• International Journal of Industrial Entomology and Biomaterials
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• 제46권2호
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• pp.60-66
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• 2023

Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases and is more common in older and obese individuals. Silkworm male pupae exerts tonic effects by increasing testosterone secretion and the forced swimming time and muscle ratio increased in mice consuming silkworm pupae, which may be beneficial to the older population. Therefore, it will be beneficial to investigate the effects of silkworm pupal extracts (SPE) on OA. To confirm this effect, we prepared SPE in different solvents, and their ability to attenuate matrix metalloproteinases (MMPs) and inflammatory mediators (interleukin-6 [IL-6], interleukin-8 [IL-8] and tumor necrosis factor-α [TNF-α]) were evaluated in an interleukin-1β (IL-1β)-induced SW1353 human chondrosarcoma cell line. 70% ethanolic SPE outperformed the other solvents, reducing MMP-1 and MMP-3 expression by up to 53% and 13%, respectively. Further experiments were performed using 70% ethanolic SPE from three distinct pupation stages in males and females. SPE treatment alleviated MMP-1 expression (43.9-47.4%) regardless of pupation stage and sex. Among the inflammatory mediators, 70% ethanolic SPE alleviated IL-6 and TNF-α levels, and the concentrations thereof were lowest in the early-stage male SPE-treated group (43.15% and 56.74%, respectively). In conclusion, 70% ethanolic SPE may prevent IL-1β-induced osteoarthritis by inhibiting MMPs and inflammatory cytokines. Therefore, SPE is a potential therapeutic agent for the treatment of OA.

• 한방재활의학과학회지
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• 제33권3호
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• pp.17-32
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• 2023

Objectives The purpose of this study was to investigate the antioxidant, anti-inflammatory and cartilage regeneration effects of Euiiin-tang water extract (EIIT) in the treatment of monosodium iodoacetate (MIA)-induced osteoarthritis in rats. Methods Animal models were divided into five groups. The normal group didn't do any treatments causing osteoarthritis. The control group was orally administerd distilled water instead of the drug, the positive control group used indomethacin 5 mg/kg, the EIIT 100 group used EIIT 100 mg/kg and the EIIT 200 group used EIIT 200 mg/kg, and seven rats were placed per group. We administered drug to rats for 2 weeks and analyzed oxidative stress-related proteins in joint tissue. Inflammation mediators and inflammatory cytokines induced by the activity of inflammation-related proteins were analyzed. In addition, the expression of anti-inflammatory cytokines and collagen-related factors were analyzed, and H&E staining and Safranin-O staining were performed to see the effect on histopathological changes. Results 1) Oxidative stress-related proteins were significantly reduced. 2) Inflammationrelated proteins, inflammatory mediators and inflammatory cytokines were significantly reduced. 3) Anti-inflammatory cytokines were significantly increased. 4) Collagen proteolysis factors significantly decreased, and collagen degradation inhibitory factor was significantly increased. 5) EIIT administration significantly reduced cartilage degeneration and deformation in H&E staining, and reduced proteoglycan destruction in Safranin-O staining. Conclusions From the above experimental results, it judges that Euiiin-tang has antioxidant, anti-inflammatory, and cartilage regeneration effects on osteoarthritis in rats induced by MIA.

• Physical Therapy Rehabilitation Science
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• 제12권2호
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• pp.123-129
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• 2023

Objective: Kinesio tape has been applied to the ankle to improve balance and gait. Stroke patients show abnormal gait patterns due to foot drop. This study aimed to determine the effects of ankle balance taping which to support the ankle joint on balance and gait in patients with chronic stroke. Design: A randomized controlled trial. Methods: Twenty-four chronic stroke patients were selected and randomized into experimental group (n=12) and control group (n=12). The experimental group applied kinesio taping three times a week for three weeks, and the control group applied placebo taping for the same amount of time. To evaluate the effectiveness of the treatment, the subjects' walking ability, static balance, and dynamic balance were assessed before and after the experiment. Gait speed and spatiotemporal gait ability were measured to examine walking ability, postural sway velocity and velocity moment for static balance, and Timed-Up and Go test and Berg Balance Scale were conducted to check dynamic balance. Results: The experimental group showed a significant increase in walking ability, static balance, and dynamic balance in the within-group pre-post difference (p<0.05). In the between-group comparison, the experimental group had a significant difference in walking ability than the control group (p<0.05). Conclusions: Ankle balance taping can help improve gait, and this study can be used as a basis for future studies of ankle balance taping.

• Geomechanics and Engineering
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• 제32권4호
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• pp.375-385
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• 2023

There are many joint fissures distributed in the engineering rock mass. In the process of geological history, the underground rock mass undergoes strong geological processes, and undergoes complex geological processes such as fracture breeding, expansion, recementation, and re-expansion. In this paper, the damage-stick-slip process (DSSP), an analysis model used for rock mass failure slip, was established to examine the master control and time-dependent mechanical properties of the new and primary fractures of a multi-fractured rock mass under the action of stress loading. The experimental system for the recemented multi-fractured rock mass was developed to validate the above theory. First, a rock mass failure test was conducted. Then, the failure stress state was kept constant, and the fractured rock mass was grouted and cemented. A secondary loading was applied until the grouted mass reached the intended strength to investigate the bearing capacity of the recemented multi-fractured rock mass, and an acoustic emission (AE) system was used to monitor AE events and the update of damage energy. The results show that the initial fracture angle and direction had a significant effect on the re-failure process of the cement rock mass; Compared with the monitoring results of the acoustic emission (AE) measurements, the master control surface, key blocks and other control factors in the multi-fractured rock mass were obtained; The triangular shaped block in rock mass plays an important role in the stress and displacement change of multi-fracture rock mass and the long fissure and the fractures with close fracture tip are easier to activate, and the position where the longer fractures intersect with the smaller fractures is easier to generate new fractures. The results are of great significance to a multi-block structure, which affects the safety of underground coal mining.

• Journal of Nutrition and Health
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• 제56권3호
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• pp.330-347
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• 2023

Purpose: This study identified words closely associated with the keyword "dietary supplement" (DS) using big data in Korean social media and investigated consumer perceptions and trends related to DSs before (2019) and after the coronavirus disease 2019 (COVID-19) pandemic (2021). Methods: A total of 37,313 keywords were found for the 2019 period, and 35,336 keywords were found for the 2021 period using blogs and cafes on Daum and Naver. Results were derived by text mining, semantic networking, network visualization analysis, and sentiment analysis. Results: The DS-related keywords that frequently appeared before and after COVID-19 were "recommend", "vitamin", "health", "children", "multiple", and "lactobacillus". "Calcium", "lutein", "skin", and "immunity" also had high frequency-inverse document frequency (TF-IDF) values. These keywords imply a keen interest in DSs among Korean consumers. Big data results also reflected social phenomena related to DSs; for example, "baby" and "pregnant woman" had lower TD-IDF values after the pandemic, suggesting lower marriage and birth rates but higher values for "joint", indicating reduced physical activity. A network centered on vitamins and health care was produced by semantic network analysis in 2019. In 2021, values were highest for deficiency and need, indicating that individuals were searching for DSs after the COVID-19 pandemic due to a lack an awareness of the need for adequate nutrient intake. Before the pandemic, DSs and vitamins were associated with healthcare and life cycle-related topics, such as pregnancy, but after the COVID-19 pandemic, consumer interests changed to disease prevention and treatment. Conclusion: This study provides meaningful clues regarding consumer perceptions and trends related to DSs before and after the COVID-19 pandemic and fundamental data on the effect of the pandemic on consumer interest in dietary supplements.

• 공연문화연구
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• 제38호
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• pp.225-248
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• 2019

<짐가제굿>은 함경도의 망묵굿에서 구송되는 무가로, '살(煞)이 들어오는 걸 막는 거리'로 알려져 있다. <짐가제굿>은 서사의 길이가 짧고 조사된 각편의 수가 적으며 추가 조사 또한 어렵다. 이에 <짐가제굿> 연구는 현재도 연행되며 서사가 유사한 <차사본풀이>와의 비교 속에서 이루어졌다. <짐가제굿>을 보다 온전히 이해하기 위해서는 <짐가제굿>을 중심에 두고 논의되어야 하며, <짐가제굿>의 '살이 들어오는 걸 막는 거리'의 제의적 역할과 서사의 상관성 또한 주목할 필요가 있다. 이에 본고에서는 우선 <짐가제굿>의 서사 속 살을 막는 화소의 의미에 대해 살펴보았다. <짐가제굿>은 강림골이 주요 배경으로 나타나며, 마을 외부인의 죽음과 그 한을 해결하기 위한 일련의 과정 속에서, 개인의 문제가 마을의 문제로 확대되는 것을 확인하였다. 그로 인해 문제의 영향이 마을 전체에 미쳤으며, 마을 구성원 간에는 공포의 감정을 공유했다 이에 원혼의 해원, 악인의 징치와 더불어 살을 막아 마을 사람들의 두려움을 해소함으로써 완전한 해결이 이루어졌다고 논의했다. 나아가 <짐가제굿>은 개인굿인 망묵굿에서 구송되나 서사 속 살 막음의 의미를 통해, 이 거리는 그 제의적 기능이 개인굿의 범위를 넘어 마을의 안녕을 위한 거리로서 기능한다고 논하였다.

• Computers and Concrete
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• 제32권5호
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• pp.465-474
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• 2023

The point load test (PLT) is a widely-used alternative method in the field to determine the uniaxial compressive strength due to its simple testing machine and procedure. The point load test index can estimate the uniaxial compressive strength through conversion factors based on the rock types. However, the mechanism correlating these two parameters and the influence of the mechanical properties on PLT results are still not well understood. This study proposed a theoretical model to understand the mechanism of PLT serving as an alternative to the UCS test based on laboratory observation and literature survey. This model found that the point load test is a self-confined compression test. There is a compressive ellipsoid near the loading axis, whose dilation forms a tensile ring that provides confinement on this ellipsoid. The peak load of a point load test is linearly positive correlated to the tensile strength and negatively correlated to the Poisson ratio. The model was then verified using numerical and experimental approaches. In numerical verification, the PLT discs were simulated using flat-joint BPM of PFC3D to model the force distribution, crack propagation and BPM properties' effect with calibrated micro-parameters from laboratory UCS test and point load test of Berea sandstones. It further verified the mechanism experimentally by conducting a uniaxial compressive test, Brazilian test, and point load test on four different rocks. The findings from this study can explain the mechanism and improve the understanding of point load in determining uniaxial compressive strength.

• 한국컴퓨터정보학회논문지
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• 제28권12호
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• pp.183-189
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• 2023

본 연구의 목적은 리포머를 이용한 스쿼트 운동이 엉덩관절전치환술 환자의 근력, 관절가동범위 그리고 보행 능력에 미치는 영향을 알아보고자 하였다. 본 연구는 G시 소재의 재활병원에 입원 중인 환자 20명을 대상으로 실험을 실시하였다. 중재 방법으로 주 7회 2주간 실험군은 리포머를 이용한 스쿼트 운동을, 대조군은 스쿼트 운동을 시행하였다. 리포머군의 그룹 내 비교에서는 엉덩관절 굽힘, 폄, 벌림 근력에서 유의한 차이가 있었다(p<0.05). 리포머군의 엉덩관절 폄과 벌림의 관절가동범위와 보행에서도 그룹 내 유의한 차이가 있었다(p<0.05). 그룹 간 비교에서는 엉덩관절 폄 근력, 엉덩관절 폄, 벌림 관절가동범위 그리고 보행에서 유의한 차이가 발생하였다(p<0.05).

• 대한물리치료과학회지
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• 제30권3호
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• pp.1-13
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• 2023

Background: The bridge exercise prevents repeated damage to the tissues around the spine by reducing stimulus transmission to the ligaments and joint capsules, thereby alleviating back pain. It also contributes to strengthening the muscles of the lower extremities. Design: A Single Subject experience design. Methods: This study was conducted on 28 healthy adults in their 20s to 30s and conducted at St. Mary's Hospital in C City from May to July 2021. Four types of bridge exercise were performed in this study: the normal bridge exercise and bridge exercises with 0.5%, 1%, or 1.5% body weight resistance applied on the pelvis through manual resistance during the bridge exercise and to determine the effect of resistance applied in the bridge exercise on the activation of the trunk and lower extremities muscles. Results:This study showed that the muscle activity of the trunk and lower extremities improved significantly in response to stronger resistance when manual resistance equivalent to 0.5%, 1%, or 1.5% of body weight was applied during the bridge exercise compared to when the normal bridge exercise was performed. Conclusion: This study shows that manual resistance can be applied as an effective method of bridge exercise since muscle activity in the trunk and lower extremities increases when manual resistance causing isometric contraction is applied.

• 한국환경과학회지
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• 제33권6호
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• pp.417-425
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• 2024

This study investigated the effects of various planting models on the joint cultivation of eggplant (Solanum melongena) and marigold (Tagetes erecta)to enhance sustainable rooftop urban farming. Rooftop agriculture is increasingly valued to boost the food supply and benefit the environment. Integrating such practices into urban planning is viewed as a way to sustainably manage resources and improve the food-energy-water cycle in cities. The experiment was conducted on a rooftop in Chungju, South Korea from May to August. Four different planting setups were used: central eggplant with peripheral marigold (SET), eggplant with a protective net (SIC), central marigold with peripheral eggplant (TES), and control with only eggplant (CON S). These models tested the effects of companion planting versus monoculture using a lightweight soil mix ideal for rooftops made from cocopeat and perlite and enriched with organic fertilizer. Measurements focused on soil conditions and plant health and assessed soil temperature, moisture, conductivity, plant height, width, and leaf size. The results indicated that the SET modelyielded the best growth. This setup benefited from marigold pest control properties and its ability to improve soil conditions by enhancing moisture and nutrient levels and aiding eggplant growth. These findings underscore the potential of mixed planting on rooftops and suggest that such approaches can be effectively incorporated into urban agriculture to boost yield and environmental sustainability. This study supports the idea that diverse planting methods can significantly affect plant growth and promote urban greening and food security.