. GAP and HACCP certification types affecting the education·specialization factor have a (+) influence. Considering the results for each type of certification, the environment-friendly agricultural certification types on the effectiveness factor have (-) influence; the HACCP certification types on the organizing ability and effectiveness factor have a (-) influence. Conclusions - Agricultural producer organizations should develop plans as follows: The organizations need to secure education for agricultural production; increase the pooling system ratio for sustainable organizational development; and, finally, expand the number of agricultural producer organizations.

• Childhood Kidney Diseases
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• 제11권2호
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• pp.185-194
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• 2007

목 적 : HSP는 주로 소혈관을 침범하는 혈관염으로 대개 자연적으로 치유되지만 장기적 예후는 신장 침범의 정도에 달려 있으므로 신장 침범의 위험인자를 예측하고 예방하는 것이 중요하다. 이에 본 연구는 증상을 완화하기 위해 사용한 스테로이드가 HSP에서 신장 침범을 줄일 수 있는지를 알아보고자 하였다. 방 법 : 1993년 1월부터 2006년 12월까지 충북대학교병원 소아과에서 HSP로 진단 받은 환아를 대상으로 하여 스테로이드 사용 유무와 사용 기간, 지속성 자반의 유무에 따른 신장 침범의 유무와 정도를 분석하였다. 결 과 : 스테로이드 사용 유무와 사용 기간에 따른 신장 침범 빈도와 신장 침범 기간에는 유의한 차이가 없었다. 스테로이드의 사용 여부에 따른 신장 침범 양상을 보았을 때, 스테로이드를 사용한 경우에는 혈뇨가 많이 나타나고 사용하지 않은 경우에는 단백뇨가 많이 나타나는 경향을 보였으나 통계적으로는 유의한 차이가 없었다. 스테로이드의 사용과 자반의 지속성과는 유의한 관계가 없었다. 반면에 10일 이상의 지속성 자반이 있는 경우에 신장 침범이 유의하게 많은 것으로 나타났으며, 신장 침범의 기간도 지속성 자반이 있는 경우에 증가하는 것으로 나타났다. 결 론 : HSP로 진단받은 환아들에게 복통이나 관절통 등으로 스테로이드를 사용한 후 신장 침범의 유무를 비교해 본 결과, 스테로이드의 사용 여부와 사용 기간과는 유의한 결과를 보이지 않으므로 신장 침범에 대한 스테로이드의 예방효과는 없는 것으로 생각된다. 또한, 스테로이드 치료의 적응증이 아닌 자반의 지속성이 오히려 신장 침범의 유무와 기간과 관계있다는 사실은, 스테로이드가 신장 침범의 예방효과가 없음을 뒷받침해 주고 있다.